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Conserved domains on  [gi|28574316|ref|NP_647898|]
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slowdown, isoform A [Drosophila melanogaster]

Protein Classification

calcium-binding EGF-like domain-containing protein; wall-associated receptor kinase family protein( domain architecture ID 10540360)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions| wall-associated receptor kinase (WAK) family protein containing the calcium-binding EGF and serine/threonine kinase domains but lacking the WAK galacturonan-binding domain, catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates, and may function as a signaling receptor of extracellular matrix component

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 245-319 9.94e-09

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


:

Pssm-ID: 462204  Cd Length: 69  Bit Score: 52.04  E-value: 9.94e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574316   245 RHICMQQRTVTMPVKRTEVYSRPTWKHVATPCQPPTfsgqKCTRVQVVHEQAYRDVidHKTAQQMTYDCCTGWSR 319
Cdd:pfam07546   1 RNVCAYKVVSCVVVTGTESYVQPVYKPYLTWCAGHR----RCSTYRTTYRPAYRQV--YKTVTRLEWRCCPGWGG 69
EGF_CA smart00179
Calcium-binding EGF-like domain;
362-401 3.36e-08

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.55  E-value: 3.36e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 28574316    362 DVDECQTEKPCDQ--QCINTHGSYFCRCRQGFvlqSDQQSCK 401
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 336-360 1.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 1.79e-03
                        10        20
                ....*....|....*....|....*...
gi 28574316 336 CQNGGNC--TAPS-TCSCPTGFTGRFCE 360
Cdd:cd00054  11 CQNGGTCvnTVGSyRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 245-319 9.94e-09

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 52.04  E-value: 9.94e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574316   245 RHICMQQRTVTMPVKRTEVYSRPTWKHVATPCQPPTfsgqKCTRVQVVHEQAYRDVidHKTAQQMTYDCCTGWSR 319
Cdd:pfam07546   1 RNVCAYKVVSCVVVTGTESYVQPVYKPYLTWCAGHR----RCSTYRTTYRPAYRQV--YKTVTRLEWRCCPGWGG 69
EGF_CA smart00179
Calcium-binding EGF-like domain;
362-401 3.36e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.55  E-value: 3.36e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 28574316    362 DVDECQTEKPCDQ--QCINTHGSYFCRCRQGFvlqSDQQSCK 401
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 362-395 5.31e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 5.31e-08
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 28574316 362 DVDECQTEKPC--DQQCINTHGSYFCRCRQGFVLQS 395
Cdd:cd00054   1 DIDECASGNPCqnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
362-390 2.77e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.07  E-value: 2.77e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 28574316   362 DVDECQTE-KPCDQQ--CINTHGSYFCRCRQG 390
Cdd:pfam07645   1 DVDECATGtHNCPANtvCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 336-360 1.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 1.79e-03
                        10        20
                ....*....|....*....|....*...
gi 28574316 336 CQNGGNC--TAPS-TCSCPTGFTGRFCE 360
Cdd:cd00054  11 CQNGGTCvnTVGSyRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 245-319 9.94e-09

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 52.04  E-value: 9.94e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28574316   245 RHICMQQRTVTMPVKRTEVYSRPTWKHVATPCQPPTfsgqKCTRVQVVHEQAYRDVidHKTAQQMTYDCCTGWSR 319
Cdd:pfam07546   1 RNVCAYKVVSCVVVTGTESYVQPVYKPYLTWCAGHR----RCSTYRTTYRPAYRQV--YKTVTRLEWRCCPGWGG 69
EGF_CA smart00179
Calcium-binding EGF-like domain;
362-401 3.36e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.55  E-value: 3.36e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 28574316    362 DVDECQTEKPCDQ--QCINTHGSYFCRCRQGFvlqSDQQSCK 401
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 362-395 5.31e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 5.31e-08
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 28574316 362 DVDECQTEKPC--DQQCINTHGSYFCRCRQGFVLQS 395
Cdd:cd00054   1 DIDECASGNPCqnGGTCVNTVGSYRCSCPPGYTGRN 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 354-397 7.84e-07

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 50.08  E-value: 7.84e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 28574316 354 FTGRFCEQDvDECQTE-KPCDQQCINTHGSYFCRCRQGFVLQSDQ 397
Cdd:cd01475 179 FQGKICVVP-DLCATLsHVCQQVCISTPGSYLCACTEGYALLEDN 222
EGF_CA pfam07645
Calcium-binding EGF domain;
362-390 2.77e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.07  E-value: 2.77e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 28574316   362 DVDECQTE-KPCDQQ--CINTHGSYFCRCRQG 390
Cdd:pfam07645   1 DVDECATGtHNCPANtvCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
365-394 1.83e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 38.65  E-value: 1.83e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 28574316    365 ECQTEKPCDQ-QCINTHGSYFCRCRQGFVLQ 394
Cdd:smart00181   1 ECASGGPCSNgTCINTPGSYTCSCPPGYTGD 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 365-394 2.60e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.23  E-value: 2.60e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 28574316 365 ECQTEKPCD--QQCINTHGSYFCRCRQGFVLQ 394
Cdd:cd00053   1 ECAASNPCSngGTCVNTPGSYRCVCPPGYTGD 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 336-360 1.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 1.79e-03
                        10        20
                ....*....|....*....|....*...
gi 28574316 336 CQNGGNC--TAPS-TCSCPTGFTGRFCE 360
Cdd:cd00054  11 CQNGGTCvnTVGSyRCSCPPGYTGRNCE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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