NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21357697|ref|NP_649385|]
View 

RIC1 homolog, isoform A [Drosophila melanogaster]

Protein Classification

RIC1 family protein( domain architecture ID 10537194)

RIC1 family protein similar to human RAB6A-GEF complex partner protein 1 (RIC1) that interacts with RGP1 to form a complex that acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RIC1 pfam07064
RIC1; RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to ...
 714-971 1.18e-81

RIC1; RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to the cis-Golgi network. It forms a heterodimer with Rgp1 and functions as a guanyl-nucleotide exchange factor.


:

Pssm-ID: 462078  Cd Length: 246  Bit Score: 268.31  E-value: 1.18e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357697    714 RDCLWLYSGaHGMRVWLPILppgrerrEGEQGGAQRLHSFMSKRIMLSFplklYPLVVLFDNVIVLGVENESTLYANEQV 793
Cdd:pfam07064    2 RNSLWLFDG-SDMRVWLPLL-------DILRASPGFESLPESVRIPLDF----YPLSVLLDKGIILGVESELSQRRDLSF 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357697    794 SHFSLpfavmERKSQIYLHKVLRQLIKRNLGYSAWEMAQSCCSLPYFPHALELLLHEVLEEEATSKQPIP--DAQLPSIL 871
Cdd:pfam07064   70 PFFRF-----AIRTHLFLHHVLRHLLRRGLGPEALELASHYQHLPYFAHALELLLHTVLEEEADASPPGLprEALLPRVI 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357697    872 DFIREFPVYLETIVQCARKTEIALWPYLFSMAGKPKDLFQMCLQSEQLDTAASYLIILQNLEPSVVSKQYATMLLDIALQ 951
Cdd:pfam07064  145 SFLDHFPEYLDVVVQCARKTEVARWRTLFDVLGPPKDLFEECLERGRLKTAASYLLVLHNLEQLEVSSQCAVRLLVLALE 224

                          250       260
                   ....*....|....*....|
gi 21357697    952 QRKWELAKDLIRFLKAIDPN 971
Cdd:pfam07064  225 EGDWELCKELVRFLAAIDES 244
WD40 super family cl43672
WD40 repeat [General function prediction only];
274-353 3.94e-03

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357697  274 RLLAYGQESSAVKVYaiDDATGglefshRLILTeniLPDSLGSVNELKWSPDGCVLAVSWTNGGLSLWSTFGALLMSTLS 353
Cdd:COG2319  175 KLLASGSDDGTVRLW--DLATG------KLLRT---LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243
 
Name Accession Description Interval E-value
RIC1 pfam07064
RIC1; RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to ...
 714-971 1.18e-81

RIC1; RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to the cis-Golgi network. It forms a heterodimer with Rgp1 and functions as a guanyl-nucleotide exchange factor.


Pssm-ID: 462078  Cd Length: 246  Bit Score: 268.31  E-value: 1.18e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357697    714 RDCLWLYSGaHGMRVWLPILppgrerrEGEQGGAQRLHSFMSKRIMLSFplklYPLVVLFDNVIVLGVENESTLYANEQV 793
Cdd:pfam07064    2 RNSLWLFDG-SDMRVWLPLL-------DILRASPGFESLPESVRIPLDF----YPLSVLLDKGIILGVESELSQRRDLSF 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357697    794 SHFSLpfavmERKSQIYLHKVLRQLIKRNLGYSAWEMAQSCCSLPYFPHALELLLHEVLEEEATSKQPIP--DAQLPSIL 871
Cdd:pfam07064   70 PFFRF-----AIRTHLFLHHVLRHLLRRGLGPEALELASHYQHLPYFAHALELLLHTVLEEEADASPPGLprEALLPRVI 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357697    872 DFIREFPVYLETIVQCARKTEIALWPYLFSMAGKPKDLFQMCLQSEQLDTAASYLIILQNLEPSVVSKQYATMLLDIALQ 951
Cdd:pfam07064  145 SFLDHFPEYLDVVVQCARKTEVARWRTLFDVLGPPKDLFEECLERGRLKTAASYLLVLHNLEQLEVSSQCAVRLLVLALE 224

                          250       260
                   ....*....|....*....|
gi 21357697    952 QRKWELAKDLIRFLKAIDPN 971
Cdd:pfam07064  225 EGDWELCKELVRFLAAIDES 244
WD40 COG2319
WD40 repeat [General function prediction only];
274-353 3.94e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357697  274 RLLAYGQESSAVKVYaiDDATGglefshRLILTeniLPDSLGSVNELKWSPDGCVLAVSWTNGGLSLWSTFGALLMSTLS 353
Cdd:COG2319  175 KLLASGSDDGTVRLW--DLATG------KLLRT---LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243
 
Name Accession Description Interval E-value
RIC1 pfam07064
RIC1; RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to ...
 714-971 1.18e-81

RIC1; RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to the cis-Golgi network. It forms a heterodimer with Rgp1 and functions as a guanyl-nucleotide exchange factor.


Pssm-ID: 462078  Cd Length: 246  Bit Score: 268.31  E-value: 1.18e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357697    714 RDCLWLYSGaHGMRVWLPILppgrerrEGEQGGAQRLHSFMSKRIMLSFplklYPLVVLFDNVIVLGVENESTLYANEQV 793
Cdd:pfam07064    2 RNSLWLFDG-SDMRVWLPLL-------DILRASPGFESLPESVRIPLDF----YPLSVLLDKGIILGVESELSQRRDLSF 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357697    794 SHFSLpfavmERKSQIYLHKVLRQLIKRNLGYSAWEMAQSCCSLPYFPHALELLLHEVLEEEATSKQPIP--DAQLPSIL 871
Cdd:pfam07064   70 PFFRF-----AIRTHLFLHHVLRHLLRRGLGPEALELASHYQHLPYFAHALELLLHTVLEEEADASPPGLprEALLPRVI 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357697    872 DFIREFPVYLETIVQCARKTEIALWPYLFSMAGKPKDLFQMCLQSEQLDTAASYLIILQNLEPSVVSKQYATMLLDIALQ 951
Cdd:pfam07064  145 SFLDHFPEYLDVVVQCARKTEVARWRTLFDVLGPPKDLFEECLERGRLKTAASYLLVLHNLEQLEVSSQCAVRLLVLALE 224

                          250       260
                   ....*....|....*....|
gi 21357697    952 QRKWELAKDLIRFLKAIDPN 971
Cdd:pfam07064  225 EGDWELCKELVRFLAAIDES 244
WD40 COG2319
WD40 repeat [General function prediction only];
274-353 3.94e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357697  274 RLLAYGQESSAVKVYaiDDATGglefshRLILTeniLPDSLGSVNELKWSPDGCVLAVSWTNGGLSLWSTFGALLMSTLS 353
Cdd:COG2319  175 KLLASGSDDGTVRLW--DLATG------KLLRT---LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH