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Conserved domains on  [gi|24650517|ref|NP_651532|]
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uncharacterized protein Dmel_CG14259 [Drosophila melanogaster]

Protein Classification

JHBP domain-containing protein( domain architecture ID 10653726)

JHBP (juvenile hormone-binding protein) domain-containing protein similar to Drosophila melanogaster circadian clock-controlled protein that is component of the circadian clock or downstream effector of clock function

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
JHBP smart00700
Juvenile hormone binding protein domains in insects; The juvenile hormone exerts pleiotropic ...
40-270 3.18e-74

Juvenile hormone binding protein domains in insects; The juvenile hormone exerts pleiotropic functions during insect life cycles and its binding proteins regulate these functions.


:

Pssm-ID: 214779  Cd Length: 224  Bit Score: 226.79  E-value: 3.18e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650517     40 SEKPAFLPSCRIYEPGftKCSTNSIQKLLDQLNIGIPEVleRFGPFDPMRVRDIVFKQDNnEVATIRANLTDLVVKGFAN 119
Cdd:smart00700   1 AEGPAFLKPCKLGDPS--ECLRDAIEALLPQLKNGIPEY--GIPPLDPLEIDDLKISIDS-GVIGLRLTFKNVKIYGLSN 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650517    120 TKVKESRVSKKDFSWQTKIYLPKMRLDGRYEMAGRILLIPLSGSGKIFIEIDDLDILLLTKIRLYEKgGFTFDNVTAVQV 199
Cdd:smart00700  76 FEITKFKMDLKDKKIELKIEFPKLNVKGDYKLDGRLLGLPLNGKGDANFTLENVKIRGTLKLKLGPD-GKTYLKIKSLKV 154
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24650517    200 QLNLSKVRTYLDNLFNGrSKEVERSTNEFFNENWRDFYEALKPLIVETVENILYDVMSTVFHLIPANFFVE 270
Cdd:smart00700 155 NFEVGDVKSHLDNLFNG-NKDLNDAINKFLNENWKALINELLPAIVEKLESIFLDLVNKVFAKVPIDEFFV 224
 
Name Accession Description Interval E-value
JHBP smart00700
Juvenile hormone binding protein domains in insects; The juvenile hormone exerts pleiotropic ...
40-270 3.18e-74

Juvenile hormone binding protein domains in insects; The juvenile hormone exerts pleiotropic functions during insect life cycles and its binding proteins regulate these functions.


Pssm-ID: 214779  Cd Length: 224  Bit Score: 226.79  E-value: 3.18e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650517     40 SEKPAFLPSCRIYEPGftKCSTNSIQKLLDQLNIGIPEVleRFGPFDPMRVRDIVFKQDNnEVATIRANLTDLVVKGFAN 119
Cdd:smart00700   1 AEGPAFLKPCKLGDPS--ECLRDAIEALLPQLKNGIPEY--GIPPLDPLEIDDLKISIDS-GVIGLRLTFKNVKIYGLSN 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650517    120 TKVKESRVSKKDFSWQTKIYLPKMRLDGRYEMAGRILLIPLSGSGKIFIEIDDLDILLLTKIRLYEKgGFTFDNVTAVQV 199
Cdd:smart00700  76 FEITKFKMDLKDKKIELKIEFPKLNVKGDYKLDGRLLGLPLNGKGDANFTLENVKIRGTLKLKLGPD-GKTYLKIKSLKV 154
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24650517    200 QLNLSKVRTYLDNLFNGrSKEVERSTNEFFNENWRDFYEALKPLIVETVENILYDVMSTVFHLIPANFFVE 270
Cdd:smart00700 155 NFEVGDVKSHLDNLFNG-NKDLNDAINKFLNENWKALINELLPAIVEKLESIFLDLVNKVFAKVPIDEFFV 224
JHBP pfam06585
Haemolymph juvenile hormone binding protein (JHBP); This family consists of several ...
32-269 2.71e-73

Haemolymph juvenile hormone binding protein (JHBP); This family consists of several insect-specific haemolymph juvenile hormone binding proteins (JHBP). Juvenile hormone regulates embryogenesis, maintains the status quo of larval development and stimulates reproductive maturation in the adult insect. JH is transported from the sites of its synthesis to target tissues by a haemolymph carrier called juvenile hormone-binding protein (JHBP). JHBP protects the JH molecules from hydrolysis by non-specific esterases present in the insect haemolymph. The crystal structure of the JHBP from Galleria mellonella shows an unusual fold consisting of a long alpha-helix wrapped in a much curved antiparallel beta-sheet. The folding pattern for this structure closely resembles that found in some tandem-repeat mammalian lipid-binding and bactericidal permeability-increasing proteins, with a similar organization of the major cavity and a disulfide bond linking the long helix and the beta-sheet. It would appear that JHBP forms two cavities, only one of which, the one near the N- and C-termini, binds the hormone; binding induces a conformational change, of unknown significance. This family now includes DUF233, pfam03027.


Pssm-ID: 461956  Cd Length: 239  Bit Score: 224.77  E-value: 2.71e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650517    32 LVSAVAYYSEKPAFLPSCRIYEPGFTKCSTNSIQKLLDQLNIGIPEVleRFGPFDPMRVRDIVFKQDNNEVaTIRANLTD 111
Cdd:pfam06585   5 LLAVAASAAELPSYIKKCKRSDPNLNKCLKEAIEALRPQLAKGIPEL--GIPPLDPLVIDELSIDQGSGPV-GLKLNLKN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650517   112 LVVKGFANTKVKESRVSKKDFSWQTKIYLPKMRLDGRYEMAGRILLIPLSGSGKIFIEIDDLDILLLTKIRLYEKGGFTF 191
Cdd:pfam06585  82 VKIYGLSNFTIKKVKVDLKDLKIEFDLLFPKLRLEGKYKADGRILLLPINGKGDFNITLENLKAKGTLKGEPVEKNGKTY 161
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24650517   192 DNVTAVQVQLNLSKVRTYLDNLFNGrSKEVERSTNEFFNENWRDFYEALKPLIVETVENILYDVMSTVFHLIPANFFV 269
Cdd:pfam06585 162 LKITDLKVKFKVGDVKFHLDNLFNG-NKELGDAINQFLNENWREVLNELKPAIEEALSEIFTDILNKIFSNVPYDELF 238
 
Name Accession Description Interval E-value
JHBP smart00700
Juvenile hormone binding protein domains in insects; The juvenile hormone exerts pleiotropic ...
40-270 3.18e-74

Juvenile hormone binding protein domains in insects; The juvenile hormone exerts pleiotropic functions during insect life cycles and its binding proteins regulate these functions.


Pssm-ID: 214779  Cd Length: 224  Bit Score: 226.79  E-value: 3.18e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650517     40 SEKPAFLPSCRIYEPGftKCSTNSIQKLLDQLNIGIPEVleRFGPFDPMRVRDIVFKQDNnEVATIRANLTDLVVKGFAN 119
Cdd:smart00700   1 AEGPAFLKPCKLGDPS--ECLRDAIEALLPQLKNGIPEY--GIPPLDPLEIDDLKISIDS-GVIGLRLTFKNVKIYGLSN 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650517    120 TKVKESRVSKKDFSWQTKIYLPKMRLDGRYEMAGRILLIPLSGSGKIFIEIDDLDILLLTKIRLYEKgGFTFDNVTAVQV 199
Cdd:smart00700  76 FEITKFKMDLKDKKIELKIEFPKLNVKGDYKLDGRLLGLPLNGKGDANFTLENVKIRGTLKLKLGPD-GKTYLKIKSLKV 154
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24650517    200 QLNLSKVRTYLDNLFNGrSKEVERSTNEFFNENWRDFYEALKPLIVETVENILYDVMSTVFHLIPANFFVE 270
Cdd:smart00700 155 NFEVGDVKSHLDNLFNG-NKDLNDAINKFLNENWKALINELLPAIVEKLESIFLDLVNKVFAKVPIDEFFV 224
JHBP pfam06585
Haemolymph juvenile hormone binding protein (JHBP); This family consists of several ...
32-269 2.71e-73

Haemolymph juvenile hormone binding protein (JHBP); This family consists of several insect-specific haemolymph juvenile hormone binding proteins (JHBP). Juvenile hormone regulates embryogenesis, maintains the status quo of larval development and stimulates reproductive maturation in the adult insect. JH is transported from the sites of its synthesis to target tissues by a haemolymph carrier called juvenile hormone-binding protein (JHBP). JHBP protects the JH molecules from hydrolysis by non-specific esterases present in the insect haemolymph. The crystal structure of the JHBP from Galleria mellonella shows an unusual fold consisting of a long alpha-helix wrapped in a much curved antiparallel beta-sheet. The folding pattern for this structure closely resembles that found in some tandem-repeat mammalian lipid-binding and bactericidal permeability-increasing proteins, with a similar organization of the major cavity and a disulfide bond linking the long helix and the beta-sheet. It would appear that JHBP forms two cavities, only one of which, the one near the N- and C-termini, binds the hormone; binding induces a conformational change, of unknown significance. This family now includes DUF233, pfam03027.


Pssm-ID: 461956  Cd Length: 239  Bit Score: 224.77  E-value: 2.71e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650517    32 LVSAVAYYSEKPAFLPSCRIYEPGFTKCSTNSIQKLLDQLNIGIPEVleRFGPFDPMRVRDIVFKQDNNEVaTIRANLTD 111
Cdd:pfam06585   5 LLAVAASAAELPSYIKKCKRSDPNLNKCLKEAIEALRPQLAKGIPEL--GIPPLDPLVIDELSIDQGSGPV-GLKLNLKN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650517   112 LVVKGFANTKVKESRVSKKDFSWQTKIYLPKMRLDGRYEMAGRILLIPLSGSGKIFIEIDDLDILLLTKIRLYEKGGFTF 191
Cdd:pfam06585  82 VKIYGLSNFTIKKVKVDLKDLKIEFDLLFPKLRLEGKYKADGRILLLPINGKGDFNITLENLKAKGTLKGEPVEKNGKTY 161
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24650517   192 DNVTAVQVQLNLSKVRTYLDNLFNGrSKEVERSTNEFFNENWRDFYEALKPLIVETVENILYDVMSTVFHLIPANFFV 269
Cdd:pfam06585 162 LKITDLKVKFKVGDVKFHLDNLFNG-NKELGDAINQFLNENWREVLNELKPAIEEALSEIFTDILNKIFSNVPYDELF 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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