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Conserved domains on  [gi|21356481|ref|NP_649520|]
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retinophilin [Drosophila melanogaster]

Protein Classification

MORN repeat-containing protein( domain architecture ID 1003622)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  35568981|33296386

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 super family cl34799
Uncharacterized conserved protein [Function unknown];
53-153 1.61e-21

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG4642:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 88.86  E-value: 1.61e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356481  53 VGGWRYEDASRYIGEWnQRGQKHGIGHLQFADGTRYDGQFQEGLSQGVGCLWFADGAKYEGEFHQGWFHGNGIFWRADGM 132
Cdd:COG4642 139 GGIYTFPNGDVYEGEF-KNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGD 217

                        90       100
                ....*....|....*....|.
gi 21356481 133 KYEGEFRGGKIWGLGLLTFQD 153
Cdd:COG4642 218 RYEGEFKNGKRHGQGTLTYAD 238
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
53-153 1.61e-21

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 88.86  E-value: 1.61e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356481  53 VGGWRYEDASRYIGEWnQRGQKHGIGHLQFADGTRYDGQFQEGLSQGVGCLWFADGAKYEGEFHQGWFHGNGIFWRADGM 132
Cdd:COG4642 139 GGIYTFPNGDVYEGEF-KNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGD 217

                        90       100
                ....*....|....*....|.
gi 21356481 133 KYEGEFRGGKIWGLGLLTFQD 153
Cdd:COG4642 218 RYEGEFKNGKRHGQGTLTYAD 238
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 54-151 9.56e-13

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 66.01  E-value: 9.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356481   54 GGWRYEDASRYIGEWnQRGQKHGIGHLQFADGTRYDGQFQEG-----------------------LSQGVGCLWFADGAK 110
Cdd:PLN03185  24 GKYLWSDGCMYEGEW-RRGMRHGNGKISWPSGATYEGEFSGGymhgsgtytgtdgttykgrwrlnLKHGLGYQRYPNGDV 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 21356481  111 YEGEFHQGWFHGNGIFWRADGMKYEGEFRGGKIWGLGLLTF 151
Cdd:PLN03185 103 FEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTW 143
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
53-153 1.61e-21

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 88.86  E-value: 1.61e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356481  53 VGGWRYEDASRYIGEWnQRGQKHGIGHLQFADGTRYDGQFQEGLSQGVGCLWFADGAKYEGEFHQGWFHGNGIFWRADGM 132
Cdd:COG4642 139 GGIYTFPNGDVYEGEF-KNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGD 217

                        90       100
                ....*....|....*....|.
gi 21356481 133 KYEGEFRGGKIWGLGLLTFQD 153
Cdd:COG4642 218 RYEGEFKNGKRHGQGTLTYAD 238
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
58-153 1.64e-21

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 88.86  E-value: 1.64e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356481  58 YEDASRYIGEWNQrGQKHGIGHLQFADGTRYDGQFQEGLSQGVGCLWFADGAKYEGEFHQGWFHGNGIFWRADGMKYEGE 137
Cdd:COG4642 167 YADGDRYEGEFKN-GKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGE 245

                        90
                ....*....|....*.
gi 21356481 138 FRGGKIWGLGLLTFQD 153
Cdd:COG4642 246 FKNGKRHGQGTMTYAD 261
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
57-139 2.59e-17

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 77.69  E-value: 2.59e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356481  57 RYEDASRYIGEWnQRGQKHGIGHLQFADGTRYDGQFQEGLSQGVGCLWFADGAKYEGEFHQGWFHGNGIFWRADGMKYEG 136
Cdd:COG4642 189 TYANGDVYEGEF-KNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYADGSVYEG 267


                ...
gi 21356481 137 EFR 139
Cdd:COG4642 268 EWK 270
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
46-153 1.12e-16

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 75.76  E-value: 1.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356481  46 YSAGAVKVGGWRYEDASRYIGEWNQRGQKHGIGHLQFADGTRYDGQFQEGLSQGVGCLWFADGAKYEGEFHQGWFHGNGI 125
Cdd:COG4642 108 KKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGT 187

                        90       100
                ....*....|....*....|....*...
gi 21356481 126 FWRADGMKYEGEFRGGKIWGLGLLTFQD 153
Cdd:COG4642 188 LTYANGDVYEGEFKNGQRHGQGTYTYAD 215
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 54-151 9.56e-13

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 66.01  E-value: 9.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356481   54 GGWRYEDASRYIGEWnQRGQKHGIGHLQFADGTRYDGQFQEG-----------------------LSQGVGCLWFADGAK 110
Cdd:PLN03185  24 GKYLWSDGCMYEGEW-RRGMRHGNGKISWPSGATYEGEFSGGymhgsgtytgtdgttykgrwrlnLKHGLGYQRYPNGDV 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 21356481  111 YEGEFHQGWFHGNGIFWRADGMKYEGEFRGGKIWGLGLLTF 151
Cdd:PLN03185 103 FEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTW 143
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 64-147 7.87e-11

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 60.23  E-value: 7.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356481   64 YIGEWnQRGQKHGIGHLQFADGTRYDGQFQEGLSQGVGCLWFADGAKYEGEFHQGWFHGNGIFWRADGMKYEGEFRGGKI 143
Cdd:PLN03185  11 YSGSL-LGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLK 89


                 ....
gi 21356481  144 WGLG 147
Cdd:PLN03185  90 HGLG 93
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
54-117 5.71e-10

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 57.27  E-value: 5.71e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21356481  54 GGWRYEDASRYIGEWnQRGQKHGIGHLQFADGTRYDGQFQEGLSQGVGCLWFADGAKYEGEFHQ 117
Cdd:COG4642 209 GTYTYADGDRYEGEF-KNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYADGSVYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 78-147 1.37e-09

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 56.77  E-value: 1.37e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21356481   78 GHLQFADGTRYDGQFQEGLSQGVGCLWFADGAKYEGEFHQGWFHGNG-IFWrADGMKYEGEFRGGKIWGLG 147
Cdd:PLN03185   1 GELVLSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGkISW-PSGATYEGEFSGGYMHGSG 70
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 60-153 3.72e-09

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 55.61  E-value: 3.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356481   60 DASRYIGEWnQRGQKHGIGHLQFADGTRYDGQFQEGLSQGVGCLWFADGAKYEGEFHQGWFHGNGIFWRADGMKYEGEFR 139
Cdd:PLN03185  76 DGTTYKGRW-RLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWL 154

                         90
                 ....*....|....
gi 21356481  140 GGKIWGLGLLTFQD 153
Cdd:PLN03185 155 DGMMHGFGVYTWSD 168
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 57-141 1.14e-07

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 50.99  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356481   57 RYEDASRYIGEWNQrGQKHGIGHLQFADGTRYDGQFQEGLSQGVGCLWFADGAKYEGEFHQGWFHGNGIFWRADGMKYEG 136
Cdd:PLN03185  96 RYPNGDVFEGSWIQ-GLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVG 174


                 ....*
gi 21356481  137 EFRGG 141
Cdd:PLN03185 175 TWTRG 179
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 46-129 1.18e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 45.21  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356481   46 YSAGAVKVGGW---------RYEDASR--YIGEWnQRGQKHGIGHLQFADGTRYDGQFQEGLSQGVGCLWFADGAKYEGE 114
Cdd:PLN03185  97 YPNGDVFEGSWiqglqegpgKYTWANGnvYLGDM-KGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGT 175

                         90
                 ....*....|....*
gi 21356481  115 FHQGWFHGNGIFWRA 129
Cdd:PLN03185 176 WTRGLKDGKGVFYPA 190
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
54-146 9.39e-04

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 38.13  E-value: 9.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356481  54 GGWRYEDASRYIGEWNQRGQKHGIGHLQFADGT-RYDGQFQEGLSQGVGCLWFADGA-KYEGEFHQGWFHGNGIFWRADG 131
Cdd:COG2849  46 EGGKLIKKKLGKGLGKYKKGKLGEWKTYYPNGQlKSEGTYKNGKLEGEWKEYYENGKlKSEGNYKNGKLHGEWKEYYENG 125

                        90
                ....*....|....*.
gi 21356481 132 -MKYEGEFRGGKIWGL 146
Cdd:COG2849 126 kLKEEGNYKNGKKDGV 141
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
70-143 3.49e-03

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 36.58  E-value: 3.49e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21356481  70 QRGQKHGIGHLQFADGT-RYDGQFQEGLSQGVGCLWFADGA-KYEGEFHQGWFHGNGIFWRADG-MKYEGEFRGGKI 143
Cdd:COG2849  86 KNGKLEGEWKEYYENGKlKSEGNYKNGKLHGEWKEYYENGKlKEEGNYKNGKKDGVWKYYDENGkLVKEEEYKNGKK 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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