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Conserved domains on  [gi|21357995|ref|NP_649657|]
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Zinc-finger protein, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 9-87 5.09e-08

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


:

Pssm-ID: 462262  Cd Length: 75  Bit Score: 49.76  E-value: 5.09e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21357995     9 TCRVCLaQSERLQRLDEIREEGEESPNEMLIQLLGVsysNLNDREHIPDGICKSCKVELNMAYQFREKALRKQMEIEEY 87
Cdd:pfam07776   1 VCRLCL-DESDELIPIFDPSDSEKTLAEILEDCTGI---ELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQEL 75
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
250-369 4.81e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 4.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357995 250 QYACELCDAKFQVREQLRKHMYSHTG-SKPYKCSFCSRQFFYESVLKSHEN--VH--RGIKPYVCKV--CDKAFAYAHSL 322
Cdd:COG5048 260 SPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPYslCGKLFSRNDAL 339

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21357995 323 TKHELIHSDIKLYRCDY--CNKDFRLLHHMRQHEETKLHQNAVMLAESM 369
Cdd:COG5048 340 KRHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQQYKDLKNDKKSE 388
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 9-87 5.09e-08

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 49.76  E-value: 5.09e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21357995     9 TCRVCLaQSERLQRLDEIREEGEESPNEMLIQLLGVsysNLNDREHIPDGICKSCKVELNMAYQFREKALRKQMEIEEY 87
Cdd:pfam07776   1 VCRLCL-DESDELIPIFDPSDSEKTLAEILEDCTGI---ELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQEL 75
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 10-86 6.61e-07

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 46.35  E-value: 6.61e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21357995     10 CRVCLAQSERLQRLDEirEEGEESPNEMLIQLLGVSYSNLNDrehIPDGICKSCKVELNMAYQFREKALRKQMEIEE 86
Cdd:smart00868   2 CRLCLSESENLVSIFD--ESSEASLAEKIEECTGIEIEPDDG---LPKVICGDCLEKLESFHKFRERCRESDELLRE 73
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
250-369 4.81e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 4.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357995 250 QYACELCDAKFQVREQLRKHMYSHTG-SKPYKCSFCSRQFFYESVLKSHEN--VH--RGIKPYVCKV--CDKAFAYAHSL 322
Cdd:COG5048 260 SPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPYslCGKLFSRNDAL 339

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21357995 323 TKHELIHSDIKLYRCDY--CNKDFRLLHHMRQHEETKLHQNAVMLAESM 369
Cdd:COG5048 340 KRHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQQYKDLKNDKKSE 388
zf-H2C2_2 pfam13465
Zinc-finger double domain;
266-288 1.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.23e-04
                          10        20
                  ....*....|....*....|...
gi 21357995   266 LRKHMYSHTGSKPYKCSFCSRQF 288
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 9-87 5.09e-08

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 49.76  E-value: 5.09e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21357995     9 TCRVCLaQSERLQRLDEIREEGEESPNEMLIQLLGVsysNLNDREHIPDGICKSCKVELNMAYQFREKALRKQMEIEEY 87
Cdd:pfam07776   1 VCRLCL-DESDELIPIFDPSDSEKTLAEILEDCTGI---ELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQEL 75
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 10-86 6.61e-07

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 46.35  E-value: 6.61e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21357995     10 CRVCLAQSERLQRLDEirEEGEESPNEMLIQLLGVSYSNLNDrehIPDGICKSCKVELNMAYQFREKALRKQMEIEE 86
Cdd:smart00868   2 CRLCLSESENLVSIFD--ESSEASLAEKIEECTGIEIEPDDG---LPKVICGDCLEKLESFHKFRERCRESDELLRE 73
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
250-369 4.81e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 4.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357995 250 QYACELCDAKFQVREQLRKHMYSHTG-SKPYKCSFCSRQFFYESVLKSHEN--VH--RGIKPYVCKV--CDKAFAYAHSL 322
Cdd:COG5048 260 SPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPYslCGKLFSRNDAL 339

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21357995 323 TKHELIHSDIKLYRCDY--CNKDFRLLHHMRQHEETKLHQNAVMLAESM 369
Cdd:COG5048 340 KRHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQQYKDLKNDKKSE 388
zf-H2C2_2 pfam13465
Zinc-finger double domain;
266-288 1.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.23e-04
                          10        20
                  ....*....|....*....|...
gi 21357995   266 LRKHMYSHTGSKPYKCSFCSRQF 288
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-318 1.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....*
gi 21357995   294 LKSHENVHRGIKPYVCKVCDKAFAY 318
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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