Tim44 domain-containing protein similar to mitochondrial 39S ribosomal protein L45 and to mitochondrial import inner membrane translocase subunit Tim44, an essential component of the eukaryotic PAM complex which is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner
mitochondrial import inner membrane, translocase subunit; The mitochondrial protein ...
78-449
8.91e-142
mitochondrial import inner membrane, translocase subunit; The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents.These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins. This family is specific for the Tim proteins. [Transport and binding proteins, Amino acids, peptides and amines]
The actual alignment was detected with superfamily member TIGR00984:
Pssm-ID: 130057 [Multi-domain] Cd Length: 378 Bit Score: 410.81 E-value: 8.91e-142
mitochondrial import inner membrane, translocase subunit; The mitochondrial protein ...
78-449
8.91e-142
mitochondrial import inner membrane, translocase subunit; The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents.These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins. This family is specific for the Tim proteins. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 130057 [Multi-domain] Cd Length: 378 Bit Score: 410.81 E-value: 8.91e-142
Tim44-like domain; Tim44 is an essential component of the machinery that mediates the ...
304-450
9.69e-46
Tim44-like domain; Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane. Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region. This family includes the C-terminal region of Tim44 that has been shown to form a stable proteolytic fragment in yeast. This region is also found in a set of smaller bacterial proteins. The molecular function of the bacterial members of this family is unknown but transport seems likely. The crystal structure of the C terminal of Tim44 has revealed a large hydrophobic pocket which might play an important role in interacting with the acyl chains of lipid molecules in the mitochondrial membrane.
Pssm-ID: 427835 Cd Length: 145 Bit Score: 155.85 E-value: 9.69e-46
Tim44 is an essential component of the machinery that mediates the translocation of ...
304-449
1.16e-39
Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region.
Pssm-ID: 214950 Cd Length: 147 Bit Score: 139.77 E-value: 1.16e-39
Tim44/TimA family putative adaptor protein; Members of this family resemble both the ...
301-447
3.43e-18
Tim44/TimA family putative adaptor protein; Members of this family resemble both the eukaryotic protein Tim44, important to the assembly of a protein translocase in mitochondria, and the TimA protein of alpha-proteobacteria such as Caulobacter crescentus. TimA may assist in protein recruitment to the membrane, as Tim44, but appears not to be part of any complex associated with protein translocation.
Pssm-ID: 468184 Cd Length: 215 Bit Score: 83.01 E-value: 3.43e-18
mitochondrial import inner membrane, translocase subunit; The mitochondrial protein ...
78-449
8.91e-142
mitochondrial import inner membrane, translocase subunit; The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents.These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins. This family is specific for the Tim proteins. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 130057 [Multi-domain] Cd Length: 378 Bit Score: 410.81 E-value: 8.91e-142
Tim44-like domain; Tim44 is an essential component of the machinery that mediates the ...
304-450
9.69e-46
Tim44-like domain; Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane. Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region. This family includes the C-terminal region of Tim44 that has been shown to form a stable proteolytic fragment in yeast. This region is also found in a set of smaller bacterial proteins. The molecular function of the bacterial members of this family is unknown but transport seems likely. The crystal structure of the C terminal of Tim44 has revealed a large hydrophobic pocket which might play an important role in interacting with the acyl chains of lipid molecules in the mitochondrial membrane.
Pssm-ID: 427835 Cd Length: 145 Bit Score: 155.85 E-value: 9.69e-46
Tim44 is an essential component of the machinery that mediates the translocation of ...
304-449
1.16e-39
Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region.
Pssm-ID: 214950 Cd Length: 147 Bit Score: 139.77 E-value: 1.16e-39
Tim44/TimA family putative adaptor protein; Members of this family resemble both the ...
301-447
3.43e-18
Tim44/TimA family putative adaptor protein; Members of this family resemble both the eukaryotic protein Tim44, important to the assembly of a protein translocase in mitochondria, and the TimA protein of alpha-proteobacteria such as Caulobacter crescentus. TimA may assist in protein recruitment to the membrane, as Tim44, but appears not to be part of any complex associated with protein translocation.
Pssm-ID: 468184 Cd Length: 215 Bit Score: 83.01 E-value: 3.43e-18
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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