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Conserved domains on  [gi|21355245|ref|NP_648990|]
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U4-U6 small nuclear riboprotein factor 60K [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
286-553 9.70e-76

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 245.59  E-value: 9.70e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 286 KLWSVPDCELKQTLRGHASYVGGVALRPgvkaDEENVvamASGGHDGAVKLWGFNNEESIADITGHmPHRVSKVAFHPSG 365
Cdd:COG2319 145 RLWDLATGKLLRTLTGHSGAVTSVAFSP----DGKLL---ASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSPDG 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 366 RFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDF 445
Cdd:COG2319 217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 446 SPNGFHIATGSQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQEcGSFLVTCSYDSTTKIWSNKTWQPLKTLQGHDNKV 525
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375

                       250       260
                ....*....|....*....|....*...
gi 21355245 526 ISVDIAPNSQYIATTSFDRTFKLWSPDS 553
Cdd:COG2319 376 TSVAFSPDGRTLASGSADGTVRLWDLAT 403
SFM smart00500
Splicing Factor Motif, present in Prp18 and Pr04;
132-166 1.12e-10

Splicing Factor Motif, present in Prp18 and Pr04;


:

Pssm-ID: 128776  Cd Length: 44  Bit Score: 56.60  E-value: 1.12e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 21355245    132 TDDTEIKSNLRQLNEPICYFGEGPAERRRRLKELL 166
Cdd:smart00500   1 LPDSEVIRRLRELGEPITLFGEDDQERRQRLRQLL 35
CCDC66 super family cl37891
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 113-194 4.91e-03

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


The actual alignment was detected with superfamily member pfam15236:

Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 37.85  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245   113 VALLEEFERKkRARQI---NVSTDDTEIKSNLRQLNEPICYFGEGPAERR-RRLKELLaglgenainKRQYEDEERKQQQ 188
Cdd:pfam15236  41 PAQLEERERK-RQKALehqNAIKKQLEEKERQKKLEEERRRQEEQEEEERlRREREEE---------QKQFEEERRKQKE 110


                  ....*.
gi 21355245   189 REQDQA 194
Cdd:pfam15236 111 KEEAMT 116
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
286-553 9.70e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 245.59  E-value: 9.70e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 286 KLWSVPDCELKQTLRGHASYVGGVALRPgvkaDEENVvamASGGHDGAVKLWGFNNEESIADITGHmPHRVSKVAFHPSG 365
Cdd:COG2319 145 RLWDLATGKLLRTLTGHSGAVTSVAFSP----DGKLL---ASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSPDG 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 366 RFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDF 445
Cdd:COG2319 217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 446 SPNGFHIATGSQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQEcGSFLVTCSYDSTTKIWSNKTWQPLKTLQGHDNKV 525
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375

                       250       260
                ....*....|....*....|....*...
gi 21355245 526 ISVDIAPNSQYIATTSFDRTFKLWSPDS 553
Cdd:COG2319 376 TSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 286-550 1.03e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 236.08  E-value: 1.03e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 286 KLWSVPDCELKQTLRGHASYVGGVALRPGVKAdeenvvaMASGGHDGAVKLWGFNNEESIADITGHmPHRVSKVAFHPSG 365
Cdd:cd00200  34 KVWDLETGELLRTLKGHTGPVRDVAASADGTY-------LASGSSDKTIRLWDLETGECVRTLTGH-TSYVSSVAFSPDG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 366 RFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDF 445
Cdd:cd00200 106 RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAF 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 446 SPNGFHIATGSQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQEcGSFLVTCSYDSTTKIWSNKTWQPLKTLQGHDNKV 525
Cdd:cd00200 186 SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSV 264

                       250       260
                ....*....|....*....|....*
gi 21355245 526 ISVDIAPNSQYIATTSFDRTFKLWS 550
Cdd:cd00200 265 TSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 368-541 7.83e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.19  E-value: 7.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  368 LATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHS-DGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHlGAVFGVDF- 445
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQFp 626

