NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21355483|ref|NP_649472|]
View 

uncharacterized protein Dmel_CG9804, isoform A [Drosophila melanogaster]

Protein Classification

lipoyl(octanoyl) transferase( domain architecture ID 11612812)

lipoyl(octanoyl) transferase (LipB/LIPT2) catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes

CATH:  3.30.930.10
EC:  2.3.1.181
Gene Ontology:  GO:0033819|GO:0009249
SCOP:  4003908

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LipB cd16444
lipoyl/octanoyl transferase; Lipoate-protein ligase B is a octanoyl-[acyl carrier protein] ...
 10-216 2.06e-93

lipoyl/octanoyl transferase; Lipoate-protein ligase B is a octanoyl-[acyl carrier protein]-protein acyltransferase the catalyzes the first step of lipoic acid synthesis. It transfers endogenous octanoic acid attached via a thioester bond to acyl carrier protein (ACP) onto lipoyl domains, which is later converted by lipoate synthase LipA into lipoylated derivatives.


:

Pssm-ID: 319743  Cd Length: 199  Bit Score: 272.06  E-value: 2.06e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483  10 VVRAGRHSYSAGLQLQQRLARSNQILNPPaefrNYLVLQEHDPVYTVGLRTKDytaqdEDRLRRLGADFHRTDRGGLITF 89
Cdd:cd16444   2 VRDLGLIPYEEAWELQKRLVAERIAGETP----DTLWLLEHPPVYTLGRRGKP-----ENLLNNGGIPVVRTDRGGQVTY 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483  90 HGPGQLVAYPILHLGQFVPSIRWYVATLERMVVEACHQMGISSAKATKDTGIWVGDNKICAIGIHGSRYVTTHGIGLNCC 169
Cdd:cd16444  73 HGPGQLVGYPILDLRRRGLDVRRYVRALEEAVIRTLAEYGIEAGRRPGAPGVWVGDRKIASIGIRVRRGVTYHGLALNVN 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 21355483 170 TDLQWFEHIVPCGIEGKGVTSLSKELDRHFPVEEASGALLNSFAKVF 216
Cdd:cd16444 153 TDLSPFNRINPCGIKGKGVTSLSDLGGREVDMEEVKQKLVEEFAKIF 199
 
Name Accession Description Interval E-value
LipB cd16444
lipoyl/octanoyl transferase; Lipoate-protein ligase B is a octanoyl-[acyl carrier protein] ...
 10-216 2.06e-93

lipoyl/octanoyl transferase; Lipoate-protein ligase B is a octanoyl-[acyl carrier protein]-protein acyltransferase the catalyzes the first step of lipoic acid synthesis. It transfers endogenous octanoic acid attached via a thioester bond to acyl carrier protein (ACP) onto lipoyl domains, which is later converted by lipoate synthase LipA into lipoylated derivatives.


Pssm-ID: 319743  Cd Length: 199  Bit Score: 272.06  E-value: 2.06e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483  10 VVRAGRHSYSAGLQLQQRLARSNQILNPPaefrNYLVLQEHDPVYTVGLRTKDytaqdEDRLRRLGADFHRTDRGGLITF 89
Cdd:cd16444   2 VRDLGLIPYEEAWELQKRLVAERIAGETP----DTLWLLEHPPVYTLGRRGKP-----ENLLNNGGIPVVRTDRGGQVTY 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483  90 HGPGQLVAYPILHLGQFVPSIRWYVATLERMVVEACHQMGISSAKATKDTGIWVGDNKICAIGIHGSRYVTTHGIGLNCC 169
Cdd:cd16444  73 HGPGQLVGYPILDLRRRGLDVRRYVRALEEAVIRTLAEYGIEAGRRPGAPGVWVGDRKIASIGIRVRRGVTYHGLALNVN 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 21355483 170 TDLQWFEHIVPCGIEGKGVTSLSKELDRHFPVEEASGALLNSFAKVF 216
Cdd:cd16444 153 TDLSPFNRINPCGIKGKGVTSLSDLGGREVDMEEVKQKLVEEFAKIF 199
LipB COG0321
Lipoate-protein ligase B [Coenzyme transport and metabolism]; Lipoate-protein ligase B is part ...
 5-224 3.12e-83

Lipoate-protein ligase B [Coenzyme transport and metabolism]; Lipoate-protein ligase B is part of the Pathway/BioSystem: Lipoate biosynthesis


Pssm-ID: 440090  Cd Length: 211  Bit Score: 246.94  E-value: 3.12e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   5 RPLVTVVRAGRHSYSAGLQLQQRLArsNQILNPPAEfrNYLVLQEHDPVYTVGLRTKDytaqdEDRLRRLGADFHRTDRG 84
Cdd:COG0321   1 NRPLIIRDLGLVDYEEAWAAQRRLT--AARVAGDTP--DELWLLEHPPVYTLGRSGKP-----EHLLAPGGIPVVQTDRG 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483  85 GLITFHGPGQLVAYPILHLGQFVPSIRWYVATLERMVVEACHQMGISSAKATKDTGIWVGDNKICAIGIHGSRYVTTHGI 164
Cdd:COG0321  72 GQITYHGPGQLVGYPILDLRRRGLDVRAYVRRLEEAVIDTLAEYGIEAERRPGAPGVWVDGRKIAAIGLRVRRGVTYHGF 151

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483 165 GLNCCTDLQWFEHIVPCGIEGKGVTSLSKELDRHFPVEEASGALLNSFAKVFECRLQEHA 224
Cdd:COG0321 152 ALNVNPDLSPFSRIVPCGIADLGVTSLSDELGRPVTMEEVAEALIRHFAEVFGYELVELS 211
PRK14345 PRK14345
lipoyl(octanoyl) transferase LipB;
8-232 6.47e-56

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 184638  Cd Length: 234  Bit Score: 178.25  E-value: 6.47e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483    8 VTVVRAGRHSYSAGLQLQQRLARSNQILNPPaefrNYLVLQEHDPVYTVGLRTkdytaQDEDRLRRlGADFHRTDRGGLI 87
Cdd:PRK14345  12 IEVRRLGLVDYQEAWDLQRELADARVAGEGP----DTLLLLEHPAVYTAGKRT-----EPHERPTD-GTPVVDVDRGGKI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   88 TFHGPGQLVAYPILHLGQFVpSIRWYVATLERMVVEACHQMGISSAKATKDTGIWV------GDNKICAIGIHGSRYVTT 161
Cdd:PRK14345  82 TWHGPGQLVGYPIIKLAEPL-DVVDYVRRLEEALIAVCADLGLNAGRVDGRSGVWVpadggrPDRKIAAIGIRVSRGVTM 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21355483  162 HGIGLNCCTDLQWFEHIVPCGIEGKGVTSLSKELDRHFPVEEASGALLNSFAKVFECRLQEHAKKPASSAE 232
Cdd:PRK14345 161 HGFALNCDNDLAAFDAIVPCGISDAGVTTLSAELGRTVTVAEVVDPVAAALCDALDGRLPVRDHSPGSAVD 231
lipB TIGR00214
lipoate-protein ligase B; Involved in lipoate biosynthesis as the main determinant of the ...
 45-216 1.46e-46

lipoate-protein ligase B; Involved in lipoate biosynthesis as the main determinant of the lipoyl-protein ligase activity required for lipoylation of enzymes such as alpha-ketoacid dehydrogenases. Involved in activation and re-activation (following denaturation) of lipoyl-protein ligases (calcium ion-dependant process). [Protein fate, Protein modification and repair]


Pssm-ID: 272964  Cd Length: 184  Bit Score: 152.64  E-value: 1.46e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483    45 LVLQEHDPVYTVGLRTK-DYTAQDEDRLRrlgADFHRTDRGGLITFHGPGQLVAYPILHLGQFVPSIRWYVATLERMVVE 123
Cdd:TIGR00214  15 IMLVEHYPVYTQGQAGKtEHLLFDPDIPP---AEVVQSERGGQVTYHGPGQQVMYVILDLKRFQLDVRWLVTQLEQTVII 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   124 ACHQMGISSAKATKDTGIWVGDNKICAIGIHGSRYVTTHGIGLNCCTDLQWFEHIVPCGIEGKGVTSLSKELDRhFPVEE 203
Cdd:TIGR00214  92 TLAELGIEGEPIADATGVWVEGKKVASLGIRVRRGCTFHGLALNINMDLSPFSHINPCGYAGREMGSLNQFLPG-ATVEN 170

                         170
                  ....*....|...
gi 21355483   204 ASGALLNSFAKVF 216
Cdd:TIGR00214 171 VAPLLIKAFAELL 183
 
Name Accession Description Interval E-value
LipB cd16444
lipoyl/octanoyl transferase; Lipoate-protein ligase B is a octanoyl-[acyl carrier protein] ...
 10-216 2.06e-93

lipoyl/octanoyl transferase; Lipoate-protein ligase B is a octanoyl-[acyl carrier protein]-protein acyltransferase the catalyzes the first step of lipoic acid synthesis. It transfers endogenous octanoic acid attached via a thioester bond to acyl carrier protein (ACP) onto lipoyl domains, which is later converted by lipoate synthase LipA into lipoylated derivatives.


