|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
36-446 |
0e+00 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 686.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 36 VHHALVVIFLEFFAWGLLTMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPI 115
Cdd:cd17387 1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 116 PLMSINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTA 195
Cdd:cd17387 81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 196 IALLDVFFILVAVPESLSEKMRPASWGAPISWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMG 275
Cdd:cd17387 161 VALLDICFILLAVPESLPEKMRPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 276 FNYVEVSVFIAIVGILSITVQVTLGSFMQV-FGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITYPAISA 354
Cdd:cd17387 241 FEYEEVAAFIAVVGILSITAQTLLLSILMRsIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 355 FVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFNVDLNDDHDSHakSSGSRATNVEKISQHVPGPPFVFGALC 434
Cdd:cd17387 321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPVQ--SSKQRMQNPSLEGAIIPGPPFLFGAIS 398
|
410
....*....|..
gi 21357569 435 VFCAIIVSAFIP 446
Cdd:cd17387 399 VLLAILVASFIP 410
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
39-395 |
3.72e-55 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 187.79 E-value: 3.72e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 39 ALVVIFLEFFAWGLLtMPIISTLNQTF--PDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIP 116
Cdd:cd17330 1 LFLVVFLDALGFGIV-FPVLPFYVREFnkLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 117 LM--SINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALST 194
Cdd:cd17330 80 LLglSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 195 AIALLDVFFILVAVPeslsekmrpaswgapisweqadpflalrkvgtdkTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKM 274
Cdd:cd17330 160 ALALLNLVLVLFFLP----------------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRF 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 275 GFNYVEVSVFIAIVGILSITVQVTL-GSFMQVFGAKRTIIMGLALEIVQLLWYGFGS-QKWMMWSAGVVAALGSITYPAI 352
Cdd:cd17330 206 GFSPSQIGLLLALVGIAGILAQLLLiPRLAKRLGERKLLRLGLLLAIIGLLLLPFASsVPLLVLAAAILAFGTGIVFPAL 285
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 21357569 353 SAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFN 395
Cdd:cd17330 286 SALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG 328
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
39-394 |
7.17e-43 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 156.26 E-value: 7.17e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 39 ALVVIFLEFFAWGLLtMPIISTLNQTFPDHT---FLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPI 115
Cdd:cd17388 4 ILVTVLLDAMGIGLI-MPVLPTLLREFVGDSadaATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 116 PLM--SINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEmYGDT---LVV 190
Cdd:cd17388 83 LLMafAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRapfLVA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 191 ALSTAIALLDVFFILvavPESLSEKMRPASwgapiSWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYL 270
Cdd:cd17388 162 AGLNGLNFLLGLFVL---PESLPPERRRAF-----RWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 271 KLKMGFNYVEVSVFIAIVGILSITVQVTL-GSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITY 349
Cdd:cd17388 234 EDRFDWSPTMVGLSLAVFGLLHALFQAFVtGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAG 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 21357569 350 PAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLF 394
Cdd:cd17388 314 PALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAAS 358
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
40-394 |
9.87e-32 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 125.38 E-value: 9.87e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 40 LVVIFLEFFAWGLLtMPIISTLNQTFPDHTFLMnGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMS 119
Cdd:cd17325 2 SLALFLDMLGYGII-IPILPLYAESLGASVAQI-GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 120 I--NTWWFFAMISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAI 196
Cdd:cd17325 80 FatSYWQLLLARFLQGlASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 197 ALLDVFFILVAVPESLSEKmrpaswgAPISWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGF 276
Cdd:cd17325 160 ALLALVLALLLLPEPRPPP-------NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 277 NYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAISAF 355
Cdd:cd17325 233 SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGlGLVFPATLAL 312
|
330 340 350
....*....|....*....|....*....|....*....
gi 21357569 356 VSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLF 394
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
74-395 |
1.16e-28 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 116.56 E-value: 1.16e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--NTWWFFAMISISG-AFAVTFSVVFAYVADVT 150
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFahSPWLFAIALVLTGfGGGLFEPASEAMIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 151 TPEERSKAYGLASATFAASLVISPALGnALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSEKMRPaswgapiswEQA 230
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLG-GLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA---------EKT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 231 DPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKR 310
Cdd:cd17329 188 EILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRK 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 311 TIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITY-PAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGV 389
Cdd:cd17329 268 ILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVfPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGL 347
|
....*.
gi 21357569 390 VFYLFN 395
Cdd:cd17329 348 LLDLLG 353
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
40-382 |
2.36e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 115.07 E-value: 2.36e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 40 LVVIFLEFFAWGLLtMPIISTLNQTFpDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMS 119
Cdd:COG2814 16 ALGAFLSGLGIGIV-LPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 120 I--NTWWFFAMISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAI 196
Cdd:COG2814 94 LapSLWLLLAARFLQGlGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 197 ALLDVFFILVAVPESLSEKMRPASWgapisweqadpflALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGF 276
Cdd:COG2814 174 ALLALLLLLRLLPESRPAARARLRG-------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 277 NYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAISAF 355
Cdd:COG2814 241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQAL 320
|
330 340
....*....|....*....|....*..
gi 21357569 356 VSLYAAPESQGAVQGMITGMRGLCNGL 382
Cdd:COG2814 321 VAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
40-384 |
8.94e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 99.03 E-value: 8.94e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 40 LVVIFLEFFAWGLLTMPIISTLNQTFpDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLP--IPL 117
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 118 MSINTWWFFAMISISGAF-AVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAI 196
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 197 ALLDVFFILVAVPESLSEKMRPAswgAPISWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAgeyscMFVYLKLKMGF 276
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPA---EEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT-----YLPLYQEVLGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 277 NYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIV---QLLWYGFGSQKWMMWSAGVVAALG-SITYPAI 352
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGfGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|..
gi 21357569 353 SAFVSLYAAPESQGAVQGMITGMRGLCNGLGP 384
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
39-395 |
1.10e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 90.56 E-value: 1.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 39 ALVVIFLEFFAWGLLTMPIISTLNQTfpDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 118
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF--GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 119 SINT---WWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTA 195
Cdd:cd06174 79 AFAPsfwLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 196 IALLDVFFIL-VAVPESLSEKMRPaswgAPISWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKM 274
Cdd:cd06174 159 AALALLAAILlLLVVPDPPESARA----KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 275 GFNYVEVSVFIAIVGILSITVQVTLGSFMQ-VFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAI 352
Cdd:cd06174 235 GLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGlGGLLPLS 314
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 21357569 353 SAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFN 395
Cdd:cd06174 315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
71-394 |
1.09e-18 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 87.71 E-value: 1.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 71 LMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTclpipLMSINTWWF---FAMISIS----GAFAVTFSVVF 143
Cdd:cd17389 64 LFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGL-----AISYALWAVsrsFTIFLLSrivgGISKGNVSLST 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 144 AYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTA------IALLDVFFILVAVPESLSEKMR 217
Cdd:cd17389 139 AIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFFSMPalfalvLALADLLFIFFFLPETLPSNLR 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 218 PASWGApisweqadpFLALrkvgtdktvlmlcltVLLSYLpeagEYSCMFVyLKLKMGFNYVEVSVFIAIVGILSITVQv 297
Cdd:cd17389 219 RLGLVY---------FLYL---------------FLFSGL----EFTLTFL-THQRFQYTSMQQGKMFFFIGIIMALVQ- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 298 tlGSFMQ---VFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGS-ITYPAISAFVSLYAAPESQGAVQGMIT 373
Cdd:cd17389 269 --GGYVRrikPGKEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAaTVVPCLTTLVSGYGSDDQKGTVMGIFR 346
|
330 340
....*....|....*....|.
gi 21357569 374 GMRGLCNGLGPAVFGVVFYLF 394
Cdd:cd17389 347 SLGALARALGPIVACTVYWLA 367
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
74-391 |
8.07e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 81.83 E-value: 8.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSINTWWFFAMIS---ISGAFAVTFSVVFAYVADVT 150
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLAralAGLAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 151 TPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSEKMRPASwgapisweqa 230
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLG---------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 231 dPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKR 310
Cdd:cd17324 187 -LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 311 TIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAISAFVSlYAAPESQGAVQGMITGMRGLCNGLGPAVFGV 389
Cdd:cd17324 266 LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGfFAAHSALQTRVL-RLAPEARGLASSLYLAAYNLGGALGAALGGL 344
|
..
gi 21357569 390 VF 391
Cdd:cd17324 345 VL 346
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
42-391 |
9.26e-17 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 81.56 E-value: 9.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 42 VIFLEFFAWGLltmpiISTLNQTFPD--HTFLMNGLVMGIKGILSflsAPLIGALSDIWGRKFFLLVTVF-----FTCLP 114
Cdd:cd17386 7 IVFLYMFASVL-----SGPVTQNFVYaaNFYLYMNLMGSIPPLFS---SLFLGSWSDRYGRKPPLLMSLVglllsSLILV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 115 -IPLMSINT--WWFF---AMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTL 188
Cdd:cd17386 79 lIVYFTTVPsvWWFYlsaIPLALFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 189 VVALSTAIALLDVFFILVAVpeslsekmrpaswgapisweqadpflalrkvgtdKTVLMLCLTVLLSYLPEAGEYSCMFV 268
Cdd:cd17386 159 SFSISAALLLIALLYILFFL----------------------------------TLLILLLLAAFLTIFVLSGESDVLYL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 269 YLKLKMGFNYVEVSVFIAiVGILSITVQVTLG---SFMQVFGAKRTIIM-GLALEIVQLLWYGFGSQKWMMWSAGVVAAL 344
Cdd:cd17386 205 FVLEKFAWNVKDFSYFST-LGSLIYLTGMLGGvllLRCLLKMSDSTLAMlGLASHILSSLLFAFATNTWMMYLAAVVGMF 283
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 21357569 345 GSITYPAISAFVSLYAAPESQGAVQGMItgmrGLCNGLGPAVFGVVF 391
Cdd:cd17386 284 NGIVGPMIRSILSKLVPKSEQGKIFSLL----SVLESLSPLVASPIY 326
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
41-199 |
1.41e-16 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 80.73 E-value: 1.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 41 VVIFLEFFAWGLLtMPIISTLNQTFPDHTFLMnGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI 120
Cdd:cd17390 3 LVGFLDLFGVSMI-LPLLSTHIRSLGASPTVI-GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 121 NTWWFFAMIS--ISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIAL 198
Cdd:cd17390 81 STSLALLFLSriPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIF 160
|
.
gi 21357569 199 L 199
Cdd:cd17390 161 I 161
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
74-446 |
3.63e-16 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 80.72 E-value: 3.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSD----IWG-RKFFLLVTVFFTCLPIPLM--------SINTWWFFAMISISGAFAVTFS 140
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDrtrtRWGrRRPWILIGAIPLALSFVLLftapdlspTGKLIYALVTYLLLGLAYTLVN 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 141 VVF-AYVADVTT-PEERSKAYGLASATFAASLVISPALGNALMEMYGD------TLVVALSTAIALLDVFFILVAVPESL 212
Cdd:COG2211 129 IPYsALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGdaalgyRLTALIFAVLGLLAFLLTFFGTKERP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 213 SEKMRPASWGApisweqadpflALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVGILS 292
Cdd:COG2211 209 VPEEEKVSLKE-----------SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 293 ITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGF--GSQKWMMWSAGVVAALGSITY----PAISAFVSLYAAPESQG 366
Cdd:COG2211 278 LLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIGLGAIlvlpWAMLADVVDYDEWKTGR 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 367 AVQGMITGMRGLCN----GLGPAVFGVVFYLFNVDLNDDHDSHAKSSGSRATnvekisqhvpgppFVFGALCVFCAIIVS 442
Cdd:COG2211 358 RREGLYFGIFTFAIklgqALAGALAGLLLALFGYVAGAAQSPSALTGIRLLF-------------FLLPAVLLLLAALLL 424
|
....
gi 21357569 443 AFIP 446
Cdd:COG2211 425 LFYP 428
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
39-391 |
9.53e-16 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 78.77 E-value: 9.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 39 ALVVIFLEFFAWGLLTMPIISTLNQTfPDHTFLMNGLVMgikgILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 118
Cdd:COG2223 13 AFFLAFGVWYLWSVLAPPLAEEFGLS-AAQLGLLFAIPV----LVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 119 S--INTWWFFAMISISGAFA-VTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGdtlvvaLSTA 195
Cdd:COG2223 88 AlaVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG------WRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 196 IALLDVFFILVAVPESLSEKMRPASWGAPisweQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMG 275
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAAA----AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 276 FNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQ--LLWYGFGSQKWMMWSAGVVAALGSITYPAIS 353
Cdd:COG2223 238 LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGllLLALALGSLWLFLVLFLLLGLALGGGNGAVF 317
|
330 340 350
....*....|....*....|....*....|....*...
gi 21357569 354 AFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVF 391
Cdd:COG2223 318 ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
74-396 |
1.35e-15 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 78.43 E-value: 1.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVT-------VFFTCLPIPLMSINTWWFFAMISISGAFAVTFSVVF-AY 145
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllrallAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARqAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 146 VADVTTPEERSKAYGLASATFAASLVISPALGNALMemygdtLVVALSTAIALLDVFFILVAVPESLSEKMRPASWGAPI 225
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLV------ALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 226 SWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQV 305
Cdd:cd06173 191 SLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 306 FGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITY-PAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGP 384
Cdd:cd06173 271 RRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGA 350
|
330
....*....|..
gi 21357569 385 AVFGVVFYLFNV 396
Cdd:cd06173 351 LLAGLLADALGL 362
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
40-391 |
5.37e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 76.48 E-value: 5.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 40 LVVIFLEFFAWGLLtMPIISTLNQTFPDHTFLMnGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMS 119
Cdd:cd17489 2 LLANFFFFLSFYLL-LPVLPLYAHDLGGSEAVA-GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 120 I--NTWWFFAMISISGA-FAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAI 196
Cdd:cd17489 80 LatSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 197 ALLDVFFILVaVPESLSEKmrpaswgAPISWEQADPFLALRkvgtDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKmgf 276
Cdd:cd17489 160 ALLALLLVFL-VKDPPPVA-------AEEAEAGTRAFRRLV----EKKVLPPALILFLASIAYGAISTFLPLYAAER--- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 277 NYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAISAF 355
Cdd:cd17489 225 GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQAL 304
|
330 340 350
....*....|....*....|....*....|....*.