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  446 SPNGFHIATGSQDNTCKIWDLRR-RQPVYTIPAHTNLISDVKYQQEcgSFLVTCSYDSTTKIW------SNKTWQPLKTL 518
Cdd:PLN00181 627 SESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDS--STLVSSSTDNTLKLWdlsmsiSGINETPLHSF 704

                        170       180
                 ....*....|....*....|...
gi 21355245  519 QGHDNKVISVDIAPNSQYIATTS 541
Cdd:PLN00181 705 MGHTNVKNFVGLSVSDGYIATGS 727
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 426-465 1.13e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 59.25  E-value: 1.13e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21355245    426 TGRCIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWD 465
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
SFM smart00500
Splicing Factor Motif, present in Prp18 and Pr04;
132-166 1.12e-10

Splicing Factor Motif, present in Prp18 and Pr04;


Pssm-ID: 128776  Cd Length: 44  Bit Score: 56.60  E-value: 1.12e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 21355245    132 TDDTEIKSNLRQLNEPICYFGEGPAERRRRLKELL 166
Cdd:smart00500   1 LPDSEVIRRLRELGEPITLFGEDDQERRQRLRQLL 35
PRP4 pfam08799
pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. ...
 137-165 1.74e-10

pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing.


Pssm-ID: 462606 [Multi-domain]  Cd Length: 29  Bit Score: 55.77  E-value: 1.74e-10
                          10        20
                  ....*....|....*....|....*....
gi 21355245   137 IKSNLRQLNEPICYFGEGPAERRRRLKEL 165
Cdd:pfam08799   1 VRRKLRELGEPITLFGETHADRRERLRKL 29
WD40 pfam00400
WD domain, G-beta repeat;
427-465 4.85e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.66  E-value: 4.85e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21355245   427 GRCIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWD 465
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 113-194 4.91e-03

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 37.85  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245   113 VALLEEFERKkRARQI---NVSTDDTEIKSNLRQLNEPICYFGEGPAERR-RRLKELLaglgenainKRQYEDEERKQQQ 188
Cdd:pfam15236  41 PAQLEERERK-RQKALehqNAIKKQLEEKERQKKLEEERRRQEEQEEEERlRREREEE---------QKQFEEERRKQKE 110


                  ....*.
gi 21355245   189 REQDQA 194
Cdd:pfam15236 111 KEEAMT 116
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
286-553 9.70e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 245.59  E-value: 9.70e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 286 KLWSVPDCELKQTLRGHASYVGGVALRPgvkaDEENVvamASGGHDGAVKLWGFNNEESIADITGHmPHRVSKVAFHPSG 365
Cdd:COG2319 145 RLWDLATGKLLRTLTGHSGAVTSVAFSP----DGKLL---ASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSPDG 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 366 RFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDF 445
Cdd:COG2319 217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 446 SPNGFHIATGSQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQEcGSFLVTCSYDSTTKIWSNKTWQPLKTLQGHDNKV 525
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375

                       250       260
                ....*....|....*....|....*...
gi 21355245 526 ISVDIAPNSQYIATTSFDRTFKLWSPDS 553
Cdd:COG2319 376 TSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
188-553 5.83e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 243.28  E-value: 5.83e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 188 QREQDQATWYHEGPDSLRIARLWLADYSLPRAKDRLVRAREALEVPS----AARAGRMVEMQKKLQSLAPLCSQVGDTRP 263
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDgarlAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 264 VSSAAFSEDSSLLLTSSWSGLCKLWSVPDCELKQTLRGHASYVGGVALRPgvkaDEENVvamASGGHDGAVKLWGFNNEE 343
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP----DGKTL---ASGSADGTVRLWDLATGK 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 344 SIADITGHmPHRVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWD 423
Cdd:COG2319 154 LLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 424 LRTGRCIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQEcGSFLVTCSYDST 503
Cdd:COG2319 233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGT 311

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 21355245 504 TKIWSNKTWQPLKTLQGHDNKVISVDIAPNSQYIATTSFDRTFKLWSPDS 553
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 286-550 1.03e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 236.08  E-value: 1.03e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 286 KLWSVPDCELKQTLRGHASYVGGVALRPGVKAdeenvvaMASGGHDGAVKLWGFNNEESIADITGHmPHRVSKVAFHPSG 365
Cdd:cd00200  34 KVWDLETGELLRTLKGHTGPVRDVAASADGTY-------LASGSSDKTIRLWDLETGECVRTLTGH-TSYVSSVAFSPDG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 366 RFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDF 445
Cdd:cd00200 106 RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAF 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 446 SPNGFHIATGSQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQEcGSFLVTCSYDSTTKIWSNKTWQPLKTLQGHDNKV 525
Cdd:cd00200 186 SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSV 264

                       250       260
                ....*....|....*....|....*
gi 21355245 526 ISVDIAPNSQYIATTSFDRTFKLWS 550
Cdd:cd00200 265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 344-553 7.71e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 207.96  E-value: 7.71e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 344 SIADITGHmPHRVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWD 423
Cdd:cd00200   1 LRRTLKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 424 LRTGRCIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQeCGSFLVTCSYDST 503
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGT 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 21355245 504 TKIWSNKTWQPLKTLQGHDNKVISVDIAPNSQYIATTSFDRTFKLWSPDS 553
Cdd:cd00200 159 IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 247-508 8.62e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 154.42  E-value: 8.62e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 247 KLQSLAPLCSQVGDTRPVSSAAFSEDSSLLLTSSWSGLCKLWSVPDCELKQTLRGHASYvggvalrpgvkadeenvvama 326
Cdd:cd00200  79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW--------------------- 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 327 sgghdgavklwgfnneesiaditghmphrVSKVAFHPSGRFLATACYDSSWRLWDLEQKtEVLHQ-EGHAKPVHCLSYHS 405
Cdd:cd00200 138 -----------------------------VNSVAFSPDGTFVASSSQDGTIKLWDLRTG-KCVATlTGHTGEVNSVAFSP 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245 406 DGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWDLRRRQPVYTIPAHTNLISDV 485
Cdd:cd00200 188 DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267

                       250       260
                ....*....|....*....|...
gi 21355245 486 KYQQEcGSFLVTCSYDSTTKIWS 508
Cdd:cd00200 268 AWSPD-GKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 368-541 7.83e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.19  E-value: 7.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  368 LATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHS-DGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHlGAVFGVDF- 445
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQFp 626

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  446 SPNGFHIATGSQDNTCKIWDLRR-RQPVYTIPAHTNLISDVKYQQEcgSFLVTCSYDSTTKIW------SNKTWQPLKTL 518
Cdd:PLN00181 627 SESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDS--STLVSSSTDNTLKLWdlsmsiSGINETPLHSF 704

                        170       180
                 ....*....|....*....|...
gi 21355245  519 QGHDNKVISVDIAPNSQYIATTS 541
Cdd:PLN00181 705 MGHTNVKNFVGLSVSDGYIATGS 727
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 426-465 1.13e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 59.25  E-value: 1.13e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21355245    426 TGRCIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWD 465
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
SFM smart00500
Splicing Factor Motif, present in Prp18 and Pr04;
132-166 1.12e-10

Splicing Factor Motif, present in Prp18 and Pr04;


Pssm-ID: 128776  Cd Length: 44  Bit Score: 56.60  E-value: 1.12e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 21355245    132 TDDTEIKSNLRQLNEPICYFGEGPAERRRRLKELL 166
Cdd:smart00500   1 LPDSEVIRRLRELGEPITLFGEDDQERRQRLRQLL 35
PRP4 pfam08799
pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. ...
 137-165 1.74e-10

pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing.


Pssm-ID: 462606 [Multi-domain]  Cd Length: 29  Bit Score: 55.77  E-value: 1.74e-10
                          10        20
                  ....*....|....*....|....*....
gi 21355245   137 IKSNLRQLNEPICYFGEGPAERRRRLKEL 165
Cdd:pfam08799   1 VRRKLRELGEPITLFGETHADRRERLRKL 29
WD40 pfam00400
WD domain, G-beta repeat;
427-465 4.85e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.66  E-value: 4.85e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21355245   427 GRCIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWD 465
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 511-550 2.11e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 2.11e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21355245    511 TWQPLKTLQGHDNKVISVDIAPNSQYIATTSFDRTFKLWS 550
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 359-478 7.21e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.90  E-value: 7.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  359 VAFHP-SGRFLATACYDSSWRLWD-----LEQKTE--VLHQEGHAKPVHCLSYH-SDGSVLVTGGLDAFGRVWDLRTGRC 429
Cdd:PTZ00421  81 VAFNPfDPQKLFTASEDGTIMGWGipeegLTQNISdpIVHLQGHTKKVGIVSFHpSAMNVLASAGADMVVNVWDVERGKA 160

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 21355245  430 IMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWDLRRRQPVYTIPAH 478
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 356-549 8.43e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 8.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  356 VSKVAFHPSGRFLATACYDSSWRLWDLEQKTE--------VLHQEGHAKpVHCLSYHSD-GSVLVTGGLDAFGRVWDLRT 426
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKdgrdihypVVELASRSK-LSGICWNSYiKSQVASSNFEGVVQVWDVAR 564

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  427 GRCIMFLEGHLGAVFGVDFSP-NGFHIATGSQDNTCKIWDLRRRQPVYTIPAHTNlISDVKYQQECGSFLVTCSYDSTTK 505
Cdd:PLN00181 565 SQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESGRSLAFGSADHKVY 643

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 21355245  506 IWSNKTWQ-PLKTLQGHDNKVISVDIApNSQYIATTSFDRTFKLW 549
Cdd:PLN00181 644 YYDLRNPKlPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLW 687
WD40 pfam00400
WD domain, G-beta repeat;
512-550 9.12e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 9.12e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21355245   512 WQPLKTLQGHDNKVISVDIAPNSQYIATTSFDRTFKLWS 550
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 325-481 2.50e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 2.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  325 MASGGHDGAVKLWGFNNEESIADITGHmPHRVSKVAFHPSG-RFLATACYDSSWRLWDLEQKTEVLHQEGHAKpVHCLSY 403
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEH-EKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  404 HSD-GSVLVTGGLDAFGRVWDLRTGR---CIMFleGHLGAVFGVDFSPNGfHIATGSQDNTCKIWDLR------RRQPVY 473
Cdd:PLN00181 626 PSEsGRSLAFGSADHKVYYYDLRNPKlplCTMI--GHSKTVSYVRFVDSS-TLVSSSTDNTLKLWDLSmsisgiNETPLH 702


                 ....*...
gi 21355245  474 TIPAHTNL 481
Cdd:PLN00181 703 SFMGHTNV 710
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 341-381 8.48e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 8.48e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 21355245    341 NEESIADITGHmPHRVSKVAFHPSGRFLATACYDSSWRLWD 381
Cdd:smart00320   1 SGELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 286-459 2.90e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 2.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  286 KLWSVPDCELKQTLRGHASYVGGVALRpgvKADEenvVAMASGGHDGAVKLWGFNNEESIADITGHMphRVSKVAF-HPS 364
Cdd:PLN00181 558 QVWDVARSQLVTEMKEHEKRVWSIDYS---SADP---TLLASGSDDGSVKLWSINQGVSIGTIKTKA--NICCVQFpSES 629

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  365 GRFLATACYDSSWRLWDLEQ-KTEVLHQEGHAKPVHCLSYhSDGSVLVTGGLDAFGRVWDLRTGRC------IMFLEGHL 437
Cdd:PLN00181 630 GRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHT 708

                        170       180
                 ....*....|....*....|..
gi 21355245  438 GAVFGVDFSPNGFHIATGSQDN 459
Cdd:PLN00181 709 NVKNFVGLSVSDGYIATGSETN 730
PTZ00420 PTZ00420
coronin; Provisional
 468-549 4.27e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.56  E-value: 4.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  468 RRQPVYTIPAHTNLISDVKYQQECGSFLVTCSYDSTTKIWS--------NKTWQPLKTLQGHDNKVISVDIAPNSQYI-A 538
Cdd:PTZ00420  63 RKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEiphndesvKEIKDPQCILKGHKKKISIIDWNPMNYYImC 142

                         90
                 ....*....|.
gi 21355245  539 TTSFDRTFKLW 549
Cdd:PTZ00420 143 SSGFDSFVNIW 153
WD40 pfam00400
WD domain, G-beta repeat;
343-381 7.74e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.74e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21355245   343 ESIADITGHmPHRVSKVAFHPSGRFLATACYDSSWRLWD 381
Cdd:pfam00400   2 KLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 315-495 1.16e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.97  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  315 VKADEENVVAMASGGHDGAVKLWGFNNEESIADITGHMPH------RVSKVAFHPSGR-FLATACYDSSWRLWDLEQKTE 387
Cdd:PTZ00421  81 VAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHlqghtkKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKA 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  388 VLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGA-------------VFGVDFSPngfhiat 454
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksqrclwakrkdlIITLGCSK------- 233

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 21355245  455 gSQDNTCKIWDLRRRQPvytiPAHTnlisdVKYQQECGSFL 495
Cdd:PTZ00421 234 -SQQRQIMLWDTRKMAS----PYST-----VDLDQSSALFI 264
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 392-423 2.10e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.10e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 21355245    392 EGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWD 423
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
392-423 2.83e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.83e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 21355245   392 EGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWD 423
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 378-550 2.94e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.87  E-value: 2.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  378 RLWDLEQKTEVLHQEGHAKPVHCLSYHSDGS-VLVTGGLDAFGRVWDLRTG----------RCImfLEGHLGAVFGVDFS 446
Cdd:PTZ00420  57 RLENQMRKPPVIKLKGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIPHNdesvkeikdpQCI--LKGHKKKISIIDWN 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245  447 PNGFHIATGSQ-DNTCKIWDLRRRQPVYTI--PAHT---------NLIS-----------DVKYQQECGSFLVTCSYDST 503
Cdd:PTZ00420 135 PMNYYIMCSSGfDSFVNIWDIENEKRAFQInmPKKLsslkwnikgNLLSgtcvgkhmhiiDPRKQEIASSFHIHDGGKNT 214

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 21355245  504 TKIWsnktwqpLKTLQGHDNKVISVDIAPNSQyiattsfdRTFKLWS 550
Cdd:PTZ00420 215 KNIW-------IDGLGGDDNYILSTGFSKNNM--------REMKLWD 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 469-508 4.13e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.13e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21355245    469 RQPVYTIPAHTNLISDVKYQQEcGSFLVTCSYDSTTKIWS 508
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
432-503 6.10e-05

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 45.79  E-value: 6.10e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21355245 432 FLEGHLGAVFGVDFSPNGFHIATGSQdNTCKIWDLRR-RQPVYTIPAHTNL---ISDVkYQQEC--GSFLVTCSYDST 503
Cdd:COG5170 275 FFEEIVSSISDFKFSDNGRYILSRDY-LTVKIWDVNMaKNPIKTIPMHCDLmdeLNDV-YENDAifDKFEISFSGDDK 350
WD40 pfam00400
WD domain, G-beta repeat;
469-508 7.27e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 7.27e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 21355245   469 RQPVYTIPAHTNLISDVKYQQEcGSFLVTCSYDSTTKIWS 508
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 355-401 3.41e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 3.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 21355245   355 RVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCL 401
Cdd:pfam12894  40 EVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 113-194 4.91e-03

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 37.85  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355245   113 VALLEEFERKkRARQI---NVSTDDTEIKSNLRQLNEPICYFGEGPAERR-RRLKELLaglgenainKRQYEDEERKQQQ 188
Cdd:pfam15236  41 PAQLEERERK-RQKALehqNAIKKQLEEKERQKKLEEERRRQEEQEEEERlRREREEE---------QKQFEEERRKQKE 110


                  ....*.
gi 21355245   189 REQDQA 194
Cdd:pfam15236 111 KEEAMT 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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