NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24664143|ref|NP_648699|]
View 

uncharacterized protein Dmel_CG7906, isoform A [Drosophila melanogaster]

Protein Classification

Kazal-type serine protease inhibitor family protein( domain architecture ID 10541645)

Kazal-type serine protease inhibitor family protein may function as a serine protease inhibitor

CATH:  3.30.60.30
Gene Ontology:  GO:0005576|GO:0004867
PubMed:  19995574|12051857
SCOP:  4003413

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
 293-342 1.52e-08

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


:

Pssm-ID: 400135  Cd Length: 50  Bit Score: 50.18  E-value: 1.52e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 24664143   293 KCNFQCPKASLS-ICASNGKcvvNFPGQCELSQWNCFNTKNVF--HQVHDAEC 342
Cdd:pfam07648   1 NCNCQCPKTEYEpVCGSDGV---TYPSPCALCAAGCKLGKEVKeeKVKYDGSC 50
PRK00409 super family cl29770
recombination and DNA strand exchange inhibitor protein; Reviewed
 174-267 7.65e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


The actual alignment was detected with superfamily member PRK00409:

Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 41.35  E-value: 7.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664143  174 NVAEKLQKLQQHVTKVMQQAEKhiplAVNQAIKQKKEqEAQREKEQLQKDKEINKVDDKEKEVKEDQ---EDPEPSETTP 250
Cdd:PRK00409 552 ELEEKKEKLQEEEDKLLEEAEK----EAQQAIKEAKK-EADEIIKELRQLQKGGYASVKAHELIEARkrlNKANEKKEKK 626

                         90
                 ....*....|....*..
gi 24664143  251 QPSSSKAGRSLVIPDKV 267
Cdd:PRK00409 627 KKKQKEKQEELKVGDEV 643
 
Name Accession Description Interval E-value
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
 293-342 1.52e-08

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 50.18  E-value: 1.52e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 24664143   293 KCNFQCPKASLS-ICASNGKcvvNFPGQCELSQWNCFNTKNVF--HQVHDAEC 342
Cdd:pfam07648   1 NCNCQCPKTEYEpVCGSDGV---TYPSPCALCAAGCKLGKEVKeeKVKYDGSC 50
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 174-267 7.65e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 41.35  E-value: 7.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664143  174 NVAEKLQKLQQHVTKVMQQAEKhiplAVNQAIKQKKEqEAQREKEQLQKDKEINKVDDKEKEVKEDQ---EDPEPSETTP 250
Cdd:PRK00409 552 ELEEKKEKLQEEEDKLLEEAEK----EAQQAIKEAKK-EADEIIKELRQLQKGGYASVKAHELIEARkrlNKANEKKEKK 626

                         90
                 ....*....|....*..
gi 24664143  251 QPSSSKAGRSLVIPDKV 267
Cdd:PRK00409 627 KKKQKEKQEELKVGDEV 643
 
Name Accession Description Interval E-value
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
 293-342 1.52e-08

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 50.18  E-value: 1.52e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 24664143   293 KCNFQCPKASLS-ICASNGKcvvNFPGQCELSQWNCFNTKNVF--HQVHDAEC 342
Cdd:pfam07648   1 NCNCQCPKTEYEpVCGSDGV---TYPSPCALCAAGCKLGKEVKeeKVKYDGSC 50
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 174-267 7.65e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 41.35  E-value: 7.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664143  174 NVAEKLQKLQQHVTKVMQQAEKhiplAVNQAIKQKKEqEAQREKEQLQKDKEINKVDDKEKEVKEDQ---EDPEPSETTP 250
Cdd:PRK00409 552 ELEEKKEKLQEEEDKLLEEAEK----EAQQAIKEAKK-EADEIIKELRQLQKGGYASVKAHELIEARkrlNKANEKKEKK 626

                         90
                 ....*....|....*..
gi 24664143  251 QPSSSKAGRSLVIPDKV 267
Cdd:PRK00409 627 KKKQKEKQEELKVGDEV 643
PTZ00121 PTZ00121
MAEBL; Provisional
 164-247 1.59e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664143   164 VLSLPGQEPINVAEKLQKLQQHVTKVMQ-QAEKHIPLAVNQAikQKKEQEAQREKEQLQKDKEINKVdDKEKEVKEDQED 242
Cdd:PTZ00121 1597 VMKLYEEEKKMKAEEAKKAEEAKIKAEElKKAEEEKKKVEQL--KKKEAEEKKKAEELKKAEEENKI-KAAEEAKKAEED 1673


                  ....*
gi 24664143   243 PEPSE 247
Cdd:PTZ00121 1674 KKKAE 1678
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH