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Conserved domains on  [gi|442619473|ref|NP_650564|]
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uncharacterized protein Dmel_CG12783, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
synapt_SV2 super family cl31090
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 6-282 9.02e-13

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


The actual alignment was detected with superfamily member TIGR01299:

Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 70.39  E-value: 9.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473    6 ETMGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVM 85
Cdd:TIGR01299 182 EVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFC 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   86 RFITCIFVAGPSFVAATYLSEFCSHRIMVRSITHLYMF--TGFAMISCPAWATL------FLSSGLIEFEEklvgsltlr 157
Cdd:TIGR01299 262 RLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFwmIGGIYAAAMAWAIIphygwsFQMGSAYQFHS--------- 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  158 pWRVLGCLYILPGVVAFLLLLLLPESPKFLLMIGETKRGLDTMEWI------SRKNTGRTLSEDQMKRLLAYQEHVQVKr 231
Cdd:TIGR01299 333 -WRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIhdtnmrAKGHPEKVFSVNHIKTIHQEDELIEIE- 410

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442619473  232 rKEHQNFFRSMLDDAMPLVRKPYGGYFTC-----------VCMVMFVLGLLTHGLGIWYTAM 282
Cdd:TIGR01299 411 -SDTGTWYQRCFVRALSEGGGIWGNFLRCfnpevreitikLMGVWFTLSFGYYGLSVWFPDM 471
 
Name Accession Description Interval E-value
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 6-282 9.02e-13

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 70.39  E-value: 9.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473    6 ETMGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVM 85
Cdd:TIGR01299 182 EVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFC 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   86 RFITCIFVAGPSFVAATYLSEFCSHRIMVRSITHLYMF--TGFAMISCPAWATL------FLSSGLIEFEEklvgsltlr 157
Cdd:TIGR01299 262 RLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFwmIGGIYAAAMAWAIIphygwsFQMGSAYQFHS--------- 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  158 pWRVLGCLYILPGVVAFLLLLLLPESPKFLLMIGETKRGLDTMEWI------SRKNTGRTLSEDQMKRLLAYQEHVQVKr 231
Cdd:TIGR01299 333 -WRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIhdtnmrAKGHPEKVFSVNHIKTIHQEDELIEIE- 410

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442619473  232 rKEHQNFFRSMLDDAMPLVRKPYGGYFTC-----------VCMVMFVLGLLTHGLGIWYTAM 282
Cdd:TIGR01299 411 -SDTGTWYQRCFVRALSEGGGIWGNFLRCfnpevreitikLMGVWFTLSFGYYGLSVWFPDM 471
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 6-192 7.91e-11

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 63.90  E-value: 7.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   6 ETMGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVM 85
Cdd:cd17439   14 EVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFC 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  86 RFITCIFVAGPSFVAATYLSEFCSHRIMVRSITHLYMFTGFAMISCPAWATLFLSSGLIEFEekLVGSLTLRPWRVLGCL 165
Cdd:cd17439   94 RLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFQ--MGSAYQFHSWRVFVLV 171

                        170       180
                 ....*....|....*....|....*..
gi 442619473 166 YILPGVVAFLLLLLLPESPKFLLMIGE 192
Cdd:cd17439  172 CAFPSVFAIGALTTMPESPRFFLENGK 198
Sugar_tr pfam00083
Sugar (and other) transporter;
28-244 4.76e-08

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 54.97  E-value: 4.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   28 LASLTAAGFM-GIICSSYFWGYITDKKGRRWTLLRTIT---ISNLCSLASMFTVTFTGFFVMRFITCIFVAGPSFVAATY 103
Cdd:pfam00083  47 LSGLIVSIFSvGCFIGSLFAGKLGDRFGRKKSLLIANVlfvIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMY 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  104 LSEFC--SHRIMVRSITHLYMFTGFAMISCPAWATLFLSSGLiefeeklvgsltlrPWRVLGCLYILPGVVAFLLLLLLP 181
Cdd:pfam00083 127 ISEIApkKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSD--------------GWRIPLGLQLVPALLLIIGLLFLP 192

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442619473  182 ESPKFLLMIGETKRGLDTMEWIsRKNTGRTLSEDQMKRLLayqEHVQVKRRKEHQNFFRSMLD 244
Cdd:pfam00083 193 ESPRWLVEKGRLEEAREVLAKL-RGVPDVDRELDEIKDSL---EAGQEAEKASWKELFSTKTR 251
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
8-111 1.09e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.72  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   8 MGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRF 87
Cdd:COG2271   27 SNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRF 106

                         90       100
                 ....*....|....*....|....
gi 442619473  88 ITCIFVAGPSFVAATYLSEFCSHR 111
Cdd:COG2271  107 LLGLGEAGFFPAALKLIAEWFPPK 130
 
Name Accession Description Interval E-value
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 6-282 9.02e-13

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 70.39  E-value: 9.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473    6 ETMGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVM 85
Cdd:TIGR01299 182 EVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFC 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   86 RFITCIFVAGPSFVAATYLSEFCSHRIMVRSITHLYMF--TGFAMISCPAWATL------FLSSGLIEFEEklvgsltlr 157
Cdd:TIGR01299 262 RLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFwmIGGIYAAAMAWAIIphygwsFQMGSAYQFHS--------- 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  158 pWRVLGCLYILPGVVAFLLLLLLPESPKFLLMIGETKRGLDTMEWI------SRKNTGRTLSEDQMKRLLAYQEHVQVKr 231
Cdd:TIGR01299 333 -WRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIhdtnmrAKGHPEKVFSVNHIKTIHQEDELIEIE- 410

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442619473  232 rKEHQNFFRSMLDDAMPLVRKPYGGYFTC-----------VCMVMFVLGLLTHGLGIWYTAM 282
Cdd:TIGR01299 411 -SDTGTWYQRCFVRALSEGGGIWGNFLRCfnpevreitikLMGVWFTLSFGYYGLSVWFPDM 471
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 6-192 7.91e-11

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 63.90  E-value: 7.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   6 ETMGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVM 85
Cdd:cd17439   14 EVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFC 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  86 RFITCIFVAGPSFVAATYLSEFCSHRIMVRSITHLYMFTGFAMISCPAWATLFLSSGLIEFEekLVGSLTLRPWRVLGCL 165
Cdd:cd17439   94 RLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFQ--MGSAYQFHSWRVFVLV 171

                        170       180
                 ....*....|....*....|....*..
gi 442619473 166 YILPGVVAFLLLLLLPESPKFLLMIGE 192
Cdd:cd17439  172 CAFPSVFAIGALTTMPESPRFFLENGK 198
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 16-174 8.10e-11

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 63.39  E-value: 8.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  16 AAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRFITCIFVAG 95
Cdd:cd17316   26 AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGG 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442619473  96 PSFVAATYLSEFCSHRIMVRSITHLYMFTGFAMIscpawATLFLSSGLIEFEEKLVGsltlrpWRVLGCLYILPGVVAF 174
Cdd:cd17316  106 EYPGASTYVAEFAPSKRRGFALGLLQSGWALGAL-----LAALVASLLIPLLSGDWG------WRILFLIGALPALLAL 173
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 6-192 3.06e-10

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 62.25  E-value: 3.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   6 ETMGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVM 85
Cdd:cd17438   14 EVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFC 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  86 RFITCIFVAGPSFVAATYLSEFCSHRIMVRSITHLYMF--TGFAMISCPAWATL-FLSSGLiefeeKLVGSLTLRPWRVL 162
Cdd:cd17438   94 RLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFwmIGGLYASAMAWSIIpHYGWGF-----SMGTNYHFHSWRVF 168

                        170       180       190
                 ....*....|....*....|....*....|
gi 442619473 163 GCLYILPGVVAFLLLLLLPESPKFLLMIGE 192
Cdd:cd17438  169 VIICALPCIASIIALKFMPESPRFLLEMGK 198
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 6-192 4.06e-10

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 61.85  E-value: 4.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   6 ETMGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVM 85
Cdd:cd17440   14 EVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFC 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  86 RFITCIFVAGPSFVAATYLSEFCSHRIMVRSITHLYMF--TGFAMISCPAWATLflssGLIEFEEKLVGSLTLRPWRVLG 163
Cdd:cd17440   94 RLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFwmIGGIYASAMAWAII----PHYGWSFSMGSAYQFHSWRVFV 169

                        170       180
                 ....*....|....*....|....*....
gi 442619473 164 CLYILPGVVAFLLLLLLPESPKFLLMIGE 192
Cdd:cd17440  170 IVCALPCVSSVVALTFMPESPRFLLEVGK 198
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 24-207 1.88e-09

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 59.64  E-value: 1.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   24 NEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRFITCIFVAGPSFVAATY 103
Cdd:TIGR00898 125 DAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  104 LSEFC--SHRIMVrsithlymftgfAMISCPAWAT-LFLSSGLIEFeeklvgsltLRPWRVLGCLYILPGVVAFLLLLLL 180
Cdd:TIGR00898 205 NTEFLpkKQRAIV------------GTLIQVFFSLgLVLLPLVAYF---------IPDWRWLQLAVSLPTFLFFLLSWFV 263

                         170       180
                  ....*....|....*....|....*..
gi 442619473  181 PESPKFLLMIGETKRGLDTMEWISRKN 207
Cdd:TIGR00898 264 PESPRWLISQGRIEEALKILQRIAKIN 290
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 6-144 4.39e-09

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 58.14  E-value: 4.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473    6 ETMGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVM 85
Cdd:TIGR00895  32 DLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLIL 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442619473   86 RFITCIFVAGPSFVAATYLSEFCSHRImvRSITHLYMFTGFA------------MISCPAWATLFLSSGLI 144
Cdd:TIGR00895 112 RFLAGLGLGGLMPNLNALVSEYAPKRF--RGTAVGLMFCGYPigaavggflagwLIPVFGWRSLFYVGGIA 180
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 6-192 6.85e-09

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 57.88  E-value: 6.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   6 ETMGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVM 85
Cdd:cd17363   14 EVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFC 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  86 RFITCIFVAGPSFVAATYLSEFCSHRIMVRSITHLYMF--TGFAMISCPAWATL------FLSSGLIEFEEklvgsltlr 157
Cdd:cd17363   94 RLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFwmIGGLYASAMAWAIIphygwgFSMGTAYQFHS--------- 164

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 442619473 158 pWRVLGCLYILPGVVAFLLLLLLPESPKFLLMIGE 192
Cdd:cd17363  165 -WRVFVIVCALPSVASVVALTFMPESPRFLLEVGK 198
Sugar_tr pfam00083
Sugar (and other) transporter;
28-244 4.76e-08

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 54.97  E-value: 4.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   28 LASLTAAGFM-GIICSSYFWGYITDKKGRRWTLLRTIT---ISNLCSLASMFTVTFTGFFVMRFITCIFVAGPSFVAATY 103
Cdd:pfam00083  47 LSGLIVSIFSvGCFIGSLFAGKLGDRFGRKKSLLIANVlfvIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMY 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  104 LSEFC--SHRIMVRSITHLYMFTGFAMISCPAWATLFLSSGLiefeeklvgsltlrPWRVLGCLYILPGVVAFLLLLLLP 181
Cdd:pfam00083 127 ISEIApkKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSD--------------GWRIPLGLQLVPALLLIIGLLFLP 192

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442619473  182 ESPKFLLMIGETKRGLDTMEWIsRKNTGRTLSEDQMKRLLayqEHVQVKRRKEHQNFFRSMLD 244
Cdd:pfam00083 193 ESPRWLVEKGRLEEAREVLAKL-RGVPDVDRELDEIKDSL---EAGQEAEKASWKELFSTKTR 251
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
8-111 1.09e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.72  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   8 MGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRF 87
Cdd:COG2271   27 SNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRF 106

                         90       100
                 ....*....|....*....|....
gi 442619473  88 ITCIFVAGPSFVAATYLSEFCSHR 111
Cdd:COG2271  107 LLGLGEAGFFPAALKLIAEWFPPK 130
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 6-128 1.56e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 52.97  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   6 ETMGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVM 85
Cdd:cd17365   14 DLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 442619473  86 RFITCIFVAGPSFVAATYLSEFCSHRIMVRSIThlYMFTGFAM 128
Cdd:cd17365   94 RFLTGLGLGAAMPNAITLVSEYAPARRRSLAVT--LMFCGYPL 134
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
8-144 1.63e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 53.05  E-value: 1.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   8 MGMGIIGPAA---VCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFV 84
Cdd:COG2814   24 LGIGIVLPALpliAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  85 MRFITCIFVAGPSFVAATYLSEFCSHRIMVRSITHLYMFTGFAMISCPA----------WATLFLSSGLI 144
Cdd:COG2814  104 ARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLlgglladlfgWRWVFLVNAVL 173
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 6-190 7.28e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 47.50  E-value: 7.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   6 ETMGMGIIGPAA---VCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGF 82
Cdd:COG0477   26 EGLDFTIVNVALpsiAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  83 FVMRFITCIFVAGPSFVAATYLSEFCSHRIMVRSITHLYMFTGFAMISCPawatlfLSSGLIefeeklvgsLTLRPWRVL 162
Cdd:COG0477  106 IAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP------LLGGLL---------VAALGWRWI 170

                        170       180
                 ....*....|....*....|....*...
gi 442619473 163 GCLYILPGVVAFLLLLLLPESPKFLLMI 190
Cdd:COG0477  171 FLINAPLGLLALVLRLRLPESRGLLLAL 198
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 6-107 7.57e-06

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 47.91  E-value: 7.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   6 ETMGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVM 85
Cdd:cd17372   14 EMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIIL 93

                         90       100
                 ....*....|....*....|..
gi 442619473  86 RFITCIFVAGPSfVAATYLSEF 107
Cdd:cd17372   94 RCLVGLGLGGGP-QLASWYLEF 114
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 1-86 8.93e-06

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 47.89  E-value: 8.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   1 MLTIQETMGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFT 80
Cdd:cd17441    9 MADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYS 88


                 ....*.
gi 442619473  81 GFFVMR 86
Cdd:cd17441   89 WILVLR 94
MFS_1 pfam07690
Major Facilitator Superfamily;
8-142 9.20e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.41  E-value: 9.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473    8 MGMGIIGPAAVC----DLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFF 83
Cdd:pfam07690  10 LGRSLLGPALPLllaeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLL 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 442619473   84 VMRFITCIFVAGPSFVAATYLSEFCSHRIMVRSITHLYMFTGFAMISCPAWATLFLSSG 142
Cdd:pfam07690  90 VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 18-138 1.82e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 46.42  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  18 VCDlrmNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRFITCIFVAGPS 97
Cdd:cd17317   20 VCD---RDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIF 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 442619473  98 FVAATYLSEFCSHRIMVRSITHLYMFTGFAMISCPAWATLF 138
Cdd:cd17317   97 TVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLI 137
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 30-188 6.12e-05

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 45.33  E-value: 6.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  30 SLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTI---TISNLCSLASMFTVTFTGFFVMRFITCIFVAGPSFVAATYLSE 106
Cdd:cd17357   53 LIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNallVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQE 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473 107 fcshrimvrsITHLYMFTGFAMISCPAWATLFLSSGLIEFEEKLvGSLTLrpWRVLGCLYILPGVVAFLLLLLLPESPKF 186
Cdd:cd17357  133 ----------ISPSELRGALGSLTQIGVTLGILLGQVFGLPSVL-GTETL--WPYLLFFPGIPALLQLAALPFFPESPKF 199


                 ..
gi 442619473 187 LL 188
Cdd:cd17357  200 LL 201
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 10-104 1.10e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 44.10  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  10 MGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRFIT 89
Cdd:cd17319   22 ISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLL 101

                         90
                 ....*....|....*
gi 442619473  90 CIFVAgPSFVAATYL 104
Cdd:cd17319  102 GVAEA-GFFPGAIKA 115
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
8-107 1.55e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.72  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   8 MGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRF 87
Cdd:COG2223   22 YLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGL 101

                         90       100
                 ....*....|....*....|
gi 442619473  88 ITCIFVAGPSFVAATYLSEF 107
Cdd:COG2223  102 LLGIGGGGSFAVGIALVSKW 121
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 20-208 1.95e-04

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 43.72  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  20 DLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLrtitISNLCSLASMFTVTFTGFFVM----RFITCIFVAG 95
Cdd:cd17358   35 SLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLL----ISAIPCILGWLLIAFAKDVWMlylgRFLAGFGGGA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  96 PSFVAATYLSEfcshrIMVRSITHlymftgfAMISCPawaTLFLSSG-LIEFeekLVGSLTlrPWRVLGCLYILPGVVAF 174
Cdd:cd17358  111 ASVVVPVYIAE-----IAPKNVRG-------ALGSLN---QLLVNIGiLLGY---VLGSFL--PWRTLALIGAIPPVVFL 170

                        170       180       190
                 ....*....|....*....|....*....|....
gi 442619473 175 LLLLLLPESPKFLLMIGETKRGLDTMEWISRKNT 208
Cdd:cd17358  171 ILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDA 204
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 20-128 2.82e-04

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 42.82  E-value: 2.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  20 DLRMNEAQLASLTAAGFM-GIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRFITCIFVAGPSF 98
Cdd:cd17375   28 DLVCDREWLAKLIQPIFMlGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVSSGYLV 107

                         90       100       110
                 ....*....|....*....|....*....|
gi 442619473  99 VAATYLSEFCShrIMVRSITHLYMFTGFAM 128
Cdd:cd17375  108 VVFVYVTEFTG--IKARTWASMHVHAFFAV 135
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 24-193 3.59e-04

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 42.55  E-value: 3.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  24 NEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRFITCIFVAGPSFVAATY 103
Cdd:cd17359   34 TPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMY 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473 104 LSEFCSHRIMVR--SITHLYMFTGFAMISCPAWATLFLSSGLIEFEEKlvgsltlrpWRVLGCLYILPGVVAFLLLLLLP 181
Cdd:cd17359  114 IAEVAPAEIRGRlvSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEG---------WRWMLGLEAIPAILFLLGMLFIP 184

                        170
                 ....*....|..
gi 442619473 182 ESPKFLLMIGET 193
Cdd:cd17359  185 ESPRWLVSKGKP 196
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 8-95 6.21e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.84  E-value: 6.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   8 MGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTItisnLCSLASMFTVTFTGFFVMrF 87
Cdd:cd17475   13 QGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGL----LLMGAAALLMALVGSYPV-L 87


                 ....*...
gi 442619473  88 ITCIFVAG 95
Cdd:cd17475   88 LVLLFLVG 95
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 8-146 7.09e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 41.64  E-value: 7.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   8 MGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRF 87
Cdd:cd06174   13 GLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRF 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442619473  88 ITCIFVAGPSFVAATYLSEFCSHRIMVRSITHLYMFTGFAMISCPAWATLFLSSGLIEF 146
Cdd:cd06174   93 LLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGW 151
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 36-220 7.41e-04

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 41.94  E-value: 7.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   36 FMGIICSSYFWGYITDKKGRRwtllRTITISNLCS-LASMFTVTFTG------FFVMRFITCIFVAGPSFVAATYLSEFC 108
Cdd:TIGR00879  81 LVGGFIGALFAGWLSDRFGRK----KSLLIIALLFvIGAILMGLAAFalsvemLIVGRVLLGIGVGIASALVPMYLSEIA 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  109 --SHRIMVRSITHLYMFTGFAMISCPAWATLFLSSGLIefeeklvgsltlrpWRVLGCLYILPGVVAFLLLLLLPESPKF 186
Cdd:TIGR00879 157 pkALRGALTSLYQLAITFGILVAYGFGSGKVSLNNTLG--------------WRIPLGLQLIPAGLLFLGLFFLPESPRW 222

                         170       180       190
                  ....*....|....*....|....*....|....
gi 442619473  187 LLMIGETKRGLDTMEWIsRKNTGRTLSEDQMKRL 220
Cdd:TIGR00879 223 LVGKGRVEEARKSLARL-RGTSGEDKELLDELEL 255
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 18-134 1.94e-03

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 40.10  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  18 VCDLR-MNEAqlasLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRFITCIFVAGP 96
Cdd:cd17447   30 VCDRKgLNQA----TATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGF 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 442619473  97 SFVAATYLSEFCS--HRIMVRSITHLYMFTGFAMISCPAW 134
Cdd:cd17447  106 SIISMVLCVEWVDieHRTVAGVLISLFWTVGNMLLALVAY 145
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 29-188 2.64e-03

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 39.93  E-value: 2.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  29 ASLTAAGFMGIICSSYfwgyITDKKGRRWTLLRTITISNLCSLASMFTVTF-TGFFVMRFITCIFVAGPSFVAATYLSEF 107
Cdd:cd17356   52 SIVNLGSFFGALISSF----LSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKwYQLIVGRIIAGLGVGFASVLVPVYQSEV 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473 108 CsHRIMVRSITHLYMFTGFAMISCPAWATLFLSSGLIEFEeklvgsltlrpWRVLGCLYILPGVVAFLLLLLLPESPKFL 187
Cdd:cd17356  128 A-PKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDGSAQ-----------WRIPLGLQIVWGLLLLIGMFFLPESPRWL 195


                 .
gi 442619473 188 L 188
Cdd:cd17356  196 Y 196
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 37-189 3.05e-03

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 39.78  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  37 MGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRFITCIFVAGPSFVAATYLSEFCSH--RIMV 114
Cdd:cd17435   47 IGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQhrRGLL 126

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442619473 115 RSITHLYMFTGFAMISCPAWATLFLSSGliefeeklvgsltlrpWRVLGCLYILPGVVAFLLLLLLPESPKFLLM 189
Cdd:cd17435  127 VSLNELMIVIGILLAYISNYAFANVSNG----------------WKYMFGLVIPLAALQAIAMYFLPPSPRFLVM 185
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 6-97 3.31e-03

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 39.79  E-value: 3.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   6 ETMGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVM 85
Cdd:cd17442   16 EIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFL 95

                         90
                 ....*....|..
gi 442619473  86 RFITCIFVAGPS 97
Cdd:cd17442   96 RCMVGCGVSGHS 107
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 2-187 3.77e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 39.59  E-value: 3.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   2 LTIQETMGMGIIGPAAVCDLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTG 81
Cdd:cd17371   10 LDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  82 FFVMRFITCIFVAGPSFVAATYLSEFCSHRIMVRSITHLYMFTGFAMISCPAWATLFLSSGLIEFEeklvgsltlrpWRV 161
Cdd:cd17371   90 LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIA-----------WRV 158

                        170       180
                 ....*....|....*....|....*.
gi 442619473 162 LGCLYILPGVVAFLLLLLLPESPKFL 187
Cdd:cd17371  159 LFLLGALPALLVLFIRRFVKEPPQWQ 184
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 20-129 4.34e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 39.10  E-value: 4.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  20 DLRMNEAQLASLTAAGFMGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRFITCIFVAGPSFV 99
Cdd:cd17320   28 DLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVV 107

                         90       100       110
                 ....*....|....*....|....*....|
gi 442619473 100 AATYLSEFCSHRIMVRSITHLYMFTGFAMI 129
Cdd:cd17320  108 ARAIVRDLYSGAELAKIFSLLMMILAIAPA 137
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 29-188 5.25e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 39.09  E-value: 5.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  29 ASLTAAGFMGIICSsyfwGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRFITCIFVAGPSFVAATYLSEFC 108
Cdd:cd17315   41 SSLLLGAAIGSLFG----GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473 109 SHRIMVRSITHLYMFTGFAMIscpawATLFLSSGLIEFEEKLvgsltlrpWRVLGCLYILPGVVAFLLLLLLPESPKFLL 188
Cdd:cd17315  117 PAKIRGALGTLNQLMITFGIL-----LAYLLGLALSLSPPGW--------WRLMFALAAVPALLQLLLMFFLPESRALLV 183
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 1-95 5.65e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 38.75  E-value: 5.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473   1 MLTIQETMGMGIIGPAAvcDLRMNEAQLASLTAAGFMGI-----ICSSYFWGYITDKKGRRwtllRTITISNLCSLASMF 75
Cdd:cd17353  221 MFFLNATAGLMLIGQAK--PIGQEFAGLDAGIAALAVSIlsifnGGGRPFWGWLSDKIGRK----NTLSIAFLIQGVAMF 294

                         90       100
                 ....*....|....*....|
gi 442619473  76 TVTFTGFFVMRFITCIFVAG 95
Cdd:cd17353  295 LLPFIGSVAVLFVLGVALIG 314
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 20-139 6.20e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 38.81  E-value: 6.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  20 DLRMNEAQLASLTAAGFM-GIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRFITCIFVAGPSF 98
Cdd:cd17374   28 DLVCESQSLKSVAQSIFMaGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISI 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 442619473  99 VAATYLSEFCS--HRIMVRSITHL-----YMFTGFAMISCPAWATLFL 139
Cdd:cd17374  108 NTLILGTEWTTprHRALAITLTSCffsigQMLLAGLAYAIRDWRLLQL 155
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 37-125 9.81e-03

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 38.22  E-value: 9.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619473  37 MGIICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRFITCIFVAGPSFvaATYLS--EFC--SHRI 112
Cdd:cd17445   47 LGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGVYL--TLYLTrlELCdpPQRL 124

                         90
                 ....*....|...
gi 442619473 113 MVRSITHLYMFTG 125
Cdd:cd17445  125 LVAMAGGLTMVGG 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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