gi 21357569 356 VSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVF 391
Cdd:cd17489 305 AVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVA 340
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
39-208 |
2.06e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 74.53 E-value: 2.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 39 ALVVIFLEFFAWGLLtMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 118
Cdd:cd17325 204 LFLAIFVLAFAFGAL-EPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 119 SINT--WWFFAMISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTA 195
Cdd:cd17325 283 PLATsfWLLLLLLALLGlGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAA 362
|
170
....*....|...
gi 21357569 196 IALLDVFFILVAV 208
Cdd:cd17325 363 LLLLAAVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
34-390 |
6.67e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 73.35 E-value: 6.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 34 PSVHHALVVIFLEFFAWGLLTM---PIISTLNQTFpDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFF 110
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATAlwgPLIPALKDAF-GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 111 TCLPIPLMSI-NTWWFF--AMISISGAFAVTFSVVFAYVADVtTPEERSKAYGLASATFAASLVISPALGNALMEMYGDT 187
Cdd:COG0738 83 MALGLLLFALaPSYPLLllALFLLGLGLGLLDVAANPYVAAL-GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 188 LVVALSTAIALLDVFFILVAVPESLSEKMRPASwgapiswEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMF 267
Cdd:COG0738 162 SWHLPYLILAVLLLLLALLFLRSKLPEIEEEEE-------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 268 VYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-S 346
Cdd:COG0738 235 LYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGlS 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 21357569 347 ITYPAISAFVsLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVV 390
Cdd:COG0738 315 LMFPTIFSLA-LDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFL 357
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
51-375 |
3.21e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 71.07 E-value: 3.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 51 GLLTMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCL--PIPLMSINTWWFFAM 128
Cdd:cd17473 15 GAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIggVAGLFLDSLYALLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 129 ISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDT--LVVALSTAIALLDVFFIL 205
Cdd:cd17473 95 RALLGiGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRApfLVYLLALPVLILVLLFLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 206 VAVPESLSEKMRPASWGAPISWEQADPFLALrkvgtdKTVLMLCLTVLLSYLPeageyscmfVYLKLKMGFNYVEVSVFI 285
Cdd:cd17473 175 EPARKSKSAASPGAATAAALPWKRVLPIYFL------AFLAMLLFYVIPIQLP---------FLLQERGGGSAALIGLAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 286 AIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAISAFVSLYAAPES 364
Cdd:cd17473 240 AIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGfGLLLPTLNSWAMSLVPPEL 319
|
330
....*....|.
gi 21357569 365 QGAVQGMITGM 375
Cdd:cd17473 320 RGRAMGIVTSA 330
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-391 |
1.43e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 68.74 E-value: 1.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 39 ALVVIFLEFFAWGLLTMPIISTLNqtFPDHTFlmnGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 118
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLG--LSAAQL---GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 119 SI--NTWWFFAMISISGAF-AVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTA 195
Cdd:COG2271 93 GFatSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 196 IALLDVFFilvavpeslsekmrpaswgapisweqadpflalrkvgtdkTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMG 275
Cdd:COG2271 173 PGLLLALL----------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 276 FNYVEVSVFIAIVGILSITVQVTLGSFMQVFGA--KRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSI-TYPAI 352
Cdd:COG2271 213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGgAFGLL 292
|
330 340 350
....*....|....*....|....*....|....*....
gi 21357569 353 SAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVF 391
Cdd:COG2271 293 WALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
72-395 |
1.69e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 68.75 E-value: 1.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 72 MNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLP--IPLMSINTWWFFAMISISG-AFAVTFSVVFAYVAD 148
Cdd:cd17474 35 QVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGglLCGLSDSFALLLAGRALQGiGAAGLGPLALTLIGD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 149 VTTPEERSKAYGLASATFAASLVISPALGNALMEM--YGDTLVVALSTAIALLDVFFILvavpESLSEKMRPASWGAPIS 226
Cdd:cd17474 115 LFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIswRYPFFLLAALIPVAFLAILFLL----PEPKEKAKSSSATKLRD 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 227 WEQADPFLALRKVGTDKTVLMLCLTVLLSYLPeageyscmfVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQV- 305
Cdd:cd17474 191 LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP---------FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKr 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 306 FGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGS-ITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGP 384
Cdd:cd17474 262 FGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGP 341
|
330
....*....|.
gi 21357569 385 AVFGVVFYLFN 395
Cdd:cd17474 342 LLFGLLLEIFG 352
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
89-446 |
3.24e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 67.97 E-value: 3.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 89 PLIGALSDIWGRK-FFLLVTVFFT--CLpIPLMSINTWWFFAMISISGAF-AVTFSVVFAYVADVTTPEERSKAYGLASA 164
Cdd:cd17321 49 LLAGRLGDRFGRKrVFLIGLALFGlaSL-LCALAPSLAFLIAARALQGIGaAAIMPASLALIAATFPGERRGRALGLWGA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 165 TFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFIlvavpeslsekmrpaswgapisweqadpflalrkvgtdKT 244
Cdd:cd17321 128 VVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA--------------------------------------RT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 245 VLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLL 324
Cdd:cd17321 170 FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 325 WYGF---GSQKWMMWSAGVVAALGS-ITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFNVDLND 400
Cdd:cd17321 250 LLALlgaDSSVWLLLPGLVLLGLGLgLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLG 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 21357569 401 DHDSHAKSSGSRATNVEKISQhvpgpPFVFGALCVFCAIIVSAFIP 446
Cdd:cd17321 330 DSGVAALLSAAAAAFAAGFHL-----AFLVAAALALLAALLALLLP 370
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
74-395 |
7.05e-12 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 67.10 E-value: 7.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWGRK-----FFLLVTVFFTCLpIPLMSINTWWFFAMISISGAFAVTFSVVF--AYV 146
Cdd:COG2270 55 GYALAIAGLLVALLAPVLGAIADRSGRKkpflaFFTLLGVLATAA-LFFVAPGGLWLGLLLFVLANIGFEGSLVFynAFL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 147 ADVTTPEERSKAYGLASA--------TFAASLVI---SPALGnaLMEMYGDTLVVALSTAIalldvFFILVAVPESLSEK 215
Cdd:COG2270 134 PDIATPEEIGRVSGLGWAlgylggvlLLLINLALflkPEAFG--LPDAGEAVRISFLLTAL-----WWLLFALPLFLFLP 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 216 MRPASWGAPISWEQADPFLALRKVGTDKTVLMLCLTVLLSYL----PEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVGIL 291
Cdd:COG2270 207 ERPRPGPAPPRGAVRAGFRELRRTLRELRRYRDLLRFLLAYFfyrdGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIV 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 292 SITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITYPAIS-AFVSLYAAPESQG---- 366
Cdd:COG2270 287 AALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSrSLLARLIPPGREAeffg 366
|
330 340 350
....*....|....*....|....*....|.
