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Conserved domains on  [gi|21357785|ref|NP_648698|]
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uncharacterized protein Dmel_CG7924 [Drosophila melanogaster]

Protein Classification

Kazal-type serine protease inhibitor family protein( domain architecture ID 10541645)

Kazal-type serine protease inhibitor family protein may function as a serine protease inhibitor

CATH:  3.30.60.30
Gene Ontology:  GO:0005576|GO:0004867
PubMed:  19995574|12051857
SCOP:  4003413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
 255-310 5.13e-09

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


:

Pssm-ID: 400135  Cd Length: 50  Bit Score: 51.34  E-value: 5.13e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 21357785   255 NCDELCTKFEYSPICAHNGiciHEFANQCVMNTFNCKHRDLSFRavdEDVCRLGVC 310
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDG---VTYPSPCALCAAGCKLGKEVKE---EKVKYDGSC 50
PHA03378 super family cl33729
EBNA-3B; Provisional
 100-228 5.07e-07

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 51.22  E-value: 5.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357785  100 PNPGIPNHGIPNRGIPNDGIPNPGIPNHGIPNPGIPNHGIPNRGIPNDGIPNPGIPNHGIPNPGIPNHGIPNRGIPNDGI 179
Cdd:PHA03378 681 ANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAA 760

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 21357785  180 PNPGIPNHGIPNPGIPNPdASELKPVvvmPSSRTTSAPASTSMPKRVPT 228
Cdd:PHA03378 761 PGRARPPAAAPGAPTPQP-PPQAPPA---PQQRPRGAPTPQPPPQAGPT 805
 
Name Accession Description Interval E-value
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
 255-310 5.13e-09

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 51.34  E-value: 5.13e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 21357785   255 NCDELCTKFEYSPICAHNGiciHEFANQCVMNTFNCKHRDLSFRavdEDVCRLGVC 310
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDG---VTYPSPCALCAAGCKLGKEVKE---EKVKYDGSC 50
PHA03378 PHA03378
EBNA-3B; Provisional
 100-228 5.07e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 51.22  E-value: 5.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357785  100 PNPGIPNHGIPNRGIPNDGIPNPGIPNHGIPNPGIPNHGIPNRGIPNDGIPNPGIPNHGIPNPGIPNHGIPNRGIPNDGI 179
Cdd:PHA03378 681 ANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAA 760

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 21357785  180 PNPGIPNHGIPNPGIPNPdASELKPVvvmPSSRTTSAPASTSMPKRVPT 228
Cdd:PHA03378 761 PGRARPPAAAPGAPTPQP-PPQAPPA---PQQRPRGAPTPQPPPQAGPT 805
Pentapeptide_2 pfam01469
Pentapeptide repeats (8 copies); These repeats are found in many mycobacterial proteins. These ...
 96-133 5.42e-03

Pentapeptide repeats (8 copies); These repeats are found in many mycobacterial proteins. These repeats are most common in the pfam00823 family of proteins, where they are found in the MPTR subfamily of PPE proteins. The function of these repeats is unknown. The repeat can be approximately described as XNXGX, where X can be any amino acid. These repeats are similar to pfam00805, however it is not clear if these two families are structurally related.


Pssm-ID: 279771 [Multi-domain]  Cd Length: 39  Bit Score: 34.07  E-value: 5.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21357785    96 NHGIPNPGIPNHGIPNRGIPNDGIPNPGIPNHGIPNPG 133
Cdd:pfam01469   2 NTGSGNSGSGNTGFFNLGSGNTGSFNLGSGNTGNGNTG 39
 
Name Accession Description Interval E-value
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
 255-310 5.13e-09

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 51.34  E-value: 5.13e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 21357785   255 NCDELCTKFEYSPICAHNGiciHEFANQCVMNTFNCKHRDLSFRavdEDVCRLGVC 310
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDG---VTYPSPCALCAAGCKLGKEVKE---EKVKYDGSC 50
PHA03378 PHA03378
EBNA-3B; Provisional
 100-228 5.07e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 51.22  E-value: 5.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357785  100 PNPGIPNHGIPNRGIPNDGIPNPGIPNHGIPNPGIPNHGIPNRGIPNDGIPNPGIPNHGIPNPGIPNHGIPNRGIPNDGI 179
Cdd:PHA03378 681 ANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAA 760

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 21357785  180 PNPGIPNHGIPNPGIPNPdASELKPVvvmPSSRTTSAPASTSMPKRVPT 228
Cdd:PHA03378 761 PGRARPPAAAPGAPTPQP-PPQAPPA---PQQRPRGAPTPQPPPQAGPT 805
Pentapeptide_2 pfam01469
Pentapeptide repeats (8 copies); These repeats are found in many mycobacterial proteins. These ...
 96-133 5.42e-03

Pentapeptide repeats (8 copies); These repeats are found in many mycobacterial proteins. These repeats are most common in the pfam00823 family of proteins, where they are found in the MPTR subfamily of PPE proteins. The function of these repeats is unknown. The repeat can be approximately described as XNXGX, where X can be any amino acid. These repeats are similar to pfam00805, however it is not clear if these two families are structurally related.


