NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24650935|ref|NP_651665|]
View 

cullin 5 [Drosophila melanogaster]

Protein Classification

cullin( domain architecture ID 12011724)

cullin is a core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Cullin pfam00888
Cullin family;
17-744 6.29e-170

Cullin family;


:

Pssm-ID: 459983 [Multi-domain]  Cd Length: 610  Bit Score: 505.56  E-value: 6.29e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935    17 WPDKRRIVLKLLRQDtVSQREWQDLFFGVHFVCLwdEKGAAKIYDCLQQDIVEFIVQAQSQVQAQR-GEQALLATYIVEW 95
Cdd:pfam00888   1 WAKLEDAIDEILNKN-VSSLSYEELYRAVYNLCL--HKQGEKLYDKLKEYLEEHLKKLVKPLIKEAsSGEEFLKAYVKEW 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935    96 RKFFTQSNYLPLPFRQLEQSpqvkpsssgssssasvsasgastsaaaaaaatscsgqagksgastsaaagastsaaaaaa 175
Cdd:pfam00888  78 EDHTISMKMIRDIFMYLDRV------------------------------------------------------------ 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   176 stsastssaaaaaaasgsgssssstsTSKKNPtedsPVRKLMLDSWNKHIFHD-IKHRLQESAMKIVHAERNGDAYDAQL 254
Cdd:pfam00888  98 --------------------------YVKRLP----SIYDLGLELFRDHVFRIpLKDKLIDALLDLIEKERNGEVIDRSL 147
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   255 VVGVRESYVNLSSNaEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSI 334
Cdd:pfam00888 148 IKSVIDMLVSLGED-EKKDNVYEEDFEPPFLEATEEYYRAESQELLAENVAPEYLKKAERRLEEEEERVRHYLHSSTKKK 226
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   335 LTYTLVNVLIVDHLNSIIA-ECPALIRDYETERLNLMFRLMDRVmhGVGVEPMMGDLQRHIMSAGLAdMLSASEVITQDS 413
Cdd:pfam00888 227 LLDVLEEVLISDHLEELLEeELQNLLDDNKTEDLKRLYRLLSRV--PDGLEPLRKAFEEYIKKEGKA-IVKDAKEQTTDA 303
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   414 EKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSvfkmelptsianrgvkytaPESKCPELLANYCDMLL 493
Cdd:pfam00888 304 KKYVEDLLELKDKFDKIVKDAFSNDELFVKALDEAFEEFINKNT-------------------SNSKSPELLAKYIDDLL 364
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   494 RRTplSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLR-EVGMpaDYVNRLAR 572
Cdd:pfam00888 365 KKG--LKGKSEEELEEKLDKVITLFRYIQDKDVFEAFYKKHLAKRLLLGKSASDDAERSMISKLKeECGS--EFTSKLEG 440
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   573 MFQDIKVSEDLNTQFRTSISRHDA------INIKILNAGAWARcSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYH 646
Cdd:pfam00888 441 MFKDMELSKDLMKEFKEHLSENKSskkgidLSVNVLTSGAWPT-YLTSDFILPPELEKAIERFEKFYLSKHSGRKLTWLH 519
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   647 HMSNGTITFV-NNFGRYDLDVTTFQMAVLFAWNQrQHDKISYENLRLATELPDPELRRTLWSLvAFPKIKkqILLMEPAA 725
Cdd:pfam00888 520 SLGTAELKATfPKGKKHELNVSTYQMAILLLFND-DGDSLSYEEIQEATGLPDEELKRTLQSL-ACAKAK--VLLKEPMS 595
                         730
                  ....*....|....*....
gi 24650935   726 isspKDFAENTMFYINQEF 744
Cdd:pfam00888 596 ----KDINPTDTFSFNEDF 610
Cullin_Nedd8 smart00884
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
779-846 3.16e-20

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


:

Pssm-ID: 214883 [Multi-domain]  Cd Length: 68  Bit Score: 84.90  E-value: 3.16e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24650935    779 IVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDIN 846
Cdd:smart00884   1 VEEDRKLEIQAAIVRIMKSRKTLSHSELVSEVIEQLKKRFKPSVSDIKKRIESLIEREYLERDEDDPN 68
 
Name Accession Description Interval E-value
Cullin pfam00888
Cullin family;
17-744 6.29e-170

Cullin family;


Pssm-ID: 459983 [Multi-domain]  Cd Length: 610  Bit Score: 505.56  E-value: 6.29e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935    17 WPDKRRIVLKLLRQDtVSQREWQDLFFGVHFVCLwdEKGAAKIYDCLQQDIVEFIVQAQSQVQAQR-GEQALLATYIVEW 95
Cdd:pfam00888   1 WAKLEDAIDEILNKN-VSSLSYEELYRAVYNLCL--HKQGEKLYDKLKEYLEEHLKKLVKPLIKEAsSGEEFLKAYVKEW 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935    96 RKFFTQSNYLPLPFRQLEQSpqvkpsssgssssasvsasgastsaaaaaaatscsgqagksgastsaaagastsaaaaaa 175
Cdd:pfam00888  78 EDHTISMKMIRDIFMYLDRV------------------------------------------------------------ 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   176 stsastssaaaaaaasgsgssssstsTSKKNPtedsPVRKLMLDSWNKHIFHD-IKHRLQESAMKIVHAERNGDAYDAQL 254
Cdd:pfam00888  98 --------------------------YVKRLP----SIYDLGLELFRDHVFRIpLKDKLIDALLDLIEKERNGEVIDRSL 147
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   255 VVGVRESYVNLSSNaEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSI 334
Cdd:pfam00888 148 IKSVIDMLVSLGED-EKKDNVYEEDFEPPFLEATEEYYRAESQELLAENVAPEYLKKAERRLEEEEERVRHYLHSSTKKK 226
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   335 LTYTLVNVLIVDHLNSIIA-ECPALIRDYETERLNLMFRLMDRVmhGVGVEPMMGDLQRHIMSAGLAdMLSASEVITQDS 413
Cdd:pfam00888 227 LLDVLEEVLISDHLEELLEeELQNLLDDNKTEDLKRLYRLLSRV--PDGLEPLRKAFEEYIKKEGKA-IVKDAKEQTTDA 303
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   414 EKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSvfkmelptsianrgvkytaPESKCPELLANYCDMLL 493
Cdd:pfam00888 304 KKYVEDLLELKDKFDKIVKDAFSNDELFVKALDEAFEEFINKNT-------------------SNSKSPELLAKYIDDLL 364
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   494 RRTplSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLR-EVGMpaDYVNRLAR 572
Cdd:pfam00888 365 KKG--LKGKSEEELEEKLDKVITLFRYIQDKDVFEAFYKKHLAKRLLLGKSASDDAERSMISKLKeECGS--EFTSKLEG 440
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   573 MFQDIKVSEDLNTQFRTSISRHDA------INIKILNAGAWARcSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYH 646
Cdd:pfam00888 441 MFKDMELSKDLMKEFKEHLSENKSskkgidLSVNVLTSGAWPT-YLTSDFILPPELEKAIERFEKFYLSKHSGRKLTWLH 519
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   647 HMSNGTITFV-NNFGRYDLDVTTFQMAVLFAWNQrQHDKISYENLRLATELPDPELRRTLWSLvAFPKIKkqILLMEPAA 725
Cdd:pfam00888 520 SLGTAELKATfPKGKKHELNVSTYQMAILLLFND-DGDSLSYEEIQEATGLPDEELKRTLQSL-ACAKAK--VLLKEPMS 595
                         730
                  ....*....|....*....
gi 24650935   726 isspKDFAENTMFYINQEF 744
Cdd:pfam00888 596 ----KDINPTDTFSFNEDF 610
COG5647 COG5647
Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, ...
204-852 9.76e-74

Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227934 [Multi-domain]  Cd Length: 773  Bit Score: 257.04  E-value: 9.76e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 204 KKNPTEDspVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNL---SSNAEDKLEIYRENF 280
Cdd:COG5647 145 DKTLVFE--VYSLCLVKEKIESFRLIVDSLINPLLYYVERYRALQSIDRKYIEDAKDMLESLerpSDYKKENLSYYKSVF 222
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 281 EMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIVDHLNSIIAECPALIR 360
Cdd:COG5647 223 EPIFLEETWEFYEMESSEVIELLSVTEYLEKAHKILEREEELVEIYLKVSTKKPLLEVLEDVLITRHLDDLEEQGSGFRE 302
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 361 ---DYETERLNLMFRLMDRVMHgvGVEPMMGDLQRHIMSAGLADMLSASEV--------ITQDSE----KYVERLLELFN 425
Cdd:COG5647 303 aldASNLEKLQVLYRLLSETKY--GVQPLQEVFERYVKDEGVLINIETNYIfhckvdvgFLGSREclpkLYVQKLLSCHD 380
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 426 KFSDLVRNAFNDDPRFLTARDIAFKTVVNdtsvfkmelptsianrgvKYTAPESKCPELLANYCDMLLRRTplSKRLTSE 505
Cdd:COG5647 381 LFPSLVNESFEGDGSIVKALGNAFKTFIN------------------GNESADSGPSEYLAKYIDGLLKKD--GKQSFIG 440
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 506 QIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLREV-GMpaDYVNRLARMFQDIKVSEDLN 584
Cdd:COG5647 441 KIKDLLQDIITLFRYVEEKDVFEKYYKKLLAKRLLNGRSASAQAELKMISMLKKVcGQ--EFTSKLEGMFRDISLSSEFT 518
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 585 TQFRTS-ISRHDAI--NIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNFGR 661
Cdd:COG5647 519 EAFQHSpQSYNKYLdlFVWVLTQAYWPLSPEEVSIRLPKELVPILEGFKKFYSSKHNGRKLKWYWHLGSGEVKARFNEGQ 598
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 662 YDLDVTTF---QMAVLFAWNqrQHDKISYENLRLATELPDPELRRTLWSLVAFpkikKQILLMEPAAISSPkdfaeNTMF 738
Cdd:COG5647 599 KYLEISTFsvyQLLVFLLFN--DHEELTFEEILELTKLSTDDLKRVLQSLSCA----KLVVLLKDDKLVSP-----NTKF 667
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 739 YINQEFAIVKngksqRRGKLNLIGRlqlSTERSQQEDNQ-SIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNM 817
Cdd:COG5647 668 YVNENFSSKL-----ERIKINYIAE---SECMQDNLDTHeTVEEDRQAELQACIVRIMKARKKLKHGDLVKEVIAQHKSR 739
                       650       660       670
                ....*....|....*....|....*....|....*
gi 24650935 818 FLPSKKMIKEQLEWLIENKYMRRDDDDiNMFIYVA 852
Cdd:COG5647 740 FEPKVSMVKRAIETLIEKEYLERQADD-EIYVYLA 773
CULLIN smart00182
Cullin;
520-655 1.76e-47

Cullin;


Pssm-ID: 214545 [Multi-domain]  Cd Length: 143  Bit Score: 165.57  E-value: 1.76e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935    520 YVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLR-EVGMpaDYVNRLARMFQDIKVSEDLNTQFRTSISR----- 593
Cdd:smart00182   1 YIQDKDVFEKYYKKHLAKRLILNRSASDDAEENMITKLKqECGY--EFTSKLERMFRDISLSKDLNQSFKDMLENnpsak 78
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24650935    594 -HDAINIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITF 655
Cdd:smart00182  79 pIIDLNVRVLTSGYWPTSSTEVEINLPQELEDALEEFEEFYLAKHSGRKLTWLHSLGRGEVKA 141
Cullin_Nedd8 smart00884
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
779-846 3.16e-20

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


Pssm-ID: 214883 [Multi-domain]  Cd Length: 68  Bit Score: 84.90  E-value: 3.16e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24650935    779 IVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDIN 846
Cdd:smart00884   1 VEEDRKLEIQAAIVRIMKSRKTLSHSELVSEVIEQLKKRFKPSVSDIKKRIESLIEREYLERDEDDPN 68
Cullin_Nedd8 pfam10557
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
783-844 4.62e-19

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognizes and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


Pssm-ID: 463146  Cd Length: 63  Bit Score: 81.73  E-value: 4.62e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24650935   783 RILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDD 844
Cdd:pfam10557   2 RKHEIQAAIVRIMKSRKTLSHNELVNEVIEQLKSRFKPSVSDIKKRIESLIEKEYLERDEDD 63
 
Name Accession Description Interval E-value
Cullin pfam00888
Cullin family;
17-744 6.29e-170

Cullin family;


Pssm-ID: 459983 [Multi-domain]  Cd Length: 610  Bit Score: 505.56  E-value: 6.29e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935    17 WPDKRRIVLKLLRQDtVSQREWQDLFFGVHFVCLwdEKGAAKIYDCLQQDIVEFIVQAQSQVQAQR-GEQALLATYIVEW 95
Cdd:pfam00888   1 WAKLEDAIDEILNKN-VSSLSYEELYRAVYNLCL--HKQGEKLYDKLKEYLEEHLKKLVKPLIKEAsSGEEFLKAYVKEW 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935    96 RKFFTQSNYLPLPFRQLEQSpqvkpsssgssssasvsasgastsaaaaaaatscsgqagksgastsaaagastsaaaaaa 175
Cdd:pfam00888  78 EDHTISMKMIRDIFMYLDRV------------------------------------------------------------ 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   176 stsastssaaaaaaasgsgssssstsTSKKNPtedsPVRKLMLDSWNKHIFHD-IKHRLQESAMKIVHAERNGDAYDAQL 254
Cdd:pfam00888  98 --------------------------YVKRLP----SIYDLGLELFRDHVFRIpLKDKLIDALLDLIEKERNGEVIDRSL 147
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   255 VVGVRESYVNLSSNaEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSI 334
Cdd:pfam00888 148 IKSVIDMLVSLGED-EKKDNVYEEDFEPPFLEATEEYYRAESQELLAENVAPEYLKKAERRLEEEEERVRHYLHSSTKKK 226
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   335 LTYTLVNVLIVDHLNSIIA-ECPALIRDYETERLNLMFRLMDRVmhGVGVEPMMGDLQRHIMSAGLAdMLSASEVITQDS 413
Cdd:pfam00888 227 LLDVLEEVLISDHLEELLEeELQNLLDDNKTEDLKRLYRLLSRV--PDGLEPLRKAFEEYIKKEGKA-IVKDAKEQTTDA 303
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   414 EKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSvfkmelptsianrgvkytaPESKCPELLANYCDMLL 493
Cdd:pfam00888 304 KKYVEDLLELKDKFDKIVKDAFSNDELFVKALDEAFEEFINKNT-------------------SNSKSPELLAKYIDDLL 364
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   494 RRTplSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLR-EVGMpaDYVNRLAR 572
Cdd:pfam00888 365 KKG--LKGKSEEELEEKLDKVITLFRYIQDKDVFEAFYKKHLAKRLLLGKSASDDAERSMISKLKeECGS--EFTSKLEG 440
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   573 MFQDIKVSEDLNTQFRTSISRHDA------INIKILNAGAWARcSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYH 646
Cdd:pfam00888 441 MFKDMELSKDLMKEFKEHLSENKSskkgidLSVNVLTSGAWPT-YLTSDFILPPELEKAIERFEKFYLSKHSGRKLTWLH 519
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935   647 HMSNGTITFV-NNFGRYDLDVTTFQMAVLFAWNQrQHDKISYENLRLATELPDPELRRTLWSLvAFPKIKkqILLMEPAA 725
Cdd:pfam00888 520 SLGTAELKATfPKGKKHELNVSTYQMAILLLFND-DGDSLSYEEIQEATGLPDEELKRTLQSL-ACAKAK--VLLKEPMS 595
                         730
                  ....*....|....*....
gi 24650935   726 isspKDFAENTMFYINQEF 744
Cdd:pfam00888 596 ----KDINPTDTFSFNEDF 610
COG5647 COG5647
Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, ...
204-852 9.76e-74

Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227934 [Multi-domain]  Cd Length: 773  Bit Score: 257.04  E-value: 9.76e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 204 KKNPTEDspVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNL---SSNAEDKLEIYRENF 280
Cdd:COG5647 145 DKTLVFE--VYSLCLVKEKIESFRLIVDSLINPLLYYVERYRALQSIDRKYIEDAKDMLESLerpSDYKKENLSYYKSVF 222
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 281 EMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIVDHLNSIIAECPALIR 360
Cdd:COG5647 223 EPIFLEETWEFYEMESSEVIELLSVTEYLEKAHKILEREEELVEIYLKVSTKKPLLEVLEDVLITRHLDDLEEQGSGFRE 302
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 361 ---DYETERLNLMFRLMDRVMHgvGVEPMMGDLQRHIMSAGLADMLSASEV--------ITQDSE----KYVERLLELFN 425
Cdd:COG5647 303 aldASNLEKLQVLYRLLSETKY--GVQPLQEVFERYVKDEGVLINIETNYIfhckvdvgFLGSREclpkLYVQKLLSCHD 380
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 426 KFSDLVRNAFNDDPRFLTARDIAFKTVVNdtsvfkmelptsianrgvKYTAPESKCPELLANYCDMLLRRTplSKRLTSE 505
Cdd:COG5647 381 LFPSLVNESFEGDGSIVKALGNAFKTFIN------------------GNESADSGPSEYLAKYIDGLLKKD--GKQSFIG 440
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 506 QIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLREV-GMpaDYVNRLARMFQDIKVSEDLN 584
Cdd:COG5647 441 KIKDLLQDIITLFRYVEEKDVFEKYYKKLLAKRLLNGRSASAQAELKMISMLKKVcGQ--EFTSKLEGMFRDISLSSEFT 518
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 585 TQFRTS-ISRHDAI--NIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNFGR 661
Cdd:COG5647 519 EAFQHSpQSYNKYLdlFVWVLTQAYWPLSPEEVSIRLPKELVPILEGFKKFYSSKHNGRKLKWYWHLGSGEVKARFNEGQ 598
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 662 YDLDVTTF---QMAVLFAWNqrQHDKISYENLRLATELPDPELRRTLWSLVAFpkikKQILLMEPAAISSPkdfaeNTMF 738
Cdd:COG5647 599 KYLEISTFsvyQLLVFLLFN--DHEELTFEEILELTKLSTDDLKRVLQSLSCA----KLVVLLKDDKLVSP-----NTKF 667
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935 739 YINQEFAIVKngksqRRGKLNLIGRlqlSTERSQQEDNQ-SIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNM 817
Cdd:COG5647 668 YVNENFSSKL-----ERIKINYIAE---SECMQDNLDTHeTVEEDRQAELQACIVRIMKARKKLKHGDLVKEVIAQHKSR 739
                       650       660       670
                ....*....|....*....|....*....|....*
gi 24650935 818 FLPSKKMIKEQLEWLIENKYMRRDDDDiNMFIYVA 852
Cdd:COG5647 740 FEPKVSMVKRAIETLIEKEYLERQADD-EIYVYLA 773
CULLIN smart00182
Cullin;
520-655 1.76e-47

Cullin;


Pssm-ID: 214545 [Multi-domain]  Cd Length: 143  Bit Score: 165.57  E-value: 1.76e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650935    520 YVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLR-EVGMpaDYVNRLARMFQDIKVSEDLNTQFRTSISR----- 593
Cdd:smart00182   1 YIQDKDVFEKYYKKHLAKRLILNRSASDDAEENMITKLKqECGY--EFTSKLERMFRDISLSKDLNQSFKDMLENnpsak 78
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24650935    594 -HDAINIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITF 655
Cdd:smart00182  79 pIIDLNVRVLTSGYWPTSSTEVEINLPQELEDALEEFEEFYLAKHSGRKLTWLHSLGRGEVKA 141
Cullin_Nedd8 smart00884
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
779-846 3.16e-20

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


Pssm-ID: 214883 [Multi-domain]  Cd Length: 68  Bit Score: 84.90  E-value: 3.16e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24650935    779 IVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDIN 846
Cdd:smart00884   1 VEEDRKLEIQAAIVRIMKSRKTLSHSELVSEVIEQLKKRFKPSVSDIKKRIESLIEREYLERDEDDPN 68
Cullin_Nedd8 pfam10557
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
783-844 4.62e-19

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognizes and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


Pssm-ID: 463146  Cd Length: 63  Bit Score: 81.73  E-value: 4.62e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24650935   783 RILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDD 844
Cdd:pfam10557   2 RKHEIQAAIVRIMKSRKTLSHNELVNEVIEQLKSRFKPSVSDIKKRIESLIEKEYLERDEDD 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH