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Conserved domains on  [gi|24644574|ref|NP_649642|]
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uncharacterized protein Dmel_CG17917 [Drosophila melanogaster]

Protein Classification

YbhB/YbcL family Raf kinase inhibitor-like protein( domain architecture ID 10096268)

YbhB/YbcL family Raf kinase inhibitor-like protein similar to mammalian phosphatidylethanolamine-binding protein 1/2 and Schizosaccharomyces pombe mitochondrial 54S ribosomal protein L35

CATH:  3.90.280.10
SCOP:  4002457

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 44-188 1.16e-54

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


:

Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 171.40  E-value: 1.16e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574  44 LNVTYHGHLAAHCGKVLEPMQVRDEPSVKWPSA--PENYYALLMVDPDVPNAITPTHREFLHWMVLNIPGN-----LLAL 116
Cdd:cd00866   3 LTVSYGSSGVVTPGNLLTPSETQKAPTVSFSSEdpPDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSdtttgLVSK 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24644574 117 GDVRVGYMGATPLKGTGTHRFVFLLYKQRDYTKFDFPKLPKHSVKGRSGFETKRFAKKYRFGHPVAGNFFTS 188
Cdd:cd00866  83 GEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 44-188 1.16e-54

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 171.40  E-value: 1.16e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574  44 LNVTYHGHLAAHCGKVLEPMQVRDEPSVKWPSA--PENYYALLMVDPDVPNAITPTHREFLHWMVLNIPGN-----LLAL 116
Cdd:cd00866   3 LTVSYGSSGVVTPGNLLTPSETQKAPTVSFSSEdpPDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSdtttgLVSK 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24644574 117 GDVRVGYMGATPLKGTGTHRFVFLLYKQRDYTKFDFPKLPKHSVKGRSGFETKRFAKKYRFGHPVAGNFFTS 188
Cdd:cd00866  83 GEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
PLN00169 PLN00169
CETS family protein; Provisional
 44-189 5.17e-24

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 93.72  E-value: 5.17e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574   44 LNVTYhGHLAAHCGKVLEPMQVRDEPSVKWPSAP-ENYYALLMVDPDVPNAITPTHREFLHWMVLNIPGNLLA-LGDVRV 121
Cdd:PLN00169  28 LRVTY-GSREVNNGCELKPSQVVNQPRVDIGGEDlRTFYTLVMVDPDAPSPSNPNLREYLHWLVTDIPATTGAtFGQEVV 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24644574  122 GYMGATPLkgTGTHRFVFLLYKQrdytkfdfpkLPKHSVKG---RSGFETKRFAKKYRFGHPVAGNFFTSQ 189
Cdd:PLN00169 107 CYESPRPT--AGIHRFVFVLFRQ----------LGRQTVYApgwRQNFNTRDFAELYNLGSPVAAVYFNCQ 165
PBP pfam01161
Phosphatidylethanolamine-binding protein;
69-185 5.77e-17

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 73.91  E-value: 5.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574    69 PSVKWPSAPEN--YYALLMVDPDVPNAitpTHREFLHWMVLNIPGNLLALG-------------DVRVGYMGATPLKGTG 133
Cdd:pfam01161  15 PPLAWSGAPAGtkSFALVMIDPDAPKV---GGSGWLHWVVTNIPATVTELPegapagavqglndFGGAGYGGPCPPAGDG 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 24644574   134 THRFVFLLYkqrdytKFDFPKLPKHSVKGRSGFEtKRFAKKYRFGHPVAGNF 185
Cdd:pfam01161  92 PHRYVFTLY------ALDVPLLDRNWGFTKAELG-VAFAGHVLALAVLAGNY 136
PEBP COG1881
Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family ...
 69-142 3.01e-11

Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family [General function prediction only];


Pssm-ID: 441485  Cd Length: 151  Bit Score: 59.01  E-value: 3.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574  69 PSVKWPSAPEN--YYALLMVDPDVPnaitpTHREFLHWMVLNIPGNLLAL------GDV------------RVGYMGATP 128
Cdd:COG1881  27 PPLSWSGAPEGtkSFALIVEDPDAP-----TGGGFWHWVVYNIPADVTELpegagsADLpagavqgrndfgEAGYGGPCP 101

                        90
                ....*....|....
gi 24644574 129 LKGTGTHRFVFLLY 142
Cdd:COG1881 102 PPGDGPHRYVFTVY 115
TIGR00481 TIGR00481
Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]
 69-156 4.93e-04

Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]


Pssm-ID: 129572  Cd Length: 141  Bit Score: 39.00  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574    69 PSVKWPSAPENY--YALLMVDPDVPNAITpthreFLHWMVLNIPGNLLAL------GDVRV---------------GYMG 125
Cdd:TIGR00481  16 PPLSWDGVPEGAksLALTCIDPDAPTGCG-----WWHWVVVNIPADTTVLpenassDDKRLpqgvplqgrndfgksGYIG 90

                          90       100       110
                  ....*....|....*....|....*....|.
gi 24644574   126 ATPLKgtGTHRFVFLLYkqrdytKFDFPKLP 156
Cdd:TIGR00481  91 PCPPK--GDHRYLFTVY------ALDTEKLD 113
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 44-188 1.16e-54

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 171.40  E-value: 1.16e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574  44 LNVTYHGHLAAHCGKVLEPMQVRDEPSVKWPSA--PENYYALLMVDPDVPNAITPTHREFLHWMVLNIPGN-----LLAL 116
Cdd:cd00866   3 LTVSYGSSGVVTPGNLLTPSETQKAPTVSFSSEdpPDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSdtttgLVSK 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24644574 117 GDVRVGYMGATPLKGTGTHRFVFLLYKQRDYTKFDFPKLPKHSVKGRSGFETKRFAKKYRFGHPVAGNFFTS 188
Cdd:cd00866  83 GEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
PLN00169 PLN00169
CETS family protein; Provisional
 44-189 5.17e-24

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 93.72  E-value: 5.17e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574   44 LNVTYhGHLAAHCGKVLEPMQVRDEPSVKWPSAP-ENYYALLMVDPDVPNAITPTHREFLHWMVLNIPGNLLA-LGDVRV 121
Cdd:PLN00169  28 LRVTY-GSREVNNGCELKPSQVVNQPRVDIGGEDlRTFYTLVMVDPDAPSPSNPNLREYLHWLVTDIPATTGAtFGQEVV 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24644574  122 GYMGATPLkgTGTHRFVFLLYKQrdytkfdfpkLPKHSVKG---RSGFETKRFAKKYRFGHPVAGNFFTSQ 189
Cdd:PLN00169 107 CYESPRPT--AGIHRFVFVLFRQ----------LGRQTVYApgwRQNFNTRDFAELYNLGSPVAAVYFNCQ 165
PEBP cd00457
PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding ...
 55-187 3.48e-21

PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). A number of biological roles for members of the PEBP family include serine protease inhibition, membrane biogenesis, regulation of flowering plant stem architecture, and Raf-1 kinase inhibition. Although their overall structures are similar, the members of the PEBP family bind very different substrates including phospholipids, opioids, and hydrophobic odorant molecules as well as having different oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176642  Cd Length: 159  Bit Score: 85.53  E-value: 3.48e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574  55 HCGKVLEPMQVRDE----PSVKWPSAPEN--YYALLMVDPDVPnaitpTHREFLHWMVLNIPGNLLALGDVRVG------ 122
Cdd:cd00457   9 PSGSVLPPEYSFEGvgrfPSLSWDGPPPDvkEYVLVMEDPDAP-----LGRPIVHGLVYGIPANKTSLSNDDFVvtdngk 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574 123 -----------------YMGATPLKGTGTHRFVFLLYKQrdytkfDFPKLPKHSVKGRSGFETKRFAKKYRFGhPVAGNF 185
Cdd:cd00457  84 gglqggfkygknrggtvYIGPRPPLGHGPHRYFFQVYAL------DEPLDRSKLGDGRTKFEVARFAEGNVLG-AVGEWV 156


                ..
gi 24644574 186 FT 187
Cdd:cd00457 157 GQ 158
PBP pfam01161
Phosphatidylethanolamine-binding protein;
69-185 5.77e-17

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 73.91  E-value: 5.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574    69 PSVKWPSAPEN--YYALLMVDPDVPNAitpTHREFLHWMVLNIPGNLLALG-------------DVRVGYMGATPLKGTG 133
Cdd:pfam01161  15 PPLAWSGAPAGtkSFALVMIDPDAPKV---GGSGWLHWVVTNIPATVTELPegapagavqglndFGGAGYGGPCPPAGDG 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 24644574   134 THRFVFLLYkqrdytKFDFPKLPKHSVKGRSGFEtKRFAKKYRFGHPVAGNF 185
Cdd:pfam01161  92 PHRYVFTLY------ALDVPLLDRNWGFTKAELG-VAFAGHVLALAVLAGNY 136
PEBP COG1881
Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family ...
 69-142 3.01e-11

Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family [General function prediction only];


Pssm-ID: 441485  Cd Length: 151  Bit Score: 59.01  E-value: 3.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574  69 PSVKWPSAPEN--YYALLMVDPDVPnaitpTHREFLHWMVLNIPGNLLAL------GDV------------RVGYMGATP 128
Cdd:COG1881  27 PPLSWSGAPEGtkSFALIVEDPDAP-----TGGGFWHWVVYNIPADVTELpegagsADLpagavqgrndfgEAGYGGPCP 101

                        90
                ....*....|....
gi 24644574 129 LKGTGTHRFVFLLY 142
Cdd:COG1881 102 PPGDGPHRYVFTVY 115
PEBP_bact_arch cd00865
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; ...
 69-142 2.47e-09

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.


Pssm-ID: 176643  Cd Length: 150  Bit Score: 53.76  E-value: 2.47e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574  69 PSVKWPSAPEN--YYALLMVDPDVPnaitpTHREFLHWMVLNIPGNLLALGD------------------VRVGYMGATP 128
Cdd:cd00865  28 PPLSWSGVPAGtkSLALIVEDPDAP-----TGGGFVHWVVWNIPADTTELPEgasrgalpagavqgrndfGEAGYGGPCP 102

                        90
                ....*....|....
gi 24644574 129 LKGtGTHRFVFLLY 142
Cdd:cd00865 103 PDG-GPHRYVFTVY 115
PRK09818 PRK09818
kinase inhibitor;
69-142 3.33e-04

kinase inhibitor;


Pssm-ID: 182092  Cd Length: 183  Bit Score: 39.93  E-value: 3.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574   69 PSVKWPSAPE--NYYALLMVDPDvpnaiTPTHREFLHWMVLNIPGNL--------------LALGDVR-------VGYMG 125
Cdd:PRK09818  53 PSLTWSGAPEgtKSFAVTVYDPD-----APTGSGWWHWTVANIPATVtylpadagrrdgtkLPTGAVQgrndfgyAGFGG 127

                         90
                 ....*....|....*..
gi 24644574  126 ATPLKGTGTHRFVFLLY 142
Cdd:PRK09818 128 ACPPKGDKPHHYQFKVW 144
PRK10257 PRK10257
putative kinase inhibitor protein; Provisional
 69-142 3.59e-04

putative kinase inhibitor protein; Provisional


Pssm-ID: 182339  Cd Length: 158  Bit Score: 39.76  E-value: 3.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574   69 PSVKWPSAPE--NYYALLMVDPDvpnaiTPTHREFLHWMVLNIPGNLLAL------GDVRV--------------GYMGA 126
Cdd:PRK10257  32 PHLAWDDVPAgtKSFVVTCYDPD-----APTGSGWWHWVVVNLPADTRVLpqgfgsGLVALpdgvlqtrtdfgkaGYGGA 106

                         90
                 ....*....|....*.
gi 24644574  127 TPLKGTgTHRFVFLLY 142
Cdd:PRK10257 107 APPKGE-THRYIFTVH 121
TIGR00481 TIGR00481
Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]
 69-156 4.93e-04

Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]


Pssm-ID: 129572  Cd Length: 141  Bit Score: 39.00  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644574    69 PSVKWPSAPENY--YALLMVDPDVPNAITpthreFLHWMVLNIPGNLLAL------GDVRV---------------GYMG 125
Cdd:TIGR00481  16 PPLSWDGVPEGAksLALTCIDPDAPTGCG-----WWHWVVVNIPADTTVLpenassDDKRLpqgvplqgrndfgksGYIG 90

                          90       100       110
                  ....*....|....*....|....*....|.
gi 24644574   126 ATPLKgtGTHRFVFLLYkqrdytKFDFPKLP 156
Cdd:TIGR00481  91 PCPPK--GDHRYLFTVY------ALDTEKLD 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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