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Conserved domains on  [gi|45550664|ref|NP_649200|]
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golden goal [Drosophila melanogaster]

Protein Classification

CUB domain-containing protein( domain architecture ID 10641421)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 459-505 8.96e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 75.32  E-value: 8.96e-17
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 45550664     459 WGPWSEWTPCSTNCLGGTRNRYRFCDSPPPRYGAKFCEGPSVETQKC 505
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRAC 47
CUB super family cl00049
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 570-640 3.49e-05

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


The actual alignment was detected with superfamily member pfam00431:

Pssm-ID: 412131 [Multi-domain]  Cd Length: 110  Bit Score: 44.21  E-value: 3.49e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45550664    570 WLIQVDGEESISLALSFLRL----PCATQYIKVRDGPSLSSTLLvelnGgglILKGAGVPVVVDSTGGQLLVEFS 640
Cdd:pfam00431   29 WLIRAPPGFRVKLTFQDFELedhdECGYDYVEIRDGPSASSPLL----G---RFCGSGIPEDIVSSSNQMTIKFV 96
 
Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 459-505 8.96e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 75.32  E-value: 8.96e-17
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 45550664     459 WGPWSEWTPCSTNCLGGTRNRYRFCDSPPPRYGAKFCEGPSVETQKC 505
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRAC 47
TSP_1 pfam00090
Thrombospondin type 1 domain;
460-505 3.18e-13

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 65.13  E-value: 3.18e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 45550664    460 GPWSEWTPCSTNCLGGTRNRYRFCDSPPPryGAKFCEGPSVETQKC 505
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQAC 44
CUB pfam00431
CUB domain;
570-640 3.49e-05

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 44.21  E-value: 3.49e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45550664    570 WLIQVDGEESISLALSFLRL----PCATQYIKVRDGPSLSSTLLvelnGgglILKGAGVPVVVDSTGGQLLVEFS 640
Cdd:pfam00431   29 WLIRAPPGFRVKLTFQDFELedhdECGYDYVEIRDGPSASSPLL----G---RFCGSGIPEDIVSSSNQMTIKFV 96
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 570-640 7.57e-04

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 40.07  E-value: 7.57e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45550664     570 WLIQVDGEESISLALSFLRL----PCATQYIKVRDGPSLSSTLLVELNGGGLIlkgagvPVVVDSTGGQLLVEFS 640
Cdd:smart00042   20 WTIRAPPGYRIELQFTDFDLessdNCEYDYVEIYDGPSASSPLLGRFCGSEAP------PPVISSSSNSLTLTFV 88
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 460-481 2.88e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 2.88e-03
                          10        20
                  ....*....|....*....|..
gi 45550664   460 GPWSEWTPCSTNCLGGTRNRYR 481
Cdd:PTZ00441  241 GPWDEWTPCSVTCGKGTHSRSR 262
 
Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 459-505 8.96e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 75.32  E-value: 8.96e-17
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 45550664     459 WGPWSEWTPCSTNCLGGTRNRYRFCDSPPPRYGAKFCEGPSVETQKC 505
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRAC 47
TSP_1 pfam00090
Thrombospondin type 1 domain;
460-505 3.18e-13

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 65.13  E-value: 3.18e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 45550664    460 GPWSEWTPCSTNCLGGTRNRYRFCDSPPPryGAKFCEGPSVETQKC 505
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQAC 44
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 460-505 4.21e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 44.96  E-value: 4.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 45550664    460 GPWSEWTPCSTNCLGGTRNRYRFCDSpPPRYGAKFCeGPSVETQKC 505
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIV-EPQNGGRPC-PELLERRPC 47
CUB pfam00431
CUB domain;
570-640 3.49e-05

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 44.21  E-value: 3.49e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45550664    570 WLIQVDGEESISLALSFLRL----PCATQYIKVRDGPSLSSTLLvelnGgglILKGAGVPVVVDSTGGQLLVEFS 640
Cdd:pfam00431   29 WLIRAPPGFRVKLTFQDFELedhdECGYDYVEIRDGPSASSPLL----G---RFCGSGIPEDIVSSSNQMTIKFV 96
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 570-640 7.57e-04

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 40.07  E-value: 7.57e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45550664     570 WLIQVDGEESISLALSFLRL----PCATQYIKVRDGPSLSSTLLVELNGGGLIlkgagvPVVVDSTGGQLLVEFS 640
Cdd:smart00042   20 WTIRAPPGYRIELQFTDFDLessdNCEYDYVEIYDGPSASSPLLGRFCGSEAP------PPVISSSSNSLTLTFV 88
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 460-481 2.88e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 2.88e-03
                          10        20
                  ....*....|....*....|..
gi 45550664   460 GPWSEWTPCSTNCLGGTRNRYR 481
Cdd:PTZ00441  241 GPWDEWTPCSVTCGKGTHSRSR 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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