gi 21357569 367 --AVQGMITGMrglcngLGPAVFGVVFYLFN 395
Cdd:COG2270 367 lyALSGKAASF------LGPLLFGLVTQLTG 391
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
81-391 |
1.93e-11 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 65.70 E-value: 1.93e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 81 GILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--NTWWFFamIS-ISGAFAVTFSVVFAYVADVTTPEERSK 157
Cdd:cd17331 45 SVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFasSVPMLF--LSrLPSVFMHAMQAAQMVVTDLTDPGERAA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 158 AYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSEKMRPASwGAPISWEQADPFLALR 237
Cdd:cd17331 123 ALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEA-KESASPPSVFNLKEIL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 238 KVGTDKTVLMLCLTVLLSYLPeAGEYSCMF-VYLKLKMGFNYVEVSVFIAIVGILSITVQ-VTLGSFMQVFGAKRTIIMG 315
Cdd:cd17331 202 RLLRLPGVAFLLLVKLLSGLP-IGMFQSMFsLVAMDFFGLTPEENGYLMSYAGVLGMVVQgLLVGPLTKRFGERSLLKLS 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21357569 316 LALEIVQLLWYGF-GSQKWMMWSAGVVAALGSITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVF 391
Cdd:cd17331 281 VALLAIGYLLLAFvTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALL 357
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
90-344 |
2.98e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 64.90 E-value: 2.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 90 LIGALSDIWGRKFFLLVTVFFTCLP--IPLMSINTWWFFAMISISGAFAVTFSVV-FAYVADVTTPEERSKAYGLASATF 166
Cdd:cd17320 53 LYGPLSDRFGRRPVLLAGLLLFILAslLCALASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGAELAKIFSLLMMIL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 167 AASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSEKMRPASWGAPISweqadpflALRKVGTDKTVL 246
Cdd:cd17320 133 AIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLR--------AYKRVLKNRRFL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 247 MLCLTVLLSYLPEAGEYSCM-FVYLKLkMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLW 325
Cdd:cd17320 205 GYALALGLSFAGLFAYLAAApFIYIEQ-LGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALV 283
|
250
....*....|....*....
gi 21357569 326 YGFGSQKWMMWSAGVVAAL 344
Cdd:cd17320 284 LLLAALLGGLSLWPLVAPL 302
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
74-391 |
2.14e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 59.21 E-value: 2.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSINT--WWFFAMISISGAF--AVTFSVVFAYVADV 149
Cdd:cd17355 41 SLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATslWQLYLLWGLLGGGgaGTLAAVAFATVAAW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 150 TTPEERSKAYGLASATFAASLVISPALGNALMEMYG-DTLVVALSTAIALLDVFFILVAVPESLSEKMRPASWGAPiswe 228
Cdd:cd17355 121 WFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGwRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASP---- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 229 qADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKmGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGA 308
Cdd:cd17355 197 -ASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR-GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSP 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 309 KRTIIMGLALEIVQLLWYGFG-SQKWMMWSAGVVAALGSITY-PAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAV 386
Cdd:cd17355 275 RRLLAASYALRALGLALLLLLpFPPLALLLFAALFGLGWGATvPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWL 354
|
....*
gi 21357569 387 FGVVF 391
Cdd:cd17355 355 GGLLY 359
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
53-211 |
2.91e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 58.77 E-value: 2.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 53 LTMPIISTLNQTFPDHTFLMNGLVMGIKGIL-SFLSAPLiGALSDIWGRKFFLLV--TVFFTCLPIPLMSINTWWFFAMI 129
Cdd:cd17472 14 LVLPVLSVYAKSLPGATPTLIGLALGIYGLTqAIFQIPF-GLLSDRIGRKPVILFglLLFIAGSLLAAYATSIYGLILGR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 130 SISGAFAVTfSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVP 209
Cdd:cd17472 93 ALQGSGAIS-SVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVP 171
|
..
gi 21357569 210 ES 211
Cdd:cd17472 172 DP 173
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
74-395 |
6.72e-09 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 57.64 E-value: 6.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWGRK------FFLLVTVFFTCLPIPLMSINTWWFFAMISISGAFAVTfSVVFAYVA 147
Cdd:pfam12832 37 GLITAILPLTRILAPPIWGWLADRTGKRkavvrlASILAAVLFLSVLFIPISLTFWWLALLVVLFSFFWNA-ILPQFEVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 148 DVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTL--VVALSTAIALLDVFFILVAVPeslsekmrPASWGAPI 225
Cdd:pfam12832 116 TLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYSVGLlpSVLFYLFAALMLLSLLLPLAP--------PEMEYESK 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 226 SWEQADPFLALRkvgtDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKlKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQV 305
Cdd:pfam12832 188 GGSKAVFWNLLK----QPEVIIFFLAAFLLGFSHGPFYTFLFLYLE-NLGASNTLLGALWALGVVAEIPLFFYAHRLLRR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 306 FGAKRTIIMGLALEIVQLLWYGFGSQKWmmWSAGVVAALGSITYPAISA----FVSLYAAPESQGAVQGMITGMR-GLCN 380
Cdd:pfam12832 263 FGHRNLLIIALLLTALRWLLYAFFVENP--WLVLPIQFLHAISFGLTHAaaieYVRRIFPGSLQGTGQALYSGLYfGLGG 340
|
330
....*....|....*
gi 21357569 381 GLGPAVFGVVFYLFN 395
Cdd:pfam12832 341 ALGSLIGGQLWDLFG 355
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
74-397 |
1.11e-08 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 57.25 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDI----WG-RKFFLLVTVFFTCLPIPLMSINTWWFFAMISISGAFAVTFSVVF----- 143
Cdd:cd17313 37 GFVWTLGPILGLFVQPLVGSLSDRcnsrIGrRRPFILVGAPLAALGLILIPNAADIGLALGDGPRTWALVLFVLGivlld 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 144 -----------AYVADVTTPEERSKAYGLASATFAASLVISPALG------NALMEMYGDTLVVA--LSTAIALLDVFFI 204
Cdd:cd17313 117 famnvcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGailwdhNWFGFALGGNLKVPfyIGAIILLVCVLVT 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 205 LVAVPEslsEKMRPASWGAPISWEQADPFLALRKVGT--DKTVLMLCLTVLLSYLpeagEYSCMFVYLKLKMGFNY---- 278
Cdd:cd17313 197 LFFVKE---PPLSPEAGEHSENPSLGEVLKSLLKLLKimPRSLLRLLLVIFFWWI----AFFPFELFFTDYMGEEVyhgt 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 279 --------VEVSVFIAIVGILSITVQVT---LGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMmwsAGVVAALGSI 347
Cdd:cd17313 270 saasshygAGVRMGAWGLLIFSLAFLIFslpIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTV---ALVLFALGGI 346
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 21357569 348 TYPAIS----AFVSLYAAP--ESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFNVD 397
Cdd:cd17313 347 GWATINinpyPLVSDYHSEsgRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYG 402
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
74-395 |
1.41e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.40 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWG-RKFFLLVTVFFTCLPIPLMSINTWWFFAMISISGAF---AVTFSVVFAYVADV 149
Cdd:cd17370 37 GLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERlgkGIRTPPRDALLADA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 150 TTPEERSKAYGLASA--TFAAslVISPALGNALMEMYGDT--LVVALSTAIALLDVFFILVAVPESlSEKMRPASWGAPI 225
Cdd:cd17370 117 TPPSGRGKAFGLHRAldTLGA--VLGPLLAALLLYLLGGNyrTIFLLAAIPALLALLILLFVVKEY-PRPPKLRKKSKKT 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 226 SWEQADPFLalrkvgtdKTVLMLCLTVLLSYLPEAgeyscMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQV 305
Cdd:cd17370 194 SLKKLPKAF--------WLYLLAVALFALGNFSFA-----FLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 306 FGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGP 384
Cdd:cd17370 261 IGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLAS 340
|
330
....*....|.
gi 21357569 385 AVFGVVFYLFN 395
Cdd:cd17370 341 LIAGYLWDLIS 351
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
86-446 |
1.66e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 56.43 E-value: 1.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 86 LSAPLIGALSDIWGRKFFLLVTVFFTCLPIPL--MSINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLAS 163
Cdd:cd17504 46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLaaFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 164 ATFAASLVISPALGNALMEMYGDTLVVALSTAIALLdvFFILVavpeslsekmrpaswgapisweqadPFLALRKVgTDK 243
Cdd:cd17504 126 ATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL--LAALV-------------------------PLIDLRLL-RRR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 244 TVLMLCLTVLLSYLPEAGEYSCMFVYLKLK----MGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALE 319
Cdd:cd17504 178 NVLLANITALLAGFGMFMVFQLLPQLLQLPtptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVIS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 320 IVQLLWYGF-GSQKWMMWSAGVVAALG-SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFNVD 397
Cdd:cd17504 258 AVGLLLLALlHSSLWALVVALLLIGIGlGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVS 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 21357569 398 LNDdhdshAKSSGSRATNVEkisqhvpgppFVFGALCVFCAIIVSAFIP 446
Cdd:cd17504 338 ITS-----GGVPTEGAYVLA----------FLIGAALALAALLLSLLIP 371
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
74-390 |
1.99e-08 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 56.05 E-value: 1.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWG-RKFFLLVTVFFTCLPIPLMSINTWWFFAMISISGAFAVTFSVVFAyVADVTTP 152
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIFWLLLLLVILGAFFSAPVVP-LVDSITL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 153 E---ERSKAYGL----ASATFAASlviSPALGNALMEMYGDTlvvALSTAIALLDVFFILVAVpesLSEKMRPASWGApi 225
Cdd:cd17335 114 QylgEERERYGKqrlwGSIGFGIA---ALLVGILIDRSSTYK---NYTIAFYVFAVLMLLALL---LALKFPFRPKHP-- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 226 swEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKlKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQV 305
Cdd:cd17335 183 --EPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQ-DLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 306 FGAKRTIIMGLALEIVQLLWYGFGSQKWMMwsaGVVAALGSITY----PAISAFVSLYAAPESQGAVQGMITgmrGLCNG 381
Cdd:cd17335 260 FGHVGLLYLGLLAYVVRWLLYSFLENPWLV---LPIELLHGLTFalvwAAAVSYASAAAPPGLRATAQGLLQ---GLYFG 333
|
....*....
gi 21357569 382 LGPAVFGVV 390
Cdd:cd17335 334 LGGGLGSLI 342
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
69-390 |
2.22e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 56.03 E-value: 2.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 69 TFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--NTWWFFAMISISGAFAVTFSVVFAYV 146
Cdd:cd17478 29 SYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFapNYWLLLLLVALAGIGSAAFHPEGARL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 147 ADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESlseKMRPASWGAPIS 226
Cdd:cd17478 109 ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK---KPEAKKAAAKSS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 227 WeqadpflALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKmGFNYVEVSVFIAIVGILSITVQVTLGSFMQVF 306
Cdd:cd17478 186 A-------RSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRF 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 307 GAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITYPAISAFVSLYaAPESQGAVQGMITGMRGLCNGLGPAV 386
Cdd:cd17478 258 GRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQEL-LPGNVGLASGLMMGLSFGLGGIGAPV 336
|
....
gi 21357569 387 FGVV 390
Cdd:cd17478 337 LGAL 340
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
39-308 |
2.40e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 55.20 E-value: 2.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 39 ALVVIFLEFFAWGLLTmPIISTLNQTFPDHTFLMnGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 118
Cdd:COG0477 19 LALGTFLEGLDFTIVN-VALPSIAADLGASSAQL-GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 119 SI--NTWWFFAMISISGAF-AVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTA 195
Cdd:COG0477 97 GLapSPELLIAARALQGIGaGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 196 IALLdVFFILVAVPESLSEKMRPASWGAPISWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMG 275
Cdd:COG0477 177 LGLL-ALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250 260 270
....*....|....*....|....*....|...
gi 21357569 276 FNYVEVSVFIAIVGILSITVQVTLGSFMQVFGA 308
Cdd:COG0477 256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLL 288
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
74-210 |
1.48e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 53.34 E-value: 1.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI----NTWWFFAMISISGAFA-VTFSVVFAYVAD 148
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLallpSPALAIALLFLAGFGLgGAFGLLWALAAE 298
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21357569 149 VTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPE 210
Cdd:COG2271 299 LFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
74-397 |
3.86e-07 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 52.12 E-value: 3.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWG-RK-------FFLLVTVFFtcLPIPLMSINTWWFFAMISISGA----FAVTFSV 141
Cdd:cd17337 35 ALLFTVYGLTVAIASWLSGVLAELFGpRRvmligliIWLVFEVLF--LAFGLPSHNYPLMLLTYGLRGFgyplFAYSFLV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 142 VFAYVADvttPEERSKAYGLASATFAASL-VISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSEKMRPAS 220
Cdd:cd17337 113 WITYRTP---AERLGSAVGWFWFAFTGGLpVLGSYLASFTIPVIGEIGTLWLSLVFVALGGLIALFLVRDRTGEQPLANP 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 221 WGAPISweqaDPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLG 300
Cdd:cd17337 190 SEEPLK----ELLSGITILFRNPKIAIGGIVRIINTLSQFGFPVFMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 301 SFMQVFGAKRTII----MGLALEIVqLLWYG---FGSQKWMMWSAGVVAALGsitypaISAFVSLYA-----APESQGAV 368
Cdd:cd17337 266 ILGDKIGWRRTVRwfggVGCAISTL-LFYYVpqlFGHNYWAALIAAILFGIG------LAGFVPLSAlmpslAPEHKGAA 338
|
330 340
....*....|....*....|....*....
gi 21357569 369 QGMITGMRGLCNGLGPAVFGVVFYLFNVD 397
Cdd:cd17337 339 MSILNLGAGLSNFVGPAIVTLFLGSFGAG 367
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
44-443 |
5.27e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.45 E-value: 5.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 44 FLEFFAWGLLTMPIISTLNqtfPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--N 121
Cdd:cd17316 12 AYDFFLIGFVAPVLAAEFS---LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLlpT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 122 TWWFFAMISISGAF-AVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLvvalstaiaLLD 200
Cdd:cd17316 89 PILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDW---------GWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 201 VFFILVAVPESLSEKMRPASWGAPISWeqadpflalrkvgtdkTVLMLCLTVLLSYLPeageyscmfVYLKLKMGFNYVE 280
Cdd:cd17316 160 ILFLIGALPALLALLLRRRTLLLILLW----------------FFISFGYYGLTTFLP---------TYLQTVLGLSPAT 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 281 VSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGF---GSQKWMMWSAGVVAALGSITYPAISAFVS 357
Cdd:cd17316 215 SSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYllsGSPTLLLLLLFILSFFVGGVWGALYAYLA 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 358 LYAAPESQGavqgmiTGMrGLCNGLGPAVFGVVFYLFNVDLnddhdshakssgsratnvekISQHVPGPPFVFGALCVFC 437
Cdd:cd17316 295 ELFPTEVRA------TGV-GLSYNLGRLGGGGAPPLIALLL--------------------ASTGGTGVPALILALLAIV 347
|
....*.
