NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21357321|ref|NP_649589|]
View 

uncharacterized protein Dmel_CG1218 [Drosophila melanogaster]

Protein Classification

HPF1 family protein( domain architecture ID 10563285)

HPF1 family protein is a DUF2228 domain-containing protein similar to Homo sapiens histone PARylation factor 1 that acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF2228 pfam10228
Uncharacterized conserved protein (DUF2228); This is a family of conserved proteins of ...
 176-428 1.88e-107

Uncharacterized conserved protein (DUF2228); This is a family of conserved proteins of approximately 700 residues found from worms to humans.


:

Pssm-ID: 463010  Cd Length: 251  Bit Score: 318.01  E-value: 1.88e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357321   176 QLQLVGPFEFLAGKFHGAKlGEPGDYLRHWRFYYDPPEFQTIFVRRG-TGIHYGYWRDVPQDKeNLLIARNDSAKGCQFQ 254
Cdd:pfam10228   1 GLKLVGPFDVLAGKHKRKK-VDGEDYLLHWRFYYDPPEFQTVLVGDDkTGYHYGYWRDSPDEK-PVFVVSNDAKKGCEIT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357321   255 FVAGNAFDAFLYYLEHDFAATP--FSCGQLAGTKKAVAKYLSDNSLELaQLDRLQRERNKRVVAKTFHRAGIVVPFDQKT 332
Cdd:pfam10228  79 VVGDNVFAAVKHFLEKKLKKTDdkAKKKILKKLKKKLEDMAKELGISL-QKTEKMKKRKKKVVTKTFHGAGIVVPVDKKT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357321   333 EVGYRPLAVSDSELKKMLAMLERKDVDNgaAKQAVLEKLQPVANAANIAVDESDFGSALELGIDMFCSGHKELHMLASSL 412
Cdd:pfam10228 158 DVGYRPLPETDANLKKILKKIVEAKNDS--ERDKVFDPLQELVTFVQIANDECDYGMGLELGIDLFCYGSKYFHKVILQL 235

                         250
                  ....*....|....*.
gi 21357321   413 LVPAYSMLSRPQFIAI 428
Cdd:pfam10228 236 LPTAYKLLKRPLFAEI 251
zf-CCHH pfam10283
PBZ domain; This domain is a zinc-finger motif that in humans is part of the APLF, aprataxin- ...
 3-27 3.72e-09

PBZ domain; This domain is a zinc-finger motif that in humans is part of the APLF, aprataxin- and PNK-like forkhead association domain-containing protein. The ZnF is highly conserved both in primary sequence and in the spacing between the putative zinc coordinating residues and is configured CX5CX6HX5H. Many of the proteins containing the APLF-like ZnF are involved in DNA strand break repair and/or contain domains implicated in DNA metabolism.


:

Pssm-ID: 463043 [Multi-domain]  Cd Length: 25  Bit Score: 51.73  E-value: 3.72e-09
                          10        20
                  ....*....|....*....|....*
gi 21357321     3 KEDCKYWDKCYQQNPAHLSKYNHPK 27
Cdd:pfam10283   1 RPPCKYGAKCYRKNPQHFKEFSHPG 25
 
Name Accession Description Interval E-value
DUF2228 pfam10228
Uncharacterized conserved protein (DUF2228); This is a family of conserved proteins of ...
 176-428 1.88e-107

Uncharacterized conserved protein (DUF2228); This is a family of conserved proteins of approximately 700 residues found from worms to humans.


Pssm-ID: 463010  Cd Length: 251  Bit Score: 318.01  E-value: 1.88e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357321   176 QLQLVGPFEFLAGKFHGAKlGEPGDYLRHWRFYYDPPEFQTIFVRRG-TGIHYGYWRDVPQDKeNLLIARNDSAKGCQFQ 254
Cdd:pfam10228   1 GLKLVGPFDVLAGKHKRKK-VDGEDYLLHWRFYYDPPEFQTVLVGDDkTGYHYGYWRDSPDEK-PVFVVSNDAKKGCEIT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357321   255 FVAGNAFDAFLYYLEHDFAATP--FSCGQLAGTKKAVAKYLSDNSLELaQLDRLQRERNKRVVAKTFHRAGIVVPFDQKT 332
Cdd:pfam10228  79 VVGDNVFAAVKHFLEKKLKKTDdkAKKKILKKLKKKLEDMAKELGISL-QKTEKMKKRKKKVVTKTFHGAGIVVPVDKKT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357321   333 EVGYRPLAVSDSELKKMLAMLERKDVDNgaAKQAVLEKLQPVANAANIAVDESDFGSALELGIDMFCSGHKELHMLASSL 412
Cdd:pfam10228 158 DVGYRPLPETDANLKKILKKIVEAKNDS--ERDKVFDPLQELVTFVQIANDECDYGMGLELGIDLFCYGSKYFHKVILQL 235

                         250
                  ....*....|....*.
gi 21357321   413 LVPAYSMLSRPQFIAI 428
Cdd:pfam10228 236 LPTAYKLLKRPLFAEI 251
zf-CCHH pfam10283
PBZ domain; This domain is a zinc-finger motif that in humans is part of the APLF, aprataxin- ...
 3-27 3.72e-09

PBZ domain; This domain is a zinc-finger motif that in humans is part of the APLF, aprataxin- and PNK-like forkhead association domain-containing protein. The ZnF is highly conserved both in primary sequence and in the spacing between the putative zinc coordinating residues and is configured CX5CX6HX5H. Many of the proteins containing the APLF-like ZnF are involved in DNA strand break repair and/or contain domains implicated in DNA metabolism.


Pssm-ID: 463043 [Multi-domain]  Cd Length: 25  Bit Score: 51.73  E-value: 3.72e-09
                          10        20
                  ....*....|....*....|....*
gi 21357321     3 KEDCKYWDKCYQQNPAHLSKYNHPK 27
Cdd:pfam10283   1 RPPCKYGAKCYRKNPQHFKEFSHPG 25
 
Name Accession Description Interval E-value
DUF2228 pfam10228
Uncharacterized conserved protein (DUF2228); This is a family of conserved proteins of ...
 176-428 1.88e-107

Uncharacterized conserved protein (DUF2228); This is a family of conserved proteins of approximately 700 residues found from worms to humans.


Pssm-ID: 463010  Cd Length: 251  Bit Score: 318.01  E-value: 1.88e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357321   176 QLQLVGPFEFLAGKFHGAKlGEPGDYLRHWRFYYDPPEFQTIFVRRG-TGIHYGYWRDVPQDKeNLLIARNDSAKGCQFQ 254
Cdd:pfam10228   1 GLKLVGPFDVLAGKHKRKK-VDGEDYLLHWRFYYDPPEFQTVLVGDDkTGYHYGYWRDSPDEK-PVFVVSNDAKKGCEIT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357321   255 FVAGNAFDAFLYYLEHDFAATP--FSCGQLAGTKKAVAKYLSDNSLELaQLDRLQRERNKRVVAKTFHRAGIVVPFDQKT 332
Cdd:pfam10228  79 VVGDNVFAAVKHFLEKKLKKTDdkAKKKILKKLKKKLEDMAKELGISL-QKTEKMKKRKKKVVTKTFHGAGIVVPVDKKT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357321   333 EVGYRPLAVSDSELKKMLAMLERKDVDNgaAKQAVLEKLQPVANAANIAVDESDFGSALELGIDMFCSGHKELHMLASSL 412
Cdd:pfam10228 158 DVGYRPLPETDANLKKILKKIVEAKNDS--ERDKVFDPLQELVTFVQIANDECDYGMGLELGIDLFCYGSKYFHKVILQL 235

                         250
                  ....*....|....*.
gi 21357321   413 LVPAYSMLSRPQFIAI 428
Cdd:pfam10228 236 LPTAYKLLKRPLFAEI 251
zf-CCHH pfam10283
PBZ domain; This domain is a zinc-finger motif that in humans is part of the APLF, aprataxin- ...
 3-27 3.72e-09

PBZ domain; This domain is a zinc-finger motif that in humans is part of the APLF, aprataxin- and PNK-like forkhead association domain-containing protein. The ZnF is highly conserved both in primary sequence and in the spacing between the putative zinc coordinating residues and is configured CX5CX6HX5H. Many of the proteins containing the APLF-like ZnF are involved in DNA strand break repair and/or contain domains implicated in DNA metabolism.


Pssm-ID: 463043 [Multi-domain]  Cd Length: 25  Bit Score: 51.73  E-value: 3.72e-09
                          10        20
                  ....*....|....*....|....*
gi 21357321     3 KEDCKYWDKCYQQNPAHLSKYNHPK 27
Cdd:pfam10283   1 RPPCKYGAKCYRKNPQHFKEFSHPG 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH