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Conserved domains on  [gi|442629987|ref|NP_647819|]
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uncharacterized protein Dmel_CG42324, isoform K [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 46-167 2.06e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.31  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629987   46 AAAEIEQLQQALIEKQTQLYALESACLRETERQVELEDSViawQDKYDRLYESHKRVQKVNQSLEDKMLKLvDRNAGERA 125
Cdd:COG1196   244 LEAELEELEAELEELEAELAELEAELEELRLELEELELEL---EEAQAEEYELLAELARLEQDIARLEERR-RELEERLE 319

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 442629987  126 QLTSDVATLSVRLAQANFNIAKLQREIERYKADISLAIQLLQ 167
Cdd:COG1196   320 ELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA 361
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 46-167 2.06e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.31  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629987   46 AAAEIEQLQQALIEKQTQLYALESACLRETERQVELEDSViawQDKYDRLYESHKRVQKVNQSLEDKMLKLvDRNAGERA 125
Cdd:COG1196   244 LEAELEELEAELEELEAELAELEAELEELRLELEELELEL---EEAQAEEYELLAELARLEQDIARLEERR-RELEERLE 319

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 442629987  126 QLTSDVATLSVRLAQANFNIAKLQREIERYKADISLAIQLLQ 167
Cdd:COG1196   320 ELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA 361
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 89-153 2.34e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 40.27  E-value: 2.34e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442629987    89 QDKYDRLYESHKRVQKVNQSLEDKMLKLV----DRNAGERAQLTSDVATLSVRLAQANFNIAKLQREIE 153
Cdd:pfam15619   80 QEKERDLERKLKEKEAELLRLRDQLKRLEklseDKNLAEREELQKKLEQLEAKLEDKDEKIQDLERKLE 148
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 48-201 4.28e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 4.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629987    48 AEIEQLQQ--------------ALIEKQTQLYALESACLRETERQVELEDSVIAWQDKYDRLYESHKRVQKVNQSLEDKM 113
Cdd:TIGR02168  677 REIEELEEkieeleekiaelekALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKEL 756

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629987   114 LKLvdrnAGERAQLTSDVATLSVRLAQANFNIAKLQREIERYKADISLAIQLLqckpdSFVSQKVSSLPIDIQSKVSAYM 193
Cdd:TIGR02168  757 TEL----EAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL-----DELRAELTLLNEEAANLRERLE 827


                   ....*...
gi 442629987   194 RLETNSHS 201
Cdd:TIGR02168  828 SLERRIAA 835
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 46-167 2.06e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.31  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629987   46 AAAEIEQLQQALIEKQTQLYALESACLRETERQVELEDSViawQDKYDRLYESHKRVQKVNQSLEDKMLKLvDRNAGERA 125
Cdd:COG1196   244 LEAELEELEAELEELEAELAELEAELEELRLELEELELEL---EEAQAEEYELLAELARLEQDIARLEERR-RELEERLE 319

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 442629987  126 QLTSDVATLSVRLAQANFNIAKLQREIERYKADISLAIQLLQ 167
Cdd:COG1196   320 ELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA 361
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 46-167 3.63e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.54  E-value: 3.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629987   46 AAAEIEQLQQALIEKQTQLYALESACLRETERQVELEDSVIAWQDKYDRLYESHKRVQKVNQSLEDKMLKL---VDRNAG 122
Cdd:COG1196   335 LEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELeeaEEALLE 414

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 442629987  123 ERAQLTSDVATLSVRLAQANFNIAKLQREIERYKADISLAIQLLQ 167
Cdd:COG1196   415 RLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEE 459
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
48-159 5.78e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.99  E-value: 5.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629987   48 AEIEQLQQALIEKQTQLYALESAC--------LRETERQV--------ELEDSVIAWQDKYDRLYESHKRVQKVNQSLED 111
Cdd:COG4717   102 EELEELEAELEELREELEKLEKLLqllplyqeLEALEAELaelperleELEERLEELRELEEELEELEAELAELQEELEE 181

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 442629987  112 KMLKLVDRNAGERAQLTSDVATLSVRLAQANFNIAKLQREIERYKADI 159
Cdd:COG4717   182 LLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEEL 229
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 89-153 2.34e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 40.27  E-value: 2.34e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442629987    89 QDKYDRLYESHKRVQKVNQSLEDKMLKLV----DRNAGERAQLTSDVATLSVRLAQANFNIAKLQREIE 153
Cdd:pfam15619   80 QEKERDLERKLKEKEAELLRLRDQLKRLEklseDKNLAEREELQKKLEQLEAKLEDKDEKIQDLERKLE 148
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 48-201 4.28e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 4.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629987    48 AEIEQLQQ--------------ALIEKQTQLYALESACLRETERQVELEDSVIAWQDKYDRLYESHKRVQKVNQSLEDKM 113
Cdd:TIGR02168  677 REIEELEEkieeleekiaelekALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKEL 756

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629987   114 LKLvdrnAGERAQLTSDVATLSVRLAQANFNIAKLQREIERYKADISLAIQLLqckpdSFVSQKVSSLPIDIQSKVSAYM 193
Cdd:TIGR02168  757 TEL----EAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL-----DELRAELTLLNEEAANLRERLE 827


                   ....*...
gi 442629987   194 RLETNSHS 201
Cdd:TIGR02168  828 SLERRIAA 835
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
48-162 8.14e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.14  E-value: 8.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629987   48 AEIEQLQQALIE---KQTQLYALESACLRETERQVELEDSVIAWQDKYDRL------YESHKRVQKVNQSLEDKMLKLvd 118
Cdd:COG4717    71 KELKELEEELKEaeeKEEEYAELQEELEELEEELEELEAELEELREELEKLekllqlLPLYQELEALEAELAELPERL-- 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 442629987  119 RNAGERAQltsDVATLSVRLAQANFNIAKLQREIERYKADISLA 162
Cdd:COG4717   149 EELEERLE---ELRELEEELEELEAELAELQEELEELLEQLSLA 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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