grappa, isoform E [Drosophila melanogaster]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
DOT1 | pfam08123 | Histone methylation protein DOT1; The DOT1 domain regulates gene expression by methylating ... |
121-323 | 2.64e-102 | ||||
Histone methylation protein DOT1; The DOT1 domain regulates gene expression by methylating histone H3. H3 methylation by DOT1 has been shown to be required for the DNA damage checkpoint in yeast. : Pssm-ID: 149273 Cd Length: 205 Bit Score: 326.18 E-value: 2.64e-102
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CC_DOT1L | cd20902 | coiled coil domain of disruptor of telomeric-silencing 1-like (DOT1L) and similar proteins; ... |
657-721 | 1.94e-16 | ||||
coiled coil domain of disruptor of telomeric-silencing 1-like (DOT1L) and similar proteins; This family contains DOT1L (disruptor of telomeric-silencing 1-like), a non-SET domain histone lysine methyltransferase (HKMT) that catalyzes monomethylation, dimethylation, and trimethylation of nucleosomal H3K79. DOT1L is recruited to the homeobox A by AF10 (ALL1-Fused gene from chromosome 10 protein), one of the mixed-lineage leukemia 1 (MLL1)-fusion partners that function in acute myeloid leukemia (ALL). Aberration of the MLL gene is implicated in acute leukemia; chromosomal translocations of MLL1 generate oncogenic chimeric proteins, containing the non-catalytic N-terminal portion of MLL1 fused with many partners such as AF10. The aberrant recruitment of DOT1L by MLL fusions and the resulting H3K79 methylation are thought to affect gene expression by altering chromatin accessibility. AF10 and DOT1L interact through their coiled coil domains. : Pssm-ID: 411016 [Multi-domain] Cd Length: 65 Bit Score: 75.04 E-value: 1.94e-16
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Name | Accession | Description | Interval | E-value | ||||
DOT1 | pfam08123 | Histone methylation protein DOT1; The DOT1 domain regulates gene expression by methylating ... |
121-323 | 2.64e-102 | ||||
Histone methylation protein DOT1; The DOT1 domain regulates gene expression by methylating histone H3. H3 methylation by DOT1 has been shown to be required for the DNA damage checkpoint in yeast. Pssm-ID: 149273 Cd Length: 205 Bit Score: 326.18 E-value: 2.64e-102
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CC_DOT1L | cd20902 | coiled coil domain of disruptor of telomeric-silencing 1-like (DOT1L) and similar proteins; ... |
657-721 | 1.94e-16 | ||||
coiled coil domain of disruptor of telomeric-silencing 1-like (DOT1L) and similar proteins; This family contains DOT1L (disruptor of telomeric-silencing 1-like), a non-SET domain histone lysine methyltransferase (HKMT) that catalyzes monomethylation, dimethylation, and trimethylation of nucleosomal H3K79. DOT1L is recruited to the homeobox A by AF10 (ALL1-Fused gene from chromosome 10 protein), one of the mixed-lineage leukemia 1 (MLL1)-fusion partners that function in acute myeloid leukemia (ALL). Aberration of the MLL gene is implicated in acute leukemia; chromosomal translocations of MLL1 generate oncogenic chimeric proteins, containing the non-catalytic N-terminal portion of MLL1 fused with many partners such as AF10. The aberrant recruitment of DOT1L by MLL fusions and the resulting H3K79 methylation are thought to affect gene expression by altering chromatin accessibility. AF10 and DOT1L interact through their coiled coil domains. Pssm-ID: 411016 [Multi-domain] Cd Length: 65 Bit Score: 75.04 E-value: 1.94e-16
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Name | Accession | Description | Interval | E-value | ||||
DOT1 | pfam08123 | Histone methylation protein DOT1; The DOT1 domain regulates gene expression by methylating ... |
121-323 | 2.64e-102 | ||||
Histone methylation protein DOT1; The DOT1 domain regulates gene expression by methylating histone H3. H3 methylation by DOT1 has been shown to be required for the DNA damage checkpoint in yeast. Pssm-ID: 149273 Cd Length: 205 Bit Score: 326.18 E-value: 2.64e-102
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CC_DOT1L | cd20902 | coiled coil domain of disruptor of telomeric-silencing 1-like (DOT1L) and similar proteins; ... |
657-721 | 1.94e-16 | ||||
coiled coil domain of disruptor of telomeric-silencing 1-like (DOT1L) and similar proteins; This family contains DOT1L (disruptor of telomeric-silencing 1-like), a non-SET domain histone lysine methyltransferase (HKMT) that catalyzes monomethylation, dimethylation, and trimethylation of nucleosomal H3K79. DOT1L is recruited to the homeobox A by AF10 (ALL1-Fused gene from chromosome 10 protein), one of the mixed-lineage leukemia 1 (MLL1)-fusion partners that function in acute myeloid leukemia (ALL). Aberration of the MLL gene is implicated in acute leukemia; chromosomal translocations of MLL1 generate oncogenic chimeric proteins, containing the non-catalytic N-terminal portion of MLL1 fused with many partners such as AF10. The aberrant recruitment of DOT1L by MLL fusions and the resulting H3K79 methylation are thought to affect gene expression by altering chromatin accessibility. AF10 and DOT1L interact through their coiled coil domains. Pssm-ID: 411016 [Multi-domain] Cd Length: 65 Bit Score: 75.04 E-value: 1.94e-16
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Blast search parameters | ||||
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