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Conserved domains on  [gi|28573062|ref|NP_650137|]
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uncharacterized protein Dmel_CG10005, isoform A [Drosophila melanogaster]

Protein Classification

zona pellucida domain-containing protein( domain architecture ID 1903244)

zona pellucida (ZP) domain-containing protein may function as a structural component of egg coats, appendicularian mucous houses, and nematode dauer larvae, or as a mechanotransducer in flies, or as a receptor in mammals and nonmammals

CATH:  2.60.40.4100|2.60.40.3210
Gene Ontology:  GO:0031012
PubMed:  15952882|29853186|20598543

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZP super family cl42957
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 59-162 7.00e-05

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


The actual alignment was detected with superfamily member smart00241:

Pssm-ID: 214579  Cd Length: 252  Bit Score: 42.76  E-value: 7.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573062     59 KCGADSMNVVLETEKPFMGVMYTRGSFYKQSApCfmKPSSSQ-GSRTMEMNFQLDQCQTIR----DGDLYTNIVVIQ-ND 132
Cdd:smart00241   1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPS-C--RPQFTDaTSAFVSFEVPLNGCGTRRqvnpDGIVYSNTLVVSpFH 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 28573062    133 PELITPGD-SAFSLECDFRQPRNLDVEASMQ 162
Cdd:smart00241  78 PGFITRDDrAAYHFQCFYPENEKVSLNLDVS 108
 
Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 59-162 7.00e-05

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 42.76  E-value: 7.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573062     59 KCGADSMNVVLETEKPFMGVMYTRGSFYKQSApCfmKPSSSQ-GSRTMEMNFQLDQCQTIR----DGDLYTNIVVIQ-ND 132
Cdd:smart00241   1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPS-C--RPQFTDaTSAFVSFEVPLNGCGTRRqvnpDGIVYSNTLVVSpFH 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 28573062    133 PELITPGD-SAFSLECDFRQPRNLDVEASMQ 162
Cdd:smart00241  78 PGFITRDDrAAYHFQCFYPENEKVSLNLDVS 108
 
Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 59-162 7.00e-05

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 42.76  E-value: 7.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573062     59 KCGADSMNVVLETEKPFMGVMYTRGSFYKQSApCfmKPSSSQ-GSRTMEMNFQLDQCQTIR----DGDLYTNIVVIQ-ND 132
Cdd:smart00241   1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPS-C--RPQFTDaTSAFVSFEVPLNGCGTRRqvnpDGIVYSNTLVVSpFH 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 28573062    133 PELITPGD-SAFSLECDFRQPRNLDVEASMQ 162
Cdd:smart00241  78 PGFITRDDrAAYHFQCFYPENEKVSLNLDVS 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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