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Conserved domains on  [gi|45550809|ref|NP_651220|]
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kallmann syndrome 1 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 94-139 4.11e-11

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


:

Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 57.82  E-value: 4.11e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 45550809    94 RAGSCPKIGrqsrARLSCLDNCQYDHECPEVQKCCPSSCGPMCVEP 139
Cdd:pfam00095   1 KPGCCPRLG----ARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
fn3 pfam00041
Fibronectin type III domain;
177-245 1.05e-05

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 1.05e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45550809   177 YFHVEVRShigrhfaARKLGPWQWQKVEKTmeenighsKHTYIFFHMRPGRWYEVRVAAVNAYGFRGYS 245
Cdd:pfam00041  32 GYEVEYRP-------KNSGEPWNEITVPGT--------TTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
225-342 9.58e-05

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.99  E-value: 9.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550809 225 PGRWYEVRVAAVNAYGFRgySEPSDPFPSTGNPKPPKSPNDSKIIGKQFDGrymtLKLVWCPSkSNLPVEKYKI------ 298
Cdd:COG3401 294 NGTTYYYRVTAVDAAGNE--SAPSNVVSVTTDLTPPAAPSGLTATAVGSSS----ITLSWTAS-SDADVTGYNVyrstsg 366

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 45550809 299 --TWSLYvnsakASMITNSSYVkDThqfeikELLPNSSYYIQVQAI 342
Cdd:COG3401 367 ggTYTKI-----AETVTTTSYT-DT------GLTPGTTYYYKVTAV 400
 
Name Accession Description Interval E-value
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 94-139 4.11e-11

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 57.82  E-value: 4.11e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 45550809    94 RAGSCPKIGrqsrARLSCLDNCQYDHECPEVQKCCPSSCGPMCVEP 139
Cdd:pfam00095   1 KPGCCPRLG----ARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
WAP smart00217
Four-disulfide core domains;
94-139 8.96e-09

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 51.22  E-value: 8.96e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 45550809     94 RAGSCPKIGRQSRARLSCLDNCQYDHECPEVQKCCPSSCGPMCVEP 139
Cdd:smart00217   1 KPGSCPWPTIASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTP 46
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 93-139 1.22e-08

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 51.30  E-value: 1.22e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 45550809  93 PRAGSCPKIGRQSRArlSCLDNCQYDHECPEVQKCCPSSCGPMCVEP 139
Cdd:cd00199  15 EKPGRCPMVNPPSLG--IPPNRCSSDSDCPGDKKCCENGCGKSCLTP 59
fn3 pfam00041
Fibronectin type III domain;
177-245 1.05e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 1.05e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45550809   177 YFHVEVRShigrhfaARKLGPWQWQKVEKTmeenighsKHTYIFFHMRPGRWYEVRVAAVNAYGFRGYS 245
Cdd:pfam00041  32 GYEVEYRP-------KNSGEPWNEITVPGT--------TTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 193-254 1.38e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 1.38e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45550809 193 RKLGPWQWQKVEKTMeenigHSKHTYIFFHMRPGRWYEVRVAAVNAYgfrGYSEPSDPFPST 254
Cdd:cd00063  39 REKGSGDWKEVEVTP-----GSETSYTLTGLKPGTEYEFRVRAVNGG---GESPPSESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
225-342 9.58e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.99  E-value: 9.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550809 225 PGRWYEVRVAAVNAYGFRgySEPSDPFPSTGNPKPPKSPNDSKIIGKQFDGrymtLKLVWCPSkSNLPVEKYKI------ 298
Cdd:COG3401 294 NGTTYYYRVTAVDAAGNE--SAPSNVVSVTTDLTPPAAPSGLTATAVGSSS----ITLSWTAS-SDADVTGYNVyrstsg 366

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 45550809 299 --TWSLYvnsakASMITNSSYVkDThqfeikELLPNSSYYIQVQAI 342
Cdd:COG3401 367 ggTYTKI-----AETVTTTSYT-DT------GLTPGTTYYYKVTAV 400
fn3 pfam00041
Fibronectin type III domain;
286-343 9.09e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.16  E-value: 9.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 45550809   286 PSKSNLPVEKYKITWSLYVNSAKASMITNSsyvKDTHQFEIKELLPNSSYYIQVQAIS 343
Cdd:pfam00041  23 PPDGNGPITGYEVEYRPKNSGEPWNEITVP---GTTTSVTLTGLKPGTEYEVRVQAVN 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 279-343 1.57e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.86  E-value: 1.57e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45550809 279 TLKLVWCPSKS-NLPVEKYKITWSLyVNSAKASMITNSsyVKDTHQFEIKELLPNSSYYIQVQAIS 343
Cdd:cd00063  16 SVTLSWTPPEDdGGPITGYVVEYRE-KGSGDWKEVEVT--PGSETSYTLTGLKPGTEYEFRVRAVN 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 199-240 5.16e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.05  E-value: 5.16e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 45550809    199 QWQKVEKTmeenigHSKHTYIFFHMRPGRWYEVRVAAVNAYG 240
Cdd:smart00060  46 EWKEVNVT------PSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 279-347 7.56e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 35.67  E-value: 7.56e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45550809    279 TLKLVWCPSKSNlPVEKYKITWSLYVNSAKASMITNSSYVKDTHqFEIKELLPNSSYYIQVQAISYLGS 347
Cdd:smart00060  16 SVTLSWEPPPDD-GITGYIVGYRVEYREEGSEWKEVNVTPSSTS-YTLTGLKPGTEYEFRVRAVNGAGE 82
 
Name Accession Description Interval E-value
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 94-139 4.11e-11

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 57.82  E-value: 4.11e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 45550809    94 RAGSCPKIGrqsrARLSCLDNCQYDHECPEVQKCCPSSCGPMCVEP 139
Cdd:pfam00095   1 KPGCCPRLG----ARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
WAP smart00217
Four-disulfide core domains;
94-139 8.96e-09

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 51.22  E-value: 8.96e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 45550809     94 RAGSCPKIGRQSRARLSCLDNCQYDHECPEVQKCCPSSCGPMCVEP 139
Cdd:smart00217   1 KPGSCPWPTIASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTP 46
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 93-139 1.22e-08

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 51.30  E-value: 1.22e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 45550809  93 PRAGSCPKIGRQSRArlSCLDNCQYDHECPEVQKCCPSSCGPMCVEP 139
Cdd:cd00199  15 EKPGRCPMVNPPSLG--IPPNRCSSDSDCPGDKKCCENGCGKSCLTP 59
fn3 pfam00041
Fibronectin type III domain;
177-245 1.05e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 1.05e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45550809   177 YFHVEVRShigrhfaARKLGPWQWQKVEKTmeenighsKHTYIFFHMRPGRWYEVRVAAVNAYGFRGYS 245
Cdd:pfam00041  32 GYEVEYRP-------KNSGEPWNEITVPGT--------TTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 193-254 1.38e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 1.38e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45550809 193 RKLGPWQWQKVEKTMeenigHSKHTYIFFHMRPGRWYEVRVAAVNAYgfrGYSEPSDPFPST 254
Cdd:cd00063  39 REKGSGDWKEVEVTP-----GSETSYTLTGLKPGTEYEFRVRAVNGG---GESPPSESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
225-342 9.58e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.99  E-value: 9.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550809 225 PGRWYEVRVAAVNAYGFRgySEPSDPFPSTGNPKPPKSPNDSKIIGKQFDGrymtLKLVWCPSkSNLPVEKYKI------ 298
Cdd:COG3401 294 NGTTYYYRVTAVDAAGNE--SAPSNVVSVTTDLTPPAAPSGLTATAVGSSS----ITLSWTAS-SDADVTGYNVyrstsg 366

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 45550809 299 --TWSLYvnsakASMITNSSYVkDThqfeikELLPNSSYYIQVQAI 342
Cdd:COG3401 367 ggTYTKI-----AETVTTTSYT-DT------GLTPGTTYYYKVTAV 400
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
225-381 3.10e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 43.45  E-value: 3.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550809 225 PGRWYEVRVAAVNAygfRGYSEPSDPFPSTGNPKPPKSPndSKIIGK-QFDGRymtLKLVWCPSkSNLPVEKYKITWSLy 303
Cdd:COG3401 201 PGTTYYYRVAATDT---GGESAPSNEVSVTTPTTPPSAP--TGLTATaDTPGS---VTLSWDPV-TESDATGYRVYRSN- 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550809 304 VNSAKASMI---TNSSYVkDThqfeikELLPNSSYYIQVQAISYLGSRRLKSEQWSMlfNTTLQPLEPITPLQCSGNGNR 380
Cdd:COG3401 271 SGDGPFTKVatvTTTSYT-DT------GLTNGTTYYYRVTAVDAAGNESAPSNVVSV--TTDLTPPAAPSGLTATAVGSS 341


                .
gi 45550809 381 R 381
Cdd:COG3401 342 S 342
fn3 pfam00041
Fibronectin type III domain;
286-343 9.09e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.16  E-value: 9.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 45550809   286 PSKSNLPVEKYKITWSLYVNSAKASMITNSsyvKDTHQFEIKELLPNSSYYIQVQAIS 343
Cdd:pfam00041  23 PPDGNGPITGYEVEYRPKNSGEPWNEITVP---GTTTSVTLTGLKPGTEYEVRVQAVN 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 279-343 1.57e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.86  E-value: 1.57e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45550809 279 TLKLVWCPSKS-NLPVEKYKITWSLyVNSAKASMITNSsyVKDTHQFEIKELLPNSSYYIQVQAIS 343
Cdd:cd00063  16 SVTLSWTPPEDdGGPITGYVVEYRE-KGSGDWKEVEVT--PGSETSYTLTGLKPGTEYEFRVRAVN 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 199-240 5.16e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.05  E-value: 5.16e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 45550809    199 QWQKVEKTmeenigHSKHTYIFFHMRPGRWYEVRVAAVNAYG 240
Cdd:smart00060  46 EWKEVNVT------PSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 279-347 7.56e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 35.67  E-value: 7.56e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45550809    279 TLKLVWCPSKSNlPVEKYKITWSLYVNSAKASMITNSSYVKDTHqFEIKELLPNSSYYIQVQAISYLGS 347
Cdd:smart00060  16 SVTLSWEPPPDD-GITGYIVGYRVEYREEGSEWKEVNVTPSSTS-YTLTGLKPGTEYEFRVRAVNGAGE 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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