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Conserved domains on  [gi|221331209|ref|NP_648855|]
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uncharacterized protein Dmel_CG4950, isoform B [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-411 3.20e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 3.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209  96 LKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSvfiganvLMRLDLSYNEISSLSvNAFCGLHTISQIYLTG 175
Cdd:COG4886   74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTN-------LESLDLSGNQLTDLP-EELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 176 NLLKELHNDIfKDNEYLEKVSFEGNLLTSIqPEVFRNMRRIKEVNLSNNRLIFIhPDTFADAASLENLVLSYNELKNfql 255
Cdd:COG4886  146 NQLTDLPEPL-GNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTD--- 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 256 teknivhqLHLDNNYLTNLTInatrfVRASHNQISEL-FLHQSLHIETLDLSANKLSSISNITNITHMLYLDVSDNPIGP 334
Cdd:COG4886  220 --------LPEPLANLTNLET-----LDLSNNQLTDLpELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD 286

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221331209 335 LNISTFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNNLTILNLDMFVPYLTNLKKFLIDGNGLTELQGN 411
Cdd:COG4886  287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-411 3.20e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 3.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209  96 LKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSvfiganvLMRLDLSYNEISSLSvNAFCGLHTISQIYLTG 175
Cdd:COG4886   74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTN-------LESLDLSGNQLTDLP-EELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 176 NLLKELHNDIfKDNEYLEKVSFEGNLLTSIqPEVFRNMRRIKEVNLSNNRLIFIhPDTFADAASLENLVLSYNELKNfql 255
Cdd:COG4886  146 NQLTDLPEPL-GNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTD--- 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 256 teknivhqLHLDNNYLTNLTInatrfVRASHNQISEL-FLHQSLHIETLDLSANKLSSISNITNITHMLYLDVSDNPIGP 334
Cdd:COG4886  220 --------LPEPLANLTNLET-----LDLSNNQLTDLpELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD 286

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221331209 335 LNISTFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNNLTILNLDMFVPYLTNLKKFLIDGNGLTELQGN 411
Cdd:COG4886  287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363
LRR_8 pfam13855
Leucine rich repeat;
118-178 6.71e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 6.71e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221331209  118 SNLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLL 178
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-381 1.66e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.55  E-value: 1.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209  47 FCTVTGFTVTHSQNVVIKNIPPGNMvkfmkfyESTLLYMPFHLfetfPYLKTLDVSNTNIL-ELTRNAFSAASNLTYLNL 125
Cdd:PLN00113  57 VCLWQGITCNNSSRVVSIDLSGKNI-------SGKISSAIFRL----PYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 126 AYNNLTSIQTSVFIgaNVLMRLDLSYNEISSlsvnafcglhtisqiyltgnllkELHNDI--FKDNEYLEkvsFEGNLLT 203
Cdd:PLN00113 126 SNNNFTGSIPRGSI--PNLETLDLSNNMLSG-----------------------EIPNDIgsFSSLKVLD---LGGNVLV 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 204 SIQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKN------FQLTEKNivhqlHLDNNYlTNLTIN 277
Cdd:PLN00113 178 GKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGeipyeiGGLTSLN-----HLDLVY-NNLTGP 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 278 atrfVRASHNQISEL---FLHQslhietldlsaNKLS-SISN-ITNITHMLYLDVSDNPIGPLNISTFSQLKRLRGLNLR 352
Cdd:PLN00113 252 ----IPSSLGNLKNLqylFLYQ-----------NKLSgPIPPsIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLF 316

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 221331209 353 G---TG-------------IRELKFGMFS--------KQKYLEELDLSFNNLT 381
Cdd:PLN00113 317 SnnfTGkipvaltslprlqVLQLWSNKFSgeipknlgKHNNLTVLDLSTNNLT 369
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 207-432 1.76e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 1.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 207 PEVFRNMRRIKEVNLSNNRLifihpdTFADAASLENLvlsyneLKNFQLteknivHQLHLDNNyltNLTINATRFVRASh 286
Cdd:cd00116   74 LQGLTKGCGLQELDLSDNAL------GPDGCGVLESL------LRSSSL------QELKLNNN---GLGDRGLRLLAKG- 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 287 nqiselFLHQSLHIETLDLSANKLSSISNI------TNITHMLYLDVSDNPIGPLNIST----FSQLKRLRGLNLRGTGI 356
Cdd:cd00116  132 ------LKDLPPALEKLVLGRNRLEGASCEalakalRANRDLKELNLANNGIGDAGIRAlaegLKANCNLEVLDLNNNGL 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 357 REL---KFGM-FSKQKYLEELDLSFNNLTILNLDMFVPYL----TNLKKFLIDGNGLTELqGNRTFSEA---FPQLQKLG 425
Cdd:cd00116  206 TDEgasALAEtLASLKSLEVLNLGDNNLTDAGAAALASALlspnISLLTLSLSCNDITDD-GAKDLAEVlaeKESLLELD 284


                 ....*..
gi 221331209 426 VSRNRFN 432
Cdd:cd00116  285 LRGNKFG 291
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-411 3.20e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 3.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209  96 LKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSvfiganvLMRLDLSYNEISSLSvNAFCGLHTISQIYLTG 175
Cdd:COG4886   74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTN-------LESLDLSGNQLTDLP-EELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 176 NLLKELHNDIfKDNEYLEKVSFEGNLLTSIqPEVFRNMRRIKEVNLSNNRLIFIhPDTFADAASLENLVLSYNELKNfql 255
Cdd:COG4886  146 NQLTDLPEPL-GNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTD--- 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 256 teknivhqLHLDNNYLTNLTInatrfVRASHNQISEL-FLHQSLHIETLDLSANKLSSISNITNITHMLYLDVSDNPIGP 334
Cdd:COG4886  220 --------LPEPLANLTNLET-----LDLSNNQLTDLpELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD 286

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221331209 335 LNISTFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNNLTILNLDMFVPYLTNLKKFLIDGNGLTELQGN 411
Cdd:COG4886  287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-429 9.37e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 9.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209  73 KFMKFYESTLLYMPFHLFETFPYLKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSVFIGANvLMRLDLSYN 152
Cdd:COG4886   28 LLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTN-LTELDLSGN 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 153 eisslsvNAFCGLHTISQIYLTGNLLKELHNDIfKDNEYLEKVSFEGNLLTSIqPEVFRNMRRIKEVNLSNNRLIFIhPD 232
Cdd:COG4886  107 -------EELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PE 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 233 TFADAASLENLVLSYNELKNFQLTEKNivhqlhldnnyLTNLTinatrFVRASHNQISEL--FLHQSLHIETLDLSANKL 310
Cdd:COG4886  177 ELGNLTNLKELDLSNNQITDLPEPLGN-----------LTNLE-----ELDLSGNQLTDLpePLANLTNLETLDLSNNQL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 311 SSISNITNITHMLYLDVSDNPIGplNISTFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNNLTILNLDMFVP 390
Cdd:COG4886  241 TDLPELGNLTNLEELDLSNNQLT--DLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 221331209 391 YLTNLKKFLIDGNGLTELQGNRTFSEAFPQLQKLGVSRN 429
Cdd:COG4886  319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
119-457 5.80e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 5.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 119 NLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFE 198
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 199 GNLLTSIQPEVFRNMRRIKEVNLSNNRLIFihpdtfaDAASLENLVLSYNELKNFQLTEKNIVH--QLHLDNNYLTNL-- 274
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELS-------NLTNLESLDLSGNQLTDLPEELANLTNlkELDLSNNQLTDLpe 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 275 ---TINATRFVRASHNQISEL--FLHQSLHIETLDLSANKLSSISN-ITNITHMLYLDVSDNPIGPLNIStFSQLKRLRG 348
Cdd:COG4886  154 plgNLTNLKSLDLSNNQLTDLpeELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLPEP-LANLTNLET 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 349 LNLRGTGIRELKFgmFSKQKYLEELDLSFNNLTILNldmFVPYLTNLKKFLIDGNGLTELQGNRTFSEAFPQLQKLGVSR 428
Cdd:COG4886  233 LDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307

