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Conserved domains on  [gi|24656255|ref|NP_647748|]
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Autophagy-related 2, isoform A [Drosophila melanogaster]

Protein Classification

Chorein_N and ATG_C domain-containing protein( domain architecture ID 10576638)

protein containing domains Chorein_N, ATG2_CAD, and ATG_C

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
1814-1902 1.74e-30

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


:

Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 116.45  E-value: 1.74e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656255   1814 PKDLREGVANAYTIVREGINESANTLIEAAITEHDQKGYSGAVGAVVRQIPQLVVCPAVLATQATTNILGGAKSSLIPEA 1893
Cdd:pfam09333    8 PEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVRNQLDPEN 87

                   ....*....
gi 24656255   1894 KLEARDKWK 1902
Cdd:pfam09333   88 RRESEDKYK 96
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
13-117 2.38e-22

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


:

Pssm-ID: 463646  Cd Length: 116  Bit Score: 93.78  E-value: 2.38e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656255     13 KMCRYLLQRYLGQFFENnLNLEQLKVDLYNGKAVVEDIFLKVNAFNDLfedqGWAFEVVSGHIGRLTVVVPWNALMTNDS 92
Cdd:pfam12624    3 SLVASLLNRYLGEYVEN-LDPDQLKVGLWSGDVVLENLKLKKEALDKL----DLPIEVKSGHIGKLTLKIPWTNLKSEPV 77
                           90       100
                   ....*....|....*....|....*
gi 24656255     93 SLEIHNLTITLRPVTRYQSGTTMLE 117
Cdd:pfam12624   78 VIEIEDVYLLAVPKDESEEYDEEEE 102
ATG2_CAD super family cl16238
Autophagy-related protein 2 CAD motif; The Atg2 protein, an integral membrane protein, is ...
1116-1185 9.52e-03

Autophagy-related protein 2 CAD motif; The Atg2 protein, an integral membrane protein, is required for a range of functions including the regulation of autophagy in conjunction with the Atg1-Atg13 complex. Atg2 binds Atg9. The precise function of this region, with its characteriztic highly conserved CAD sequence motif, is not known.


The actual alignment was detected with superfamily member pfam13329:

Pssm-ID: 433120  Cd Length: 155  Bit Score: 38.76  E-value: 9.52e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656255   1116 IPVLNLGLLNISFRLNAEGSGQPRVDLRSSIHDMHLKTCYDSAAALAQLIAyvandrDLCPPEEPILNED 1185
Cdd:pfam13329   88 VSIGSISSAKVGVTVNENKDGEKSVDVEVRDDLLVLETCADSTQTLIQLLN------DLKPPTTPPSDEE 151
 
Name Accession Description Interval E-value
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
1814-1902 1.74e-30

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 116.45  E-value: 1.74e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656255   1814 PKDLREGVANAYTIVREGINESANTLIEAAITEHDQKGYSGAVGAVVRQIPQLVVCPAVLATQATTNILGGAKSSLIPEA 1893
Cdd:pfam09333    8 PEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVRNQLDPEN 87

                   ....*....
gi 24656255   1894 KLEARDKWK 1902
Cdd:pfam09333   88 RRESEDKYK 96
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
13-117 2.38e-22

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 93.78  E-value: 2.38e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656255     13 KMCRYLLQRYLGQFFENnLNLEQLKVDLYNGKAVVEDIFLKVNAFNDLfedqGWAFEVVSGHIGRLTVVVPWNALMTNDS 92
Cdd:pfam12624    3 SLVASLLNRYLGEYVEN-LDPDQLKVGLWSGDVVLENLKLKKEALDKL----DLPIEVKSGHIGKLTLKIPWTNLKSEPV 77
                           90       100
                   ....*....|....*....|....*
gi 24656255     93 SLEIHNLTITLRPVTRYQSGTTMLE 117
Cdd:pfam12624   78 VIEIEDVYLLAVPKDESEEYDEEEE 102
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
18-87 3.13e-05

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 49.50  E-value: 3.13e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656255   18 LLQRYLGQFFENnLNLEQLKVDLYNGKAVVEDIFLKVNAFNDLfedqGWAFEVVSGHIGRLTVVVPWNAL 87
Cdd:COG5043    9 LLNRLLGSYVEN-FDTKQLNVGVWGGDVSLHNLRIKPSALDKL----GLPIEVTSGLIGTLTLEIPWSSL 73
ATG2_CAD pfam13329
Autophagy-related protein 2 CAD motif; The Atg2 protein, an integral membrane protein, is ...
1116-1185 9.52e-03

Autophagy-related protein 2 CAD motif; The Atg2 protein, an integral membrane protein, is required for a range of functions including the regulation of autophagy in conjunction with the Atg1-Atg13 complex. Atg2 binds Atg9. The precise function of this region, with its characteriztic highly conserved CAD sequence motif, is not known.


Pssm-ID: 433120  Cd Length: 155  Bit Score: 38.76  E-value: 9.52e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656255   1116 IPVLNLGLLNISFRLNAEGSGQPRVDLRSSIHDMHLKTCYDSAAALAQLIAyvandrDLCPPEEPILNED 1185
Cdd:pfam13329   88 VSIGSISSAKVGVTVNENKDGEKSVDVEVRDDLLVLETCADSTQTLIQLLN------DLKPPTTPPSDEE 151
 
Name Accession Description Interval E-value
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
1814-1902 1.74e-30

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 116.45  E-value: 1.74e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656255   1814 PKDLREGVANAYTIVREGINESANTLIEAAITEHDQKGYSGAVGAVVRQIPQLVVCPAVLATQATTNILGGAKSSLIPEA 1893
Cdd:pfam09333    8 PEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVRNQLDPEN 87

                   ....*....
gi 24656255   1894 KLEARDKWK 1902
Cdd:pfam09333   88 RRESEDKYK 96
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
13-117 2.38e-22

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 93.78  E-value: 2.38e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656255     13 KMCRYLLQRYLGQFFENnLNLEQLKVDLYNGKAVVEDIFLKVNAFNDLfedqGWAFEVVSGHIGRLTVVVPWNALMTNDS 92
Cdd:pfam12624    3 SLVASLLNRYLGEYVEN-LDPDQLKVGLWSGDVVLENLKLKKEALDKL----DLPIEVKSGHIGKLTLKIPWTNLKSEPV 77
                           90       100
                   ....*....|....*....|....*
gi 24656255     93 SLEIHNLTITLRPVTRYQSGTTMLE 117
Cdd:pfam12624   78 VIEIEDVYLLAVPKDESEEYDEEEE 102
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
18-87 3.13e-05

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 49.50  E-value: 3.13e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656255   18 LLQRYLGQFFENnLNLEQLKVDLYNGKAVVEDIFLKVNAFNDLfedqGWAFEVVSGHIGRLTVVVPWNAL 87
Cdd:COG5043    9 LLNRLLGSYVEN-FDTKQLNVGVWGGDVSLHNLRIKPSALDKL----GLPIEVTSGLIGTLTLEIPWSSL 73
ATG2_CAD pfam13329
Autophagy-related protein 2 CAD motif; The Atg2 protein, an integral membrane protein, is ...
1116-1185 9.52e-03

Autophagy-related protein 2 CAD motif; The Atg2 protein, an integral membrane protein, is required for a range of functions including the regulation of autophagy in conjunction with the Atg1-Atg13 complex. Atg2 binds Atg9. The precise function of this region, with its characteriztic highly conserved CAD sequence motif, is not known.


Pssm-ID: 433120  Cd Length: 155  Bit Score: 38.76  E-value: 9.52e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656255   1116 IPVLNLGLLNISFRLNAEGSGQPRVDLRSSIHDMHLKTCYDSAAALAQLIAyvandrDLCPPEEPILNED 1185
Cdd:pfam13329   88 VSIGSISSAKVGVTVNENKDGEKSVDVEVRDDLLVLETCADSTQTLIQLLN------DLKPPTTPPSDEE 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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