gi 21357569 438 AIIVSA 443
Cdd:cd17316 348 ALIVAL 353
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
74-208 |
6.99e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.42 E-value: 6.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWGRK---FFLLVTVFFTCLPIPLMSINTWWFF-AMISISGAFAVTFSVVFAYVADV 149
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRrvlLIVFALMALGLLLLALALGSLWLFLvLFLLLGLALGGGNGAVFALVPDI 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 21357569 150 TTPEERSKAYGLASATFAASLVISPALGNALMEMYGdtlvvALSTAIALLDVFFILVAV 208
Cdd:COG2223 324 FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG-----SYTAAFLVFAVLALVALV 377
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
16-205 |
1.46e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 50.23 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 16 RNRAHKSKSVFTSSGIGEPSVHHALVVIFLefFAWGLLTMPIISTLNQTFPDHTFLMnGLVMGIKGILSFLSAPLIGALS 95
Cdd:cd17370 182 RPPKLRKKSKKTSLKKLPKAFWLYLLAVAL--FALGNFSFAFLILRAQELGLSAALI-PLLYALFNLVYALAAYPAGRLS 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 96 DIWGRKFFLLVTV---FFTCLPIPLMSINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVI 172
Cdd:cd17370 259 DRIGRKKLLILGYlslALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLL 338
|
170 180 190
....*....|....*....|....*....|...
gi 21357569 173 SPALGNALMEMYGDTLVVALSTAIALLDVFFIL 205
Cdd:cd17370 339 ASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
39-174 |
1.47e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.11 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 39 ALVVIFLEFFAWGLLTMpIISTLNQTFpDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVF------FTC 112
Cdd:pfam07690 205 LLLALLLFGFAFFGLLT-YLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLllilaaLGL 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21357569 113 LPIPLMSINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISP 174
Cdd:pfam07690 283 LLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
71-390 |
1.64e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 50.25 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 71 LMNGLVMGIKGILSFLSAPLIGALSDIWG--RKFFLLVTVFFTCLPIPLMSINTWWFFAMISISG-AFAVTFSVVFAYVA 147
Cdd:cd17477 31 ALIGLVASAYYLGILLGSPLVPRLIRRVGhiRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGiGLAGLFVVSESWLN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 148 DVTTPEERSKAYGLASATFAASLVISPALGnALMEMYGDT--LVVALSTAIALLDVFFILVAVPESLSEkmrpaswgapi 225
Cdd:cd17477 111 ALATNENRGRVLGLYSTVLGLGFALGPLLL-ALVGTAGALpfLIAAVLLLLALVPLLLTRRAAPEIEEA----------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 226 swEQADPFLALRKVGtdktvlMLCLTVLLSYLPEAGEYSCMFVYLkLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQV 305
Cdd:cd17477 179 --ESISLRRLLRIAP------LALLGAFVAGFLEGAFYSLLPLYG-LRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADR 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 306 FGAKRTII-MGLALEIVQLLWYGFGSQKWMMWSAGVV--AALGSItYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGL 382
Cdd:cd17477 250 FDRRRVLLgCALLGALAALLLPLVPGLPLALLVLLFLwgGAAGPL-YTLALALAGDRLPGDELVAANAALLLLYGLGSVI 328
|
....*...
gi 21357569 383 GPAVFGVV 390
Cdd:cd17477 329 GPLLAGAL 336
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
74-204 |
2.78e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.48 E-value: 2.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVF---FTCLPIPLMSINTWWFFAMISISGAFAVT-FSVVFAYVADV 149
Cdd:cd17477 226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALlgaLAALLLPLVPGLPLALLVLLFLWGGAAGPlYTLALALAGDR 305
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 21357569 150 TTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFI 204
Cdd:cd17477 306 LPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
39-166 |
3.13e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.20 E-value: 3.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 39 ALVVIFLEFFAWGLLtMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 118
Cdd:COG2814 212 LLLLAFLLGFGFFAL-FTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL 290
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 21357569 119 SI--NTWWFFAMISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATF 166
Cdd:COG2814 291 ALagSLWLLLLALFLLGfGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
53-210 |
3.17e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 49.19 E-value: 3.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 53 LTMPI----ISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--NTWWFF 126
Cdd:cd17391 14 LIAPFlplyIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFvtNVWQLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 127 AMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILV 206
Cdd:cd17391 94 ILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLF 173
|
....
gi 21357569 207 AVPE 210
Cdd:cd17391 174 FVKE 177
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
248-395 |
1.12e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 248 LCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYG 327
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21357569 328 FGSQKWMMWSAGVVAALG-SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFN 395
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG 149
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
42-205 |
1.45e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 47.22 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 42 VIFLEFF---AWGLLTMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRK---FFLLVTVFFTCLPI 115
Cdd:cd17353 217 LLWLMFFlnaTAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKntlSIAFLIQGVAMFLL 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 116 PLMSINTWWFFAMISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALST 194
Cdd:cd17353 297 PFIGSVAVLFVLGVALIGfCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAA 376
|
170
....*....|.
gi 21357569 195 AIALLDVFFIL 205
Cdd:cd17353 377 ALSLVALALAL 387
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
41-180 |
2.57e-05 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 46.43 E-value: 2.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 41 VVIFLEFFAWGLLTMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVT-----VFFTCLPI 115
Cdd:cd17326 6 LTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVsiliaIVGNILYA 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21357569 116 PLMSINTWWFFAMIS---ISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNAL 180
Cdd:cd17326 86 LAEYFPSNRKYVMLVarfLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAF 153
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
39-206 |
2.98e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.06 E-value: 2.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 39 ALVVIFLEFFAWGLLTMPIISTLNQTFPDHTFLMnGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 118
Cdd:cd17316 182 LILLWFFISFGYYGLTTFLPTYLQTVLGLSPATS-SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 119 SI----NTWWFFAMISISGAFAVTFSVVF-AYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALS 193
Cdd:cd17316 261 FYllsgSPTLLLLLLFILSFFVGGVWGALyAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALI 340
|
170
....*....|...
gi 21357569 194 TAIALLDVFFILV 206
Cdd:cd17316 341 LALLAIVALIVAL 353
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
269-395 |
3.54e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 3.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 269 YLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGS-I 347
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAgA 114
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 21357569 348 TYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFN 395
Cdd:COG2814 115 LFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
41-208 |
4.20e-05 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 45.87 E-value: 4.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 41 VVIFLEFFAWGLLTMPIISTLNQTFPDHTFLMNGLvMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFF------TCLP 114
Cdd:cd17314 213 IAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKL-MSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTilglglCAFL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 115 IPLMSINtWWFFAMISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALS 193
Cdd:cd17314 292 FLLKMTP-VGLVLTGSLLGfSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYI 370
|
170
....*....|....*
gi 21357569 194 TAIALLDVFFILVAV 208
Cdd:cd17314 371 YAVIVFLASAILLAV 385
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
55-177 |
6.48e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 45.26 E-value: 6.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 55 MPIISTLNQTFPDHTFLMNgLVMGIKgILSFLSAPLIGA-LSDIWGRKFFLLVTVF-FTCLPIPL-MSINTWWFFAMISI 131
Cdd:cd17323 19 SPALPQIAEDFHVSEEVAN-LGVSLF-VLGFGLGPLIWApLSELYGRRPVYLVSLFiFVIFQIGCaLAPNIAMLIILRFL 96
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 21357569 132 SGAFAVTF-SVVFAYVADVTTPEERSKAYGLasatFAASLVISPALG 177
Cdd:cd17323 97 QGFFGSSPlAIGAGTIADLFTPEERGKAMGV----YSLGPLLGPALG 139
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
74-208 |
8.74e-05 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 44.52 E-value: 8.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWGRK-----FFLLVTVFFTCLPIpLMSINTWWFFAMISISGAFAVTFSVVF--AYV 146
Cdd:cd17482 42 GYANSIASLVIALLAPILGAIADYSGRKkrflaFFCLIGVVSTALLF-FVTPGQWLLALLLFILANIGFSGANVFydAFL 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21357569 147 ADVTTPEERSKAYGLASATFAASLVISPALgNALMEMYGDTLVVALSTAIALLdvfFILVAV 208
Cdd:cd17482 121 PDVASPERMDRVSSLGYALGYIGGGLLFAV-NLVLILGPDAFGLDTAEAVRLS---FLSVAL 178
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-205 |
2.13e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 43.31 E-value: 2.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 34 PSVHHALVVIFLEFFAWGLLtMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFT-- 111
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFAL-YTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAaa 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 112 CLPIPLMSINTWWFFAMISISG-AFAVTFSVVFAYVADVTtPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVV 190
Cdd:cd17324 277 LLLLTLLGPSPLLLLVGLVLWGlGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVG 355
|
170
....*....|....*
gi 21357569 191 ALSTAIALLDVFFIL 205
Cdd:cd17324 356 WVGAALLLLALLLAL 370
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
21-206 |
3.34e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 42.98 E-value: 3.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 21 KSKSVFTSSGIGEPSVHHALVVIFLEFFAWGLLTMPIISTLNQTFPDHTFL---MNGLVMGIKGILSFLS-APLIGALSD 96
Cdd:cd17331 190 SPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLtpeENGYLMSYAGVLGMVVqGLLVGPLTK 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 97 IWGRKFFLLVTVFFTCLPIPLMSI--NTWWFFAMISISGAFAVTFSVVF-AYVADVTTPEERSKAYGLASATFAASLVIS 173
Cdd:cd17331 270 RFGERSLLKLSVALLAIGYLLLAFvtTVWQLLVLLLPLVIGGSVLYTVItSLLTKAVPPEDTGTALGLSHALFSLVRTVS 349
|
170 180 190
....*....|....*....|....*....|...
gi 21357569 174 PALGNALMEMYGDTLVVALSTAIALLDVFFILV 206
Cdd:cd17331 350 PTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
87-180 |
3.35e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 42.55 E-value: 3.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 87 SAPLIGALSDIWGRKFFLLVTVFFTCLPIPL--MSINTWWFFAMISISGAFA-VTFSVVFAYVADVTTPEERSKAYGLAS 163
Cdd:cd17502 46 FQPIYGKLSDLFGRKWVLLIAIVIFELGSLLcgLAPNMTMLIVGRAIQGIGGgGLMSLAFIIIADLVPPRERGKYQGYIG 125
|
90
....*....|....*..
gi 21357569 164 ATFAASLVISPALGNAL 180
Cdd:cd17502 126 AVFGIASVAGPLIGGAF 142
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
72-318 |
4.00e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.59 E-value: 4.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 72 MNGLVMGIKGILSFLSAPLIGALSDIWG-RKFFLLVTVFFTCL--PIPLMSINTWWFFAMISISGAFAVTFSVVFAYVAD 148
Cdd:cd17490 32 MIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLasLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 149 VTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDT---LVVALSTAIALLDVFFIlvavPESLSEKMRPASWGApi 225
Cdd:cd17490 112 YFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRapfLLAALAGVLGFILSLFI----KEERREKKPVLTELK-- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 226 sweqadpflALRKVGTDKTVLMLC-LTVLLSYLPEAGEYSCMFVYLKLkMGFNYVE---VSVFIAIVGILSITVQVTLgs 301
Cdd:cd17490 186 ---------ELLSVLKDKKLLFFSlLAILQQMITFSTTFGFTPLIAKQ-LGASSFQlglLSIIYLLPNALASLLSGTL-- 253
|
250
....*....|....*..
gi 21357569 302 FMQVFGAKRTIIMGLAL 318
Cdd:cd17490 254 FYKKLGERNTIIIGFLL 270
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
74-391 |
4.51e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.55 E-value: 4.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--NTWWFFA-MISISGAFAVTFSVVFAYVADVT 150
Cdd:COG2807 56 GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLapSVALLLAgTALIGAGIAVGNVLLPGLIKRWF 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 151 tPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESlsekmRPASWGAPISWeqa 230
Cdd:COG2807 136 -PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR-----PAAAAAAPAAA--- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 231 dpflALRKVGTDKTVLMLCLTVLLSylpeAGEYSCMFVYLK---LKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFG 307
Cdd:COG2807 207 ----SLRSLWRSPLAWLLTLFFGLQ----SLLYYAVVAWLPpilRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 308 AKRTIIMG-LALEIVQLLWYGFGSQKWMMWSAGVVAALGSITYPAISAFVSLYAAPESQ-GAVQGMITGMRGLCNGLGPA 385
Cdd:COG2807 279 DRRPLLLLlGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPL 358
|
....*.
gi 21357569 386 VFGVVF 391
Cdd:COG2807 359 LVGALH 364
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
89-446 |
8.30e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.79 E-value: 8.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 89 PLIGALSDIWG-RKFFLLVTVFFTclpipLMSI------NTWWFFAMISISGAF-AVTFSVVFAYVADVTTPEERSKAYG 160
Cdd:cd17503 49 PLSGWLADRFGtRRLFLTALALFT-----LGSLlcglapNLASLIIFRILQGFGgGVLIPLAQTILLRIYPPEKRGAAMG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 161 LASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFIlvavpeslsekmrpaswgapisweqadPFLALRkVG 240
Cdd:cd17503 124 LVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA---------------------------PLLDLR-LF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 241 TDKTVLMLCLTVLLSYLpeaGEYSCMFV---YLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLA 317
Cdd:cd17503 176 KDRNFTLGLLLSFLLGL---GLFGAMFLlplYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 318 LEIVQLLWYGFGS-QKWMMWSAGVVAALG---SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYL 393
Cdd:cd17503 253 LLALGTLLLAFLTpDTSLWLIILPLFIRGlgmGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTN 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 21357569 394 FNvdlnddHDSHAKSSGSRATNVEKISQHVP-GPPFVFGALCVFCAIIVSAFIP 446
Cdd:cd17503 333 RT------QFHHSRLSELLAQQVQKQALIIAfNDAFLVSAILLLVGLLLALFLR 380
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
74-235 |
1.32e-03 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 41.14 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLV--TVFFTCLPIPLMSINTWWFFAMISISG---AFAVTFSvvFAYVAD 148
Cdd:cd17383 33 GVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIglTVMFLSTAVFAFGESYAVLFFARSLQGvgsAFADTAG--LAMIAD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 149 VTTPE-ERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFIL-VAVPESLSEKMR-PASWGAPI 225
Cdd:cd17383 111 RFTEEaERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLLlVMKPVRRETRANmPEPVGTPI 190
|
170
....*....|
gi 21357569 226 SWEQADPFLA 235
Cdd:cd17383 191 HRLLMDPYIA 200
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
71-335 |
1.50e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 41.06 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 71 LMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--NTWWFFAMISISGAFAVTFSVVFAYVAD 148
Cdd:PRK09874 54 MWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLaqNIWQFLILRALLGLLGGFVPNANALIAT 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 149 VTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSekmrpaswgaPISWE 228
Cdd:PRK09874 134 QVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQ----------PVSKK 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 229 QadpFLALRKVGTD----KTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMG--FNYVEVSVFIAIV-GILSITVQVTLGS 301
Cdd:PRK09874 204 E---MLHMREVVTSlknpKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGnvSNIAFISGMIASVpGVAALLSAPRLGK 280
|
250 260 270
....*....|....*....|....*....|....
