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Conserved domains on  [gi|24646363|ref|NP_650223|]
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glycine N-methyltransferase [Drosophila melanogaster]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 40-178 1.10e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 77.73  E-value: 1.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  40 DKNSRTDNYKNFLIDMLRNKGCKRVLDVACGTGVDSLMLVEEGFEVVSVDASDKMLKYAlKERWARRNEAAfdKWVIEEA 119
Cdd:COG2226   2 DRVAARYDGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELA-RERAAEAGLNV--EFVVGDA 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24646363 120 NWLTLYDdiqehiqDGFDAVICLgNSFAHLMDgfgdqreHKQAIGNFEKCLKPGGVLLI 178
Cdd:COG2226  79 EDLPFPD-------GSFDLVISS-FVLHHLPD-------PERALAEIARVLKPGGRLVV 122
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 40-178 1.10e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 77.73  E-value: 1.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  40 DKNSRTDNYKNFLIDMLRNKGCKRVLDVACGTGVDSLMLVEEGFEVVSVDASDKMLKYAlKERWARRNEAAfdKWVIEEA 119
Cdd:COG2226   2 DRVAARYDGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELA-RERAAEAGLNV--EFVVGDA 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24646363 120 NWLTLYDdiqehiqDGFDAVICLgNSFAHLMDgfgdqreHKQAIGNFEKCLKPGGVLLI 178
Cdd:COG2226  79 EDLPFPD-------GSFDLVISS-FVLHHLPD-------PERALAEIARVLKPGGRLVV 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 64-174 1.27e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 67.97  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363    64 VLDVACGTGVDSLMLVEE-GFEVVSVDASDKMLKYAlKERWARRNEAAfdKWVIEEANWLTLYDdiqehiqDGFDAVICL 142
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERA-RERAAEAGLNV--EFVQGDAEDLPFPD-------GSFDLVVSS 70

                          90       100       110
                  ....*....|....*....|....*....|..
gi 24646363   143 GnSFAHLmdgfgDQREHKQAIGNFEKCLKPGG 174
Cdd:pfam13649  71 G-VLHHL-----PDPDLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 63-178 2.42e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.06  E-value: 2.42e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  63 RVLDVACGTGVDSLMLVE-EGFEVVSVDASDKMLKYAlKERWARRNEaafDKWVIEEANWLTLYDDIQEHiqdgFDAVIC 141
Cdd:cd02440   1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELA-RKAAAALLA---DNVEVLKGDAEELPPEADES----FDVIIS 72

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 24646363 142 lGNSFAHLMDgfgdqrEHKQAIGNFEKCLKPGGVLLI 178
Cdd:cd02440  73 -DPPLHHLVE------DLARFLEEARRLLKPGGVLVL 102
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 49-258 2.07e-09

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 56.70  E-value: 2.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363   49 KNFLIDMLRNKGCKRVLDVACGTGVDSLMLVEEG---FEVVSVDASDKMLKYAlKERWARRNEAAFDKWVIEEANWLTLY 125
Cdd:PRK00216  40 RRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVgktGEVVGLDFSEGMLAVG-REKLRDLGLSGNVEFVQGDAEALPFP 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  126 DDIqehiqdgFDAV-IclgnsfahlmdGFGdQR---EHKQAIGNFEKCLKPGGVLLidhrnydnILETgATPAKSIyynt 201
Cdd:PRK00216 119 DNS-------FDAVtI-----------AFG-LRnvpDIDKALREMYRVLKPGGRLV--------ILEF-SKPTNPP---- 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 24646363  202 shtadIKTSVLFYCGKpALVSMDYLIAGNKltSEFRlsYYPHGLKRF--QEILAEIFSA 258
Cdd:PRK00216 167 -----LKKAYDFYLFK-VLPLIGKLISKNA--EAYS--YLAESIRAFpdQEELAAMLEE 215
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 47-178 2.49e-07

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 50.34  E-value: 2.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363    47 NYKNFLIDMLRNKGCKRVLDVACGTGVDSLML---VEEGFEVVSVDASDKMLKYAlKERWARRNEAafdKWVIEEANWLT 123
Cdd:TIGR01934  26 LWRRRAVKLIGVFKGQKVLDVACGTGDLAIELaksAPDRGKVTGVDFSSEMLEVA-KKKSELPLNI---EFIQADAEALP 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 24646363   124 LYDdiqehiqDGFDAVIClgnSFahlmdGFGDQREHKQAIGNFEKCLKPGGVLLI 178
Cdd:TIGR01934 102 FED-------NSFDAVTI---AF-----GLRNVTDIQKALREMYRVLKPGGRLVI 141
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 40-178 1.10e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 77.73  E-value: 1.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  40 DKNSRTDNYKNFLIDMLRNKGCKRVLDVACGTGVDSLMLVEEGFEVVSVDASDKMLKYAlKERWARRNEAAfdKWVIEEA 119
Cdd:COG2226   2 DRVAARYDGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELA-RERAAEAGLNV--EFVVGDA 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24646363 120 NWLTLYDdiqehiqDGFDAVICLgNSFAHLMDgfgdqreHKQAIGNFEKCLKPGGVLLI 178
Cdd:COG2226  79 EDLPFPD-------GSFDLVISS-FVLHHLPD-------PERALAEIARVLKPGGRLVV 122
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 52-178 1.36e-17

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 76.98  E-value: 1.36e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  52 LIDMLRNKGcKRVLDVACGTGVDSLMLVEEGFEVVSVDASDKMLKYAlkERWARRNEAAFDKWVIEEanwLTLYDdiqeh 131
Cdd:COG2227  17 LLARLLPAG-GRVLDVGCGTGRLALALARRGADVTGVDISPEALEIA--RERAAELNVDFVQGDLED---LPLED----- 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 24646363 132 iqDGFDAVICLgNSFAHLmdgfgdqREHKQAIGNFEKCLKPGGVLLI 178
Cdd:COG2227  86 --GSFDLVICS-EVLEHL-------PDPAALLRELARLLKPGGLLLL 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 64-174 1.27e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 67.97  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363    64 VLDVACGTGVDSLMLVEE-GFEVVSVDASDKMLKYAlKERWARRNEAAfdKWVIEEANWLTLYDdiqehiqDGFDAVICL 142
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERA-RERAAEAGLNV--EFVQGDAEDLPFPD-------GSFDLVVSS 70

                          90       100       110
                  ....*....|....*....|....*....|..
gi 24646363   143 GnSFAHLmdgfgDQREHKQAIGNFEKCLKPGG 174
Cdd:pfam13649  71 G-VLHHL-----PDPDLEAALREIARVLKPGG 96
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 51-178 3.46e-14

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 68.80  E-value: 3.46e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  51 FLIDMLRNKGCKRVLDVACGTGVDSLMLVEE-GFEVVSVDASDKMLKYAlKERWARRNEAafDKWVIEEANWLTLYDDiq 129
Cdd:COG2230  42 LILRKLGLKPGMRVLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYA-RERAAEAGLA--DRVEVRLADYRDLPAD-- 116

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 24646363 130 ehiqDGFDAVICLGnSFAHLmdgfgDQREHKQAIGNFEKCLKPGGVLLI 178
Cdd:COG2230 117 ----GQFDAIVSIG-MFEHV-----GPENYPAYFAKVARLLKPGGRLLL 155
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 63-178 2.42e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.06  E-value: 2.42e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  63 RVLDVACGTGVDSLMLVE-EGFEVVSVDASDKMLKYAlKERWARRNEaafDKWVIEEANWLTLYDDIQEHiqdgFDAVIC 141
Cdd:cd02440   1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELA-RKAAAALLA---DNVEVLKGDAEELPPEADES----FDVIIS 72

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 24646363 142 lGNSFAHLMDgfgdqrEHKQAIGNFEKCLKPGGVLLI 178
Cdd:cd02440  73 -DPPLHHLVE------DLARFLEEARRLLKPGGVLVL 102
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
63-180 3.17e-12

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 61.76  E-value: 3.17e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  63 RVLDVACGTGVDSLMLVEE--GFEVVSVDASDKMLKYALkerwARRNEAAFdkwviEEANWLTLyddiqeHIQDGFDAVI 140
Cdd:COG4106   4 RVLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARAR----ARLPNVRF-----VVADLRDL------DPPEPFDLVV 68

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 24646363 141 ClGNSFAHLmdgfgdqREHKQAIGNFEKCLKPGGVLLIDH 180
Cdd:COG4106  69 S-NAALHWL-------PDHAALLARLAAALAPGGVLAVQV 100
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
23-185 3.28e-12

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 63.86  E-value: 3.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  23 DQYADgkaakVWEIFIGDKN--SRTDNYKNFLIDMLRNKGCKRVLDVACGTGVDSLMLVEEGFEVVSVDASDKMLKYAlk 100
Cdd:COG4976  12 DQYAD-----SYDAALVEDLgyEAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKA-- 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363 101 erwarRNEAAFDKWVIEEANWLTLYDdiqehiqDGFDAVICLGnSFAHlmdgFGDQREHKQAIGNfekCLKPGGVLLIDH 180
Cdd:COG4976  85 -----REKGVYDRLLVADLADLAEPD-------GRFDLIVAAD-VLTY----LGDLAAVFAGVAR---ALKPGGLFIFSV 144


                ....*
gi 24646363 181 RNYDN 185
Cdd:COG4976 145 EDADG 149
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 65-178 2.20e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 59.22  E-value: 2.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363    65 LDVACGTGVDSLMLVEEGFEVVSVDASDKMLKYAlkerwARRNEAAFDKWVIEEANWLTLyddiqehiQDG-FDAVICLg 143
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELA-----REKAPREGLTFVVGDAEDLPF--------PDNsFDLVLSS- 66

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 24646363   144 NSFAHLMDgfgdqreHKQAIGNFEKCLKPGGVLLI 178
Cdd:pfam08241  67 EVLHHVED-------PERALREIARVLKPGGILII 94
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 47-192 2.18e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 58.77  E-value: 2.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  47 NYKNFLIDMLRNKGCKRVLDVACGTGVDSLMLVEE-GFEVVSVDASDKMLKyalkerWARRNEAAFDKWVIE--EANWLT 123
Cdd:COG0500  13 GLAALLALLERLPKGGRVLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIA------LARARAAKAGLGNVEflVADLAE 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24646363 124 LYDDIQEHiqdgFDAVICLGnSFAHLmdgfgDQREHKQAIGNFEKCLKPGGVLLIDHRNYDNILETGAT 192
Cdd:COG0500  87 LDPLPAES----FDLVVAFG-VLHHL-----PPEEREALLRELARALKPGGVLLLSASDAAAALSLARL 145
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 49-258 2.07e-09

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 56.70  E-value: 2.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363   49 KNFLIDMLRNKGCKRVLDVACGTGVDSLMLVEEG---FEVVSVDASDKMLKYAlKERWARRNEAAFDKWVIEEANWLTLY 125
Cdd:PRK00216  40 RRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVgktGEVVGLDFSEGMLAVG-REKLRDLGLSGNVEFVQGDAEALPFP 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  126 DDIqehiqdgFDAV-IclgnsfahlmdGFGdQR---EHKQAIGNFEKCLKPGGVLLidhrnydnILETgATPAKSIyynt 201
Cdd:PRK00216 119 DNS-------FDAVtI-----------AFG-LRnvpDIDKALREMYRVLKPGGRLV--------ILEF-SKPTNPP---- 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 24646363  202 shtadIKTSVLFYCGKpALVSMDYLIAGNKltSEFRlsYYPHGLKRF--QEILAEIFSA 258
Cdd:PRK00216 167 -----LKKAYDFYLFK-VLPLIGKLISKNA--EAYS--YLAESIRAFpdQEELAAMLEE 215
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 65-176 9.27e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 51.98  E-value: 9.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363    65 LDVACGTGVDSLMLVEE--GFEVVSVDASDKMLKYALKErwarrneaaFDKWVIEEANWLTLYD-DIQEHIQDGFDAVIC 141
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlpGLEYTGLDISPAALEAARER---------LAALGLLNAVRVELFQlDLGELDPGSFDVVVA 71

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 24646363   142 LgNSFAHLmdgfgdqREHKQAIGNFEKCLKPGGVL 176
Cdd:pfam08242  72 S-NVLHHL-------ADPRAVLRNIRRLLKPGGVL 98
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 62-148 1.30e-07

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 51.38  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363   62 KRVLDVACGTGVDSLMLVEEGFEVVSVDASDKMLKYAlKErwaRRNEAAFDKWVIEEANwltlydDIqEHIQDGFDAVIC 141
Cdd:PRK07580  65 LRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEA-RE---RAPEAGLAGNITFEVG------DL-ESLLGRFDTVVC 133


                 ....*..
gi 24646363  142 LgNSFAH 148
Cdd:PRK07580 134 L-DVLIH 139
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 58-180 1.67e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 49.72  E-value: 1.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363    58 NKGCkRVLDVACGTGVDSLMLVEEGF---EVVSVDASDKMLKYALKErwARRNEAAFDKWVIEEANwltlydDIQEHIQD 134
Cdd:pfam13847   2 DKGM-RVLDLGCGTGHLSFELAEELGpnaEVVGIDISEEAIEKAREN--AQKLGFDNVEFEQGDIE------ELPELLED 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 24646363   135 G-FDAVIClgNSFAHLMdgfGDQRehkQAIGNFEKCLKPGGVLLIDH 180
Cdd:pfam13847  73 DkFDVVIS--NCVLNHI---PDPD---KVLQEILRVLKPGGRLIISD 111
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 47-178 2.49e-07

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 50.34  E-value: 2.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363    47 NYKNFLIDMLRNKGCKRVLDVACGTGVDSLML---VEEGFEVVSVDASDKMLKYAlKERWARRNEAafdKWVIEEANWLT 123
Cdd:TIGR01934  26 LWRRRAVKLIGVFKGQKVLDVACGTGDLAIELaksAPDRGKVTGVDFSSEMLEVA-KKKSELPLNI---EFIQADAEALP 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 24646363   124 LYDdiqehiqDGFDAVIClgnSFahlmdGFGDQREHKQAIGNFEKCLKPGGVLLI 178
Cdd:TIGR01934 102 FED-------NSFDAVTI---AF-----GLRNVTDIQKALREMYRVLKPGGRLVI 141
PRK08317 PRK08317
hypothetical protein; Provisional
 48-186 4.63e-07

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 49.94  E-value: 4.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363   48 YKNFLIDMLRNKGCKRVLDVACGTGVDSLML---VEEGFEVVSVDASDKMLKYAlKERWArrNEAAFDKWVIEEANWLTL 124
Cdd:PRK08317   7 YRARTFELLAVQPGDRVLDVGCGPGNDARELarrVGPEGRVVGIDRSEAMLALA-KERAA--GLGPNVEFVRGDADGLPF 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24646363  125 YDdiqehiqDGFDAVICLgNSFAHLMDgfgdqreHKQAIGNFEKCLKPGGVLLIDHRNYDNI 186
Cdd:PRK08317  84 PD-------GSFDAVRSD-RVLQHLED-------PARALAEIARVLRPGGRVVVLDTDWDTL 130
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 62-178 1.64e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 47.04  E-value: 1.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363    62 KRVLDVACGTGVDSLMLVEEGFEVVSVDASDKMlkyalkERWARRNEAAFDKWVIEEANWLTLYDdiqehiqdgfdavic 141
Cdd:pfam13489  24 GRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIA------IERALLNVRFDQFDEQEAAVPAGKFD--------------- 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 24646363   142 lgnsFAHLMDGFGDQREHKQAIGNFEKCLKPGGVLLI 178
Cdd:pfam13489  83 ----VIVAREVLEHVPDPPALLRQIAALLKPGGLLLL 115
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 62-199 2.21e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 46.87  E-value: 2.21e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  62 KRVLDVACGTGVdslMLVEE---GFEVVSVDASDKMLKYalkerwARRNEAAFDKWVIEEANWltlydDIQE-HIQDG-F 136
Cdd:COG1041  28 DTVLDPFCGTGT---ILIEAgllGRRVIGSDIDPKMVEG------ARENLEHYGYEDADVIRG-----DARDlPLADEsV 93

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24646363 137 DAVIC----------LGNSFAHLMdgfgdqrehKQAIGNFEKCLKPGG--VLLIDHRNYDNILETGATPAKSIYY 199
Cdd:COG1041  94 DAIVTdppygrsskiSGEELLELY---------EKALEEAARVLKPGGrvVIVTPRDIDELLEEAGFKVLERHEQ 159
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 51-180 2.30e-06

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 46.72  E-value: 2.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  51 FLIDMLRNKGCKRVLDVACGTGVDSLMLVE---EGFEVVSVDASDKMLKYAlKERWARRNEAafDKWVIEEANWLTLYDD 127
Cdd:COG4122   7 LLYLLARLLGAKRILEIGTGTGYSTLWLARalpDDGRLTTIEIDPERAAIA-RENFARAGLA--DRIRLILGDALEVLPR 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24646363 128 IQEhiqDGFDAViclgnsfahLMDGfgdqrEHKQAIGNFEKC---LKPGGVLLIDH 180
Cdd:COG4122  84 LAD---GPFDLV---------FIDA-----DKSNYPDYLELAlplLRPGGLIVADN 122
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
63-187 1.25e-05

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 45.72  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363   63 RVLDVACGTGVDSLMLVEEGFEVVSVDASDKMLkyalkerwARRNEAAFDKWVIEEANWL-TLYDDIQEHIQDGFDAVIc 141
Cdd:PRK11036  47 RVLDAGGGEGQTAIKLAELGHQVILCDLSAEMI--------QRAKQAAEAKGVSDNMQFIhCAAQDIAQHLETPVDLIL- 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 24646363  142 lgnsFAHLMDGFGDQrehKQAIGNFEKCLKPGGVLLIDHRNYDNIL 187
Cdd:PRK11036 118 ----FHAVLEWVADP---KSVLQTLWSVLRPGGALSLMFYNANGLL 156
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 62-177 2.84e-05

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 45.17  E-value: 2.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  62 KRVLDVACGTGvdslmlveeGF----------EVVSVDASDKMLKyalkerWARRNEAA--FD---KWVIEEA-NWLTLY 125
Cdd:COG1092 218 KRVLNLFSYTG---------GFsvhaaaggakSVTSVDLSATALE------WAKENAALngLDdrhEFVQADAfDWLREL 282

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 24646363 126 DDIQEHiqdgFDAVIC----LGNSFAHLMDGFGDQRE-HKQAIgnfeKCLKPGGVLL 177
Cdd:COG1092 283 AREGER----FDLIILdppaFAKSKKDLFDAQRDYKDlNRLAL----KLLAPGGILV 331
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 40-188 1.86e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 41.04  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363    40 DKNSRtdnyknFLIDMLRNKGCKRVLDVACGTGVDSLMLVEEG--FEVVSVDASdkmlKYALKErwARRNEAAFDKWVIe 117
Cdd:pfam05175  17 DIGSR------LLLEHLPKDLSGKVLDLGCGAGVLGAALAKESpdAELTMVDIN----ARALES--ARENLAANGLENG- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363   118 EANWLTLYDDIQEhiqDGFDAVIC-------LGNSFAHLMDGFGDQREHkqaignfekcLKPGGVLLI---DHRNYDNIL 187
Cdd:pfam05175  84 EVVASDVYSGVED---GKFDLIISnppfhagLATTYNVAQRFIADAKRH----------LRPGGELWIvanRFLGYPPLL 150


                  .
gi 24646363   188 E 188
Cdd:pfam05175 151 E 151
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 53-180 2.14e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 42.07  E-value: 2.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363   53 IDMLRNKGCKRVLDVACGTGVDSLMLVEE--GFEVVSVDASDKmlkyALkeRWARRNeAAF---DKWVIEEANWLTLYDD 127
Cdd:PRK09328 101 LEALLLKEPLRVLDLGTGSGAIALALAKErpDAEVTAVDISPE----AL--AVARRN-AKHglgARVEFLQGDWFEPLPG 173

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24646363  128 IQehiqdgFDAVIC----LGNSFAHLMDgfGDQREH----------------KQAIGNFEKCLKPGGVLLIDH 180
Cdd:PRK09328 174 GR------FDLIVSnppyIPEADIHLLQ--PEVRDHephlalfggedgldfyRRIIEQAPRYLKPGGWLLLEI 238
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 52-110 3.95e-04

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 40.90  E-value: 3.95e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 24646363   52 LIDMLRNKGCKRVLDVACGTGVDSLMLVEEGFEVVSVDASDKMLKYalkerwARRNEAA 110
Cdd:PRK10258  34 LLAMLPQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQ------ARQKDAA 86
PRK14968 PRK14968
putative methyltransferase; Provisional
 52-100 4.96e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 40.27  E-value: 4.96e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 24646363   52 LIDMLRNKGCKRVLDVACGTGVDSLMLVEEGFEVVSVDASDKMLKYALK 100
Cdd:PRK14968  15 LAENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKC 63
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 49-178 6.16e-04

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 40.89  E-value: 6.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363   49 KNFlIDMLRNKGCKRVLDVACGTGVDSLMLVEE-GFEVVSVDASDKMLKYALKERWARRNEAAFdkwviEEANWLTlydd 127
Cdd:PLN02336 256 KEF-VDKLDLKPGQKVLDVGCGIGGGDFYMAENfDVHVVGIDLSVNMISFALERAIGRKCSVEF-----EVADCTK---- 325

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 24646363  128 iQEHIQDGFDaVICLGNSFAHLMDgfgdqrehKQAI-GNFEKCLKPGGVLLI 178
Cdd:PLN02336 326 -KTYPDNSFD-VIYSRDTILHIQD--------KPALfRSFFKWLKPGGKVLI 367
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 53-180 1.01e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 39.75  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  53 IDMLRNKGCKRVLDVACGTGVDSLMLVEE--GFEVVSVDASDKmlkyALKerWARRNEAAF---DKWVIEEANWLtlyDD 127
Cdd:COG2890 105 LALLPAGAPPRVLDLGTGSGAIALALAKErpDARVTAVDISPD----ALA--VARRNAERLgleDRVRFLQGDLF---EP 175

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24646363 128 IQEHIQdgFDAVIClgN------SFAHLMDGfgDQREH----------------KQAIGNFEKCLKPGGVLLIDH 180
Cdd:COG2890 176 LPGDGR--FDLIVS--NppyipeDEIALLPP--EVRDHeprlaldggedgldfyRRIIAQAPRLLKPGGWLLLEI 244
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 51-178 1.03e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 39.40  E-value: 1.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  51 FLIDMLRNKGCKRVLDVACGTGVDSLMLVEE--GFEVVSVDASDKMLKYalkerwARRNEAAFDkwvIEEANwlTLYDDI 128
Cdd:COG2813  40 LLLEHLPEPLGGRVLDLGCGYGVIGLALAKRnpEARVTLVDVNARAVEL------ARANAAANG---LENVE--VLWSDG 108

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24646363 129 QEHIQDG-FDAVIClgN-----------SFAHLMdgFGDQREHkqaignfekcLKPGGVLLI 178
Cdd:COG2813 109 LSGVPDGsFDLILS--NppfhagravdkEVAHAL--IADAARH----------LRPGGELWL 156
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 62-178 1.12e-03

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 39.48  E-value: 1.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  62 KRVLDVACGTGVDSLMLVEEGF-EVVSVDASDKMLKYAlkERWARRNEAAFDkwvIEEANWLtlyddiQEHIQDGFDAVI 140
Cdd:COG3897  72 KRVLELGCGLGLVGIAAAKAGAaDVTATDYDPEALAAL--RLNAALNGVAIT---TRLGDWR------DPPAAGGFDLIL 140

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 24646363 141 ClgnsfahlmdgfGD---QREHKQAIGNF-EKCLKPGGVLLI 178
Cdd:COG3897 141 G------------GDvlyERDLAEPLLPFlDRLAAPGGEVLI 170
PRK12335 PRK12335
tellurite resistance protein TehB; Provisional
 63-178 1.44e-03

tellurite resistance protein TehB; Provisional


Pssm-ID: 183450 [Multi-domain]  Cd Length: 287  Bit Score: 39.54  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363   63 RVLDVACGTGVDSLMLVEEGFEVVSVDasdkmlkyalkerwarRNEAAFDKWVI----EEANWLTLYDDIQEH-IQDGFD 137
Cdd:PRK12335 123 KALDLGCGQGRNSLYLALLGFDVTAVD----------------INQQSLENLQEiaekENLNIRTGLYDINSAsIQEEYD 186

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 24646363  138 AVIclgnSFAHLMdgFGDQREHKQAIGNFEKCLKPGGVLLI 178
Cdd:PRK12335 187 FIL----STVVLM--FLNRERIPAIIKNMQEHTNPGGYNLI 221
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 59-141 2.80e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 38.20  E-value: 2.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  59 KGCKRVLDVACGTGVDSLMLVE--EGFEVVSVDASDKMlkYALkerwARRNeaafdkwvIEEANW---LTLY-DDIQE-- 130
Cdd:COG4123  36 KKGGRVLDLGTGTGVIALMLAQrsPGARITGVEIQPEA--AEL----ARRN--------VALNGLedrITVIhGDLKEfa 101

                        90
                ....*....|...
gi 24646363 131 --HIQDGFDAVIC 141
Cdd:COG4123 102 aeLPPGSFDLVVS 114
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 62-178 4.54e-03

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 37.83  E-value: 4.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363  62 KRVLDVACGTGVDSLMLV----EEGfEVVSVDASDKMLKyalkerWARRNEAAF---DKWVIEEAnwltlydDIQEHIQD 134
Cdd:COG2519  93 ARVLEAGTGSGALTLALAravgPEG-KVYSYERREDFAE------IARKNLERFglpDNVELKLG-------DIREGIDE 158

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 24646363 135 G-FDAVIclgnsfahLmdgfgDQREHKQAIGNFEKCLKPGGVLLI 178
Cdd:COG2519 159 GdVDAVF--------L-----DMPDPWEALEAVAKALKPGGVLVA 190
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
48-178 6.77e-03

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 37.03  E-value: 6.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646363    48 YKNFLIDMLRNKGCKRVLDVACGTG---VDSLMLVEEGFEVVSVDASDKMLKYALKErwaRRNEAAFD-KWVIEEANWLT 123
Cdd:pfam01209  30 WKDFTMKCMGVKRGNKFLDVAGGTGdwtFGLSDSAGSSGKVVGLDINENMLKEGEKK---AKEEGKYNiEFLQGNAEELP 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 24646363   124 LYDDIQEHIQDGFdaviclgnsfahlmdGFGDQREHKQAIGNFEKCLKPGGVLLI 178
Cdd:pfam01209 107 FEDDSFDIVTISF---------------GLRNFPDYLKVLKEAFRVLKPGGRVVC 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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