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Conserved domains on  [gi|24648030|ref|NP_650742|]
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uncharacterized protein Dmel_CG7706 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FHA_Kanadaptin cd22677
forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also ...
 65-191 8.93e-55

forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also called human lung cancer oncogene 3 protein (HLC-3), kidney anion exchanger adapter protein, or solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP), is a nuclear protein widely expressed in mammalian tissues. It was originally isolated as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is a highly mobile nucleocytoplasmic shuttling and multilocalizing protein. Its role in mammalian cells remains unclear. It contains an FHA domain, which is a small phosphopeptide recognition module.


:

Pssm-ID: 438729 [Multi-domain]  Cd Length: 106  Bit Score: 183.14  E-value: 8.93e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  65 YSFEVLKSGQIIDTVHqLQQQAVWTFGRLPENDVPAAHPTISRFHVVLQYKPKAPpkpetakeddemeeedeepknDQPE 144
Cdd:cd22677   2 YSLEVLKNGVIVETLD-LNGKSFYVFGRLPGCDVVLEHPSISRYHAVLQYRGDAD---------------------DHDG 59

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 24648030 145 GWYIYDMGSTHGTFLNKQRVPPKVYIRMRVGHMLKLGGSTRVYILQG 191
Cdd:cd22677  60 GFYLYDLGSTHGTFLNKQRIPPKQYYRLRVGHVLKFGGSTRLYILQG 106
DSRM_Kanadaptin cd19856
double-stranded RNA binding motif of Kanadaptin and similar proteins; Kanadaptin (also known ...
 263-345 9.35e-40

double-stranded RNA binding motif of Kanadaptin and similar proteins; Kanadaptin (also known as human lung cancer oncogene 3 protein (HLC-3), kidney anion exchanger adapter protein, or solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP)) is a nuclear protein widely expressed in mammalian tissues. It was originally isolated as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is a highly mobile nucleocytoplasmic shuttling and multilocalizing protein. Its role in mammalian cells remains unclear. The double-stranded RNA binding motif (DSRM) is not sequence specific, but highly specific for dsRNAs of various origin and structure.


:

Pssm-ID: 380685  Cd Length: 86  Bit Score: 140.83  E-value: 9.35e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030 263 EELFFDDPKKTLRGFFEREGLNLEYKCDELSTGS---FVCRVELPLDDSNGRPIIVEVNHKGRKKDCVVQCALEACRTLD 339
Cdd:cd19856   1 EAFYLKDPKKALKGFFDREGEELEYEVEEQGSGRtrkYVCRIELPLDDASGGPIVAEASVSGKKKEAVVACALEACRILD 80


                ....*.
gi 24648030 340 RHGVLR 345
Cdd:cd19856  81 RHGLLR 86
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
 316-699 5.15e-07

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 53.51  E-value: 5.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030   316 EVNHKGRKKDCVVQcaleacrTLDRHGVLRQANQeaQKRKQLKNRDSDDEDEFWDRTGDvarkkQRKDNAGVSVTLTYED 395
Cdd:PTZ00108 1025 ELVITNAKKKDLVK-------ELKKLGYVRFKDI--IKKKSEKITAEEEEGAEEDDEAD-----DEDDEEELGAAVSYDY 1090

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030   396 LLKQEIdLNMEMEKVEQEISTYQQNEKKLKELAAKQQAegddldnfmDMLTKDVEQLDKTEIKKLRLEQQRIKGEQQKVE 475
Cdd:PTZ00108 1091 LLSMPI-WSLTKEKVEKLNAELEKKEKELEKLKNTTPK---------DMWLEDLDKFEEALEEQEEVEEKEIAKEQRLKS 1160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030   476 RLLKIAKPTALPFTTSLAAGSKESAAQEGGAAKKKQLPMIGKRNQFSKFKvvKASPSTQTMTQSNAFASDEEEVEEEEVK 555
Cdd:PTZ00108 1161 KTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLD--DKPDNKKSNSSGSDQEDDEEQKTKPKKS 1238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030   556 EKVKEKEAEVDNLEKEETEPESTTKPSTPENDSLKETKlPAQPEESKPTVAKTEVLKPENVRSTKVSTEAPPAP----SH 631
Cdd:PTZ00108 1239 SVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPK-RVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKkrleGS 1317

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24648030   632 TVASTNPDEDMSTPVEDSSAPAEDITARANDTSEPEEAQKKRRQRQRQRNKQRQDVDMDLDELAEHED 699
Cdd:PTZ00108 1318 LAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSEDEDDEDDE 1385
 
Name Accession Description Interval E-value
FHA_Kanadaptin cd22677
forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also ...
 65-191 8.93e-55

forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also called human lung cancer oncogene 3 protein (HLC-3), kidney anion exchanger adapter protein, or solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP), is a nuclear protein widely expressed in mammalian tissues. It was originally isolated as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is a highly mobile nucleocytoplasmic shuttling and multilocalizing protein. Its role in mammalian cells remains unclear. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438729 [Multi-domain]  Cd Length: 106  Bit Score: 183.14  E-value: 8.93e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  65 YSFEVLKSGQIIDTVHqLQQQAVWTFGRLPENDVPAAHPTISRFHVVLQYKPKAPpkpetakeddemeeedeepknDQPE 144
Cdd:cd22677   2 YSLEVLKNGVIVETLD-LNGKSFYVFGRLPGCDVVLEHPSISRYHAVLQYRGDAD---------------------DHDG 59

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 24648030 145 GWYIYDMGSTHGTFLNKQRVPPKVYIRMRVGHMLKLGGSTRVYILQG 191
Cdd:cd22677  60 GFYLYDLGSTHGTFLNKQRIPPKQYYRLRVGHVLKFGGSTRLYILQG 106
DSRM_Kanadaptin cd19856
double-stranded RNA binding motif of Kanadaptin and similar proteins; Kanadaptin (also known ...
 263-345 9.35e-40

double-stranded RNA binding motif of Kanadaptin and similar proteins; Kanadaptin (also known as human lung cancer oncogene 3 protein (HLC-3), kidney anion exchanger adapter protein, or solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP)) is a nuclear protein widely expressed in mammalian tissues. It was originally isolated as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is a highly mobile nucleocytoplasmic shuttling and multilocalizing protein. Its role in mammalian cells remains unclear. The double-stranded RNA binding motif (DSRM) is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380685  Cd Length: 86  Bit Score: 140.83  E-value: 9.35e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030 263 EELFFDDPKKTLRGFFEREGLNLEYKCDELSTGS---FVCRVELPLDDSNGRPIIVEVNHKGRKKDCVVQCALEACRTLD 339
Cdd:cd19856   1 EAFYLKDPKKALKGFFDREGEELEYEVEEQGSGRtrkYVCRIELPLDDASGGPIVAEASVSGKKKEAVVACALEACRILD 80


                ....*.
gi 24648030 340 RHGVLR 345
Cdd:cd19856  81 RHGLLR 86
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
69-190 1.23e-13

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 67.29  E-value: 1.23e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  69 VLKSGQIIDTVHQLQQqAVWTFGRLPENDVPAAHPTISRFHVVLQYkpkappkpetakeddemeeedeepkndQPEGWYI 148
Cdd:COG1716   5 VVLEGPLAGRRFPLDG-GPLTIGRAPDNDIVLDDPTVSRRHARIRR---------------------------DGGGWVL 56

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 24648030 149 YDMGSTHGTFLNKQRVPPKVYIrmRVGHMLKLGGSTRVYILQ 190
Cdd:COG1716  57 EDLGSTNGTFVNGQRVTEPAPL--RDGDVIRLGKTELRFRLS 96
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 88-180 2.45e-12

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 62.21  E-value: 2.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030    88 WTFGRLPENDVPAAHPTISRFHVVLQYkpkappkpetakeddemeeedeepknDQPEGWYIYDMGSTHGTFLNKQRVPPK 167
Cdd:pfam00498   1 VTIGRSPDCDIVLDDPSVSRRHAEIRY--------------------------DGGGRFYLEDLGSTNGTFVNGQRLGPE 54

                          90
                  ....*....|...
gi 24648030   168 vYIRMRVGHMLKL 180
Cdd:pfam00498  55 -PVRLKDGDVIRL 66
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 88-164 1.49e-07

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 48.33  E-value: 1.49e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24648030     88 WTFGRLPE-NDVPAAHPTISRFHVVLQYkpkappkpetakeddemeeedeepknDQPEGWYIYDMGSTHGTFLNKQRV 164
Cdd:smart00240   1 VTIGRSSEdCDIQLDGPSISRRHAVIVY--------------------------DGGGRFYLIDLGSTNGTFVNGKRI 52
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 316-699 5.15e-07

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 53.51  E-value: 5.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030   316 EVNHKGRKKDCVVQcaleacrTLDRHGVLRQANQeaQKRKQLKNRDSDDEDEFWDRTGDvarkkQRKDNAGVSVTLTYED 395
Cdd:PTZ00108 1025 ELVITNAKKKDLVK-------ELKKLGYVRFKDI--IKKKSEKITAEEEEGAEEDDEAD-----DEDDEEELGAAVSYDY 1090

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030   396 LLKQEIdLNMEMEKVEQEISTYQQNEKKLKELAAKQQAegddldnfmDMLTKDVEQLDKTEIKKLRLEQQRIKGEQQKVE 475
Cdd:PTZ00108 1091 LLSMPI-WSLTKEKVEKLNAELEKKEKELEKLKNTTPK---------DMWLEDLDKFEEALEEQEEVEEKEIAKEQRLKS 1160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030   476 RLLKIAKPTALPFTTSLAAGSKESAAQEGGAAKKKQLPMIGKRNQFSKFKvvKASPSTQTMTQSNAFASDEEEVEEEEVK 555
Cdd:PTZ00108 1161 KTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLD--DKPDNKKSNSSGSDQEDDEEQKTKPKKS 1238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030   556 EKVKEKEAEVDNLEKEETEPESTTKPSTPENDSLKETKlPAQPEESKPTVAKTEVLKPENVRSTKVSTEAPPAP----SH 631
Cdd:PTZ00108 1239 SVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPK-RVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKkrleGS 1317

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24648030   632 TVASTNPDEDMSTPVEDSSAPAEDITARANDTSEPEEAQKKRRQRQRQRNKQRQDVDMDLDELAEHED 699
Cdd:PTZ00108 1318 LAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSEDEDDEDDE 1385
 
Name Accession Description Interval E-value
FHA_Kanadaptin cd22677
forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also ...
 65-191 8.93e-55

forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also called human lung cancer oncogene 3 protein (HLC-3), kidney anion exchanger adapter protein, or solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP), is a nuclear protein widely expressed in mammalian tissues. It was originally isolated as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is a highly mobile nucleocytoplasmic shuttling and multilocalizing protein. Its role in mammalian cells remains unclear. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438729 [Multi-domain]  Cd Length: 106  Bit Score: 183.14  E-value: 8.93e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  65 YSFEVLKSGQIIDTVHqLQQQAVWTFGRLPENDVPAAHPTISRFHVVLQYKPKAPpkpetakeddemeeedeepknDQPE 144
Cdd:cd22677   2 YSLEVLKNGVIVETLD-LNGKSFYVFGRLPGCDVVLEHPSISRYHAVLQYRGDAD---------------------DHDG 59

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 24648030 145 GWYIYDMGSTHGTFLNKQRVPPKVYIRMRVGHMLKLGGSTRVYILQG 191
Cdd:cd22677  60 GFYLYDLGSTHGTFLNKQRIPPKQYYRLRVGHVLKFGGSTRLYILQG 106
DSRM_Kanadaptin cd19856
double-stranded RNA binding motif of Kanadaptin and similar proteins; Kanadaptin (also known ...
 263-345 9.35e-40

double-stranded RNA binding motif of Kanadaptin and similar proteins; Kanadaptin (also known as human lung cancer oncogene 3 protein (HLC-3), kidney anion exchanger adapter protein, or solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP)) is a nuclear protein widely expressed in mammalian tissues. It was originally isolated as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is a highly mobile nucleocytoplasmic shuttling and multilocalizing protein. Its role in mammalian cells remains unclear. The double-stranded RNA binding motif (DSRM) is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380685  Cd Length: 86  Bit Score: 140.83  E-value: 9.35e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030 263 EELFFDDPKKTLRGFFEREGLNLEYKCDELSTGS---FVCRVELPLDDSNGRPIIVEVNHKGRKKDCVVQCALEACRTLD 339
Cdd:cd19856   1 EAFYLKDPKKALKGFFDREGEELEYEVEEQGSGRtrkYVCRIELPLDDASGGPIVAEASVSGKKKEAVVACALEACRILD 80


                ....*.
gi 24648030 340 RHGVLR 345
Cdd:cd19856  81 RHGLLR 86
FHA_SNIP1_DDL-like cd22676
forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA ...
 65-190 1.68e-24

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA domain-containing protein DDL, and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This family also includes Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins. DDL, also called protein DAWDLE, is involved in the microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438728 [Multi-domain]  Cd Length: 111  Bit Score: 98.52  E-value: 1.68e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  65 YSFEVLKSGQIIDTVHqLQQQAVWTFGRLPEN-DVPAAHPTISRFHVVLQYKPKAPPKPETAKeddemeeedeepKNDQP 143
Cdd:cd22676   1 WRLYVFKGGEQLETID-IHRQSAYLIGRDRRVaDIPLDHPSCSKQHAVIQFREVEKRNEGDVI------------ENIRP 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 24648030 144 egwYIYDMGSTHGTFLNKQRVPPKVYIRMRVGHMLKLGGSTRVYILQ 190
Cdd:cd22676  68 ---YIIDLGSTNGTFLNGEKIEPRRYYELREKDVLKFGLSTREYVLL 111
FHA_PPP1R8 cd22674
forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 ...
 65-191 3.78e-20

forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 (PPP1R8) and similar proteins; PPP1R8, also called nuclear inhibitor of protein phosphatase 1 (NIPP-1), is an inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. It may also be involved in pre-mRNA splicing and binds DNA and might act as a transcriptional repressor. PPP1R8 seems to be required for cell proliferation. PPP1R8 contains an FHA domain that mediates interactions with threonine-phosphorylated maternal embryonic leucine zipper kinase (MELK). The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438726 [Multi-domain]  Cd Length: 108  Bit Score: 86.17  E-value: 3.78e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  65 YSFEVLKSGQIIDTVHqLQQQAVWTFGRLPE-NDVPAAHPTISRFHVVLQYKPKAppkpetakeddemeeedeepkndqp 143
Cdd:cd22674   7 LHLDVVKDGKLIEKLM-IDEKKYYLFGRNSDvCDFVLDHPSCSRVHAALVYHKHL------------------------- 60

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 24648030 144 EGWYIYDMGSTHGTFLNKQRVPPKVYIRMRVGHMLKLGGSTRVYILQG 191
Cdd:cd22674  61 NRVFLIDLGSTHGTFVGGIRLEPHKPQQLPIDSTLRFGASTRRYILRE 108
FHA_PS1-like cd22691
forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) ...
 64-191 1.27e-15

forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) and similar proteins; PS1 is an FHA domain-containing protein required for normal spindle orientation at male meiosis II and normal formation of tetrad of microspores. It is not involved in female meiosis. Mutations in PS1 lead to the production of diploid pollen grains. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438743 [Multi-domain]  Cd Length: 113  Bit Score: 73.22  E-value: 1.27e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  64 IYSFEVLKSGQIIDTV--HQLQQQA----VWTFGRLPENDVPAAHPTISRFHVVLQYKPKAppkpetakeddemeeedee 137
Cdd:cd22691   1 IPVLTVLKNGSVLKNIflHGKFSKSeeedILVVGRHPDCDIVLDHPSISRFHLEIRIIPSR------------------- 61

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 24648030 138 pkndqpEGWYIYDMGSTHGTFLNKQRVPPKVYIRMRVGHMLKLGGSTRVYILQG 191
Cdd:cd22691  62 ------RKITLTDLSSVHGTWVNGQRIEPGVPVELEEGDTVRLGASTRVYRLHW 109
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 84-184 3.25e-15

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 71.54  E-value: 3.25e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  84 QQAVWTFGRLPENDVPAAHPTISRFHVVLQYKPKappkpetakeddemeeedeepkndqpeGWYIYDMGSTHGTFLNKQR 163
Cdd:cd00060  17 TKGVVTIGRSPDCDIVLDDPSVSRRHARIEVDGG---------------------------GVYLEDLGSTNGTFVNGKR 69

                        90       100
                ....*....|....*....|.
gi 24648030 164 VPPKVYIrmRVGHMLKLGGST 184
Cdd:cd00060  70 ITPPVPL--QDGDVIRLGDTT 88
FHA_SNIP1 cd22718
forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and ...
 52-189 2.57e-14

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex, which associates with both the 3'end of the CCND1 gene and its mRNA. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438770  Cd Length: 149  Bit Score: 70.89  E-value: 2.57e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  52 VPKWSAPPAENQ------IYSFevlKSGQIIDTVHqLQQQAVWTFGRLPE-NDVPAAHPTISRFHVVLQYKPKAPPKPET 124
Cdd:cd22718  20 VIKYSEPPEARKpkkrwrLYPF---KGDEALPVLY-IHRQSAYLLGRDRKiADIPIDHPSCSKQHAVLQYRLVEYTRPDG 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24648030 125 AKEddemeeedeepKNDQPegwYIYDMGSTHGTFLNKQRVPPKVYIRMRVGHMLKLGGSTRVYIL 189
Cdd:cd22718  96 TKG-----------RRVRP---YIIDLESANGTFLNNKKIEPQRYYELKEKDVLKFGFSSREYVL 146
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
69-190 1.23e-13

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 67.29  E-value: 1.23e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  69 VLKSGQIIDTVHQLQQqAVWTFGRLPENDVPAAHPTISRFHVVLQYkpkappkpetakeddemeeedeepkndQPEGWYI 148
Cdd:COG1716   5 VVLEGPLAGRRFPLDG-GPLTIGRAPDNDIVLDDPTVSRRHARIRR---------------------------DGGGWVL 56

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 24648030 149 YDMGSTHGTFLNKQRVPPKVYIrmRVGHMLKLGGSTRVYILQ 190
Cdd:COG1716  57 EDLGSTNGTFVNGQRVTEPAPL--RDGDVIRLGKTELRFRLS 96
FHA_DDL-like cd22719
forkhead associated (FHA) domain found in Arabidopsis thaliana FHA domain-containing protein ...
 69-189 2.44e-12

forkhead associated (FHA) domain found in Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins; DDL, also called protein DAWDLE, is involved in microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438771 [Multi-domain]  Cd Length: 130  Bit Score: 64.43  E-value: 2.44e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  69 VLKSGQIIDTVHQLQQQAVWTFGR-LPENDVPAAHPTISRFHVVLQYKPKAPPKPETAKEddemeeedeepKNDQPegwY 147
Cdd:cd22719  20 VFKDGEPLNEPLHIHRQSCYLFGReRKVADIPTDHPSCSKQHAVIQYRLTEKEGGDGMMG-----------KAVRP---Y 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 24648030 148 IYDMGSTHGTFLNKQRVPPKVYIRMRVGHMLKLGGSTRVYIL 189
Cdd:cd22719  86 IMDLGSTNGTFLNGERIEPQRYYELLEKDTIKFGNSSREYVL 127
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 88-180 2.45e-12

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 62.21  E-value: 2.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030    88 WTFGRLPENDVPAAHPTISRFHVVLQYkpkappkpetakeddemeeedeepknDQPEGWYIYDMGSTHGTFLNKQRVPPK 167
Cdd:pfam00498   1 VTIGRSPDCDIVLDDPSVSRRHAEIRY--------------------------DGGGRFYLEDLGSTNGTFVNGQRLGPE 54

                          90
                  ....*....|...
gi 24648030   168 vYIRMRVGHMLKL 180
Cdd:pfam00498  55 -PVRLKDGDVIRL 66
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 88-164 1.49e-07

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 48.33  E-value: 1.49e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24648030     88 WTFGRLPE-NDVPAAHPTISRFHVVLQYkpkappkpetakeddemeeedeepknDQPEGWYIYDMGSTHGTFLNKQRV 164
Cdd:smart00240   1 VTIGRSSEdCDIQLDGPSISRRHAVIVY--------------------------DGGGRFYLIDLGSTNGTFVNGKRI 52
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 316-699 5.15e-07

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 53.51  E-value: 5.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030   316 EVNHKGRKKDCVVQcaleacrTLDRHGVLRQANQeaQKRKQLKNRDSDDEDEFWDRTGDvarkkQRKDNAGVSVTLTYED 395
Cdd:PTZ00108 1025 ELVITNAKKKDLVK-------ELKKLGYVRFKDI--IKKKSEKITAEEEEGAEEDDEAD-----DEDDEEELGAAVSYDY 1090

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030   396 LLKQEIdLNMEMEKVEQEISTYQQNEKKLKELAAKQQAegddldnfmDMLTKDVEQLDKTEIKKLRLEQQRIKGEQQKVE 475
Cdd:PTZ00108 1091 LLSMPI-WSLTKEKVEKLNAELEKKEKELEKLKNTTPK---------DMWLEDLDKFEEALEEQEEVEEKEIAKEQRLKS 1160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030   476 RLLKIAKPTALPFTTSLAAGSKESAAQEGGAAKKKQLPMIGKRNQFSKFKvvKASPSTQTMTQSNAFASDEEEVEEEEVK 555
Cdd:PTZ00108 1161 KTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLD--DKPDNKKSNSSGSDQEDDEEQKTKPKKS 1238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030   556 EKVKEKEAEVDNLEKEETEPESTTKPSTPENDSLKETKlPAQPEESKPTVAKTEVLKPENVRSTKVSTEAPPAP----SH 631
Cdd:PTZ00108 1239 SVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPK-RVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKkrleGS 1317

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24648030   632 TVASTNPDEDMSTPVEDSSAPAEDITARANDTSEPEEAQKKRRQRQRQRNKQRQDVDMDLDELAEHED 699
Cdd:PTZ00108 1318 LAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSEDEDDEDDE 1385
FHA_Par42-like cd22675
forkhead associated (FHA) domain found in Trypanosoma brucei Parvulin 42 (TbPar42) and similar ...
 82-192 4.91e-06

forkhead associated (FHA) domain found in Trypanosoma brucei Parvulin 42 (TbPar42) and similar proteins; TbPar42 is a nuclear protein that plays a key role in parasite cell proliferation. It exhibits an N-terminal forkhead associated (FHA)-domain and a peptidyl-prolyl-cis/trans-isomerase (PPIase) domain, both connected by a linker. Its PPIase domain adopts a parvulin fold and reflects structural elements of Pin1-type proteins but is catalytically inactive. Its FHA domain may be involved in the binding of phosphorylated target proteins. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438727 [Multi-domain]  Cd Length: 113  Bit Score: 46.01  E-value: 4.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  82 LQQQAVWTFGRLPENDVPAAHPTISRFHVVLQYkpkappkpetakeddemeeedeepkNDQPEGWYIYDMGSTHGTFLNK 161
Cdd:cd22675  25 LDRFPFYLFGRSPVCDYVLEHPSISSVHAVLVF-------------------------HGEQKCFVLMDLGSTNGVKLNG 79

                        90       100       110
                ....*....|....*....|....*....|..
gi 24648030 162 QRVPPKVYIRMRVGHMLKLGGSTRVYILQ-GP 192
Cdd:cd22675  80 KRIEKGRPLPLPVGSVIQFGFSARKYKVRkGP 111
FHA_Cep170 cd22704
forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) ...
 147-190 1.13e-05

forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) family; The Cep170 family includes Cep170 and Cep170B. Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438756 [Multi-domain]  Cd Length: 102  Bit Score: 44.62  E-value: 1.13e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 24648030 147 YIYDMGSTHGTFLNKQRVPPKVYIRMRVGHMLKLGGSTRVYILQ 190
Cdd:cd22704  52 KIKDLGSLNGTFVNDSRIPEQTYITLKLGDSIRFGYDTNVYRFE 95
FHA_ArnA-like cd22680
forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing ...
 65-188 3.00e-05

forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing protein ArnA and similar proteins; ArnA is an FHA domain-containing protein from Sulfolobus acidocaldarius that was shown to strongly interact with ArnB, a von Willebrand domain-containing protein. They act synergistically and negatively to modulate motility. ArnA is involved in regulating archaella expression in S. acidocaldarius. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438732 [Multi-domain]  Cd Length: 96  Bit Score: 43.10  E-value: 3.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  65 YSFEVLKSGQIIDTVHQLQQQAVwTFGRLPENDVPAAHPTISRFHVVLQYKPKappkpetakeddemeeedeepkndqpe 144
Cdd:cd22680   1 LVLEILSSPNLTGKKFPFDFSSV-SIGRDPENVIVIPDPFVSRNHARITVDSN--------------------------- 52

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 24648030 145 GWYIYDMGSTHGTFLN-KQRVPPKvyirMRVGH--MLKLGGSTRVYI 188
Cdd:cd22680  53 EIYIEDLGSTNGTFVNdFKRIKGP----AKLHPndIIKLGRTTVLKV 95
FHA_Cep170B cd22725
forkhead associated (FHA) domain found in centrosomal protein of 170 kDa protein B (Cep170B) ...
 141-190 6.79e-05

forkhead associated (FHA) domain found in centrosomal protein of 170 kDa protein B (Cep170B) and similar proteins; Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438777 [Multi-domain]  Cd Length: 106  Bit Score: 42.61  E-value: 6.79e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 24648030 141 DQPEGWyIYDMGSTHGTFLNKQRVPPKVYIRMRVGHMLKLGGSTRVYILQ 190
Cdd:cd22725  51 DTDEHW-VKDLGSLNGTFVNDVRIPDQKYITLKLNDVIRFGYDSNMYVLE 99
FHA_DMA-like cd22692
forkhead associated (FHA) domain found in Saccharomyces cerevisiae defective in mitotic arrest ...
 146-185 2.59e-04

forkhead associated (FHA) domain found in Saccharomyces cerevisiae defective in mitotic arrest protein 1 (DMA1), 2 (DMA2) and similar proteins; DMA1 (also known as checkpoint forkhead associated with RING domains-containing protein 1, or CHF1) and DMA2 (also known as checkpoint forkhead associated with RING domains-containing protein 2, or CHF2) are E3 ubiquitin-protein ligases which function in cell cycle retarding in conjunction with the UBC4 and UBC13/MMS2 complex, two E2 ubiquitin conjugating enzymes. They are involved in nutritional control of the cell cycle and required for proper spindle positioning, likely regulating septin ring deposition at the bud neck. DMA1 targets the degradation of G1 cyclin PCL1. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438744 [Multi-domain]  Cd Length: 139  Bit Score: 41.78  E-value: 2.59e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 24648030 146 WYIYDMGSTHGTFLNKQRVPP-----KVYiRMRVGHMLKLGGSTR 185
Cdd:cd22692  77 WYIKDVKSSSGTFLNHQRLSPasrtsKPY-PLRDGDILQLGMDYR 120
FHA_Cep170A cd22724
forkhead associated (FHA) domain found in centrosomal protein of 170 kDa (Cep170) and similar ...
 148-191 4.68e-04

forkhead associated (FHA) domain found in centrosomal protein of 170 kDa (Cep170) and similar proteins; Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438776 [Multi-domain]  Cd Length: 106  Bit Score: 40.34  E-value: 4.68e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 24648030 148 IYDMGSTHGTFLNKQRVPPKVYIRMRVGHMLKLGGSTRVY-ILQG 191
Cdd:cd22724  57 VKDLGSLNGTFVNDVRIPEQTYITLKLDDKLRFGYDTNLFtVVRG 101
FHA_PML1-like cd22681
forkhead associated (FHA) domain found in Saccharomyces cerevisiae pre-mRNA leakage protein 1 ...
 58-189 1.11e-03

forkhead associated (FHA) domain found in Saccharomyces cerevisiae pre-mRNA leakage protein 1 (PML1) and similar proteins; PML1 is an FHA domain-containing protein required for efficient splicing and pre-mRNA nuclear retention. It is a component of the pre-mRNA retention and splicing (RES) complex composed of at least BUD13, IST3, and PML1. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438733 [Multi-domain]  Cd Length: 129  Bit Score: 39.73  E-value: 1.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  58 PPAENQIYSFEVLK--SGQIIDTvHQLQQQAVWTFGRLPEN-------DVPAAHPTISRFHVVLQY-KPKAPPKPetake 127
Cdd:cd22681  11 PERDRTLYKLVIYRnnSKGPIEE-YELNSPSCYLIGREKGEsteivvaDIGIPEETCSKQHCVIQFrNVKGILKP----- 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24648030 128 ddemeeedeepkndqpegwYIYDMGSTHGTFLNKQRVPPKVYIRMRVGHMLKLGGSTRVYIL 189
Cdd:cd22681  85 -------------------YIMDLDSSNGTCLNDNVIPSSRYVELRSGDVITFSKSNDYELV 127
FHA_FhaB-like cd22693
forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing ...
 89-183 1.26e-03

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaB and similar proteins; FhaB, also called FtsZ-interacting protein A (FipA), is a putative virulence factor involved in regulating cell shape. It can interact with polyketide-associated protein PapA5, a putative membrane protein involved in the biosynthesis of virulence enhancing lipids. FhaB regulates growth and cell division. It is probably required for divisomal protein assembly under oxidative stress. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438745 [Multi-domain]  Cd Length: 91  Bit Score: 38.44  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  89 TFGRLPENDVPAAHPTISRFHVVLQYKPKAppkpetakeddemeeedeepkndqpegWYIYDMGSTHGTFLNKQRVPPKV 168
Cdd:cd22693  21 TIGRADDNDLVLSDDFVSSRHARIYLQGSS---------------------------WYLEDLGSTNGTFVNGNRVTQPV 73

                        90
                ....*....|....*
gi 24648030 169 yiRMRVGHMLKLGGS 183
Cdd:cd22693  74 --VVQPGDTIRIGAT 86
FHA_DgcB-like cd22682
forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB ...
 91-181 1.27e-03

forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB and similar proteins; DgcB is a GGDEF enzyme that produces cyclic-di-GMP in response to an unknown stimulus. It appends the C-terminal GGDEF enzymatic domain with an N-terminal forkhead-associated (FHA) domain that acts as a consensus phosphopeptide sensor. The GGDEF and sensory FHA domains form an asymmetrical dimer.


Pssm-ID: 438734 [Multi-domain]  Cd Length: 96  Bit Score: 38.66  E-value: 1.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  91 GRLPENDVPAAHPTISRFHVVLQYKPKAPPkpetakeddemeeedeepkndqpegwyIYDMGSTHGTFLNKQRVPPKVYI 170
Cdd:cd22682  25 GRSVESQVQIDDDSVSRYHAKLAVNPSAVS---------------------------IIDLGSTNGTIVNGKKIPKLASC 77

                        90
                ....*....|.
gi 24648030 171 RMRVGHMLKLG 181
Cdd:cd22682  78 DLQNGDQIKIG 88
FHA_FHAD1 cd22700
forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 ...
 69-190 1.34e-03

forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 (FHAD1) and similar proteins; FHAD1, also called FHA domain-containing protein 1, is an uncharacterized FHA domain-containing protein. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438752 [Multi-domain]  Cd Length: 96  Bit Score: 38.39  E-value: 1.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  69 VLKSGqiiDTVHQLQQQaVWTFGRlPENDVPAAHPTISRFHVVLQYkpkappkpetakeddemeeedeepkNDQPEGWYI 148
Cdd:cd22700   3 YLKSS---DGIFQLDPK-VTTIGR-EGCDLVLQSPGVEEQHAVIEY-------------------------SEQENCFVL 52

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 24648030 149 YDMGSTHGTFLNKQRVpPKVYIRMRVGHMLKLGGSTRVYILQ 190
Cdd:cd22700  53 QDLNTAQGTYVNDCRI-QNAAVRLAPGDVLRFGFGGLPYELV 93
FHA_RAD53-like_rpt2 cd22690
second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine ...
 69-166 1.58e-03

second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the second one. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438742 [Multi-domain]  Cd Length: 105  Bit Score: 38.43  E-value: 1.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  69 VLKSgqiIDTVHQ--LQQQAVWTFGRLPENDVPAAHPTISRFHVVLQYKPKAPPKPETakeddemeeedeepkndqpegw 146
Cdd:cd22690   3 RLKS---LNPSYPdiELTQNTTFIGRSKDCDEEITDPRISKHHCIITRKRSGKGLDDV---------------------- 57

                        90       100
                ....*....|....*....|
gi 24648030 147 YIYDMgSTHGTFLNKQRVPP 166
Cdd:cd22690  58 YVTDT-STNGTFINNNRLGK 76
FHA_MDC1 cd22665
forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) ...
 91-181 3.51e-03

forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also called nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438717 [Multi-domain]  Cd Length: 97  Bit Score: 37.21  E-value: 3.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648030  91 GRLPENDVPAAHPTISRFHVVLQYkpkappkpetakeddemeeedeepkndQPEGWYIYDMGSTHGTFLN-KQRVPPKVY 169
Cdd:cd22665  26 GRDPSCSVVLPDKSVSKQHACIEV---------------------------DGGTHLIEDLGSTNGTRIGnKVRLKPNVR 78

                        90
                ....*....|..
gi 24648030 170 IRMRVGHMLKLG 181
Cdd:cd22665  79 YELIDGDLLLFG 90
FHA_PP2C70-like cd22678
forkhead associated (FHA) domain found in Arabidopsis thaliana protein phosphatase 2C 70 ...
 146-188 4.25e-03

forkhead associated (FHA) domain found in Arabidopsis thaliana protein phosphatase 2C 70 (AtPP2C70) and similar proteins; AtPP2C70, also called kinase-associated protein phosphatase, or protein ROOT ATTENUATED GROWTH 1, dephosphorylates the serine/threonine receptor-like kinase RLK5. It may function as a signaling component in a pathway involving RLK5. It acts as a negative regulator of the CLAVATA1 signaling in plant development by binding and dephosphorylating CLAVATA1. It is also a component of a signaling pathway which mediates adaptation to NaCl stress. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438730 [Multi-domain]  Cd Length: 102  Bit Score: 37.34  E-value: 4.25e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 24648030 146 WYIYDMGSTHGTFLNKQR-VPPKVYIRMRVGHMLKLGGSTRVYI 188
Cdd:cd22678  58 WELVDLGSLNGTLVNGESiSPNGRPVVLSSGDVITLGSETKILV 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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