|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
31-481 |
7.12e-50 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 175.50 E-value: 7.12e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 31 AICAFLATCLHAAMRNMLGMIILKMVmprpedalvvpaglsrltegnvTSTGRCGSPRVVFNPQIQETQSGDLPWTRNQE 110
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMV----------------------NSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQ 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 111 LTFPGVYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLPAMAHSSFEAGVVDLVICGLLAGCGNPAMYKLFVT 190
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAK 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 191 WAHPTERTALLSFAYSGLLMGSMLVYPVASYL-SNFGWELSFYVVGGVGLsfgiACCFLVYDTVeqhprisneevdylrq 269
Cdd:cd17318 139 WAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLcESLGWPSIFYIFGGLGL----LWCLLWFFLV---------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 270 gksqlgqqrqpvvtipwksllaaPPVYAFILTHMFHTYTFLVIVQLMPRFMREAMEFDLREVGFLSAAPYLGGIcskVMC 349
Cdd:cd17318 199 -----------------------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMW---ICS 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 350 ILGGS---YVERRVGPDQNCVRRMLYGICSILtTSLIGVIILANCDDKILVLVMFAFMMATTDMGFSGYWPTLLYFAPSF 426
Cdd:cd17318 253 IVGGYladWLRSRGILSTTTVRKLFTSIGFLG-PGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNY 331
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 281361682 427 AGLLSGLANGMAHLSGFLAPHLVAALVHTG-SKDEWNVVLMTLIVFNTMAMLVFAF 481
Cdd:cd17318 332 AGTLMGITNTAATIAGIISPLIVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLI 387
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
77-498 |
2.53e-36 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 140.26 E-value: 2.53e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 77 NVTSTGRCGSPRVVFNPQIQETQSGDLPWTRNQELTFPGVYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLP 156
Cdd:TIGR00894 45 MVNKENSTDLACLSAENELDNIKNPNFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIP 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 157 AmahsSFEAGVVDLVICGLLAGCGNPAM----YKLFVTWAHPTERTALLSFAYSGLLMGSMLVYPVASYL--SNFGWELS 230
Cdd:TIGR00894 125 W----AAGGGIALVVFCRVIQGLAQGSVspatHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLceSWGGWPMI 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 231 FYVVGGVGLSFGIACCFLVYDTVEQHPRISNEEVDYL-RQGKSQLGQQRQPvvtIPWKSLLAAPPVYAFILTHMFHTYTF 309
Cdd:TIGR00894 201 FYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYInSSLQGQKGSTRQS---LPIKAIPKSLPVWAIWFAIFGHFWLY 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 310 LVIVQLMPRFMREAMEFDLREVGFLSAAPYLGG-ICSKVMCILGGSYVERRvgpdqncvRRMLYGICSILT-TSLIGVII 387
Cdd:TIGR00894 278 TILPTYLPTFISWVLRVSGKENGLLSSLPYLFAwLCSIFAGYLADFLKSSK--------TLSLTAARKIFNgIGGLGPGI 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 388 LANC-----DDKILVLVMFAFMMATTDMGFSGYWPTLLYFAPSFAGLLSGLANGMAHLSGFLAPHLVAALVHTGSKDEWN 462
Cdd:TIGR00894 350 FAYAlpylsAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQDSKNVWL 429
|
410 420 430
....*....|....*....|....*....|....*.
gi 281361682 463 VVLMTLIVFNTMAMLVFAFCSSTNLQPWDPRSRMEK 498
Cdd:TIGR00894 430 IVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
79-480 |
2.40e-32 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 127.97 E-value: 2.40e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 79 TSTGRCGSPRVVFNPQIQETQSGDL-PWTRNQELTFPGVYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLPA 157
Cdd:cd17381 35 SNNSSNACPEHSSSPSVEHNETGKKyDWDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 158 MAHSSFEAGVVDLVICGLLAGCGNPAMYKLFVTWAHPTERTALLSFAYSGLLMGSMLVYPVASYLSNF-GWELSFYVVGG 236
Cdd:cd17381 115 AADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYlDWTYVFYIFGA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 237 VGLSFGIACCFLVYdtveqhprisneevdylrqgksqlgqqrqpvvtipwksllaapPVYAFILTHMFHTYTFLVIVQLM 316
Cdd:cd17381 195 VGLLWFFLWIWLVM-------------------------------------------PLWAIVVAHFSYNWTFYTLLTLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 317 PRFMREAMEFDLREVGFLSAAPYLGGICSKVMCILGGSYVERRVGPDQNCVRRMLYGICSILTTSLIGVIILANCDDKIL 396
Cdd:cd17381 232 PTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 397 VlvmfAFMMATTDMG---FSGYWPTLLYFAPSFAGLLSGLANGMAHLSGFLAPHLVAALVHTGSKDEWNVVLMTLIVFNT 473
Cdd:cd17381 312 V----AFLTISSTLGgfsASGFNINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTHNNTVEEWQTVFYISAAINV 387
|
....*..
gi 281361682 474 MAMLVFA 480
Cdd:cd17381 388 FGAIFFT 394
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
105-483 |
4.71e-29 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 117.66 E-value: 4.71e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 105 WTRNQELTFPGVYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLPAMAHSSFEAGVVDLVICGLLAGCGNPAM 184
Cdd:cd17380 31 WSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSM 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 185 YKLFVTWAHPTERTALLSFAYSGLLMGSMLVYPVASYL-SNFGWELSFYVVGgvGLSFGIACCFLVYdtveqhprisnee 263
Cdd:cd17380 111 TSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLlEYYGWPSVFYFFG--LLGLLWALVWLIY------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 264 vdylrqgksqlgqqrqpvvtipwksllaAPPVYAFILTHMFHTYTFLVIVQLMPRFMREAMeFDLREVGFLSAAPYLGGI 343
Cdd:cd17380 176 ----------------------------LPPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 344 CSKVMC-ILGGSYVERRVgpDQNCVRRMLYGICSILttSLIGVIILANCDDKILVLVMFAFMMATTDMGFSGYWPTLLYF 422
Cdd:cd17380 227 PSSNVAgWLADHLISRGW--TVTSVRKLMQSIGFLG--PALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDI 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281361682 423 APSFAGLLSGLANGMAHLSGFLAPHLVAALVH-TGSkdeWNVVLMTLIVFNTMAMLVFAFCS 483
Cdd:cd17380 303 APNYAGIVFGISNTAGTIPGIVGVYLTGYILEaTGS---WSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
90-481 |
1.53e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 113.43 E-value: 1.53e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 90 VFNPQIQEtqsgDLPWTRNQELTFPGVYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLpAMAHSsFEAGVVD 169
Cdd:COG2271 31 VAAPPLQA----DLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF-GFATS-FWQLLLL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 170 LVICGLLAGCGNPAMYKLFVTWAHPTERTALLSFAYSGLLMGSMLVYPVASYL-SNFGWELSFYVVGGVGLsfgiaccfl 248
Cdd:COG2271 105 RFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLlAAFGWRAAFLILGLPGL--------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 249 vydtveqhprisneevdylrqgksqlgqqrqpvvtipwksLLAAPPVYAFILTHMFHTYTFLVIVQLMPRFMREAMEFDL 328
Cdd:COG2271 176 ----------------------------------------LLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 329 REVGFLSAAPYLGGIcskVMCILGGsYVERRVGPdqncVRRMLYGICSILttSLIGVIILANCDDKILVLVMFAFMMATT 408
Cdd:COG2271 216 AQAGLLLSLPFLAGI---VGSLLGG-WLSDRLGR----RRKLVLAIGLLL--AALALLLLALLPSPALAIALLFLAGFGL 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281361682 409 DMGFSGYWPTLL-YFAPSFAGLLSGLANGMAHLSGFLAPHLVAALVHTGSkdeWNVVLMTLIVFNTMAMLVFAF 481
Cdd:COG2271 286 GGAFGLLWALAAeLFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG---YQAAFLLLAALALLAALLALL 356
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
31-478 |
2.19e-27 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 113.20 E-value: 2.19e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 31 AICAFLATCLHAAMRNMLGMIILKMVmprpedalvvpaglsrlteGNVTstgrcgsprvVFNPQIQETQSGDLPWTRNQE 110
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMV-------------------NNFT----------DAYGGKVIVHKAEFNWTPETV 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 111 LTFPGVYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLPAMAHSSFEAGVVDLVICGLLAGCGNPAMYKLFVT 190
Cdd:cd17382 52 GLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRK 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 191 WAHPTERTALLSFAYSGLLMGSMLVYPVASYL-SNFGWELSFYVVGGVGLsfgIACCFlvydtveqhprisneevdylrq 269
Cdd:cd17382 132 WAPPLERSRLATTAFCGSYAGAVVGMPLSGILvQYVGWSSPFYVYGVFGI---IWYMF---------------------- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 270 gksqlgqqrqpvvtipWksLLAAPPVYAFILTHMFHTYTFLVIVQLMPRFMREAMEFDLREVGFLSAAPYLggicskVMC 349
Cdd:cd17382 187 ----------------W--MLVSMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHL------VMT 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 350 I---LGGS---YVERRVGPDQNCVRRMLYgiCSILTTSLIGVIILANCDDKilVLVMFAFMMATTDMGF--SGYWPTLLY 421
Cdd:cd17382 243 IivpIGGQladYLRSRGILSTTAVRKIFN--CGGFGMEATFLLVVAFSHSP--TVAISFLVLAVGFSGFaiSGFNVNHLD 318
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 281361682 422 FAPSFAGLLSGLANGMAHLSGFLAPHLVAALVHTGSKDEWNVVLmtlivfnTMAMLV 478
Cdd:cd17382 319 IAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTREEWQYVF-------LIASLV 368
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
115-446 |
4.29e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 97.49 E-value: 4.29e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 115 GVYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLpaMAHSSFEAGVVDLVICGLLAGCGNPAMYKLFVTWAHP 194
Cdd:pfam07690 39 TLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL--LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPP 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 195 TERTALLSFAYSGLLMGSMLVYPVASYL-SNFGWELSFYVVGGVGLSFGIACCFLVYDTVEQHPRISNEEVdylrqgksq 273
Cdd:pfam07690 117 EERGRALGLVSAGFGLGAALGPLLGGLLaSLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEAR--------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 274 lgqqrqPVVTIPWKSLLaAPPVYAFILTHMFHTYTFLVIVQLMPRFMrEAMEFDLREVGFLSAAPYLGGIcskVMCILGG 353
Cdd:pfam07690 188 ------LSLIVAWKALL-RDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGA---IGRLLLG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 354 SYVERRVGpdqncvRRMLYGICSILTTSLIGVIILANCDDKILVLVMFAFMMATTDMGFSGYWPTLLYFAP-SFAGLLSG 432
Cdd:pfam07690 257 RLSDRLGR------RRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPkEERGTASG 330
|
330
....*....|....
gi 281361682 433 LANGMAHLSGFLAP 446
Cdd:pfam07690 331 LYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
90-482 |
3.54e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.47 E-value: 3.54e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 90 VFNPQIQEtqsgDLPWTRNQELTFPGVYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLpAMAHSsfeagVVD 169
Cdd:COG2223 26 VLAPPLAE----EFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL-ALAVS-----YWL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 170 LVICGLLAGCGNPAMY----KLFVTWAHPTERTALLSFAYSGLLMGSMLVYPVASYL-SNFGWELSFYVVGGVGLSFGIA 244
Cdd:COG2223 96 LLLLGLLLGIGGGGSFavgiALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLiAAFGWRNAFLILGILLLVVAVL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 245 CCFLVYDTVEQHPrisneevdylRQGKSQLGQQRQpvvtipwksLLAAPPVYAFILTHMFHTYTFLVIVQLMPRFMREAM 324
Cdd:COG2223 176 AWLFLRDPPAGAA----------AAAKASLRDQLE---------ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 325 EFDLREVGFLSAAPYLGGIcskVMCILGGsYVERRVGPdqncvRRMLYGICSILTTSLIGVIILAncDDKILVLVMFAFM 404
Cdd:COG2223 237 GLSAATAGLLAALFALLGA---LGRPLGG-WLSDRIGG-----RRVLLIVFALMALGLLLLALAL--GSLWLFLVLFLLL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 405 MATTDMGFSGYWPTL-LYFAPSFAGLLSGLANGMAHLSGFLAPHLVAALV-HTGSkdeWNVVLMTLIVFNTMAMLVFAFC 482
Cdd:COG2223 306 GLALGGGNGAVFALVpDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLdATGS---YTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
115-481 |
5.37e-18 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 85.31 E-value: 5.37e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 115 GVYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLpAMAHSSFEAGVVDLVIcGLLAGCGNPAMYKLFVTWAHP 194
Cdd:cd17319 45 SAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT-GFATSLTSLYVLRFLL-GVAEAGFFPGAIKALAEWFPA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 195 TERTALLSFAYSGLLMGSMLVYPVASYL-SNFGWELSFYVVGGVGLSFGIACCFLVydtveqhprisneevdylrqgksq 273
Cdd:cd17319 123 RERGRATGLFNSGAPLGAAIGPPLSGWLlLLFGWRWAFIIEGLLGLLLAVLWWFYL------------------------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 274 lgqqrqpvvtipwksllaaPPVYAFILTHMFHTYTFLVIVQLMPRFMREAMEFDLREVGFLSAAPYLGGIcskVMCILGG 353
Cdd:cd17319 179 -------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGA---IGMILGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 354 SYVERRVgpdqNCVRRMLYGICSILTTSLIGVIILAncDDKILVLVMFAFMMATTDMGFSGYWPTLL-YFAPSFAGLLSG 432
Cdd:cd17319 237 RLSDRLL----RGARRLVIIIGLLLAAVGLLLAYLT--TSPVVAVILLSLAGFGIGAASPVFWSLPAdLLPGEAAATAGG 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 281361682 433 LANGMAHLSGFLAPHLVAALV-HTGSkdeWNVVLMTLIVFNTMAMLVFAF 481
Cdd:cd17319 311 LINSGGNLGGFVAPLLIGYLVdATGS---YTAAFLFLAAVALLAALLVLL 357
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
102-479 |
1.53e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 81.32 E-value: 1.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 102 DLPWTRNQELTFPGVYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLPAMAhsSFEAGVVDLVICGLLAGCGN 181
Cdd:cd06174 25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP--SFWLLLLGRFLLGLGSGLID 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 182 PAMYKLFVTWAHPTERTALLSFAYSGLLMGSMLVYPVASYLSNFGWELSFYVVGGVGLSFGIaCCFLVYDTVEQHPRISN 261
Cdd:cd06174 103 PAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALL-AAILLLLVVPDPPESAR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 262 EEVDYLRQGKsqlgqqrqpvVTIPWKSLLAAPPVYAFILTHMFHTYTFLVIVQLMPRFMREAMEFDLREVGFLSAAPYLG 341
Cdd:cd06174 182 AKNEEASSKS----------VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 342 GIcskVMCILGGSYVERRVGpdqncvRRMLYGICSILTTslIGVIILANCDDKILVLVMFAFMMATTDMGFSGYWP-TLL 420
Cdd:cd06174 252 GA---LGSLLLGLLSDRLIG------RKPLLLIGLLLMA--LGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAlIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 281361682 421 YFAPSFAGLLSGLANGMAHLSGFLAPhLVAALVHTGSKDeWNVVLMTLIVFNTMAMLVF 479
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGP-LLAGFLLAATFG-LTGAFLVLAVLLLLAAILL 377
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
121-453 |
3.39e-14 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 73.95 E-value: 3.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 121 YVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLPAMahSSFEAGVVDLVICGLLAGCGNPAMYKLFVTWAHPTERTAL 200
Cdd:TIGR00881 43 YGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS--TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 201 LSFAYSGLLMGSMLVYPVASYLSNF--GWELSFYVVGGVGLSFGIACCFLVYDTVEQH--PRISNEEVDYLRQGKSQLGQ 276
Cdd:TIGR00881 121 VSFWNCSHNVGGGLLPPLVLFGIAElySWHWVFIVPGIIAIIVSLICFLLLRDSPQSCglPPAEEMPNEEPDGDAEKKEE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 277 QRQPvVTIPWKSLLAAPPVYAFILTHMFHTYTFLVIVQLMPRFMREAMEFDLREVGFLSAAPYLGGICSKVMC-ILGGSY 355
Cdd:TIGR00881 201 ELTK-KQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAgWLSDKL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 356 VERRVGPdQNCVRRMLygicsiLTTSLIGVIILANCDDkilvLVMFAFMMATtdmGFSGYWPTLLY------FAPSFA-G 428
Cdd:TIGR00881 280 FNGRRGP-LAVFFMAL------IIVSLLVYWLNPAANP----LMDLICLFAL---GFLVYGPQMLIgviaseLAPKKAaG 345
|
330 340
....*....|....*....|....*
gi 281361682 429 LLSGLANGMAHLSGFLAPHLVAALV 453
Cdd:TIGR00881 346 TAAGFVGFFAYLGGILAGLPLGYLA 370
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
120-482 |
8.12e-13 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 69.96 E-value: 8.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 120 GYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLPAM--AHSSFEAGVVDLVICGLLAGCGNPAMYKLFVTWAHPTER 197
Cdd:cd17345 50 AYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVpsATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKER 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 198 TALLSFAYSGLLMGSMLVYPVA----SYLSNFGWELSFYVVGGVGLSFGIACCFLVYDTVEQH--PRISNEEVDYLRQGK 271
Cdd:cd17345 130 GTWTSIWNISHNVGGGLVGPLAglglAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEglPPIEEYKGDYPEEAD 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 272 SQLGQQRQPVVTIPWKSLLAAPPVYAFILTHMFhtyTFLV---IVQLMPRFMREAMEFDLREVGFLSAAPYLGGICSKVM 348
Cdd:cd17345 210 GEEEEQELSAWEIFVKYVLKNKLLWYIAIANVF---VYLVrygILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLL 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 349 CilggSYVERRVGPDqncvRRMLYG-ICSILTTSLIGVIILANCddkilVLVMFAFMMAttdMGFSGYWPTLLY------ 421
Cdd:cd17345 287 A----GWLSDKLFKG----RRAPTGiIFMILVIVALIVYWLAPN-----VLVDLIALIA---LGFLIYGPVMLIglqale 350
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281361682 422 FAPSFAGllsGLANGMAHLSGFLAPHLVAALV------HTGskdeWNVVLMTLIVFNTMAMLVFAFC 482
Cdd:cd17345 351 LVPKKAA---GTAAGLTGLFGYLGGSVLATALigiivdHFG----WNGGFIVLLASCILAIIFLALV 410
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
115-445 |
1.17e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 69.23 E-value: 1.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 115 GVYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLpAMAHsSFEAGVVDLVICGLLAGCGNPAMYKLFVTWAHP 194
Cdd:COG2814 52 TAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC-ALAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPP 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 195 TERTALLSFAYSGLLMGSMLVYPVASYLSN-FGWELSFYVVGGVGLSFGIACCFLVYDTVEqhprisneevdylrqgksq 273
Cdd:COG2814 130 ERRGRALGLLGAGLGLGPALGPLLGGLLADlFGWRWVFLVNAVLALLALLLLLRLLPESRP------------------- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 274 lgqQRQPVVTIPWKSLLAAPPVYAFILTHMFHTYTFLVIVQLMPRFMREAMEFDLREVGFLSAAPYLGGIcskVMCILGG 353
Cdd:COG2814 191 ---AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV---LGALLAG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 354 SYVeRRVGpdqncvRRMLYGICSILTtsLIGVIILANCDDKILVLVMFAFMMATTDMGFSGYWPTLL-YFAPSFAGLLSG 432
Cdd:COG2814 265 RLA-DRFG------RRRLLLIGLLLL--ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAeLAPPEARGRASG 335
|
330
....*....|...
gi 281361682 433 LANGMAHLSGFLA 445
Cdd:COG2814 336 LYNSAFFLGGPLA 348
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
120-480 |
2.88e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 64.95 E-value: 2.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 120 GYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLpAMAHsSFEAGVVDLVICGLLAGCGNPAMYKLFVTWAHPTERTA 199
Cdd:cd17475 43 GVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLM-ALVG-SYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 200 LLSFAYSGLLMG----SMLVYPVAsylSNFGWELSFyVVGGVGLSFGIACCFLVYDTVEQHPRISNEEVDYLRQGKSQLG 275
Cdd:cd17475 121 AMGIRQTGVPLGgalaAALLPPLA---LHYGWRAAF-VVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLKEVLR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 276 qqRQPVVTIPWKSLLAAPPVYAFIlthmfhtyTFLVIvqlmprFMREAMEFDLREVGFLSAAPYLGGICSKVmcilGGSY 355
Cdd:cd17475 197 --NRDVWLIAIAGALLVAPQFALL--------TFLLL------FLHDHLGLSVVAAGALLAVAQLGGALGRI----GLGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 356 VERRVGPDQncvRRMLYGICSILTTSLIGVIILANCDDKILVLVMFAFMMATTDMGFSGYWPTLL--YFAPSFAGLLSGL 433
Cdd:cd17475 257 VSDRVFGGR---RRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVaeSAGPEQAGTALGL 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 281361682 434 ANGMAHLSGFLAPHLVAALV-HTGSkdeWNVVLMTLIVFNTMAMLVFA 480
Cdd:cd17475 334 ANTINFIGIAIGPPLFGLLVdATHS---YAPAWLALALLLVLAALLLL 378
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
116-485 |
4.36e-10 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 61.52 E-value: 4.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 116 VYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLpAMAHSSFEAGVVdLVICGLLAGCGNPAMYKLFVTWAHPT 195
Cdd:cd17312 46 AFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFM-GFSTSLWFFAVL-WGLNGLFQSMGWPPCVKLLGNWFSKK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 196 ERTALLSFAYSGLLMGSMLVYPVA-SYLSNFGWELSFYVVGGVGLSFGIACCFLVYDtveqhprisneevdylrqgksql 274
Cdd:cd17312 124 ERGTVYGIWSTSHNFGGILAPILAaSLASYYGWRAAFLVPGIVGLVVAIILFFFLRD----------------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 275 gqqRQPVVtipWKSLLAappvYAFIlthMFHTYTFLVIVQLmprFMREAMEFDLREVGFLSAAPYLGGIcskVMCILGGs 354
Cdd:cd17312 181 ---SPPYV---WVLSLA----YAFV---YIVRYACLDWGPL---YLYEVKGYSLIDAGWFSSLYEVGGI---AGTILAG- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 355 YVERRVGPDQNCVRRMLYGICSILTTSLIGVIIlANCDDKILVLVMFAFMMATTDMGFSGYWPTLlyFAPSFA-GLLSGL 433
Cdd:cd17312 241 LLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFP-HNKLLSIVLLFLIGFFVGGPINLIGGAAAQD--IGRKEAaGTATGF 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 281361682 434 ANGMAHLSGFLAPHLVAAL-VHTGskdeWNVVLMTLIVfntMAMLVFAFCSST 485
Cdd:cd17312 318 VGLFGYLGASLAGLPLGYIiDHYG----WSTVFYFLIS---AALLSVLLLLSL 363
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
116-457 |
9.93e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 60.25 E-value: 9.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 116 VYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLPAMAhsSFEAGVVDLVICGLLAGCGNPAMYkLFVTWAHPT 195
Cdd:COG0738 51 AFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAP--SYPLLLLALFLLGLGLGLLDVAAN-PYVAALGPE 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 196 ERTALLSFAYSGLLMGSMLVYPVASYLSNFG----WELSFYVVGGVGLSFGIACCFLVYdtveqhPRISNEEVDYLRQGK 271
Cdd:COG0738 128 TAASRLNLLHAFFSLGALLGPLLGGLLILLGlslsWHLPYLILAVLLLLLALLFLRSKL------PEIEEEEEEAAGSAA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 272 SQlgqqrqpvvtipwKSLLAAPPVYAFILTHMFHTYTFLVIVQLMPRFMREAMEFDLREVGFLSAApYLGGICskVMCIL 351
Cdd:COG0738 202 SL-------------KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL-FWGGMT--IGRFL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 352 GGsYVERRVGPdqncvRRMLyGICSILTTSLIGVIILANcddkILVLVMFAFMMAttDMGFSGYWPTLLYFAPSFAGLLS 431
Cdd:COG0738 266 GG-FLLKRFGP-----VRLL-RLSALLAAVGLLLALLAP----GPWLALIGLALV--GLGLSLMFPTIFSLALDGLGKRT 332
|
330 340 350
....*....|....*....|....*....|
gi 281361682 432 GLANG----MAHLSGFLAPHLVAALVHTGS 457
Cdd:COG0738 333 AAAVSavliMGIVGGAIGPPLIGFLADAFG 362
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
116-480 |
4.11e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 58.33 E-value: 4.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 116 VYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAyILLPAMAhSSFEAgvvdLVICGLLAGCGNPAMYKLFVTWA--- 192
Cdd:cd17324 42 AYALGYALGALLLGPLSDRIERRRLLLVLLLLFILG-NLLAALA-PSFAL----LLLARALAGLAHGGFWAIAAAYAadl 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 193 -HPTERTALLSFAYSGLLMGSMLVYPVASYLSN-FGWELSFYVVGGVGLSFGIACCFLVydtveqhPRISNEEVDYLRQG 270
Cdd:cd17324 116 vPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQlLGWRAAFLAIAVLALLAALLLWRLL-------PSLPPKKPGSLGLL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 271 KSQLGQQRQPVVtipWKSLLAAppvyAFILTHMFHTYTFLVIvqlmprFMREAMEFDLREVGFLSAAPYLGGIcskVMCI 350
Cdd:cd17324 189 SSLLLLLRNPRL---RLAYLIT----FLLFGGFFALYTYLAP------FLTDVPGFSSSAIIGLLLLFGVAGV---VGSP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 351 LGGSYVERRvgpdqncVRRMLYGICSILTtsLIGVIILANCDDKILVLVMFAFMMATTDMGFSGYWPTLLYFAPSFAGLL 430
Cdd:cd17324 253 LAGRLADRG-------GRRALLIALLLLA--AALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLA 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 281361682 431 SGLANGMAHLSGFLAPHLVAALVHTGSkdeWNVVLMTLIVFNTMAMLVFA 480
Cdd:cd17324 324 SSLYLAAYNLGGALGAALGGLVLDHGG---WAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
115-481 |
7.46e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.59 E-value: 7.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 115 GVYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLpAMAHsSFEAGVVDLVICGLLAGCGNPAMYKLFVTWAHP 194
Cdd:cd17325 38 AAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF-AFAT-SYWQLLLARFLQGLASAAVWPAAMALIADIAPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 195 TERTALLSFAYSGLLMGSMLVYPVASYLSN-FGWELSFYVVGGVGLSFGIACCFLVYDTVEQHPRisneevdylrqgksq 273
Cdd:cd17325 116 EERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALALLALVLALLLLPEPRPPPNK--------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 274 lGQQRQPVVTIPWKSLLAAPPVYAFILTHMFHTYTFLVIVQLMPRFMREAMEFDLREVGFLSAAPYLGGIcskVMCILGG 353
Cdd:cd17325 181 -RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASA---LSQPPAG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 354 SYVERRvgpdqncVRRMLYGICSILTTSLIGVIILANCddkilvLVMFAFMMATTDMGFSGYWPTLL-----YFAPSFAG 428
Cdd:cd17325 257 KLSDRI-------GRKPLILIGLLLSAVALLLLPLATS------FWLLLLLLALLGLGLGLVFPATLalladIVPPEGRG 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 281361682 429 LLSGLANGMAHLSGFLAPHLVAALVHTGSkdeWNVVLMTLIVFNTMAMLVFAF 481
Cdd:cd17325 324 TAMGLFNTAFSLGMVLGPLLGGFLYDAFG---FATPFLAAAALLLLAAVLFLL 373
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
127-404 |
1.60e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.83 E-value: 1.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 127 LSGYLADRCSSKR-----LFIVSLIFEAVAYILLPAMAHSSFEAGVVDLVICGLLAGCGNPAMYKLFVTWA-----HPTE 196
Cdd:COG2211 65 LIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGaeltpDYEE 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 197 RTALLS----FAYSGLLMGSMLVYPVASYLSN---FGWELSFYVVGGVGLSFGIACCFlvydTVEQHPRISNEEVDYLRQ 269
Cdd:COG2211 145 RTRLSSwrfaFAGLGGLLASVLPPPLVAAFGGdaaLGYRLTALIFAVLGLLAFLLTFF----GTKERPVPEEEKVSLKES 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 270 gksqlgqqrqpvvtipWKSLLAAPPVYAFILTHMFHTYTFLVIVQLMPRFMREAMEFDLREVGFLSAAPYLGGICSkvmc 349
Cdd:COG2211 221 ----------------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLG---- 280
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 281361682 350 ILGGSYVERRVGpdqncvRRMLYGICSILTTSLIGVIILANCDDKILVLVMFAFM 404
Cdd:COG2211 281 APLWPRLAKRFG------KKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALA 329
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
129-431 |
7.06e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 54.55 E-value: 7.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 129 GYLADRCSSKRLFIVSLIFEAVAYILLPAMahSSFEAGVVDLVICGL-LAGCGNPA---MYKLFVtwahPTERTALLSFA 204
Cdd:cd17328 55 GYLGDRYNRKWILAVGILIWSAATLLSSFA--PNFWQLLLFRALVGIgEASYSPIAptiIADLFP----KEKRTRALGVF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 205 YSGLLMGSMLVYPVASYLSNF--GWELSFYVVGGVGLSFGIACCFLVYDTveqhPRISNEEVDYLRQGKSQLGQQrqpvv 282
Cdd:cd17328 129 YFAIPLGSGLGYVVGGLVAQAtgGWRWAFRVTGVLGVLLAILLLLFVREP----PRGAAEGGVMAKSTATSFLAD----- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 283 tipWKSLLAAPP----VYAFILTHmFHTYTFlviVQLMPRFMREAMEFDLREVGFLSAapYLGGIC--SKVMCILGGSYV 356
Cdd:cd17328 200 ---LKALAKNPSfilsTLGFTAVS-FVTGAL---AFWAPTFFLRAFGVGDLSSADVGL--IFGAITciAGVLGVLLGGIL 270
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281361682 357 ERRVGPDQNCVRRMLYGICSILTTSLIGVIILANCDDKILVLVMFAFmmattdmgfsGYWPTLLYFAPSFAGLLS 431
Cdd:cd17328 271 ADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFL----------GEFLLSLNWAPVFAILLY 335
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
93-457 |
7.45e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.42 E-value: 7.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 93 PQIQETQSGDLPWTRNQELTFPGVyyyGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYiLLPAMAhSSFEAGVVDLVI 172
Cdd:cd17473 23 PAIAQHFVPNSELLVPLLLTLPAL---FIALFAPLAGWLADRFGRKRLLIAGLLLYGIGG-VAGLFL-DSLYALLASRAL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 173 CGLLAGCGNPAMYKLFVTWAHPTERTALLSFAYSGLLMGSMLVYPVASYLSNFGWELSFYVVgGVGLSFGIACCFLVYDT 252
Cdd:cd17473 98 LGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVY-LLALPVLILVLLFLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 253 VeqhprisneevdylRQGKSQLGQQRQPVVTIPWKSLLaapPVYAFILTHMFhtyTFLVIVQLMPRFMREAMEFDLREVG 332
Cdd:cd17473 177 A--------------RKSKSAASPGAATAAALPWKRVL---PIYFLAFLAML---LFYVIPIQLPFLLQERGGGSAALIG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 333 FLSAAPYLGGicskvmcILGGSYVERRVgpdQNCVRRMLYGICSILTTslIGVIILANCDDKILVLVMFAFMMattdMGF 412
Cdd:cd17473 237 LALAIASLAG-------AIGALLFGRLK---RRLGKRRLLAIGFALMA--LGFLLLALASGLWVVLLGAILAG----LGF 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 281361682 413 SGYWPTLLYFA-----PSFAGLLSGLANGMAHLSGFLAPHLVAALVHTGS 457
Cdd:cd17473 301 GLLLPTLNSWAmslvpPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
120-482 |
1.06e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.78 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 120 GYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLpaMAHSSFEAGVVDLVICGLLAGCGNPAMYkLFVTWAHPTERTA 199
Cdd:cd17333 43 GYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALI--FATPSIYLFVVLMFLAGLGAGILDTGAN-TFVGALFEESSAT 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 200 LLSFAYSGLLMGSMLVYPVASYL--SNFGWELSFYVVGgvGLSFGIACCFLvydtveqhpRISNEEVDYLRQGKSQLGQQ 277
Cdd:cd17333 120 RLNVLHGFFGLGALIGPLIATSLltSELSWSWAYLIIG--LIYLLLAILIL---------LTLFPELPSARNPQQSVGAF 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 278 RQPVvtipwKSLLAAPPVYAFILTHMFHTYTFLVIVQLMPRFMREAMEFDLREVGFLSAApYLGGIcskVMCILGGSYVE 357
Cdd:cd17333 189 SASA-----SRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSG-FWVGI---TIGRLLGGPIS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 358 RRVGPdqncvRRMLYGICSILTTSLIGVIILANcddkilvLVMFAFMMATTDMGFSGYWPTLLYFAPSFAGLLSGLANGM 437
Cdd:cd17333 260 RRIKP-----HTLLVLSGSGALLGLLILLLAPT-------LVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSV 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 281361682 438 ----AHLSGFLAPHLVAALVHTGSkdewnvVLMTLIVFNTMAMLVFAFC 482
Cdd:cd17333 328 llaaGSIGGAIIPFIMGFIAEAVG------IQTAMLLITILYAIIFVLA 370
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
127-257 |
2.24e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 49.88 E-value: 2.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 127 LSGYLADRCSSKRLFIVSLIFEAVAYILLpAMAHSSFEAGVVDLVICGLLAGCGNPAMYKLFVTWAHPTERTALLSFAYS 206
Cdd:COG2223 260 LGGWLSDRIGGRRVLLIVFALMALGLLLL-ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGA 338
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 281361682 207 GLLMGSMLVYPVASYLSNF--GWELSFYVVGGVGLsFGIACCFLVYDTVEQHP 257
Cdd:COG2223 339 AGGLGGFLGPLLFGALLDAtgSYTAAFLVFAVLAL-VALVLTLLLYRRPRRAA 390
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
86-239 |
7.81e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 48.04 E-value: 7.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 86 SPRVVFNPQIQETQsgdlpWTRnqeLTFPGVYYYGYVVSISLS---GYLADRCSSKRLFIVSLIFEAVAYILLpAMAHSS 162
Cdd:cd17355 21 YFGVFIIPIIAEFG-----WSR---AVISLAFTVGLLAFGLAQpfvGRLLDRFGPRRVMLLGLLLLAAGLVLL-ALATSL 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281361682 163 FEAGVVDLVICGLLAGCGNPAMYKLFVTWAHPTERTALLSFAYSGLLMGSMLVYP-VASYLSNFGWELSFYVVGGVGL 239
Cdd:cd17355 92 WQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPlGAALIEAFGWRTALLVLALLAL 169
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
127-481 |
9.67e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 47.95 E-value: 9.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 127 LSGYLADRCSSKRLFIVSLIFEAVAYILLpamahsSFEAGVVDLVICGLLAGCG----NPAMYKLFVTWAhPTERTALLS 202
Cdd:COG2807 72 LAPRLARRFGLERTLLLALLLLAAGLLLR------SLAPSVALLLAGTALIGAGiavgNVLLPGLIKRWF-PDRVGLMTG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 203 FAYSGLLMGSMLVYPVASYLSN-FGWELSFYVVGGVGLsfgIACCFLVYDTVEQHPRisneevdylrqgksqlgqQRQPV 281
Cdd:COG2807 145 LYTAAMGLGAALAAGLTVPLAAaLGWRGALAVWALLAL---LALLLWLPLLRRRPAA------------------AAAAP 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 282 VTIPWKSLLAAPPVYAFILTHMFHTYTFLVIVQLMPRFMREAmEFDLREVGFLSAAPYLGGIcskVMCILGGSYVERRVG 361
Cdd:COG2807 204 AAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGI---PGSLLVPLLADRLGD 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 362 pdqncvRRMLYGICSILTtsLIGVIILANCDDKILVLVMFAFMMattdmGFSGYWPTLLYFA------PSFAGLLSGLAN 435
Cdd:COG2807 280 ------RRPLLLLLGLLG--LAGLLGLLLAPGSLPWLWAVLLGL-----GQGGLFPLALTLIglrartPAEAAALSGMAQ 346
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 281361682 436 GMAHLSGFLAPHLVAALV-HTGSkdeWNVVLMTLIVFnTMAMLVFAF 481
Cdd:COG2807 347 SVGYLLAALGPLLVGALHdATGS---WTAALLLLAAL-AVLMLVAGL 389
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
121-293 |
1.12e-05 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 47.71 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 121 YVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLpamAHSSFEAGVVDLVIC-GLLAGCGNPAMYKLFVTWAHPTERT- 198
Cdd:cd17343 51 YAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAF---SGSSSVWVFSILWFLnGLAQGLGWPPCAKILRKWFSPSQFGt 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 199 --ALLSfaYSGLLMGSMLVYPVASYLSNFGWELSFYVVGGVGLSFGIACCFLVYDtveqhpRISNEEVDYLRQGKSQLGQ 276
Cdd:cd17343 128 wwSVLS--TSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKN------EPSDVGLNNIEEEESKGKK 199
|
170
....*....|....*..
gi 281361682 277 QRQPVVTIPWKSLLAAP 293
Cdd:cd17343 200 KKSPRGESTLKELLLSP 216
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
127-481 |
1.13e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 47.61 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 127 LSGYLADRCSSKRLFIVSLIFEAVAYILLpaMAHSSFEAGVVDLVICGLLAGCGNPAMYKLFVTWAHPTERTALLSFAYS 206
Cdd:cd17329 54 IGGRLADRFGRKPVMLAGLLLRALGFALL--GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYW 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 207 GLLMGSMLVYPVASYLSNFGWELSFYVVGGVglsFGIACCFLVYdtveqhprisneevdYLRQGKSQLGQQRQPVVTIPW 286
Cdd:cd17329 132 AINLGVAIGPLLGGLLLLYSFRLLFLAAAVL---FLLAALVLLF---------------LLPETRPKRRAAEKTEILRGY 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 287 KSLLAAPPVYAFILTHMFhtyTFLVIVQL---MPRFMREAMEFDLREVGFLSAApylggicsKVMCILGGSYVERRVGPD 363
Cdd:cd17329 194 KIVLRDRAFLLFLLASFL---ISLIYFQLestLPVYVVEILGLGESLLGLLLAL--------NALLIVLLQFPVARLVER 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 364 QNCVRRMLYGICsILTTSLIGVIILANcddkilvLVMFAFMMATTDMGFSGYWPTLLYFAPSFA-----GLLSGLANGMA 438
Cdd:cd17329 263 FRLRKILMIGIL-LFAIGFAVLAFANT-------LAVLILAMIVLTLGEMLVFPAVQTLVAALAppdkrGSYMGFYALAW 334
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 281361682 439 HLSGFLAPhLVAALVHTGSKDEWNVVLMTLIVFNTMAMLVFAF 481
Cdd:cd17329 335 GLGRAIGP-LVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
120-249 |
7.57e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 44.87 E-value: 7.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 120 GYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLPAMahSSFEAGVVDLVICGLLAGCGNPAMYKLFVTWAHPTERTA 199
Cdd:cd17325 247 ASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA--TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGT 324
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 281361682 200 LLSFAYSGLLMGSMLVYPVASYLS-NFGWELSFYVVGGVGLSFGIACCFLV 249
Cdd:cd17325 325 AMGLFNTAFSLGMVLGPLLGGFLYdAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
127-404 |
7.75e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.91 E-value: 7.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 127 LSGYLADRCSSKRLFIVSLIFEAVAYILLPAMAHSSFeAGVVDLVICGLLAGCGN----PAMYKLFVTWAHPTERTALLS 202
Cdd:cd06173 53 FAGVLADRFDRRRLLILADLLRALLAAVLALLALLGS-LSLWLLLVLAFLLGIASaffgPARQALLPELVPKEQLVRANA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 203 FaYSGLLMGSMLV-YPVASYL-SNFGWELSFYVVGGVGLSFGIACCFLVYDTVEQHPRISNEEVDYLRQGksqlgqqrqp 280
Cdd:cd06173 132 L-NSLATQLARIIgPALGGLLvALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREG---------- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 281 vvtipWKSLLAAPPVYAFILTHMFHTYTFLVIVQLMPRFMREAMEFDLREVGFLSAAPYLGGIcskVMCILGGSYVERRv 360
Cdd:cd06173 201 -----LRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGAL---LGALLLGRLSKRR- 271
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 281361682 361 gpdqncVRRMLYGICSILTTSLIGVIILANcdDKILVLVMFAFM 404
Cdd:cd06173 272 ------RRGRLLLIGALLLGLALLVLGLSP--SLWLLLAALFLL 307
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
120-453 |
1.54e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.88 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 120 GYVVSISL---------SGYLADRCSSKRLFIVSLIFEAVayillpAMAHSSFEAGVVDLVICGLLAGCGNPAMY----K 186
Cdd:TIGR00895 55 GFLFSAGLigmafgalfFGPLADRIGRRRVLLWSILLFSV------FTLLCALATNVTQLLILRFLAGLGLGGLMpnlnA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 187 LFVTWAHPTERTALLSFAYSGLLMGSMLVYPVASYL-SNFGWELSFYVVGGVGLSFGI--------ACCFLVYDTVEQHP 257
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLiPVFGWRSLFYVGGIAPLLLLLllmrflpeSIDFLVSKRPETVR 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 258 RISNEEVDYLRQGkSQLGQQRQPVVTIPWKSLLAA--PPVYAFILTHMFHTYTFLVIV-----QLMPRFMREAmEFDLRE 330
Cdd:TIGR00895 209 RIVNAIAPQMQAE-AQSALPEQKSTQGTKRSVFKAlfQGKTARITVLLWLLYFMLLVGvyfltNWLPKLMVEL-GFSLSL 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 331 VGFLSAAPYLGGICSkvmCILGGSYVERrvgpdqncVRRMLYGICSILTTSLIGVIILANCDDKILVLVMFAFMMATTDM 410
Cdd:TIGR00895 287 AATGGALFNFGGVIG---SIIFGWLADR--------LGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGG 355
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 281361682 411 --GFSGYWPtlLYFAPSFAGLLSGLANGMAHLSGFLAPHLVAALV 453
Cdd:TIGR00895 356 qsGLYALMA--LFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
115-477 |
3.73e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.59 E-value: 3.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 115 GVYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAyILLPAMAhSSFEAGVVDLVICGLLAGCGNPAMYKLFVTWAHP 194
Cdd:cd17316 43 AAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLA-TLLIGLL-PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPS 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 195 TERTALLSFAYSGLLMGSMLVYPVASYLS-----NFGWELSFYVvGGVGLSFGIaccflvydtveqhprisneevdYLRq 269
Cdd:cd17316 121 KRRGFALGLLQSGWALGALLAALVASLLIpllsgDWGWRILFLI-GALPALLAL----------------------LLR- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 270 gksqlgqqrqpvvtipwKSLLAAppvyafILTHMFHTYTFLVIVQLMPRFMREAMEFDLREVGFLSAAPYLGGIcskVMC 349
Cdd:cd17316 177 -----------------RRTLLL------ILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGAL---VGA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 350 ILGGSYVErRVGpdqncvRRMLYGICSILttSLIGVIILANCDDKILVLVMFA-FMMATTDMGFSGYWPTLL--YFAPSF 426
Cdd:cd17316 231 LIAGLLSD-RIG------RKKTLVIGLIL--SGILALPLFYLLSGSPTLLLLLlFILSFFVGGVWGALYAYLaeLFPTEV 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 281361682 427 AGLLSGLANGMAHL-SGFLAPHLVAALVHTGSKDEWNVVLMTLIVFNTMAML 477
Cdd:cd17316 302 RATGVGLSYNLGRLgGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
115-254 |
5.41e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.16 E-value: 5.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 115 GVYYYGYVVSISLSGYLADRCSS--KRLFIVSLIFEAVAYILLPAMahSSFEAGVVDLVICGLLAGCGNPAMYKLFVTWA 192
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281361682 193 HPTERTALLSFAYSGLLMGSMLVYPVASYL-SNFGWELSFYVVGGVGLSFGIACCFLVYDTVE 254
Cdd:COG2271 301 PKKARGTASGLVNTFGFLGGALGPLLVGYLlDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
117-252 |
1.22e-03 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 41.23 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 117 YYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLPamAHSSFEAGVVDLVICGLLAGCGNPAMYKLFVTWAHPTE 196
Cdd:PRK11663 67 FYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFG--FSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTE 144
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 281361682 197 RTALLSFAYSGLLMGSMLVYPVASYLS-NFGWELSFYVVGGVGLSFGIACCFLVYDT 252
Cdd:PRK11663 145 RGGWWAIWNTAHNVGGALIPLVVGAIAlHYGWRYGMMIAGIIAIVVGLFLCWRLRDK 201
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
116-252 |
1.30e-03 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 41.24 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 116 VYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLpAMAhSSFEAGVVDLVICGLLAGCGNPAMYKLFVTWAHPT 195
Cdd:cd17488 46 LFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILF-GFS-SSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRN 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 281361682 196 ERTALLSFAYSGLLMGSMLVYPVASYLSNF-GWELSFYVVGGVGLSFGIACCFLVYDT 252
Cdd:cd17488 124 ERGFWWSIWNTSHNIGGALIPILTGFAALTyGWRAGMYVPGIIAILMGIVLCWRLRDR 181
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
116-406 |
4.58e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 39.54 E-value: 4.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 116 VYYYGYVVSISLSGYLADRC-SSKRLFIVSLIFEAVayILLPAMAHSSfeAGVVDL-VICGLLAGCGNPAMYKLFVTWAH 193
Cdd:cd17327 49 VFYVGYIIFELPGNLLLQRFpPSKWLSVFIVLWGLL--TLLTAAVKNF--GGLIALrFFLGLFESGVFPGFILYLGMWYK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 194 PTERTALLSFAYSGLLMGSMLV----YPVASYLSN---FGWELSFYVVGGVGLSFGIACCFLVYDTVEQHPRISNEE--- 263
Cdd:cd17327 125 REEQAKRIAFFYAAAGLGSIFGgllaYGVFKILGVgglAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEkel 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 264 -VDYLRQGKSQLGQQRqpvvtIPWKSLLAA---PPVYAFILTHMFHTYTFLVIVQLMPRFMREaMEFDLREVGFLSAAPY 339
Cdd:cd17327 205 aVERLRANQTGKGDQK-----FKWKQIKEAfkdPRTWLLFLFFFCSQITNNGISNFLPLILKS-LGFYSLQTNLLSVPIG 278
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281361682 340 LGGicskVMCILGGSYVERRVGPdqncvrRMLYGICSILTTsLIGVIILANCDDKIlVLVMFAFMMA 406
Cdd:cd17327 279 ALG----AVSLLIAALLSDRFKK------RGLFAIFACVLA-LVGSIILLAAPNPP-GAYFAAYILG 333
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
116-248 |
5.66e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.64 E-value: 5.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361682 116 VYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLpAMAHsSFEAGVVDLVICGLLAGCGNPAMYKLFVTWAHPT 195
Cdd:COG0477 57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC-GLAP-SPELLIAARALQGIGAGGLMPGALALIAELFPAR 134
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 281361682 196 ERTALLSFAYSGLLMGSMLVYPVASYLSN-FGWELSFYVVGGVGLSFGIACCFL 248
Cdd:COG0477 135 ERGRALGLWGAAIGLGLALGPLLGGLLVAaLGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
113-185 |
8.61e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 38.73 E-value: 8.61e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281361682 113 FPGVYYYGYVVSISLSGYLADRCSSKRLFIVSLIFEAVAYILLPAMAHSSFEAGVVDLVICGLLAGCGNPAMY 185
Cdd:COG2211 269 LLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPW 341
|
|
| |
