NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24645819|ref|NP_650037|]
View 

leash [Drosophila melanogaster]

Protein Classification

arrestin family protein( domain architecture ID 10432337)

arrestin family protein with both N-terminal and C-terminal Ig-like beta-sandwich domains found in arrestin (S antigen)

CATH:  2.60.40.840
PubMed:  7720881|7833798
SCOP:  4007521

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Arrestin_N super family cl22903
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 6-152 2.49e-28

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


The actual alignment was detected with superfamily member pfam00339:

Pssm-ID: 451447  Cd Length: 148  Bit Score: 110.07  E-value: 2.49e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645819     6 LRITLDSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEilRKNSNNNEYSRS-LFYTSKEVYEHSETPL 84
Cdd:pfam00339   1 FTIEFDKPDGVYFPGETVTGRVLLENEEPKKARAVKIELRGKARTGWEE--SEVRKEGLTFRKdLYYKGTEVYLPTETSL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24645819    85 PDFEPRGLE-LSAGEHTFIFEVALGRQLPSSFKGSYGAIKYKMRVLIQRPWTFDERHTIPFTVVKNMPL 152
Cdd:pfam00339  79 WGSKTGGQNkLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPWKFNKSFRRVFTVIPKLDL 147
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 191-308 3.30e-15

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


:

Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 72.76  E-value: 3.30e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645819    191 VRGEPLRICATVINNSTTAVEKLRFTVLQYVTYY-SHVPLRVQKVECIAVATKETGSVQKK---------TERSFAHELL 260
Cdd:smart01017  17 VPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYVsSDGPVKRSLAEKSKEKKADRKTLVKEldggpvlpgNKDKFEGQLK 96

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 24645819    261 LPDgAQPTDeQMSGVITIVYELRVEAVLRGFFKNLILNLPFKVYSQDP 308
Cdd:smart01017  97 VPP-LPPTS-RTCRLIKVEYKLKVKLRLSGKHSELRLELPITIGTVPL 142
 
Name Accession Description Interval E-value
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 6-152 2.49e-28

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 110.07  E-value: 2.49e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645819     6 LRITLDSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEilRKNSNNNEYSRS-LFYTSKEVYEHSETPL 84
Cdd:pfam00339   1 FTIEFDKPDGVYFPGETVTGRVLLENEEPKKARAVKIELRGKARTGWEE--SEVRKEGLTFRKdLYYKGTEVYLPTETSL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24645819    85 PDFEPRGLE-LSAGEHTFIFEVALGRQLPSSFKGSYGAIKYKMRVLIQRPWTFDERHTIPFTVVKNMPL 152
Cdd:pfam00339  79 WGSKTGGQNkLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPWKFNKSFRRVFTVIPKLDL 147
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 191-308 3.30e-15

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 72.76  E-value: 3.30e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645819    191 VRGEPLRICATVINNSTTAVEKLRFTVLQYVTYY-SHVPLRVQKVECIAVATKETGSVQKK---------TERSFAHELL 260
Cdd:smart01017  17 VPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYVsSDGPVKRSLAEKSKEKKADRKTLVKEldggpvlpgNKDKFEGQLK 96

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 24645819    261 LPDgAQPTDeQMSGVITIVYELRVEAVLRGFFKNLILNLPFKVYSQDP 308
Cdd:smart01017  97 VPP-LPPTS-RTCRLIKVEYKLKVKLRLSGKHSELRLELPITIGTVPL 142
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 193-305 7.71e-12

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 62.73  E-value: 7.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645819   193 GEPLRICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQKVECIAVATKETGSVQKKTERSFAHE--LLLPDGAQPTDE 270
Cdd:pfam02752  19 GETIPVTIEIDNQSKKKIKKIKISLVQQLTYKAKTPLGESKREERVVAKEKNPGVAPGSKDKWEKElqLQIPTDLPPSST 98

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 24645819   271 QmSGVITIVYELRVEAVLRGFFKNLILNLPFKVYS 305
Cdd:pfam02752  99 K-CKIIKVEYKLKVTVDLSGSASELRLELPITIGT 132
 
Name Accession Description Interval E-value
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 6-152 2.49e-28

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 110.07  E-value: 2.49e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645819     6 LRITLDSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEilRKNSNNNEYSRS-LFYTSKEVYEHSETPL 84
Cdd:pfam00339   1 FTIEFDKPDGVYFPGETVTGRVLLENEEPKKARAVKIELRGKARTGWEE--SEVRKEGLTFRKdLYYKGTEVYLPTETSL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24645819    85 PDFEPRGLE-LSAGEHTFIFEVALGRQLPSSFKGSYGAIKYKMRVLIQRPWTFDERHTIPFTVVKNMPL 152
Cdd:pfam00339  79 WGSKTGGQNkLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPWKFNKSFRRVFTVIPKLDL 147
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 191-308 3.30e-15

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 72.76  E-value: 3.30e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645819    191 VRGEPLRICATVINNSTTAVEKLRFTVLQYVTYY-SHVPLRVQKVECIAVATKETGSVQKK---------TERSFAHELL 260
Cdd:smart01017  17 VPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYVsSDGPVKRSLAEKSKEKKADRKTLVKEldggpvlpgNKDKFEGQLK 96

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 24645819    261 LPDgAQPTDeQMSGVITIVYELRVEAVLRGFFKNLILNLPFKVYSQDP 308
Cdd:smart01017  97 VPP-LPPTS-RTCRLIKVEYKLKVKLRLSGKHSELRLELPITIGTVPL 142
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 193-305 7.71e-12

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 62.73  E-value: 7.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645819   193 GEPLRICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQKVECIAVATKETGSVQKKTERSFAHE--LLLPDGAQPTDE 270
Cdd:pfam02752  19 GETIPVTIEIDNQSKKKIKKIKISLVQQLTYKAKTPLGESKREERVVAKEKNPGVAPGSKDKWEKElqLQIPTDLPPSST 98

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 24645819   271 QmSGVITIVYELRVEAVLRGFFKNLILNLPFKVYS 305
Cdd:pfam02752  99 K-CKIIKVEYKLKVTVDLSGSASELRLELPITIGT 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH