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Conserved domains on  [gi|21357709|ref|NP_649392|]
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uncharacterized protein Dmel_CG11438, isoform A [Drosophila melanogaster]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0042577|GO:0046839|GO:0008610
PubMed:  9122162|12447906|9260289
SCOP:  3001110|4001226

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 104-257 1.87e-66

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 205.94  E-value: 1.87e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709 104 LYRQVIFYLYGLAMVTFTTMLTKLCLGRLRPHFLAVCQPMLPDGSSCQDAQNLGryidsfTCSNANMTDYQFKELYQSFP 183
Cdd:cd03384   2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIA------DCTCCTGDPDLIREARLSFP 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21357709 184 SGHASMAMYAMLYLAIYLQAALSTRVSKLLKHLLQFLFVMFGWYVSLTRIIDYYHHWSDVLAGAALGVVFAWLT 257
Cdd:cd03384  76 SGHASLSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFL 149
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 104-257 1.87e-66

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 205.94  E-value: 1.87e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709 104 LYRQVIFYLYGLAMVTFTTMLTKLCLGRLRPHFLAVCQPMLPDGSSCQDAQNLGryidsfTCSNANMTDYQFKELYQSFP 183
Cdd:cd03384   2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIA------DCTCCTGDPDLIREARLSFP 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21357709 184 SGHASMAMYAMLYLAIYLQAALSTRVSKLLKHLLQFLFVMFGWYVSLTRIIDYYHHWSDVLAGAALGVVFAWLT 257
Cdd:cd03384  76 SGHASLSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFL 149
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 111-261 5.58e-20

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 84.39  E-value: 5.58e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709   111 YLYGLAMVTFTTMLTKLCLGRLRPHFLAVCQPMLPDGsscqdaqnlgryidsftcsnanmtdYQFKELYQSFPSGHASMA 190
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAP-------------------------STLPGLGYSFPSGHSATA 56

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21357709   191 MYAMLYLAIYLqaalsTRVSKLLKHLLQFLFVMFGWYVSLTRIIDYYHHWSDVLAGAALGVVFAWLTSAYV 261
Cdd:pfam01569  57 FALALLLALLL-----RRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02250 PLN02250
lipid phosphate phosphatase
 13-254 3.11e-18

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 83.82  E-value: 3.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709   13 DLLIWVALSVASVLLHKMgRPFRRgfFCGDETL---SYPARDGTIS--SKVIIAIVLgvPNAVIVVVELFRqlpggplre 87
Cdd:PLN02250  25 DWLILLLLVVIEVVLNVI-EPFHR--FVGKDMLtdlSYPLQDNTIPfwAVPLIAILL--PFAVILVYYFIR--------- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709   88 aggkRDSCRIAHR-LGVLYRQVIfylyglamvtfTTMLT---KLCLGRLRPHFLAVCqpmLPDGSSCQDAQNlgryiDSF 163
Cdd:PLN02250  91 ----RDVYDLHHAiLGLLFSVLI-----------TGVITdaiKDAVGRPRPDFFWRC---FPDGKGVFHPVT-----TDV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709  164 TCSNANMTdyqFKELYQSFPSGHASMAMYAMLYLAIYLQAALST--RVSKLLKHLLQFLFVMFGWYVSLTRIIDYYHHWS 241
Cdd:PLN02250 148 LCTGAKSV---IKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVfdRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQ 224

                        250
                 ....*....|...
gi 21357709  242 DVLAGAALGVVFA 254
Cdd:PLN02250 225 DVFAGALIGLTVA 237
acidPPc smart00014
Acid phosphatase homologues;
112-257 6.57e-17

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 75.46  E-value: 6.57e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709    112 LYGLAMVTFTTMLTKLCLGRLRPHFLAvcqpmlpdgsscqdaqnlgrYIDSFTCSNANMTDYQFKelyqSFPSGHASMAM 191
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLS--------------------IGDACCTPNFLLTLEAGY----SFPSGHTAFAF 56

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21357709    192 YAMLYLAIYLQAALStrvskllKHLLQFLFVMFGWYVSLTRIIDYYHHWSDVLAGAALGVVFAWLT 257
Cdd:smart00014  57 AFALFLLLYLPARAG-------RKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVL 115
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 181-261 4.70e-08

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 52.35  E-value: 4.70e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709 181 SFPSGHASMAMyAMLYLAIYLqaalstrvskLLKHLLQFLFVMFGWYVSLTRIIDYYHHWSDVLAGAALGVVFAWLTSAY 260
Cdd:COG0671 118 SFPSGHAAAAF-ALALVLALL----------LPRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLAL 186


                .
gi 21357709 261 V 261
Cdd:COG0671 187 L 187
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 104-257 1.87e-66

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 205.94  E-value: 1.87e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709 104 LYRQVIFYLYGLAMVTFTTMLTKLCLGRLRPHFLAVCQPMLPDGSSCQDAQNLGryidsfTCSNANMTDYQFKELYQSFP 183
Cdd:cd03384   2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIA------DCTCCTGDPDLIREARLSFP 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21357709 184 SGHASMAMYAMLYLAIYLQAALSTRVSKLLKHLLQFLFVMFGWYVSLTRIIDYYHHWSDVLAGAALGVVFAWLT 257
Cdd:cd03384  76 SGHASLSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFL 149
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 44-256 2.59e-32

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 119.25  E-value: 2.59e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709  44 TLSYP-ARDGTISSKVIIAIVLGVPNAVIVVVELFRQlpggplreaggkrdscriaHRLGVLYRQVIFYLYGLAMVTFTT 122
Cdd:cd03390   2 SISYPfAESETVPTWLLVIISVGIPLLVIILISLFFR-------------------RSLWDLHTSLLGLLLSVSLNGVIT 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709 123 MLTKLCLGRLRPHFLAVCQPMLpdgsscQDAQNLGRYIDSftCSNANMtdYQFKELYQSFPSGHASMAMYAMLYLAIYLQ 202
Cdd:cd03390  63 NVLKNYAGRPRPDFLARCFPDG------GTPSDTLVGIDI--CCTGDP--GVLKEGRKSFPSGHSSFAFAGLGFLSLYLA 132

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21357709 203 AALST--RVSKLLKHLLQFLFVMFGWYVSLTRIIDYYHHWSDVLAGAALGVVFAWL 256
Cdd:cd03390 133 GKLHIfdPRGSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYL 188
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 104-257 2.59e-20

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 85.20  E-value: 2.59e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709 104 LYRQVIFYLYGLAMVTFTTMLTKLCLGRLRPHFLAVCQPmlpdgsscqdaqnlgryidsftcsnaNMTDYQFKELYQSFP 183
Cdd:cd01610   1 RRLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGP--------------------------DGDPLLLTEGGYSFP 54

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21357709 184 SGHASMAMYAMLYLAIYLQaalstrvSKLLKHLLQFLFVMFGWYVSLTRIIDYYHHWSDVLAGAALGVVFAWLT 257
Cdd:cd01610  55 SGHAAFAFALALFLALLLP-------RRLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLV 121
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 111-261 5.58e-20

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 84.39  E-value: 5.58e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709   111 YLYGLAMVTFTTMLTKLCLGRLRPHFLAVCQPMLPDGsscqdaqnlgryidsftcsnanmtdYQFKELYQSFPSGHASMA 190
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAP-------------------------STLPGLGYSFPSGHSATA 56

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21357709   191 MYAMLYLAIYLqaalsTRVSKLLKHLLQFLFVMFGWYVSLTRIIDYYHHWSDVLAGAALGVVFAWLTSAYV 261
Cdd:pfam01569  57 FALALLLALLL-----RRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02250 PLN02250
lipid phosphate phosphatase
 13-254 3.11e-18

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 83.82  E-value: 3.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709   13 DLLIWVALSVASVLLHKMgRPFRRgfFCGDETL---SYPARDGTIS--SKVIIAIVLgvPNAVIVVVELFRqlpggplre 87
Cdd:PLN02250  25 DWLILLLLVVIEVVLNVI-EPFHR--FVGKDMLtdlSYPLQDNTIPfwAVPLIAILL--PFAVILVYYFIR--------- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709   88 aggkRDSCRIAHR-LGVLYRQVIfylyglamvtfTTMLT---KLCLGRLRPHFLAVCqpmLPDGSSCQDAQNlgryiDSF 163
Cdd:PLN02250  91 ----RDVYDLHHAiLGLLFSVLI-----------TGVITdaiKDAVGRPRPDFFWRC---FPDGKGVFHPVT-----TDV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709  164 TCSNANMTdyqFKELYQSFPSGHASMAMYAMLYLAIYLQAALST--RVSKLLKHLLQFLFVMFGWYVSLTRIIDYYHHWS 241
Cdd:PLN02250 148 LCTGAKSV---IKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVfdRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQ 224

                        250
                 ....*....|...
gi 21357709  242 DVLAGAALGVVFA 254
Cdd:PLN02250 225 DVFAGALIGLTVA 237
acidPPc smart00014
Acid phosphatase homologues;
112-257 6.57e-17

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 75.46  E-value: 6.57e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709    112 LYGLAMVTFTTMLTKLCLGRLRPHFLAvcqpmlpdgsscqdaqnlgrYIDSFTCSNANMTDYQFKelyqSFPSGHASMAM 191
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLS--------------------IGDACCTPNFLLTLEAGY----SFPSGHTAFAF 56

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21357709    192 YAMLYLAIYLQAALStrvskllKHLLQFLFVMFGWYVSLTRIIDYYHHWSDVLAGAALGVVFAWLT 257
Cdd:smart00014  57 AFALFLLLYLPARAG-------RKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVL 115
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 14-251 8.32e-13

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 68.13  E-value: 8.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709   14 LLIWVALSVASVLLHkmgrPFRRgfFCGDET---LSYPARDGTISSKVIIAIVLGVPnAVIVVVELFRqlpggplreagg 90
Cdd:PLN02731  48 LVLLVILECVLLIIH----PFYR--FVGKDMmtdLSYPLKSNTVPIWSVPVYAMLLP-LVIFIFIYFR------------ 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709   91 KRDSCRIAHrlgvlyrQVIFYLYGLAMVTFTTMLTKLCLGRLRPHFLAVCqpmLPDGSSCQDAqnLGRYIdsftCSNANM 170
Cdd:PLN02731 109 RRDVYDLHH-------AVLGLLYSVLVTAVLTDAIKNAVGRPRPDFFWRC---FPDGKALYDS--LGDVI----CHGDKS 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709  171 TdyqFKELYQSFPSGHASMAMYAMLYLAIYLQAALST-----RVSKLLKHLLQFLFVMFgwyVSLTRIIDYYHHWSDVLA 245
Cdd:PLN02731 173 V---IREGHKSFPSGHTSWSFSGLGFLSLYLSGKIQAfdgkgHVAKLCIVILPLLFAAL---VGISRVDDYWHHWQDVFA 246


                 ....*.
gi 21357709  246 GAALGV 251
Cdd:PLN02731 247 GGLLGL 252
PLN02715 PLN02715
lipid phosphate phosphatase
 104-254 9.92e-13

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 68.16  E-value: 9.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709  104 LYRQVIFYLYGLAMVTFTTMLTKLCLGRLRPHFLAVCqpmLPDGSSCQDAqnlgryIDSFTCSNANMtdyQFKELYQSFP 183
Cdd:PLN02715 121 LHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRC---FPDGKELYDA------LGGVICHGKAA---EVKEGHKSFP 188

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21357709  184 SGHASMAMYAMLYLAIYLQAALSTRVSKllKHLLQFLFVMF----GWYVSLTRIIDYYHHWSDVLAGAALGVVFA 254
Cdd:PLN02715 189 SGHTSWSFAGLTFLSLYLSGKIKAFNGE--GHVAKLCLVIFpllaACLVGISRVDDYWHHWQDVFAGALIGILVA 261
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 181-260 1.02e-08

