Methyl-CpG binding domain protein-like, isoform B [Drosophila melanogaster]
MBDa and MBD_C domain-containing protein( domain architecture ID 11244108)
MBDa and MBD_C domain-containing protein
List of domain hits
Name | Accession | Description | Interval | E-value | |||
MBD_C | pfam14048 | C-terminal domain of methyl-CpG binding protein 2 and 3; CpG-methylation is a frequently ... |
131-224 | 3.41e-33 | |||
C-terminal domain of methyl-CpG binding protein 2 and 3; CpG-methylation is a frequently occurring epigenetic modification of vertebrate genomes resulting in transcriptional repression. This domain was found at the C-terminus of the methyl-CpG-binding domain (MBD) containing proteins MBD2 and MBD3, the latter was shown to not bind directly to methyl-CpG DNA but rather interact with components of the NuRD/Mi2 complex, an abundant deacetylase complex. The domain is subject to structure determination by the Joint Center of Structural Genomics. : Pssm-ID: 464072 Cd Length: 94 Bit Score: 115.03 E-value: 3.41e-33
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MBDa | pfam16564 | p55-binding region of Methyl-CpG-binding domain proteins MBD; MBDa is a second MBD domain of ... |
57-127 | 3.75e-26 | |||
p55-binding region of Methyl-CpG-binding domain proteins MBD; MBDa is a second MBD domain of Methyl-CpG-binding domain proteins. region implicated in binding the RbAp46/48 (retinoblastoma protein-associated protein) homolog p55, which is one of the components of the MBD2-NuRD complex. The MBD2-NuRD complex is a nucleosome remodelling and deacetylation complex. : Pssm-ID: 465179 Cd Length: 68 Bit Score: 96.17 E-value: 3.75e-26
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Name | Accession | Description | Interval | E-value | |||
MBD_C | pfam14048 | C-terminal domain of methyl-CpG binding protein 2 and 3; CpG-methylation is a frequently ... |
131-224 | 3.41e-33 | |||
C-terminal domain of methyl-CpG binding protein 2 and 3; CpG-methylation is a frequently occurring epigenetic modification of vertebrate genomes resulting in transcriptional repression. This domain was found at the C-terminus of the methyl-CpG-binding domain (MBD) containing proteins MBD2 and MBD3, the latter was shown to not bind directly to methyl-CpG DNA but rather interact with components of the NuRD/Mi2 complex, an abundant deacetylase complex. The domain is subject to structure determination by the Joint Center of Structural Genomics. Pssm-ID: 464072 Cd Length: 94 Bit Score: 115.03 E-value: 3.41e-33
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MBDa | pfam16564 | p55-binding region of Methyl-CpG-binding domain proteins MBD; MBDa is a second MBD domain of ... |
57-127 | 3.75e-26 | |||
p55-binding region of Methyl-CpG-binding domain proteins MBD; MBDa is a second MBD domain of Methyl-CpG-binding domain proteins. region implicated in binding the RbAp46/48 (retinoblastoma protein-associated protein) homolog p55, which is one of the components of the MBD2-NuRD complex. The MBD2-NuRD complex is a nucleosome remodelling and deacetylation complex. Pssm-ID: 465179 Cd Length: 68 Bit Score: 96.17 E-value: 3.75e-26
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Name | Accession | Description | Interval | E-value | |||
MBD_C | pfam14048 | C-terminal domain of methyl-CpG binding protein 2 and 3; CpG-methylation is a frequently ... |
131-224 | 3.41e-33 | |||
C-terminal domain of methyl-CpG binding protein 2 and 3; CpG-methylation is a frequently occurring epigenetic modification of vertebrate genomes resulting in transcriptional repression. This domain was found at the C-terminus of the methyl-CpG-binding domain (MBD) containing proteins MBD2 and MBD3, the latter was shown to not bind directly to methyl-CpG DNA but rather interact with components of the NuRD/Mi2 complex, an abundant deacetylase complex. The domain is subject to structure determination by the Joint Center of Structural Genomics. Pssm-ID: 464072 Cd Length: 94 Bit Score: 115.03 E-value: 3.41e-33
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MBDa | pfam16564 | p55-binding region of Methyl-CpG-binding domain proteins MBD; MBDa is a second MBD domain of ... |
57-127 | 3.75e-26 | |||
p55-binding region of Methyl-CpG-binding domain proteins MBD; MBDa is a second MBD domain of Methyl-CpG-binding domain proteins. region implicated in binding the RbAp46/48 (retinoblastoma protein-associated protein) homolog p55, which is one of the components of the MBD2-NuRD complex. The MBD2-NuRD complex is a nucleosome remodelling and deacetylation complex. Pssm-ID: 465179 Cd Length: 68 Bit Score: 96.17 E-value: 3.75e-26
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MBD | pfam01429 | Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one ... |
9-126 | 5.66e-12 | |||
Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase. Pssm-ID: 396147 [Multi-domain] Cd Length: 76 Bit Score: 59.30 E-value: 5.66e-12
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Blast search parameters | ||||
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