                        330       340
                 ....*....|....*....|....*....
gi 221331209 429 NRFNCSYLHHLLIPPSLPESVVLNIEPDT 457
Cdd:COG4886  308 LNLLELLILLLLLTTLLLLLLLLKGLLVT 336
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-411 6.85e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 6.85e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209  90 FETFPYLKTLDVSNTNileltrnAFSAASNLTYLNLAYNNLTSIQTSVFIGANvLMRLDLSYNEISSLSvNAFCGLHTIS 169
Cdd:COG4886   92 LGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANLTN-LKELDLSNNQLTDLP-EPLGNLTNLK 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 170 QIYLTGNLLKELHNDIFKDNEyLEKVSFEGNLLTSIqPEVFRNMRRIKEVNLSNNRLIFIhPDTFADAASLENLVLSYNE 249
Cdd:COG4886  163 SLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 250 LKNF-QLTEKNIVHQLHLDNNYLTNLTinatrfvrashnqiselFLHQSLHIETLDLSANKLSSISNITNITHMLYLDVS 328
Cdd:COG4886  240 LTDLpELGNLTNLEELDLSNNQLTDLP-----------------PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 329 DNPIGPLNISTFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNNLTILNLDMFVPYLTNLKKFLIDGNGLTEL 408
Cdd:COG4886  303 LLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382


                 ...
gi 221331209 409 QGN 411
Cdd:COG4886  383 ALL 385
LRR_8 pfam13855
Leucine rich repeat;
118-178 6.71e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 6.71e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221331209  118 SNLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLL 178
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
192-250 1.65e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.65e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 221331209  192 LEKVSFEGNLLTSIQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNEL 250
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-381 1.66e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.55  E-value: 1.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209  47 FCTVTGFTVTHSQNVVIKNIPPGNMvkfmkfyESTLLYMPFHLfetfPYLKTLDVSNTNIL-ELTRNAFSAASNLTYLNL 125
Cdd:PLN00113  57 VCLWQGITCNNSSRVVSIDLSGKNI-------SGKISSAIFRL----PYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 126 AYNNLTSIQTSVFIgaNVLMRLDLSYNEISSlsvnafcglhtisqiyltgnllkELHNDI--FKDNEYLEkvsFEGNLLT 203
Cdd:PLN00113 126 SNNNFTGSIPRGSI--PNLETLDLSNNMLSG-----------------------EIPNDIgsFSSLKVLD---LGGNVLV 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 204 SIQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKN------FQLTEKNivhqlHLDNNYlTNLTIN 277
Cdd:PLN00113 178 GKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGeipyeiGGLTSLN-----HLDLVY-NNLTGP 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 278 atrfVRASHNQISEL---FLHQslhietldlsaNKLS-SISN-ITNITHMLYLDVSDNPIGPLNISTFSQLKRLRGLNLR 352
Cdd:PLN00113 252 ----IPSSLGNLKNLqylFLYQ-----------NKLSgPIPPsIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLF 316

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 221331209 353 G---TG-------------IRELKFGMFS--------KQKYLEELDLSFNNLT 381
Cdd:PLN00113 317 SnnfTGkipvaltslprlqVLQLWSNKFSgeipknlgKHNNLTVLDLSTNNLT 369
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-332 2.07e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 2.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209  94 PYLKTLDVSNTNILELTrNAFSAASNLTYLNLAYNNLTSIqTSVFIGANVLMRLDLSYNEISSLSvnAFCGLHTISQIYL 173
Cdd:COG4886  182 TNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 174 TGNLLKELhnDIFKDNEYLEKVSFEGNLLTSIQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKNF 253
Cdd:COG4886  258 SNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221331209 254 QLTEKNIVHQLHLDNNYLTNLTINATRFVRASHNQISELFLHQSLHIETLDLSANKLSSISNITNITHMLYLDVSDNPI 332
Cdd:COG4886  336 TLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR_8 pfam13855
Leucine rich repeat;
94-154 2.54e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.54e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221331209   94 PYLKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEI 154
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
98-292 4.02e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.70  E-value: 4.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209  98 TLDVSNTNILELTRNAfsaASNLTYLNLAYNNLTSIQTSVfigANVLMRLDLSYNEISSLSVNAFCGLHTISqiyLTGNL 177
Cdd:PRK15370 203 TLILDNNELKSLPENL---QGNIKTLYANSNQLTSIPATL---PDTIQEMELSINRITELPERLPSALQSLD---LFHNK 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 178 LKELHNDIfkdNEYLEKVSFEGNLLTSIqPEVFRNmrRIKEVNLSNNRLIFIhPDTF--------ADAASLENLVLSYN- 248
Cdd:PRK15370 274 ISCLPENL---PEELRYLSVYDNSIRTL-PAHLPS--GITHLNVQSNSLTAL-PETLppglktleAGENALTSLPASLPp 346

