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Conserved domains on  [gi|24657540|ref|NP_647892|]
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uncharacterized protein Dmel_CG15014 [Drosophila melanogaster]

Protein Classification

THUMP domain-containing protein( domain architecture ID 10185044)

THUMP domain-containing protein similar to human THUMP domain-containing protein 1 (THUMPD1) that functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation

CATH:  3.30.2300.10
Gene Ontology:  GO:0006400|GO:0003723
PubMed:  11295541
SCOP:  4002010

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THUMP_THUMPD1_like cd11717
THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins ...
 123-260 1.14e-46

THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


:

Pssm-ID: 212586  Cd Length: 158  Bit Score: 155.05  E-value: 1.14e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657540 123 RFQNVDTNTTNCVFIRTQ-LEDPVALGKHIINDIATTGKSMSRFVLRLVPIEVVCRANMPDIITAAGELFDKHFL--KEP 199
Cdd:cd11717  21 LLQSVETGVKNVVFIKTRpPVDPVELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKELLKKHFPtaEPP 100

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24657540 200 TSYGIIFNHRYNQQIKRDQIITQLAELVNSKnvgNKVDLKEAKKSIIVEVLRGWCLLSVID 260
Cdd:cd11717 101 KTFAVECKSRNNNKLSRDEVIKAVAELVPEI---HKVDLKNPDKVILVEVIKNVCGISVVK 158
 
Name Accession Description Interval E-value
THUMP_THUMPD1_like cd11717
THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins ...
 123-260 1.14e-46

THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212586  Cd Length: 158  Bit Score: 155.05  E-value: 1.14e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657540 123 RFQNVDTNTTNCVFIRTQ-LEDPVALGKHIINDIATTGKSMSRFVLRLVPIEVVCRANMPDIITAAGELFDKHFL--KEP 199
Cdd:cd11717  21 LLQSVETGVKNVVFIKTRpPVDPVELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKELLKKHFPtaEPP 100

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24657540 200 TSYGIIFNHRYNQQIKRDQIITQLAELVNSKnvgNKVDLKEAKKSIIVEVLRGWCLLSVID 260
Cdd:cd11717 101 KTFAVECKSRNNNKLSRDEVIKAVAELVPEI---HKVDLKNPDKVILVEVIKNVCGISVVK 158
Tan1 COG1818
tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure ...
 121-259 8.21e-12

tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure and biogenesis]; tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441423  Cd Length: 162  Bit Score: 62.60  E-value: 8.21e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657540 121 KMRFQNVdtnttncVFIRTQLeDPVALGKHIINDIATTgksmsRFVLRLVPIEVVCRANMPDIITAAGELFdKHFLKEPT 200
Cdd:COG1818  34 PTGFSGV-------LLVKTSL-DPYEAVEKLKEEPWEP-----RYILRVIPVDRVVKTDLEEIVEAAKELA-KKKIPEGE 99

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24657540 201 SYGIIFNHRYNQQIKRDQIITQLAELVNSknvGNKVDLKEAKKSIIVEVLRGWCLLSVI 259
Cdd:COG1818 100 TFAVRCEKRGKSKLSSREVIRAIGEAIKR---GAKVDLENPDWVVLVEILGDKAGISVL 155
THUMP pfam02926
THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and ...
 133-260 2.45e-07

THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs. The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterized RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 460749  Cd Length: 143  Bit Score: 49.36  E-value: 2.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657540   133 NCVFIRTQLEDPVALGKHIINDIATtgksmSRFVLRLvPIEVVCRANMPDIITAAGELFDKHFLKEPTSYGIIFNHRY-N 211
Cdd:pfam02926  22 GRILVVLKGENPEEDRELLKEALEK-----APGIERF-PVAETCEADLEDILELAKEIIKDKFKKEGETFAVRVKRRGkN 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 24657540   212 QQIKRDQIITQLAELVNSKNvGNKVDLKEAKKSIIVEVLRGWCLLSVID 260
Cdd:pfam02926  96 HEFTSLEINREVGKAIVEKT-GLKVDLENPDIVVHVEIIKDKAYISIDR 143
THUMP smart00981
The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP ...
 179-258 2.85e-04

The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 214952 [Multi-domain]  Cd Length: 83  Bit Score: 39.18  E-value: 2.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657540    179 NMPDIITAAGELFDKHF-LKEPTSYGIIFNHRYNQ-QIKRDQIITQLAELVNSKNVGNKVDLKEAKKSIIVEVLRGWCLL 256
Cdd:smart00981   1 DLEDLYETALELIRWEKiFKEGKTFAVRAKRRGKNhEFTSLEVKRAIGDKLLEKTGGRKVDLKNPDVVIRVELRKDKAYL 80


