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Conserved domains on  [gi|45550623|ref|NP_648789|]
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phaser [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
594-787 2.45e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 2.45e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550623 594 SSATISPHNSSTDESFTSIKRESSEESQHNGIGGIHTCNFCGKTFKRFSRMQDHLR--LHTGE--KPYVCG--QCGRAFR 667
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFS 334

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550623 668 LKMRLVEHQLRHRAEKAYKCDICSMP------LATKQDLSLHMRHHKNDRRYKC---DKCNKGFVRSSDLSIHVRIHTGE 738
Cdd:COG5048 335 RNDALKRHILLHTSISPAKEKLLNSSskfsplLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSF 414

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 45550623 739 KPYSCD--LCGKAFRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDMRVH 787
Cdd:COG5048 415 RPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
783-808 2.99e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 45550623   783 DMRVHMRRHTGEKPYNCDACQRGYSS 808
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
594-787 2.45e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 2.45e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550623 594 SSATISPHNSSTDESFTSIKRESSEESQHNGIGGIHTCNFCGKTFKRFSRMQDHLR--LHTGE--KPYVCG--QCGRAFR 667
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFS 334

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550623 668 LKMRLVEHQLRHRAEKAYKCDICSMP------LATKQDLSLHMRHHKNDRRYKC---DKCNKGFVRSSDLSIHVRIHTGE 738
Cdd:COG5048 335 RNDALKRHILLHTSISPAKEKLLNSSskfsplLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSF 414

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 45550623 739 KPYSCD--LCGKAFRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDMRVH 787
Cdd:COG5048 415 RPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
727-750 3.23e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 3.23e-05
                          10        20
                  ....*....|....*....|....
gi 45550623   727 DLSIHVRIHTGEKPYSCDLCGKAF 750
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
783-808 2.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 45550623   783 DMRVHMRRHTGEKPYNCDACQRGYSS 808
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
629-651 8.16e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 8.16e-03
                           10        20
                   ....*....|....*....|...
gi 45550623    629 HTCNFCGKTFKRFSRMQDHLRLH 651
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
594-787 2.45e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 2.45e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550623 594 SSATISPHNSSTDESFTSIKRESSEESQHNGIGGIHTCNFCGKTFKRFSRMQDHLR--LHTGE--KPYVCG--QCGRAFR 667
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFS 334

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550623 668 LKMRLVEHQLRHRAEKAYKCDICSMP------LATKQDLSLHMRHHKNDRRYKC---DKCNKGFVRSSDLSIHVRIHTGE 738
Cdd:COG5048 335 RNDALKRHILLHTSISPAKEKLLNSSskfsplLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSF 414

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 45550623 739 KPYSCD--LCGKAFRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDMRVH 787
Cdd:COG5048 415 RPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
727-750 3.23e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 3.23e-05
                          10        20
                  ....*....|....*....|....
gi 45550623   727 DLSIHVRIHTGEKPYSCDLCGKAF 750
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
783-808 2.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 45550623   783 DMRVHMRRHTGEKPYNCDACQRGYSS 808
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
708-772 3.47e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 3.47e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45550623 708 KNDRRYKCDKCNKGFVRSSDLSIHVRIHTGEKPYSC--DLCGKAFRARQNLVVHRRTHLGDKPIQCE 772
Cdd:COG5048  29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 713-735 3.96e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 3.96e-04
                          10        20
                  ....*....|....*....|...
gi 45550623   713 YKCDKCNKGFVRSSDLSIHVRIH 735
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
755-780 4.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 4.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 45550623   755 NLVVHRRTHLGDKPIQCELCDKRFAR 780
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
643-666 5.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.95e-04
                          10        20
                  ....*....|....*....|....
gi 45550623   643 RMQDHLRLHTGEKPYVCGQCGRAF 666
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 741-763 1.98e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|...
gi 45550623   741 YSCDLCGKAFRARQNLVVHRRTH 763
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 770-791 1.98e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|..
gi 45550623   770 QCELCDKRFARKIDMRVHMRRH 791
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
699-724 3.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 45550623   699 DLSLHMRHHKNDRRYKCDKCNKGFVR 724
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 629-651 6.96e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 6.96e-03
                          10        20
                  ....*....|....*....|...
gi 45550623   629 HTCNFCGKTFKRFSRMQDHLRLH 651
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
629-651 8.16e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 8.16e-03
                           10        20
                   ....*....|....*....|...
gi 45550623    629 HTCNFCGKTFKRFSRMQDHLRLH 651
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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