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 221331209 249 ELKNFQLTEKNI----------VHQLHLDNNYLTNLTIN---ATRFVRASHNQISEL 292
Cdd:PRK15370 347 ELQVLDVSKNQItvlpetlpptITTLDVSRNALTNLPENlpaALQIMQASRNNLVRL 403
LRR_8 pfam13855
Leucine rich repeat;
171-226 1.21e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.21e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 221331209  171 IYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLTSIQPEVFRNMRRIKEVNLSNNRL 226
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 207-432 1.76e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 1.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 207 PEVFRNMRRIKEVNLSNNRLifihpdTFADAASLENLvlsyneLKNFQLteknivHQLHLDNNyltNLTINATRFVRASh 286
Cdd:cd00116   74 LQGLTKGCGLQELDLSDNAL------GPDGCGVLESL------LRSSSL------QELKLNNN---GLGDRGLRLLAKG- 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 287 nqiselFLHQSLHIETLDLSANKLSSISNI------TNITHMLYLDVSDNPIGPLNIST----FSQLKRLRGLNLRGTGI 356
Cdd:cd00116  132 ------LKDLPPALEKLVLGRNRLEGASCEalakalRANRDLKELNLANNGIGDAGIRAlaegLKANCNLEVLDLNNNGL 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 357 REL---KFGM-FSKQKYLEELDLSFNNLTILNLDMFVPYL----TNLKKFLIDGNGLTELqGNRTFSEA---FPQLQKLG 425
Cdd:cd00116  206 TDEgasALAEtLASLKSLEVLNLGDNNLTDAGAAALASALlspnISLLTLSLSCNDITDD-GAKDLAEVlaeKESLLELD 284


                 ....*..
gi 221331209 426 VSRNRFN 432
Cdd:cd00116  285 LRGNKFG 291
LRR_8 pfam13855
Leucine rich repeat;
345-405 1.06e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.06e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221331209  345 RLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNNLTILNLDMFVPyLTNLKKFLIDGNGL 405
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG-LPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-254 2.64e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 2.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 114 FSAASNLTYLNLAYNNLTSIQtsvfiGANVLMRL---DLSYNEISSLSvnafcGLHTISQiyltgnlLKELH---NDIFK 187
Cdd:cd21340   42 LEFLTNLTHLYLQNNQIEKIE-----NLENLVNLkklYLGGNRISVVE-----GLENLTN-------LEELHienQRLPP 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221331209 188 DneylEKVSFEGNLLTSIQPevfrnmrRIKEVNLSNNRLIFIHPdtFADAASLENLVLSYNELKNFQ 254
Cdd:cd21340  105 G----EKLTFDPRSLAALSN-------SLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLE 158
LRR_8 pfam13855
Leucine rich repeat;
214-253 2.93e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 2.93e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 221331209  214 RRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKNF 253
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTL 40
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-178 3.26e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 3.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209  90 FETFPYLKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAFCGLHTIS 169
Cdd:PLN00113 495 LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLV 574


                 ....*....
gi 221331209 170 QIYLTGNLL 178
Cdd:PLN00113 575 QVNISHNHL 583
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 165-384 5.37e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 5.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 165 LHTISQIYLTGNLLKELHNDIFKDNeyLEKVSFEGNLLTSIqpEVFRNMRRIKEVNLSNNRLIFIhpDTFADAASLENLV 244
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKN--LKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331209 245 LSYNE---LKNF----QLTEknivhqLHLDNNYLTN---LTINAtrfvrASHNQISElflhqSLHIetLDLSANKLSSIS 314
Cdd:cd21340   75 LGGNRisvVEGLenltNLEE------LHIENQRLPPgekLTFDP-----RSLAALSN-----SLRV--LNISGNNIDSLE 136

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221331209 315 NITNITHMLYLDVSDNPIGPLN--ISTFSQLKRLRGLNLRGTGIRelkfgmfSKQKYLEELDLSFNNLTILN 384
Cdd:cd21340  137 PLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVC-------KKPKYRDKIILASKSLEVLD 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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