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Conserved domains on  [gi|21355291|ref|NP_649803|]
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uncharacterized protein Dmel_CG11737, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM135_C_rich super family cl24526
N-terminal cysteine-rich region of Transmembrane protein 135; TMEM135_C_rich is a family of ...
 15-145 1.91e-26

N-terminal cysteine-rich region of Transmembrane protein 135; TMEM135_C_rich is a family of putative peroxisomal membrane proteins found in eukaryotes. This is the highly conserved N-terminal region that has several highly conserved cysteine residues. The domain is associated with family Tim17, pfam02466.


The actual alignment was detected with superfamily member pfam15982:

Pssm-ID: 374269  Cd Length: 134  Bit Score: 103.80  E-value: 1.91e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355291    15 CKEFQHPWTDHCVSATAGILLSATPYCLRVYTIVYALSLLMRHRIPSRDdLRKTLLGIIQSTAFLVTNAYTFILYNCALR 94
Cdd:pfam15982   4 CYEIGHTWSPSCSQSALDITRSALEESLKIYAPLYLIAAMLRRRKFDYY-FRELVPEILRSSSFLTFNGFAVIVFFCFLR 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 21355291    95 HMLGRYNFYTVAFVPCFLASFSAILVERPARRPLLTLYVANVATEALWKMA 145
Cdd:pfam15982  83 RSLGKFYSWLIGFGPALPASYIAILLERKSRRGLLTIYMANLATETLFRMA 133
 
Name Accession Description Interval E-value
TMEM135_C_rich pfam15982
N-terminal cysteine-rich region of Transmembrane protein 135; TMEM135_C_rich is a family of ...
 15-145 1.91e-26

N-terminal cysteine-rich region of Transmembrane protein 135; TMEM135_C_rich is a family of putative peroxisomal membrane proteins found in eukaryotes. This is the highly conserved N-terminal region that has several highly conserved cysteine residues. The domain is associated with family Tim17, pfam02466.


Pssm-ID: 374269  Cd Length: 134  Bit Score: 103.80  E-value: 1.91e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355291    15 CKEFQHPWTDHCVSATAGILLSATPYCLRVYTIVYALSLLMRHRIPSRDdLRKTLLGIIQSTAFLVTNAYTFILYNCALR 94
Cdd:pfam15982   4 CYEIGHTWSPSCSQSALDITRSALEESLKIYAPLYLIAAMLRRRKFDYY-FRELVPEILRSSSFLTFNGFAVIVFFCFLR 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 21355291    95 HMLGRYNFYTVAFVPCFLASFSAILVERPARRPLLTLYVANVATEALWKMA 145
Cdd:pfam15982  83 RSLGKFYSWLIGFGPALPASYIAILLERKSRRGLLTIYMANLATETLFRMA 133
 
Name Accession Description Interval E-value
TMEM135_C_rich pfam15982
N-terminal cysteine-rich region of Transmembrane protein 135; TMEM135_C_rich is a family of ...
 15-145 1.91e-26

N-terminal cysteine-rich region of Transmembrane protein 135; TMEM135_C_rich is a family of putative peroxisomal membrane proteins found in eukaryotes. This is the highly conserved N-terminal region that has several highly conserved cysteine residues. The domain is associated with family Tim17, pfam02466.


Pssm-ID: 374269  Cd Length: 134  Bit Score: 103.80  E-value: 1.91e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355291    15 CKEFQHPWTDHCVSATAGILLSATPYCLRVYTIVYALSLLMRHRIPSRDdLRKTLLGIIQSTAFLVTNAYTFILYNCALR 94
Cdd:pfam15982   4 CYEIGHTWSPSCSQSALDITRSALEESLKIYAPLYLIAAMLRRRKFDYY-FRELVPEILRSSSFLTFNGFAVIVFFCFLR 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 21355291    95 HMLGRYNFYTVAFVPCFLASFSAILVERPARRPLLTLYVANVATEALWKMA 145
Cdd:pfam15982  83 RSLGKFYSWLIGFGPALPASYIAILLERKSRRGLLTIYMANLATETLFRMA 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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