                   ..
gi 24657540    257 SV 258
Cdd:smart00981  81 SI 82
 
Name Accession Description Interval E-value
THUMP_THUMPD1_like cd11717
THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins ...
 123-260 1.14e-46

THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212586  Cd Length: 158  Bit Score: 155.05  E-value: 1.14e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657540 123 RFQNVDTNTTNCVFIRTQ-LEDPVALGKHIINDIATTGKSMSRFVLRLVPIEVVCRANMPDIITAAGELFDKHFL--KEP 199
Cdd:cd11717  21 LLQSVETGVKNVVFIKTRpPVDPVELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKELLKKHFPtaEPP 100

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24657540 200 TSYGIIFNHRYNQQIKRDQIITQLAELVNSKnvgNKVDLKEAKKSIIVEVLRGWCLLSVID 260
Cdd:cd11717 101 KTFAVECKSRNNNKLSRDEVIKAVAELVPEI---HKVDLKNPDKVILVEVIKNVCGISVVK 158
Tan1 COG1818
tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure ...
 121-259 8.21e-12

tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure and biogenesis]; tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441423  Cd Length: 162  Bit Score: 62.60  E-value: 8.21e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657540 121 KMRFQNVdtnttncVFIRTQLeDPVALGKHIINDIATTgksmsRFVLRLVPIEVVCRANMPDIITAAGELFdKHFLKEPT 200
Cdd:COG1818  34 PTGFSGV-------LLVKTSL-DPYEAVEKLKEEPWEP-----RYILRVIPVDRVVKTDLEEIVEAAKELA-KKKIPEGE 99

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24657540 201 SYGIIFNHRYNQQIKRDQIITQLAELVNSknvGNKVDLKEAKKSIIVEVLRGWCLLSVI 259
Cdd:COG1818 100 TFAVRCEKRGKSKLSSREVIRAIGEAIKR---GAKVDLENPDWVVLVEILGDKAGISVL 155
THUMP pfam02926
THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and ...
 133-260 2.45e-07

THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs. The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterized RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 460749  Cd Length: 143  Bit Score: 49.36  E-value: 2.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657540   133 NCVFIRTQLEDPVALGKHIINDIATtgksmSRFVLRLvPIEVVCRANMPDIITAAGELFDKHFLKEPTSYGIIFNHRY-N 211
Cdd:pfam02926  22 GRILVVLKGENPEEDRELLKEALEK-----APGIERF-PVAETCEADLEDILELAKEIIKDKFKKEGETFAVRVKRRGkN 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 24657540   212 QQIKRDQIITQLAELVNSKNvGNKVDLKEAKKSIIVEVLRGWCLLSVID 260
Cdd:pfam02926  96 HEFTSLEINREVGKAIVEKT-GLKVDLENPDIVVHVEIIKDKAYISIDR 143
THUMP cd11688
THUMP domain, predicted to bind RNA; The THUMP domain is named after THioUridine synthases, ...
 163-254 2.86e-06

THUMP domain, predicted to bind RNA; The THUMP domain is named after THioUridine synthases, RNA Methyltransferases and Pseudo-uridine synthases. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212583  Cd Length: 148  Bit Score: 46.33  E-value: 2.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657540 163 SRFVLRLVPIEVVCRANMPDIITAAGELFDKHFLKEPTSYGIIFNHRYNQQIKRDQIITQLAELVnsKNVGN-KVDLKEA 241
Cdd:cd11688  55 SRLISRIMPPLGECKADLEDLYETALEINEPEMGNEGAKFAVRARRRNKTILNSQEIAMKVGDAI--VDAFNpEVDLDNP 132

                        90
                ....*....|...
gi 24657540 242 KKSIIVEVLRGWC 254
Cdd:cd11688 133 DIVVNVEVHKEIA 145
THUMP smart00981
The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP ...
 179-258 2.85e-04

The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 214952 [Multi-domain]  Cd Length: 83  Bit Score: 39.18  E-value: 2.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657540    179 NMPDIITAAGELFDKHF-LKEPTSYGIIFNHRYNQ-QIKRDQIITQLAELVNSKNVGNKVDLKEAKKSIIVEVLRGWCLL 256
Cdd:smart00981   1 DLEDLYETALELIRWEKiFKEGKTFAVRAKRRGKNhEFTSLEVKRAIGDKLLEKTGGRKVDLKNPDVVIRVELRKDKAYL 80


                   ..
gi 24657540    257 SV 258
Cdd:smart00981  81 SI 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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