gi 21357569 302 FMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMM 335
Cdd:PRK09874 281 LGDRIGPEKILITALIFSVLLLIPMSFVQTPLQL 314
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
74-391 |
1.61e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 40.63 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 74 GLVMGIKGILSFLSAPLIGALSDIWG-RKFFLLVTVFFTCLPIPLMSINTWWFFAMISI-SGAF-AVTFSVVFAYVADVT 150
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGaRKVLAVSMLLWSLFTALTGFATSLTSLYVLRFlLGVAeAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 151 TPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLsekmrpaswgapisweqa 230
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQVW------------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 231 dpFLALRKVGTDktvlmLCLTVLLSYLPeageyscmfVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLG---SFMQVFG 307
Cdd:cd17319 183 --GLALGYFGIN-----YALYGLLTWLP---------TYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGrlsDRLLRGA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 308 AKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAV 386
Cdd:cd17319 247 RRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGiGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLL 326
|
....*
gi 21357569 387 FGVVF 391
Cdd:cd17319 327 IGYLV 331
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
85-211 |
1.67e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 40.77 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 85 FLSAPLIGALSDIWGRKFFLLVTVFFTCLP--IPLMSINTWWFFAMISISGAFAVTFSVV-FAYVADVTTPEERSKAYGL 161
Cdd:TIGR00898 141 LLGSFVFGYLSDRFGRKKVLLLSTLVTAVSgvLTAFSPNYTVFLVFRLLVGMGIGGIWVQaVVLNTEFLPKKQRAIVGTL 220
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 21357569 162 ASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFilvaVPES 211
Cdd:TIGR00898 221 IQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWF----VPES 266
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
75-203 |
1.87e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.59 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 75 LVMGIKGILSFLSAPLIGALSDIWGRK-FFLLVTVFFTCLPIPLMSI-----NTWWFFAMISISGAF-AVTFSVVFAYVA 147
Cdd:cd17369 268 LAVLIASVVAAITIPLFGWLSDRVGRRpVYLAGALLAALFAFPFFWLldtgsTWLIVLAAVVVLGVLhGMMYGPQAAFLA 347
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21357569 148 DVTTPEER----SKAYGLASATFAAslvISPALGNALMEMYGDT----LVVALSTAIALLDVFF 203
Cdd:cd17369 348 ELFPTRVRytgaSLGYQLGAILGGG---FAPLIATALVAATGSWwpvaLYLAALAVISLVAALF 408
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
75-329 |
1.89e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 40.36 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 75 LVMGIKGILSflsapliGALSDIWGRKFFLLVTV----FFTCLpipLMSINTWWFFAMI-SISG-AFAVTFSVVFAYVAD 148
Cdd:cd17371 45 AGGAIGGILG-------GILADRFGRVRVLVITIllfaVFTLL---CGFAQNYWQLLILrALAGlGFGGEWAAGAALMAE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 149 VTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTL---VVALSTAIALLDVFFILVAVPEslsekmrPASWGAPI 225
Cdd:cd17371 115 YVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIawrVLFLLGALPALLVLFIRRFVKE-------PPQWQAAR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 226 SWEQADPFLA-LRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMF---VYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGS 301
Cdd:cd17371 188 AARRHFADRPsLRELFSPPLLRTTLLASLLATGALGGYYGITTwlpSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGF 267
|
250 260
....*....|....*....|....*...
gi 21357569 302 FMQVFGAKRTIIMGLALEIVQLLWYGFG 329
Cdd:cd17371 268 LADRIGRRNNFALFALGSAISILLYFFL 295
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
44-189 |
2.51e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.90 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 44 FLEFFAWGLLTMPIISTLNQTFPDH-------TFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLV-TVFFT--CL 113
Cdd:cd17329 202 FLLFLLASFLISLIYFQLESTLPVYvveilglGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIgILLFAigFA 281
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21357569 114 PIPLMSINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLV 189
Cdd:cd17329 282 VLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLP 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
243-394 |
3.77e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.47 E-value: 3.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 243 KTVLMLCLTVLLSYLPEAGeYSCMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQ 322
Cdd:COG2271 10 RILALLFLAYFLNYLDRSN-LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21357569 323 LLWYGFGSQKWMMWSAGVVAALG-SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLF 394
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
|
| Nuc_H_symport |
pfam03825 |
Nucleoside H+ symporter; |
41-397 |
4.39e-03 |
|
Nucleoside H+ symporter;
Pssm-ID: 461066 [Multi-domain] Cd Length: 399 Bit Score: 39.37 E-value: 4.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 41 VVIFLEFFAWGLLTMPIISTLNQTFPDHTFLmnGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM-- 118
Cdd:pfam03825 9 VMMFLQFFIWGAWLVTLGSYMFVTGFDGASI--GAVYSSLGIAAIFMPALLGIIADRWFSAERVLAVCHLIGAITLFMaa 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 119 -SINTWWFFAMISISG-----AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVAl 192
Cdd:pfam03825 87 qVTTFEAFFLVILVNSlaympTLALTNSIAFANLQDPVTDFPPIRVWGTIGWIMASWPFVMWVVSLAGFELSHMQLLIA- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 193 STAIALLDVFfilvavpeSLSEKMRPASWGAPISWEQA---DPFLALRkvgtDKTVLMLCLTVLLSYLPEAGEYSCMFVY 269
Cdd:pfam03825 166 AGLSALLVLF--------ALTLPHTPAKQKANQSWTTLlglDAFALLK----NKRMAVFFIFSFLLGAELQIYNVFANTF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 270 LKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGS---------QKWMMWSAGV 340
Cdd:pfam03825 234 LTSFDKFIVKHASIIMSLGQISEILFMLTLPFFLKRFGIKNVMLIGIVAWALRFAFFAYGAdptpfgtalLLLSMIVHGV 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 21357569 341 VAALGSITypaISAFVSLYAAPESQGAVQGMITGM-RGLCNGLGPAVFGVVFYLFNVD 397
Cdd:pfam03825 314 AYDFFNIT---GYIFVDKEVPPAIRASAQGLFLLMtNGFGCILGSILSGMVVEMFTQD 368
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
248-456 |
4.90e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.33 E-value: 4.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 248 LCLTVLLSYLPEAGEYScMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYG 327
Cdd:cd06174 1 LLLGFFLTGLARGLISP-LLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 328 FGSQKWMMWSAGVVAALG-SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFnvdlnddhdsha 406
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGsGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL------------ 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 21357569 407 kssgsratnvekiSQHVPGPPFVFGALCVFCAIIVSAFIPEGQTSTLEKK 456
Cdd:cd06174 148 -------------GFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKN 184
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
39-199 |
6.83e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.56 E-value: 6.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 39 ALVVIFLEFFAWGLLTMPIISTLNQTFPDHTFLMN---GLVMGIKGILSFLSAPLIGALSD-IWGRKFFLLVTVFFT--C 112
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVavaGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMalG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357569 113 LPIPLMSINTWWFFAMISISGAFAVTFSVV-FAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVA 191
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLsFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF 363
|
....*...
gi 21357569 192 LSTAIALL 199
Cdd:cd06174 364 LVLAVLLL 371
|
|
| |
