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Conserved domains on  [gi|24645513|ref|NP_649945|]
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matotopetli [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
612-637 2.69e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.69e-05
                          10        20
                  ....*....|....*....|....*.
gi 24645513   612 ALKNHQRIHTGEKPYSCLFCTKTFRQ 637
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
450-647 5.02e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 5.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645513 450 TSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREketrntgagrirQYLCDI--CGKSYTQSSHLW 527
Cdd:COG5048 273 SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLK------------PFSCPYslCGKLFSRNDALK 340

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645513 528 QHLRFHQGVKPFVCQEENCDRKFTI----RPDLNDHIRKCHTGERPYLCLV--CGKRFLTGSVFYQHRLIHRGERRYECE 601
Cdd:COG5048 341 RHILLHTSISPAKEKLLNSSSKFSPllnnEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCK 420

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 24645513 602 --ECGKRFYRADALKNHQRIHTgEKPYSCLFCTKTFRQRGDRDKHIRA 647
Cdd:COG5048 421 npPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGKD 467
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
612-637 2.69e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.69e-05
                          10        20
                  ....*....|....*....|....*.
gi 24645513   612 ALKNHQRIHTGEKPYSCLFCTKTFRQ 637
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
450-647 5.02e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 5.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645513 450 TSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREketrntgagrirQYLCDI--CGKSYTQSSHLW 527
Cdd:COG5048 273 SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLK------------PFSCPYslCGKLFSRNDALK 340

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645513 528 QHLRFHQGVKPFVCQEENCDRKFTI----RPDLNDHIRKCHTGERPYLCLV--CGKRFLTGSVFYQHRLIHRGERRYECE 601
Cdd:COG5048 341 RHILLHTSISPAKEKLLNSSSKFSPllnnEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCK 420

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 24645513 602 --ECGKRFYRADALKNHQRIHTgEKPYSCLFCTKTFRQRGDRDKHIRA 647
Cdd:COG5048 421 npPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGKD 467
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 598-620 2.48e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 2.48e-04
                          10        20
                  ....*....|....*....|...
gi 24645513   598 YECEECGKRFYRADALKNHQRIH 620
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
612-637 2.69e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.69e-05
                          10        20
                  ....*....|....*....|....*.
gi 24645513   612 ALKNHQRIHTGEKPYSCLFCTKTFRQ 637
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
450-647 5.02e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 5.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645513 450 TSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREketrntgagrirQYLCDI--CGKSYTQSSHLW 527
Cdd:COG5048 273 SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLK------------PFSCPYslCGKLFSRNDALK 340

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645513 528 QHLRFHQGVKPFVCQEENCDRKFTI----RPDLNDHIRKCHTGERPYLCLV--CGKRFLTGSVFYQHRLIHRGERRYECE 601
Cdd:COG5048 341 RHILLHTSISPAKEKLLNSSSKFSPllnnEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCK 420

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 24645513 602 --ECGKRFYRADALKNHQRIHTgEKPYSCLFCTKTFRQRGDRDKHIRA 647
Cdd:COG5048 421 npPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
598-658 2.46e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 2.46e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24645513 598 YECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRqRGDRDK-HIRARHSHLDANSRL 658
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKS-FSRPLElSRHLRTHHNNPSDLN 94
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 598-620 2.48e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 2.48e-04
                          10        20
                  ....*....|....*....|...
gi 24645513   598 YECEECGKRFYRADALKNHQRIH 620
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 511-533 1.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|...
gi 24645513   511 YLCDICGKSYTQSSHLWQHLRFH 533
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
539-649 2.58e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 41.16  E-value: 2.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645513 539 FVCQEENCDRKFTIRPDLNDHIRKCHtgeRPYLCLVCGKrfltgsvfyqHRlihrgeRRYECEEcgkRFYRADALKNHQR 618
Cdd:COG5236 152 FKCPKSKCHRRCGSLKELKKHYKAQH---GFVLCSECIG----------NK------KDFWNEI---RLFRSSTLRDHKN 209

                        90       100       110
                ....*....|....*....|....*....|....*
gi 24645513 619 IHTGEKPYS----CLFCTKTFRQRGDRDKHIRARH 649
Cdd:COG5236 210 GGLEEEGFKghplCIFCKIYFYDDDELRRHCRLRH 244
zf-H2C2_2 pfam13465
Zinc-finger double domain;
555-581 5.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.54e-03
                          10        20
                  ....*....|....*....|....*..
gi 24645513   555 DLNDHIRKcHTGERPYLCLVCGKRFLT 581
Cdd:pfam13465   1 NLKRHMRT-HTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
585-609 7.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.82e-03
                          10        20
                  ....*....|....*....|....*
gi 24645513   585 FYQHRLIHRGERRYECEECGKRFYR 609
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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