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Conserved domains on  [gi|28573095|ref|NP_650036|]
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uncharacterized protein Dmel_CG6621, isoform A [Drosophila melanogaster]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 708416)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 226-425 1.80e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 77.34  E-value: 1.80e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 226 LPKYYSKIHNLDHPSASHYEDELNKALEfENPNYDLLFQMNGLQPNENLSLMSYLRAGFPEEENAAELRQKQASQWAFRs 305
Cdd:COG3914   6 LLALAALAAAALLAAAAAAELALAAELE-AAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLEL- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 306 vaDGIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVnarkymgETLVALGR 385
Cdd:COG3914  84 --AALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFA-------EAYLNLGE 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 28573095 386 SYEEENRIAEAVKAYSDCLNLLPLHEEARQSL-DALHRSGD 425
Cdd:COG3914 155 ALRRLGRLEEAIAALRRALELDPDNAEALNNLgNALQDLGR 195
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 226-425 1.80e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 77.34  E-value: 1.80e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 226 LPKYYSKIHNLDHPSASHYEDELNKALEfENPNYDLLFQMNGLQPNENLSLMSYLRAGFPEEENAAELRQKQASQWAFRs 305
Cdd:COG3914   6 LLALAALAAAALLAAAAAAELALAAELE-AAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLEL- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 306 vaDGIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVnarkymgETLVALGR 385
Cdd:COG3914  84 --AALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFA-------EAYLNLGE 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 28573095 386 SYEEENRIAEAVKAYSDCLNLLPLHEEARQSL-DALHRSGD 425
Cdd:COG3914 155 ALRRLGRLEEAIAALRRALELDPDNAEALNNLgNALQDLGR 195
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 240-420 3.24e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.77  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095   240 SASHYEDELNKALEFENP----NYDLLFQMNGL-QPNENLSLMSYLRAGfpEEENAAELrqkqasqWAFRSVAdgieHFK 314
Cdd:TIGR02917  71 DYAAAEKELRKALSLGYPknqvLPLLARAYLLQgKFQQVLDELPGKTLL--DDEGAAEL-------LALRGLA----YLG 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095   315 NGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNARKYMGETLVALGrsyeeenRIA 394
Cdd:TIGR02917 138 LGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLG-------NIE 210

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 28573095   395 EAVKAYSDCLNLLPLH-----------------EEARQSLDAL 420
Cdd:TIGR02917 211 LALAAYRKAIALRPNNiavllalatilieagefEEAEKHADAL 253
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 284-375 7.05e-05

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 46.61  E-value: 7.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095   284 FPEEENAAELR------QKQASQWAFRSVADGIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQ 357
Cdd:PRK11447  245 FSDGDSVAAARsqlaeqQKQLADPAFRARAQGLAAVDSGQGGKAIPELQQAVRANPKDSEALGALGQAYSQQGDRARAVA 324

                          90
                  ....*....|....*...
gi 28573095   358 DFEKALHLNKYHVNARKY 375
Cdd:PRK11447  325 QFEKALALDPHSSNRDKW 342
TPR_12 pfam13424
Tetratricopeptide repeat;
338-407 3.98e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 39.68  E-value: 3.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28573095   338 ALVARGALYANRGSFLKGLQDFEKAL-HLNKYHVNARKYMGETLVALGRSYEEENRIAEAVKAYSDCLNLL 407
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALeIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 311-376 1.66e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 41.46  E-value: 1.66e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28573095 311 EHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHvNARKYM 376
Cdd:cd24142   9 ELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDG-GYEKYL 73
BTAD smart01043
Bacterial transcriptional activator domain; Found in the DNRI/REDD/AFSR family of regulators. ...
 301-425 5.16e-03

Bacterial transcriptional activator domain; Found in the DNRI/REDD/AFSR family of regulators. This region of AFSR along with the C terminal region is capable of independently directing actinorhodin production. This family contains TPR repeats.


Pssm-ID: 198111 [Multi-domain]  Cd Length: 145  Bit Score: 38.44  E-value: 5.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095    301 WAFRSVADGIEHFKNGQQVEAFQCLNKALnidprnvealvargALYanRGSFLKGLQDF----EKALHLNKYHVNArkym 376
Cdd:smart01043   4 DRFERLVAAARAALAADPEAALALLEAAL--------------ALY--RGPLLADVPDEdwaeAERERLRELRLEA---- 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 28573095    377 getLVALGRSYEEENRIAEAVKAYSDCLNLLPLHEEA-RQSLDALHRSGD 425
Cdd:smart01043  64 ---LEALAEALLALGRHEEALALLERLLALDPLRERLhRLLMRALYRAGR 110
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 226-425 1.80e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 77.34  E-value: 1.80e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 226 LPKYYSKIHNLDHPSASHYEDELNKALEfENPNYDLLFQMNGLQPNENLSLMSYLRAGFPEEENAAELRQKQASQWAFRs 305
Cdd:COG3914   6 LLALAALAAAALLAAAAAAELALAAELE-AAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLEL- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 306 vaDGIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVnarkymgETLVALGR 385
Cdd:COG3914  84 --AALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFA-------EAYLNLGE 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 28573095 386 SYEEENRIAEAVKAYSDCLNLLPLHEEARQSL-DALHRSGD 425
Cdd:COG3914 155 ALRRLGRLEEAIAALRRALELDPDNAEALNNLgNALQDLGR 195
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 288-415 1.19e-13

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 68.49  E-value: 1.19e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 288 ENAAELRQKQASQWAFRSVAdgieHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNK 367
Cdd:COG4235   7 RQALAANPNDAEGWLLLGRA----YLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDP 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 28573095 368 YHVNARKYmgetlvaLGRSYEEENRIAEAVKAYSDCLNLLPLHEEARQ 415
Cdd:COG4235  83 DNPEALYL-------LGLAAFQQGDYAEAIAAWQKLLALLPADAPARL 123
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
309-425 5.82e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 69.65  E-value: 5.82e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 309 GIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNArkymgetLVALGRSYE 388
Cdd:COG0457  15 GLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA-------LNNLGLALQ 87

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 28573095 389 EENRIAEAVKAYSDCLNLLPLHEEARQSL-DALHRSGD 425
Cdd:COG0457  88 ALGRYEEALEDYDKALELDPDDAEALYNLgLALLELGR 125
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
288-423 6.45e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 69.27  E-value: 6.45e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 288 ENAAELRQKQASQWAFRsvadGIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNK 367
Cdd:COG0457  32 EKALELDPDDAEALYNL----GLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDP 107

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28573095 368 YHVNARKYMGETLVALGRsYEeenriaEAVKAYSDCLNLLPLHEEARQSLDALHRS 423
Cdd:COG0457 108 DDAEALYNLGLALLELGR-YD------EAIEAYERALELDPDDADALYNLGIALEK 156
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 251-417 1.17e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 71.56  E-value: 1.17e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 251 ALEFENPNYDLLFQMNGLQPNENLSLMSYLRAGFPEEENAAELRQKQASQWAFRSVAD------------GIEHFKNGQQ 318
Cdd:COG3914  49 AALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALAlnpdnaealfnlGNLLLALGRL 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 319 VEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNArkymgetLVALGRSYEEENRIAEAVK 398
Cdd:COG3914 129 EEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEA-------LNNLGNALQDLGRLEEAIA 201

                       170
                ....*....|....*....
gi 28573095 399 AYSDCLNLLPLHEEARQSL 417
Cdd:COG3914 202 AYRRALELDPDNADAHSNL 220
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 309-431 2.09e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 65.21  E-value: 2.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 309 GIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNARKYMGETLVALGrsye 388
Cdd:COG4783  11 AQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAG---- 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 28573095 389 eenRIAEAVKAYSDCLNLLPLHEEARQSL-DALHRSGDGKRRIS 431
Cdd:COG4783  87 ---DYDEALALLEKALKLDPEHPEAYLRLaRAYRALGRPDEAIA 127
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 298-432 1.08e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 66.29  E-value: 1.08e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 298 ASQWAFRsvadGIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNArkymg 377
Cdd:COG2956   8 ALGWYFK----GLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEA----- 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28573095 378 etLVALGRSYEEENRIAEAVKAYSDCLNLLPLHEEARQSL-DALHRSGDGKRRIST 432
Cdd:COG2956  79 --LLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLaEIYEQEGDWEKAIEV 132
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 290-409 9.69e-11

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 61.13  E-value: 9.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 290 AAELRQKQASQWAFRSVADGIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYH 369
Cdd:COG5010  42 LAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDN 121

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 28573095 370 VNARKymgetlvALGRSYEEENRIAEAVKAYSDCLNLLPL 409
Cdd:COG5010 122 PNAYS-------NLAALLLSLGQDDEAKAALQRALGTSPL 154
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 313-402 1.59e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 59.82  E-value: 1.59e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 313 FKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNARKYMGETLVALGRSYEEENR 392
Cdd:COG4783  49 LQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAA 128

                        90
                ....*....|
gi 28573095 393 IAEAVKAYSD 402
Cdd:COG4783 129 LEKALELDPD 138
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 245-425 1.78e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.82  E-value: 1.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 245 EDELNKALEFENPNYDLLFQMnglqpnenlsLMSYLRAGfpEEENAAELRQK---QASQWAFRSVADGIEHFKNGQQVEA 321
Cdd:COG2956  96 EELLEKLLELDPDDAEALRLL----------AEIYEQEG--DWEKAIEVLERllkLGPENAHAYCELAELYLEQGDYDEA 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 322 FQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVnarkymgETLVALGRSYEEENRIAEAVKAYS 401
Cdd:COG2956 164 IEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYL-------PALPRLAELYEKLGDPEEALELLR 236

                       170       180
                ....*....|....*....|....
gi 28573095 402 DCLNLLPLHEEARQSLDALHRSGD 425
Cdd:COG2956 237 KALELDPSDDLLLALADLLERKEG 260
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
248-422 2.33e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.95  E-value: 2.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 248 LNKALEFeNPNYDLLFQMNGLqpnenlslmSYLRAGFPEE-----ENAAELRQKQASQWAFRSVAdgieHFKNGQQVEAF 322
Cdd:COG0457  31 YEKALEL-DPDDAEALYNLGL---------AYLRLGRYEEaladyEQALELDPDDAEALNNLGLA----LQALGRYEEAL 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 323 QCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNARKYMGETLVALGrsyeeenRIAEAVKAYSD 402
Cdd:COG0457  97 EDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLG-------RYEEALELLEK 169

                       170       180
                ....*....|....*....|
gi 28573095 403 CLNLLPLHEEARQSLDALHR 422
Cdd:COG0457 170 LEAAALAALLAAALGEAALA 189
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
312-408 1.78e-09

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 55.56  E-value: 1.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 312 HFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQdFEKALHLNKYHVNArkymgetLVALGRSYEEEN 391
Cdd:COG3063   2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEA-------LLNLAELLLELG 73

                        90
                ....*....|....*..
gi 28573095 392 RIAEAVKAYSDCLNLLP 408
Cdd:COG3063  74 DYDEALAYLERALELDP 90
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
244-389 3.98e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 57.62  E-value: 3.98e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 244 YEDELNKALEFENPNYDLLFQMNGLQPNENLSLMSYLRAGFPEEENAAELRQKQASQWAFRSVAD-------GIEHFKNG 316
Cdd:COG4785   8 LLLALALAAAAASKAAILLAALLFAAVLALAIALADLALALAAAALAAAALAAERIDRALALPDLaqlyyerGVAYDSLG 87

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28573095 317 QQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNARKYMGETLVALGRsYEE 389
Cdd:COG4785  88 DYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGR-YEL 159
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 246-425 1.68e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.66  E-value: 1.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 246 DELNKALEFENPNYDLLFQMNGLqpnenlslmsYLRAGfpEEENAAELRQKQASQWAFRSVAD---GIEHFKNGQQVEAF 322
Cdd:COG2956  29 DLLEEALELDPETVEAHLALGNL----------YRRRG--EYDRAIRIHQKLLERDPDRAEALlelAQDYLKAGLLDRAE 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 323 QCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNARKYmgetlvaLGRSYEEENRIAEAVKAYSD 402
Cdd:COG2956  97 ELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCE-------LAELYLEQGDYDEAIEALEK 169

                       170       180
                ....*....|....*....|....
gi 28573095 403 CLNLLPLHEEARQSL-DALHRSGD 425
Cdd:COG2956 170 ALKLDPDCARALLLLaELYLEQGD 193
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 320-425 4.88e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 52.32  E-value: 4.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 320 EAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNARKYMGETLVALGRSyeeenriAEAVKA 399
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDT-------EEAEEL 73

                        90       100
                ....*....|....*....|....*..
gi 28573095 400 YSDCLNLLPLHEEARQSL-DALHRSGD 425
Cdd:COG4235  74 LERALALDPDNPEALYLLgLAAFQQGD 100
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
329-425 1.58e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.47  E-value: 1.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 329 LNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNArkymgetLVALGRSYEEENRIAEAVKAYSDCLNLLP 408
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEA-------LYNLGLAYLRLGRYEEALADYEQALELDP 73

                        90
                ....*....|....*...
gi 28573095 409 LHEEARQSL-DALHRSGD 425
Cdd:COG0457  74 DDAEALNNLgLALQALGR 91
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
245-422 5.82e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.46  E-value: 5.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 245 EDELNKALEFENPNYDLLFqmnglqpneNLSLmSYLRAGFPEE-----ENAAELRQKQASQWAFRSVAdgieHFKNGQQV 319
Cdd:COG0457  62 LADYEQALELDPDDAEALN---------NLGL-ALQALGRYEEaledyDKALELDPDDAEALYNLGLA----LLELGRYD 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 320 EAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALhlnKYHVNARKYMGETLVALGRSYEEENRIAEAVKA 399
Cdd:COG0457 128 EAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLE---AAALAALLAAALGEAALALAAAEVLLALLLALE 204

                       170       180
                ....*....|....*....|...
gi 28573095 400 YSDCLNLLPLHEEARQSLDALHR 422
Cdd:COG0457 205 QALRKKLAILTLAALAELLLLAL 227
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 310-422 1.01e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 45.37  E-value: 1.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 310 IEHFKNGQQVEAFQCLNKALNIDPRNV---EALVARGALYANRGSFLKGLQDFEKALHLNKYHvnarKYMGETLVALGRS 386
Cdd:COG1729   1 KALLKAGDYDEAIAAFKAFLKRYPNSPlapDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDS----PKAPDALLKLGLS 76

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 28573095 387 YEEENRIAEAVKAYSDCLNLLPLHEEARQSLDALHR 422
Cdd:COG1729  77 YLELGDYDKARATLEELIKKYPDSEAAKEARARLAR 112
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 334-425 2.67e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.80  E-value: 2.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 334 RNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNARKYMGETLVALGrsyeeenRIAEAVKAYSDCLNLLPLHEEA 413
Cdd:COG4783   2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLG-------DLDEAIVLLHEALELDPDEPEA 74

                        90
                ....*....|...
gi 28573095 414 RQSL-DALHRSGD 425
Cdd:COG4783  75 RLNLgLALLKAGD 87
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 240-420 3.24e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.77  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095   240 SASHYEDELNKALEFENP----NYDLLFQMNGL-QPNENLSLMSYLRAGfpEEENAAELrqkqasqWAFRSVAdgieHFK 314
Cdd:TIGR02917  71 DYAAAEKELRKALSLGYPknqvLPLLARAYLLQgKFQQVLDELPGKTLL--DDEGAAEL-------LALRGLA----YLG 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095   315 NGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNARKYMGETLVALGrsyeeenRIA 394
Cdd:TIGR02917 138 LGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLG-------NIE 210

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 28573095   395 EAVKAYSDCLNLLPLH-----------------EEARQSLDAL 420
Cdd:TIGR02917 211 LALAAYRKAIALRPNNiavllalatilieagefEEAEKHADAL 253
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 284-375 7.05e-05

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 46.61  E-value: 7.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095   284 FPEEENAAELR------QKQASQWAFRSVADGIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQ 357
Cdd:PRK11447  245 FSDGDSVAAARsqlaeqQKQLADPAFRARAQGLAAVDSGQGGKAIPELQQAVRANPKDSEALGALGQAYSQQGDRARAVA 324

                          90
                  ....*....|....*...
gi 28573095   358 DFEKALHLNKYHVNARKY 375
Cdd:PRK11447  325 QFEKALALDPHSSNRDKW 342
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 288-398 9.09e-05

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 45.57  E-value: 9.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095  288 ENAAELRQKQASQWAFRsvadgIEHF---------KNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQD 358
Cdd:PRK11788 162 DVAERLEKLGGDSLRVE-----IAHFycelaqqalARGDLDAARALLKKALAADPQCVRASILLGDLALAQGDYAAAIEA 236

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 28573095  359 FEKALHLNKyhvnarKYMGETLVALGRSYEEENRIAEAVK 398
Cdd:PRK11788 237 LERVEEQDP------EYLSEVLPKLMECYQALGDEAEGLE 270
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 284-425 1.98e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.64  E-value: 1.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 284 FPEEENAAELRQKQASQWAFRSVADGIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKAL 363
Cdd:COG5010   2 RALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQAL 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28573095 364 HLNKYHVNArkymgetLVALGRSYEEENRIAEAVKAYSDCLNLLPLHEEARQSL-DALHRSGD 425
Cdd:COG5010  82 QLDPNNPEL-------YYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLaALLLSLGQ 137
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
279-366 3.45e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.54  E-value: 3.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095 279 YLRAGFPEE-----ENAAELRQKQASQWAFRSVAdgieHFKNGQQVEAFQcLNKALNIDPRNVEALVARGALYANRGSFL 353
Cdd:COG3063   2 YLKLGDLEEaeeyyEKALELDPDNADALNNLGLL----LLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYD 76

                        90
                ....*....|...
gi 28573095 354 KGLQDFEKALHLN 366
Cdd:COG3063  77 EALAYLERALELD 89
TPR_12 pfam13424
Tetratricopeptide repeat;
338-407 3.98e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 39.68  E-value: 3.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28573095   338 ALVARGALYANRGSFLKGLQDFEKAL-HLNKYHVNARKYMGETLVALGRSYEEENRIAEAVKAYSDCLNLL 407
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALeIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
TPR_11 pfam13414
TPR repeat;
309-350 7.96e-04

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 37.84  E-value: 7.96e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 28573095   309 GIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRG 350
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 282-366 8.24e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 43.05  E-value: 8.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095   282 AGFPEEENAAELRQKQASQWAFRsvadGIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEK 361
Cdd:TIGR00990 315 RAFEKALDLGKLGEKEAIALNLR----GTFKCLKGKHLEALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDK 390


                  ....*
gi 28573095   362 ALHLN 366
Cdd:TIGR00990 391 ALKLN 395
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 311-376 1.66e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 41.46  E-value: 1.66e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28573095 311 EHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHvNARKYM 376
Cdd:cd24142   9 ELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDG-GYEKYL 73
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 264-432 2.50e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095   264 QMNGLQPNENLSL-MSYLRAGFPEEENAA--ELRQKQ---ASQWAFRsvadGIEHFKNGQQVEAFQCLNKALNIDPRNVE 337
Cdd:TIGR02917 425 QLDPELGRADLLLiLSYLRSGQFDKALAAakKLEKKQpdnASLHNLL----GAIYLGKGDLAKAREAFEKALSIEPDFFP 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095   338 ALVARGALYANRGSFLKGLQDFEKALHLNKYHVNArkymgetLVALGRSYEEENRIAEAVKAYSDCLNLLPLHEEARQSL 417
Cdd:TIGR02917 501 AAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRA-------ILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALAL 573

                         170
                  ....*....|....*.
gi 28573095   418 DALHRS-GDGKRRIST 432
Cdd:TIGR02917 574 AQYYLGkGQLKKALAI 589
BTAD smart01043
Bacterial transcriptional activator domain; Found in the DNRI/REDD/AFSR family of regulators. ...
 301-425 5.16e-03

Bacterial transcriptional activator domain; Found in the DNRI/REDD/AFSR family of regulators. This region of AFSR along with the C terminal region is capable of independently directing actinorhodin production. This family contains TPR repeats.


Pssm-ID: 198111 [Multi-domain]  Cd Length: 145  Bit Score: 38.44  E-value: 5.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573095    301 WAFRSVADGIEHFKNGQQVEAFQCLNKALnidprnvealvargALYanRGSFLKGLQDF----EKALHLNKYHVNArkym 376
Cdd:smart01043   4 DRFERLVAAARAALAADPEAALALLEAAL--------------ALY--RGPLLADVPDEdwaeAERERLRELRLEA---- 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 28573095    377 getLVALGRSYEEENRIAEAVKAYSDCLNLLPLHEEA-RQSLDALHRSGD 425
Cdd:smart01043  64 ---LEALAEALLALGRHEEALALLERLLALDPLRERLhRLLMRALYRAGR 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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