Pssm-ID: 319743  Cd Length: 199  Bit Score: 272.06  E-value: 2.06e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483  10 VVRAGRHSYSAGLQLQQRLARSNQILNPPaefrNYLVLQEHDPVYTVGLRTKDytaqdEDRLRRLGADFHRTDRGGLITF 89
Cdd:cd16444   2 VRDLGLIPYEEAWELQKRLVAERIAGETP----DTLWLLEHPPVYTLGRRGKP-----ENLLNNGGIPVVRTDRGGQVTY 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483  90 HGPGQLVAYPILHLGQFVPSIRWYVATLERMVVEACHQMGISSAKATKDTGIWVGDNKICAIGIHGSRYVTTHGIGLNCC 169
Cdd:cd16444  73 HGPGQLVGYPILDLRRRGLDVRRYVRALEEAVIRTLAEYGIEAGRRPGAPGVWVGDRKIASIGIRVRRGVTYHGLALNVN 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 21355483 170 TDLQWFEHIVPCGIEGKGVTSLSKELDRHFPVEEASGALLNSFAKVF 216
Cdd:cd16444 153 TDLSPFNRINPCGIKGKGVTSLSDLGGREVDMEEVKQKLVEEFAKIF 199
LipB COG0321
Lipoate-protein ligase B [Coenzyme transport and metabolism]; Lipoate-protein ligase B is part ...
 5-224 3.12e-83

Lipoate-protein ligase B [Coenzyme transport and metabolism]; Lipoate-protein ligase B is part of the Pathway/BioSystem: Lipoate biosynthesis


Pssm-ID: 440090  Cd Length: 211  Bit Score: 246.94  E-value: 3.12e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   5 RPLVTVVRAGRHSYSAGLQLQQRLArsNQILNPPAEfrNYLVLQEHDPVYTVGLRTKDytaqdEDRLRRLGADFHRTDRG 84
Cdd:COG0321   1 NRPLIIRDLGLVDYEEAWAAQRRLT--AARVAGDTP--DELWLLEHPPVYTLGRSGKP-----EHLLAPGGIPVVQTDRG 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483  85 GLITFHGPGQLVAYPILHLGQFVPSIRWYVATLERMVVEACHQMGISSAKATKDTGIWVGDNKICAIGIHGSRYVTTHGI 164
Cdd:COG0321  72 GQITYHGPGQLVGYPILDLRRRGLDVRAYVRRLEEAVIDTLAEYGIEAERRPGAPGVWVDGRKIAAIGLRVRRGVTYHGF 151

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483 165 GLNCCTDLQWFEHIVPCGIEGKGVTSLSKELDRHFPVEEASGALLNSFAKVFECRLQEHA 224
Cdd:COG0321 152 ALNVNPDLSPFSRIVPCGIADLGVTSLSDELGRPVTMEEVAEALIRHFAEVFGYELVELS 211
PRK14345 PRK14345
lipoyl(octanoyl) transferase LipB;
8-232 6.47e-56

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 184638  Cd Length: 234  Bit Score: 178.25  E-value: 6.47e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483    8 VTVVRAGRHSYSAGLQLQQRLARSNQILNPPaefrNYLVLQEHDPVYTVGLRTkdytaQDEDRLRRlGADFHRTDRGGLI 87
Cdd:PRK14345  12 IEVRRLGLVDYQEAWDLQRELADARVAGEGP----DTLLLLEHPAVYTAGKRT-----EPHERPTD-GTPVVDVDRGGKI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   88 TFHGPGQLVAYPILHLGQFVpSIRWYVATLERMVVEACHQMGISSAKATKDTGIWV------GDNKICAIGIHGSRYVTT 161
Cdd:PRK14345  82 TWHGPGQLVGYPIIKLAEPL-DVVDYVRRLEEALIAVCADLGLNAGRVDGRSGVWVpadggrPDRKIAAIGIRVSRGVTM 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21355483  162 HGIGLNCCTDLQWFEHIVPCGIEGKGVTSLSKELDRHFPVEEASGALLNSFAKVFECRLQEHAKKPASSAE 232
Cdd:PRK14345 161 HGFALNCDNDLAAFDAIVPCGISDAGVTTLSAELGRTVTVAEVVDPVAAALCDALDGRLPVRDHSPGSAVD 231
PRK14348 PRK14348
lipoyl(octanoyl) transferase LipB;
41-211 2.66e-47

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 172824  Cd Length: 221  Bit Score: 155.95  E-value: 2.66e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   41 FRNYLVLQEHDPVYTVGLRTKDYTAQ-DEDRLRRLGADFHRTDRGGLITFHGPGQLVAYPILHLGQFVPSIRWYVATLER 119
Cdd:PRK14348  37 YENRIIFCEHPHVYTLGRSGKENNMLlGEEQLKTIGATLYHIDRGGDITYHGPGQLVCYPILNLEEFGLGLKEYVHLLEE 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483  120 MVVEACHQMGISSAKATKDTGIWV-GDN----KICAIGIHGSRYVTTHGIGLNCCTDLQWFEHIVPCGIEGKGVTSLSKE 194
Cdd:PRK14348 117 AVIRVCASYGVVAGRLEKATGVWLeGDTsrarKICAIGVRSSHYVTMHGLALNVNTDLRYFSYIHPCGFIDKGVTSLQQE 196

                        170       180
                 ....*....|....*....|....
gi 21355483  195 LDRHFPVEEAS-------GALLNS 211
Cdd:PRK14348 197 LGHSIDMAEVKerlgrelLAALLS 220
lipB TIGR00214
lipoate-protein ligase B; Involved in lipoate biosynthesis as the main determinant of the ...
 45-216 1.46e-46

lipoate-protein ligase B; Involved in lipoate biosynthesis as the main determinant of the lipoyl-protein ligase activity required for lipoylation of enzymes such as alpha-ketoacid dehydrogenases. Involved in activation and re-activation (following denaturation) of lipoyl-protein ligases (calcium ion-dependant process). [Protein fate, Protein modification and repair]


Pssm-ID: 272964  Cd Length: 184  Bit Score: 152.64  E-value: 1.46e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483    45 LVLQEHDPVYTVGLRTK-DYTAQDEDRLRrlgADFHRTDRGGLITFHGPGQLVAYPILHLGQFVPSIRWYVATLERMVVE 123
Cdd:TIGR00214  15 IMLVEHYPVYTQGQAGKtEHLLFDPDIPP---AEVVQSERGGQVTYHGPGQQVMYVILDLKRFQLDVRWLVTQLEQTVII 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   124 ACHQMGISSAKATKDTGIWVGDNKICAIGIHGSRYVTTHGIGLNCCTDLQWFEHIVPCGIEGKGVTSLSKELDRhFPVEE 203
Cdd:TIGR00214  92 TLAELGIEGEPIADATGVWVEGKKVASLGIRVRRGCTFHGLALNINMDLSPFSHINPCGYAGREMGSLNQFLPG-ATVEN 170

                         170
                  ....*....|...
gi 21355483   204 ASGALLNSFAKVF 216
Cdd:TIGR00214 171 VAPLLIKAFAELL 183
PRK14341 PRK14341
lipoyl(octanoyl) transferase LipB;
29-216 3.88e-42

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237680  Cd Length: 213  Bit Score: 142.36  E-value: 3.88e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   29 ARSNQILNPPAEFRNYLVlqEHDPVYTVGLrtkdyTAQDEDRLRRLGADFHRTDRGGLITFHGPGQLVAYPILHLGQFVP 108
Cdd:PRK14341  24 ARVAAIAAGTADELVWLL--EHPPLYTAGT-----SAKAEDLLDPDRFPVYETGRGGQYTYHGPGQRVAYVMLDLKRRRR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483  109 SIRWYVATLERMVVEACHQMGISSAKATKDTGIWVGDN--------KICAIGIHGSRYVTTHGIGLNCCTDLQWFEHIVP 180
Cdd:PRK14341  97 DVRAFVAALEEWIIATLAAFNIRGERREDRVGVWVRRPdkgsgaedKIAAIGVRLRRWVSFHGISINVEPDLSHFSGIVP 176

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 21355483  181 CGIEGKGVTSLsKELDRHFPVEEASGALLNSFAKVF 216
Cdd:PRK14341 177 CGISEHGVTSL-VDLGLPVTMDDVDAALKKAFEKVF 211
BPL_LplA_LipB cd16435
biotin-lipoate ligase family; This family includes biotin protein ligase (BPL), ...
 18-212 6.99e-37

biotin-lipoate ligase family; This family includes biotin protein ligase (BPL), lipoate-protein ligase A (LplA) and octanoyl-[acyl carrier protein]-protein acyltransferase (LipB). Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites. Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine. Lipoate-protein ligase A (LplA) catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes.


Pssm-ID: 319740  Cd Length: 198  Bit Score: 128.42  E-value: 6.99e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483  18 YSAGLQLQQRLARSNQILNPPaefrnYLVLQEHDPVYTVGLRTKDYTAQDEDRLRRLGADFHRTDRGGLITFHGPGQLVA 97
Cdd:cd16435  10 YESAWAAQEKSLRENVSNQSS-----TLLLWEHPTTVTLGRLDRELPHLELAKKIERGYELVVRNRGGRAVSHDPGQLVF 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483  98 YPILHLGqFVPSIRWYVATLERMVVEACHQMGISSAKATKDTGIWVGDNKICAIGIHGSRYVTTHGIGLNCCTDLQWFEH 177
Cdd:cd16435  85 SPVIGPN-VEFMISKFNLIIEEGIRDAIADFGQSAEVKWGRNDLWIDNRKVCGIAVRVVKEAIFHGIALNLNQDLENFTE 163

                       170       180       190
                ....*....|....*....|....*....|....*
gi 21355483 178 IVPCGIEGKGVTSLSKELDRHFPVEEASGALLNSF 212
Cdd:cd16435 164 IIPCGYKPERVTSLSLELGRKVTVEQVLERVLAAF 198
PRK14344 PRK14344
lipoyl(octanoyl) transferase LipB;
17-192 9.39e-36

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237683  Cd Length: 223  Bit Score: 125.95  E-value: 9.39e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   17 SYSAGLQLQQRLarsnqILNPPAEfrNYLVLQEHDPVYTVGlrtkdyTAQDEDRL----RRLGADFHRTDRGGLITFHGP 92
Cdd:PRK14344  32 AWKWQKEWQQAL-----IEDPSNP--QAVWLLEHQLCYTLG------RGASEDNLlfslNNPPADVFRIDRGGEVTHHMP 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   93 GQLVAYPILHLGQFVPSIRWYVATLERMVVEACHQMGISSAKATKDTGIWVGDNKICAIGIHGSRYVTTHGIGLNCCTDL 172
Cdd:PRK14344  99 GQLVTYLVLDLRRFNKDLNWYLRQLEQVLIDVLADLGIDGERLDGLTGVWIGNKKVASIGIGCRRWITQHGFSLNVDCDL 178

                        170       180
                 ....*....|....*....|
gi 21355483  173 QWFEHIVPCGIEGKGVTSLS 192
Cdd:PRK14344 179 EGFNKIVPCGLEGCQVGRLS 198
PRK14347 PRK14347
lipoyl(octanoyl) transferase LipB;
18-217 1.50e-29

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 172823  Cd Length: 209  Bit Score: 109.64  E-value: 1.50e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   18 YSAGLQLQQRLArsNQILNPPAEFRNYLVlqEHDPVYTVGLRTKDytaqdEDRLRRLGADFHRTDRGGLITFHGPGQLVA 97
Cdd:PRK14347  13 YQVTLKLMEDYV--NKVISDHEPEIVYLV--EHSEVYTAGTNYKQ-----EELLNYGDIPVIYTGRGGKFTFHGPGQRVI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   98 YPILHLGqfVPS----IRWYVATLERMVVEACHQMGISSAKATKDTGIWVGDN-----KICAIGIHGSRYVTTHGIGLNC 168
Cdd:PRK14347  84 YPILNLA--SPNrhkdLKLYIKMLEEWIINSLNYFGIKAYIIKDKVGIWVKVRkdefaKIAAIGVRVRKWVTYHGVAINI 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 21355483  169 CTDLQWFEHIVPCGIEGKGVTSLSkELDRHFPVEEASGALLNSFAKVFE 217
Cdd:PRK14347 162 STDLSKFSGIIPCGLENSLVTSLN-QLGIHVEMSEFDKIIQTEFNKIFK 209
PRK14342 PRK14342
lipoyl(octanoyl) transferase LipB;
47-223 8.95e-27

