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Conserved domains on  [gi|24645037|ref|NP_649791|]
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uncharacterized protein Dmel_CG7443, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
kgd super family cl39092
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 22-117 4.09e-06

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


The actual alignment was detected with superfamily member PRK12270:

Pssm-ID: 476867 [Multi-domain]  Cd Length: 1228  Bit Score: 44.88  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645037    22 DTDWWTILEDilYDNDSDsddagdenvlicrnctvvvqAAPNATANGSTVAPQAGGAAPGSSPGAPATPPgsTPAVPATV 101
Cdd:PRK12270   26 DPSWREFFAD--YGPGST--------------------AAPTAAAAAAAAAASAPAAAPAAKAPAAPAPA--PPAAAAPA 81

                          90
                  ....*....|....*.
gi 24645037   102 APETPAPSAPATSPQP 117
Cdd:PRK12270   82 APPKPAAAAAAAAAPA 97
 
Name Accession Description Interval E-value
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 22-117 4.09e-06

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.88  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645037    22 DTDWWTILEDilYDNDSDsddagdenvlicrnctvvvqAAPNATANGSTVAPQAGGAAPGSSPGAPATPPgsTPAVPATV 101
Cdd:PRK12270   26 DPSWREFFAD--YGPGST--------------------AAPTAAAAAAAAAASAPAAAPAAKAPAAPAPA--PPAAAAPA 81

                          90
                  ....*....|....*.
gi 24645037   102 APETPAPSAPATSPQP 117
Cdd:PRK12270   82 APPKPAAAAAAAAAPA 97
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 56-118 5.36e-05

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 41.42  E-value: 5.36e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24645037    56 VVVQAAPNATANGSTVAPQAGGAAPGSSPGAPATP-PGSTPAVPATVAPETPAP-SAPATSPQPV 118
Cdd:TIGR00601  71 VVMVSKPKTGTGKVAPPAATPTSAPTPTPSPPASPaSGMSAAPASAVEEKSPSEeSATATAPESP 135
 
Name Accession Description Interval E-value
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 22-117 4.09e-06

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.88  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645037    22 DTDWWTILEDilYDNDSDsddagdenvlicrnctvvvqAAPNATANGSTVAPQAGGAAPGSSPGAPATPPgsTPAVPATV 101
Cdd:PRK12270   26 DPSWREFFAD--YGPGST--------------------AAPTAAAAAAAAAASAPAAAPAAKAPAAPAPA--PPAAAAPA 81

                          90
                  ....*....|....*.
gi 24645037   102 APETPAPSAPATSPQP 117
Cdd:PRK12270   82 APPKPAAAAAAAAAPA 97
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 65-118 2.06e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.96  E-value: 2.06e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 24645037    65 TANGSTVAPQAGGAAPGSSPGAPATPPGSTPAVPATVAPETPAPSAPATSPQPV 118
Cdd:PRK12270   34 ADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPA 87
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 56-118 5.36e-05

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 41.42  E-value: 5.36e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24645037    56 VVVQAAPNATANGSTVAPQAGGAAPGSSPGAPATP-PGSTPAVPATVAPETPAP-SAPATSPQPV 118
Cdd:TIGR00601  71 VVMVSKPKTGTGKVAPPAATPTSAPTPTPSPPASPaSGMSAAPASAVEEKSPSEeSATATAPESP 135
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 58-118 1.51e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 1.51e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24645037   58 VQAAPNATANGSTVAPQAGGAAPGSSPGAPATPPGSTPAVPATVAPETPAPSAPATSPQPV 118
Cdd:PRK14951 385 EAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAV 445
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
52-118 1.65e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.14  E-value: 1.65e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24645037   52 RNCTVVVQAAPNATANGST---VAPQAGGAAPGSSPGAPATPPGSTPAVPATVAP-ETPAPSAPATSPQPV 118
Cdd:PRK14971 390 PQPSAAAAASPSPSQSSAAaqpSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPqAVRPAQFKEEKKIPV 460
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 54-139 8.72e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.04  E-value: 8.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645037   54 CTVVVQAAPNATANGSTVAPQAGGAAPGSSPGAPATPPGSTPAVPATVAPETPAPSAPATSPQPVVTALPTAAPPTAAPP 133
Cdd:PRK07764 582 WQVEAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPD 661


                 ....*.
gi 24645037  134 TAAPGG 139
Cdd:PRK07764 662 ASDGGD 667
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 60-117 1.14e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 37.77  E-value: 1.14e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 24645037   60 AAPNATANGSTVAPQAGGAAPGSSPGAPATPPGStpAVPATVAPETPAPSAPATSPQP 117
Cdd:PRK14951 427 AAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETV--AIPVRVAPEPAVASAAPAPAAA 482
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 58-119 2.68e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 36.77  E-value: 2.68e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24645037   58 VQAAPNATANGSTVAPQAGGAAPGSSPGAPATPPGSTPAVPATVAPETPAPSAPATSPQPVV 119
Cdd:PRK07994 362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLL 423
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 65-117 3.81e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 36.12  E-value: 3.81e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 24645037   65 TANGSTVAPQAGGAAPGSSPGAPATPPGSTPAVPATVAPETPAPSAPATSPQP 117
Cdd:PRK07764 387 VAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAP 439
PRK10856 PRK10856
cytoskeleton protein RodZ;
60-118 4.59e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 35.77  E-value: 4.59e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 24645037   60 AAPNATANGSTVAPQAGGAAPGSSPGAPATPPGSTPAVPATVAPETPAPSAPATSPQPV 118
Cdd:PRK10856 168 TTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPA 226
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
58-118 5.92e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 35.62  E-value: 5.92e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24645037   58 VQAAPNATANGSTVAPqAGGAAPGSSPGAPATPPGSTPAVPATVAPETPAPSAPATSPQPV 118
Cdd:PRK12323 433 LAAARQASARGPGGAP-APAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPA 492
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 60-118 7.03e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 35.46  E-value: 7.03e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24645037   60 AAPNATANGSTVAPQAGGAAPGSSPGAPATPPG---STPAVPATVAPETPAPSAPATSPQPV 118
Cdd:PRK14951 376 AEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAaaaSAPAAPPAAAPPAPVAAPAAAAPAAA 437
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 75-139 7.10e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 35.46  E-value: 7.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24645037   75 AGGAAPGSSPGAPATPPGSTPA---VPATVAPETPAPSAPATSPQPVVTALPTAAPPTAAPPTAAPGG 139
Cdd:PRK14951 369 AAEAAAPAEKKTPARPEAAAPAaapVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAA 436
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
57-117 7.17e-03

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 35.60  E-value: 7.17e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24645037   57 VVQAAPNATANGSTVAPQAGGAAPGSSPGAPATPPGSTPaVPATVAPETPAPSAPATSPQP 117
Cdd:PRK11907  24 KLAQAEEIVTTTPATSTEAEQTTPVESDATEEADNTETP-VAATTAAEAPSSSETAETSDP 83
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
55-115 7.72e-03

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 34.99  E-value: 7.72e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24645037   55 TVVVQAApNATANGSTVAPQAGGAAPGSSPGAPATPPGSTpaVPATVAPETPAPSAPATSP 115
Cdd:PRK13042  22 TTTTQAA-NATTPSSTKVEAPQSTPPSTKVEAPQSKPNAT--TPPSTKVEAPQQTPNATTP 79
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
60-115 9.51e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 35.24  E-value: 9.51e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 24645037   60 AAPNATANGSTVAPQAGGAAPGSSPGAPATPPGSTPAVPATVAPETPAPSAPATSP 115
Cdd:PRK12323 379 AAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALA 434
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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