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 54.15  E-value: 1.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709 181 SFPSGHASMAMYAMLYLAIYLqaaLSTRVSKLLKHLLQFLFVMFGWYVSLTRIIDYYHHWSDVLAGAALGvvFAWLTSAY 260
Cdd:cd03392 102 SFPSGHAMGATVLYGFLAYLL---ARRLPRRRVRILLLILAAILILLVGLSRLYLGVHYPSDVLAGWLLG--LAWLALLI 176
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 181-261 4.70e-08

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 52.35  E-value: 4.70e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709 181 SFPSGHASMAMyAMLYLAIYLqaalstrvskLLKHLLQFLFVMFGWYVSLTRIIDYYHHWSDVLAGAALGVVFAWLTSAY 260
Cdd:COG0671 118 SFPSGHAAAAF-ALALVLALL----------LPRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLAL 186


                .
gi 21357709 261 V 261
Cdd:COG0671 187 L 187
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 181-256 8.76e-07

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 48.08  E-value: 8.76e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21357709 181 SFPSGHASMAMYAMLYLAIYLQAALSTRVskllkhllqfLFVMFGWYVSLTRIIDYYHHWSDVLAGAALGVVFAWL 256
Cdd:cd03391  92 SFPSGHASRAAFVARFLLNHLVLAVPLRV----------LLVLWATVVGISRVLLGRHHVLDVLAGAFLGYLEALL 157
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 66-254 1.66e-06

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 47.70  E-value: 1.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709  66 VPNAVIVVVELFRQLPGGPLREAGGKRDSCRIAhrlgvlyrqvIFYLYGLAMVTFTTMLTKLCLGRLRPHFLavcqpmlp 145
Cdd:cd03389  39 IPSLLLFLLFRFGDLRGLSAPSRARFPKAAWAG----------LFLFATVALSGILVNLLKFIIGRARPKLL-------- 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357709 146 dgsscqdaQNLGRYidsftcsnaNMTDYQFKELYQSFPSGHASMAMYAMLYLAiylqaalstrvskLLKHLLQFLFVMFG 225
Cdd:cd03389 101 --------FDDGLY---------GFDPFHADYAFTSFPSGHSATAGAAAAALA-------------LLFPRYRWAFILLA 150

                       170       180
                ....*....|....*....|....*....
gi 21357709 226 WYVSLTRIIDYYHHWSDVLAGAALGVVFA 254
Cdd:cd03389 151 LLIAFSRVIVGAHYPSDVIAGSLLGAVTA 179
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 179-257 2.79e-05

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 42.70  E-value: 2.79e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21357709 179 YQSFPSGHASMAMYAmlylAIYLQAALSTRVSKLLKHLLqflfvmfGWYVSLTRIIDYYHHWSDVLAGAALGVVFAWLT 257
Cdd:cd03394  38 YRSFPSGHTASAFAA----ATFLQYRYGWRWYGIPAYAL-------ASLVGASRVVANRHWLSDVLAGAAIGILVGYLV 105
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 182-256 1.14e-04

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 41.88  E-value: 1.14e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21357709 182 FPSGHA-SMAMYAM-LYLAIYLQaaLSTRVSKLLKHLLQFLFVMFGWYVSLTRIIDYYHHWSDVLAGAALGVVFAWL 256
Cdd:cd03382  83 MPSSHSqFMGFFAVyLLLFIYLR--LGRLNSLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGIL 157
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 181-256 3.57e-03

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 38.01  E-value: 3.57e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21357709 181 SFPSGHASMAMYAMLYLAIYLQAALstrvskllkhllqFLFVMFGW--YVSLTRIIDYYHHWSDVLAGAALGVVFAWL 256
Cdd:cd03395 105 SFASSHAANSFALALFIWLFFRRGL-------------FSPVLLLWalLVGYSRVYVGVHYPGDVIAGALIGIISGLL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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