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237681  Cd Length: 213  Bit Score: 102.27  E-value: 8.95e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   47 LQEHDPVYTVGLRTKDytaqdEDRLRRLGADFHRTDRGGLITFHGPGQLVAYPILHLGQFVPSIRWYVATLERMVVEACH 126
Cdd:PRK14342  40 LVEHPPVFTQGQAGKP-----EHILNPGDIPVVQSDRGGQVTYHGPGQLVMYVLLDLKRLKLGVRQLVTAIEQTVINTLA 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483  127 QMGISSAKATKDTGIWVGDNKICAIGI---HGSRYvttHGIGLNCCTDLQWFEHIVPCGIEGKGVTSLsKELDRHFPVEE 203
Cdd:PRK14342 115 EYGIEAHAKPDAPGVYVDGKKIASLGLrirRGCSF---HGLALNVNMDLSPFLRINPCGYAGLEMTQL-SDLGGPATVDE 190

                        170       180
                 ....*....|....*....|
gi 21355483  204 ASGALLNSFAKVFECRLQEH 223
Cdd:PRK14342 191 VAPRLLAELLALLGYNDQET 210
PRK14346 PRK14346
lipoyl(octanoyl) transferase LipB;
12-192 1.23e-23

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237684  Cd Length: 230  Bit Score: 94.82  E-value: 1.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   12 RAGRHSYSAGLQLQQRLARSNQilnppAEFRNYLVLQEHDPVYTVGLrtkdyTAQDEDRLRRLGADFHRTDRGGLITFHG 91
Cdd:PRK14346   7 MLGRVDYLATVQAMQAFTAERT-----PETPDELWICEHPPVYTQGL-----AGKADHVLNPGDIPVVATNRGGQVTYHG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   92 PGQLVAYPILHLGQFVPSIRWYVATLERMVVEACHQMGISSAKATKDTGIWV---------------------------- 143
Cdd:PRK14346  77 PGQVVAYPLIDLRRAGYFVKEYVYRIEEAVIRTLAHFGVTGHRVAGAPGIYVrlddpfshaalpqrpqkrgggapqppfr 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 21355483  144 GDNKICAIGIHGSRYVTTHGIGLNCCTDLQWFEHIVPCGIEGKGVTSLS 192
Cdd:PRK14346 157 GLGKIAALGIKVSRHCTYHGVALNVAMDLEPFSRINPCGYAGLQTVDLS 205
PRK14343 PRK14343
lipoyl(octanoyl) transferase LipB;
8-185 1.11e-21

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237682  Cd Length: 235  Bit Score: 89.46  E-value: 1.11e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483    8 VTVVRAGRHSYSAGLQLQQRL--ARSnqilnppAEFRNYLVLQEHDPVYTVGLrtkdytAQDEDRLrrLGAD----FHRT 81
Cdd:PRK14343  15 VTVRWRGREPYEACFDAMRAFtdART-------ADTPDEIWLVEHPPVYTLGQ------AGDPAHL--LVADsgipLVKV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   82 DRGGLITFHGPGQLVAYPILHLGQFVPSIRWYVATLERMVVEACHQMGISSAKATKDTGIWVGDN-----KICAIGIHGS 156
Cdd:PRK14343  80 DRGGQITYHGPGQVVAYLLLDLRRRKLMVRELVTRIEQAVIDTLAAYNLASERKAGAPGIYVASGphqgaKIAALGLKIR 159

                        170       180
                 ....*....|....*....|....*....
gi 21355483  157 RYVTTHGIGLNCCTDLQWFEHIVPCGIEG 185
Cdd:PRK14343 160 NGCSYHGLSLNVKMDLRPFLAINPCGYAG 188
PRK14349 PRK14349
lipoyl(octanoyl) transferase LipB;
47-192 3.04e-18

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 172825  Cd Length: 220  Bit Score: 80.02  E-value: 3.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355483   47 LQEHDPVYTVGlrtkdYTAQDEDRLRRLGADFHRTDRGGLITFHGPGQLVAYPILHLGQFVPSIRWYVATLERMVVEACH 126
Cdd:PRK14349  35 LCEHAPVYTLG-----QAGRPEHLLNPGLIPVVHCDRGGQVTYHGPGQVLAYTLFDLRRAGLYVREYVDMLEQATLATLR 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21355483  127 QMGISSA-KATKDTGIWVGD-----NKICAIGIHGSRYVTTHGIGLNCCTDLQWFEHIVPCGIEGKGVTSLS 192
Cdd:PRK14349 110 ELGLEQAcRKPGAPGIYVPQpggelAKIAALGVKVRNGYAYHGLALNIDMDLSPFLGINPCGYEGLRTVDLA 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH