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Conserved domains on  [gi|24657574|ref|NP_647896|]
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uncharacterized protein Dmel_CG11342 [Drosophila melanogaster]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 18605031)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Drosophila melanogaster RNA methyltransferases CG1239 and CG11342

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 134-238 5.50e-26

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


:

Pssm-ID: 462022  Cd Length: 109  Bit Score: 97.23  E-value: 5.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574   134 FDAICCYSITMWIHLNHHDQGLRFFLQKLSNLAE---LLVVEPQPWKCYQKAERRLKkagEIFPLFLELKWRSDvdlQIQ 210
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRpggVLILEPQPWKSYKKAKRLSE---TIKANYKTIQLRPE---DFE 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 24657574   211 KYLEESLDrrkiFKS----------APTKWQRKICFYR 238
Cdd:pfam06859  75 EYLLSEVG----FESveelgstpegKSKGFDRPIYLFR 108
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 55-173 6.88e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 52.71  E-value: 6.88e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574  55 ILDVGCNCGVLTQLMHKyleerlhRSVKVLGVDIDPRLIQRASEENESPkDVSYACVDVLDDEAFEsvktymevnnlEKF 134
Cdd:COG2227  28 VLDVGCGTGRLALALAR-------RGADVTGVDISPEALEIARERAAEL-NVDFVQGDLEDLPLED-----------GSF 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 24657574 135 DAICCYSitMWIHLNHHDQGLRFFLQKLSNLAELLVVEP 173
Cdd:COG2227  89 DLVICSE--VLEHLPDPAALLRELARLLKPGGLLLLSTP 125
 
Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 134-238 5.50e-26

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


Pssm-ID: 462022  Cd Length: 109  Bit Score: 97.23  E-value: 5.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574   134 FDAICCYSITMWIHLNHHDQGLRFFLQKLSNLAE---LLVVEPQPWKCYQKAERRLKkagEIFPLFLELKWRSDvdlQIQ 210
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRpggVLILEPQPWKSYKKAKRLSE---TIKANYKTIQLRPE---DFE 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 24657574   211 KYLEESLDrrkiFKS----------APTKWQRKICFYR 238
Cdd:pfam06859  75 EYLLSEVG----FESveelgstpegKSKGFDRPIYLFR 108
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 55-173 6.88e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 52.71  E-value: 6.88e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574  55 ILDVGCNCGVLTQLMHKyleerlhRSVKVLGVDIDPRLIQRASEENESPkDVSYACVDVLDDEAFEsvktymevnnlEKF 134
Cdd:COG2227  28 VLDVGCGTGRLALALAR-------RGADVTGVDISPEALEIARERAAEL-NVDFVQGDLEDLPLED-----------GSF 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 24657574 135 DAICCYSitMWIHLNHHDQGLRFFLQKLSNLAELLVVEP 173
Cdd:COG2227  89 DLVICSE--VLEHLPDPAALLRELARLLKPGGLLLLSTP 125
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 55-156 1.57e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 50.64  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574    55 ILDVGCNCGVLTQLMHKYLEERlhrsvkVLGVDIDPRLIQRASEENESPK-DVSYACVDVLDDEaFESvktymevnnlEK 133
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGAR------VTGVDLSPEMLERARERAAEAGlNVEFVQGDAEDLP-FPD----------GS 63

                          90       100
                  ....*....|....*....|...
gi 24657574   134 FDAICCYSITMWIHLNHHDQGLR 156
Cdd:pfam13649  64 FDLVVSSGVLHHLPDPDLEAALR 86
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 55-162 1.80e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 42.42  E-value: 1.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574  55 ILDVGCNCGVLTQLMHKYLEERlhrsvkVLGVDIDPRLIQRASE--ENESPKDVSYACVDVLDDEAFEsvktymevnnLE 132
Cdd:cd02440   2 VLDLGCGTGALALALASGPGAR------VTGVDISPVALELARKaaAALLADNVEVLKGDAEELPPEA----------DE 65

                        90       100       110
                ....*....|....*....|....*....|
gi 24657574 133 KFDAICCySITMWIHLNHHDQGLRFFLQKL 162
Cdd:cd02440  66 SFDVIIS-DPPLHHLVEDLARFLEEARRLL 94
PRK14968 PRK14968
putative methyltransferase; Provisional
 34-138 7.19e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 36.42  E-value: 7.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574   34 DADIWLPALEDGETQKdkpyfILDVGCNCGVLTQLMHKyleerlhRSVKVLGVDIDPRLIQRAsEENESPKDVSYACVDV 113
Cdd:PRK14968  11 DSFLLAENAVDKKGDR-----VLEVGTGSGIVAIVAAK-------NGKKVVGVDINPYAVECA-KCNAKLNNIRNNGVEV 77

                         90       100
                 ....*....|....*....|....*
gi 24657574  114 LDDEAFESVKTYmevnnleKFDAIC 138
Cdd:PRK14968  78 IRSDLFEPFRGD-------KFDVIL 95
 
Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 134-238 5.50e-26

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


Pssm-ID: 462022  Cd Length: 109  Bit Score: 97.23  E-value: 5.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574   134 FDAICCYSITMWIHLNHHDQGLRFFLQKLSNLAE---LLVVEPQPWKCYQKAERRLKkagEIFPLFLELKWRSDvdlQIQ 210
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRpggVLILEPQPWKSYKKAKRLSE---TIKANYKTIQLRPE---DFE 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 24657574   211 KYLEESLDrrkiFKS----------APTKWQRKICFYR 238
Cdd:pfam06859  75 EYLLSEVG----FESveelgstpegKSKGFDRPIYLFR 108
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 55-173 6.88e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 52.71  E-value: 6.88e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574  55 ILDVGCNCGVLTQLMHKyleerlhRSVKVLGVDIDPRLIQRASEENESPkDVSYACVDVLDDEAFEsvktymevnnlEKF 134
Cdd:COG2227  28 VLDVGCGTGRLALALAR-------RGADVTGVDISPEALEIARERAAEL-NVDFVQGDLEDLPLED-----------GSF 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 24657574 135 DAICCYSitMWIHLNHHDQGLRFFLQKLSNLAELLVVEP 173
Cdd:COG2227  89 DLVICSE--VLEHLPDPAALLRELARLLKPGGLLLLSTP 125
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 39-169 1.23e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 53.38  E-value: 1.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574  39 LPALEDGETQKDKPYFILDVGCNCGVLTQLMHkyleERLHRsvKVLGVDIDPRLIQRASEENES--PKDVSYACVDVLDD 116
Cdd:COG0500  14 LAALLALLERLPKGGRVLDLGCGTGRNLLALA----ARFGG--RVIGIDLSPEAIALARARAAKagLGNVEFLVADLAEL 87

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 24657574 117 EAFEsvktymevnnLEKFDAICCYSItmwihLNHHDQGLRFFLqkLSNLAELL 169
Cdd:COG0500  88 DPLP----------AESFDLVVAFGV-----LHHLPPEEREAL--LRELARAL 123
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 55-156 1.57e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 50.64  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574    55 ILDVGCNCGVLTQLMHKYLEERlhrsvkVLGVDIDPRLIQRASEENESPK-DVSYACVDVLDDEaFESvktymevnnlEK 133
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGAR------VTGVDLSPEMLERARERAAEAGlNVEFVQGDAEDLP-FPD----------GS 63

                          90       100
                  ....*....|....*....|...
gi 24657574   134 FDAICCYSITMWIHLNHHDQGLR 156
Cdd:pfam13649  64 FDLVVSSGVLHHLPDPDLEAALR 86
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 56-165 3.10e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 47.36  E-value: 3.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574    56 LDVGCNCGVLTQlmhkYLEERLHRSvKVLGVDIDPRLIQRASEENESPKDVSYACVDVLDDEAFESVktymevnnLEKFD 135
Cdd:pfam08242   1 LEIGCGTGTLLR----ALLEALPGL-EYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELD--------PGSFD 67

                          90       100       110
                  ....*....|....*....|....*....|
gi 24657574   136 AICCYSITmwihlnHHDQGLRFFLQKLSNL 165
Cdd:pfam08242  68 VVVASNVL------HHLADPRAVLRNIRRL 91
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
55-162 1.02e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 45.97  E-value: 1.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574  55 ILDVGCNCGVLTQlmhkYLEERLHRsVKVLGVDIDPRLIQRASEENEspkDVSYACVDVLDDEAfesvktymevnnLEKF 134
Cdd:COG4106   5 VLDLGCGTGRLTA----LLAERFPG-ARVTGVDLSPEMLARARARLP---NVRFVVADLRDLDP------------PEPF 64

                        90       100
                ....*....|....*....|....*...
gi 24657574 135 DAIccYSITMWIHLNHHDQGLRFFLQKL 162
Cdd:COG4106  65 DLV--VSNAALHWLPDHAALLARLAAAL 90
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 49-177 1.52e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 46.64  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574    49 KDKPYFILDVGCNCGVLTQLMHkyleERLHRSVKVLGVDIDPRLIQRAsEENESPKDVSYACVDVLDDEAFESVKTymev 128
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELA----EELGPNAEVVGIDISEEAIEKA-RENAQKLGFDNVEFEQGDIEELPELLE---- 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 24657574   129 nnLEKFDAICCYSITMwiHLNHHDQGLRFFLQKLSNLAELLVVEPQPWK 177
Cdd:pfam13847  72 --DDKFDVVISNCVLN--HIPDPDKVLQEILRVLKPGGRLIISDPDSLA 116
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 55-162 1.80e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 42.42  E-value: 1.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574  55 ILDVGCNCGVLTQLMHKYLEERlhrsvkVLGVDIDPRLIQRASE--ENESPKDVSYACVDVLDDEAFEsvktymevnnLE 132
Cdd:cd02440   2 VLDLGCGTGALALALASGPGAR------VTGVDISPVALELARKaaAALLADNVEVLKGDAEELPPEA----------DE 65

                        90       100       110
                ....*....|....*....|....*....|
gi 24657574 133 KFDAICCySITMWIHLNHHDQGLRFFLQKL 162
Cdd:cd02440  66 SFDVIIS-DPPLHHLVEDLARFLEEARRLL 94
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
50-139 6.22e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 42.29  E-value: 6.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574  50 DKPYFILDVGCNCGVLTQLMHKyleerlhRSVKVLGVDIDPRLIQRAseeNESPKDVSYACVDVLDDEAFEsvktymevn 129
Cdd:COG4976  45 GPFGRVLDLGCGTGLLGEALRP-------RGYRLTGVDLSEEMLAKA---REKGVYDRLLVADLADLAEPD--------- 105

                        90
                ....*....|
gi 24657574 130 nlEKFDAICC 139
Cdd:COG4976 106 --GRFDLIVA 113
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 55-208 1.94e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 40.36  E-value: 1.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574  55 ILDVGCNCGVLTQLMhkyleerLHRSVKVLGVDIDPRLIQRASEEN-ESPKDVSYACVDVlDDEAFESvktymevnnlEK 133
Cdd:COG2226  26 VLDLGCGTGRLALAL-------AERGARVTGVDISPEMLELARERAaEAGLNVEFVVGDA-EDLPFPD----------GS 87

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24657574 134 FDAICCYsitmwihlnhhdQGLRFFlqklsnlaellvvePQPWKCYQKAERRLKKAGEIfpLFLELKWRSDVDLQ 208
Cdd:COG2226  88 FDLVISS------------FVLHHL--------------PDPERALAEIARVLKPGGRL--VVVDFSPPDLAELE 134
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 55-165 6.33e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 39.14  E-value: 6.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574  55 ILDVGCNCGVLTQLMHKyleerlHRSVKVLGVDIDPRLIQRASEENES---PKDVSYACVDvlddeafesvktYMEVNNL 131
Cdd:COG2230  55 VLDIGCGWGGLALYLAR------RYGVRVTGVTLSPEQLEYARERAAEaglADRVEVRLAD------------YRDLPAD 116

                        90       100       110
                ....*....|....*....|....*....|....
gi 24657574 132 EKFDAIccYSITMWIHLNHHDqgLRFFLQKLSNL 165
Cdd:COG2230 117 GQFDAI--VSIGMFEHVGPEN--YPAYFAKVARL 146
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 56-122 1.04e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 37.26  E-value: 1.04e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24657574    56 LDVGCNCGvltqLMHKYLEERLHRsvkVLGVDIDPRLIQRASEENESPKdVSYACVDV----LDDEAFESV 122
Cdd:pfam08241   1 LDVGCGTG----LLTELLARLGAR---VTGVDISPEMLELAREKAPREG-LTFVVGDAedlpFPDNSFDLV 63
PRK14968 PRK14968
putative methyltransferase; Provisional
 34-138 7.19e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 36.42  E-value: 7.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657574   34 DADIWLPALEDGETQKdkpyfILDVGCNCGVLTQLMHKyleerlhRSVKVLGVDIDPRLIQRAsEENESPKDVSYACVDV 113
Cdd:PRK14968  11 DSFLLAENAVDKKGDR-----VLEVGTGSGIVAIVAAK-------NGKKVVGVDINPYAVECA-KCNAKLNNIRNNGVEV 77

                         90       100
                 ....*....|....*....|....*
gi 24657574  114 LDDEAFESVKTYmevnnleKFDAIC 138
Cdd:PRK14968  78 IRSDLFEPFRGD-------KFDVIL 95
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 55-98 9.97e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 36.28  E-value: 9.97e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 24657574  55 ILDVGCNCGVLTqLMhkyLEERLHrSVKVLGVDIDPRLIQRASE 98
Cdd:COG4123  41 VLDLGTGTGVIA-LM---LAQRSP-GARITGVEIQPEAAELARR 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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