Pssm-ID: 279771 [Multi-domain]  Cd Length: 39  Bit Score: 34.07  E-value: 5.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21357785    96 NHGIPNPGIPNHGIPNRGIPNDGIPNPGIPNHGIPNPG 133
Cdd:pfam01469   2 NTGSGNSGSGNTGFFNLGSGNTGSFNLGSGNTGNGNTG 39
Pentapeptide_2 pfam01469
Pentapeptide repeats (8 copies); These repeats are found in many mycobacterial proteins. These ...
 126-163 5.42e-03

Pentapeptide repeats (8 copies); These repeats are found in many mycobacterial proteins. These repeats are most common in the pfam00823 family of proteins, where they are found in the MPTR subfamily of PPE proteins. The function of these repeats is unknown. The repeat can be approximately described as XNXGX, where X can be any amino acid. These repeats are similar to pfam00805, however it is not clear if these two families are structurally related.


Pssm-ID: 279771 [Multi-domain]  Cd Length: 39  Bit Score: 34.07  E-value: 5.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21357785   126 NHGIPNPGIPNHGIPNRGIPNDGIPNPGIPNHGIPNPG 163
Cdd:pfam01469   2 NTGSGNSGSGNTGFFNLGSGNTGSFNLGSGNTGNGNTG 39
Pentapeptide_2 pfam01469
Pentapeptide repeats (8 copies); These repeats are found in many mycobacterial proteins. These ...
 156-193 5.42e-03

Pentapeptide repeats (8 copies); These repeats are found in many mycobacterial proteins. These repeats are most common in the pfam00823 family of proteins, where they are found in the MPTR subfamily of PPE proteins. The function of these repeats is unknown. The repeat can be approximately described as XNXGX, where X can be any amino acid. These repeats are similar to pfam00805, however it is not clear if these two families are structurally related.


Pssm-ID: 279771 [Multi-domain]  Cd Length: 39  Bit Score: 34.07  E-value: 5.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21357785   156 NHGIPNPGIPNHGIPNRGIPNDGIPNPGIPNHGIPNPG 193
Cdd:pfam01469   2 NTGSGNSGSGNTGFFNLGSGNTGSFNLGSGNTGNGNTG 39
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 101-187 7.18e-03

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 38.13  E-value: 7.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357785   101 NPGIPNHGIPNRGIPNDGIPNPGIPNHGIPNPgiPNHGIPNRGIPNDGIPNPGIPNHGIPNPGIPNHGIPNRGIPNDGIP 180
Cdd:PTZ00395  396 NAAQSNAAQSNAGFSNAGYSNPGNSNPGYNNA--PNSNTPYNNPPNSNTPYSNPPNSNPPYSNLPYSNTPYSNAPLSNAP 473


                  ....*..
gi 21357785   181 NPGIPNH 187
Cdd:PTZ00395  474 PSSAKDH 480
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 111-245 7.31e-03

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 38.13  E-value: 7.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357785   111 NRGIPNDGIPNPGIPNHGIPNPGIPNHGIPNRgipndgiPNPGIPNHGIPNPGIPNHGIPNRGIPNDGIPNPGIPNHGIP 190
Cdd:PTZ00395  396 NAAQSNAAQSNAGFSNAGYSNPGNSNPGYNNA-------PNSNTPYNNPPNSNTPYSNPPNSNPPYSNLPYSNTPYSNAP 468

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 21357785   191 NPGIPNPDASELKPVV-VMPSSRTTSAPASTSMPKRVPTRNCFHLLMGGTTTTSPV 245
Cdd:PTZ00395  469 LSNAPPSSAKDHHSAYhAAYQHRAANQPAANLPTANQPAANNFHGAAGNSVGNPFA 524
PHA03247 PHA03247
large tegument protein UL36; Provisional
 89-225 9.39e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.00  E-value: 9.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357785    89 VSDSGIPNHGIPNPGIPNHgIPNRGIPNdgiPNPGIPNHGIPNPGIPNHGIPNRGIPNDGIPNPGIPNHGIPNPGIPNHG 168
Cdd:PHA03247 2862 VRRRPPSRSPAAKPAAPAR-PPVRRLAR---PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21357785   169 IPNRGIPndgiPNPGIPNHGIPNPGIPNPDASELKP-VVVMPSSRTTS------APASTSMPKR 225
Cdd:PHA03247 2938 RPQPPLA----PTTDPAGAGEPSGAVPQPWLGALVPgRVAVPRFRVPQpapsreAPASSTPPLT 2997
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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