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Conserved domains on  [gi|442621752|ref|NP_651742|]
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uncharacterized protein Dmel_CG34133, isoform E [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 686-1028 9.31e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 9.31e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  686 TSAVWCMKFSSCGRLLATAGQDKVLRIWVLKDaypffqdmrnkynadqkssptpsqeslvsqhsaeeaiamataaekctg 765
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET------------------------------------------------ 40

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  766 pfmPKPFCTYNGHTSDLLDVSWSKN-YFILSSSMDKTVRLWHISRKECLCCF-QHIDFVTAIAFHPrDDRYFLSGSLDGK 843
Cdd:cd00200    41 ---GELLRTLKGHTGPVRDVAASADgTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSP-DGRILSSSSRDKT 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  844 LRLWNIPDKKVALwnEVDGQTKLITAANFCQNGQFAVVGSYDGRCIFYNTDQLK-YHT-QIHVRStrgknrigrkISGIE 921
Cdd:cd00200   117 IKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKcVATlTGHTGE----------VNSVA 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  922 PMPGEDKILVTSNDSRVRLYDLRDLNLSCKYKGYLNVSSQIkgSFSHDGKYIIAGSENQCIYIWktnhDYSKLSSVRRdr 1001
Cdd:cd00200   185 FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVW----DLRTGECVQT-- 256

                         330       340
                  ....*....|....*....|....*..
gi 442621752 1002 sdfwegIKAHNATVTCAIFAPHPEAII 1028
Cdd:cd00200   257 ------LSGHTNSVTSLAWSPDGKRLA 277
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 686-1028 9.31e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 9.31e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  686 TSAVWCMKFSSCGRLLATAGQDKVLRIWVLKDaypffqdmrnkynadqkssptpsqeslvsqhsaeeaiamataaekctg 765
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET------------------------------------------------ 40

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  766 pfmPKPFCTYNGHTSDLLDVSWSKN-YFILSSSMDKTVRLWHISRKECLCCF-QHIDFVTAIAFHPrDDRYFLSGSLDGK 843
Cdd:cd00200    41 ---GELLRTLKGHTGPVRDVAASADgTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSP-DGRILSSSSRDKT 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  844 LRLWNIPDKKVALwnEVDGQTKLITAANFCQNGQFAVVGSYDGRCIFYNTDQLK-YHT-QIHVRStrgknrigrkISGIE 921
Cdd:cd00200   117 IKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKcVATlTGHTGE----------VNSVA 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  922 PMPGEDKILVTSNDSRVRLYDLRDLNLSCKYKGYLNVSSQIkgSFSHDGKYIIAGSENQCIYIWktnhDYSKLSSVRRdr 1001
Cdd:cd00200   185 FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVW----DLRTGECVQT-- 256

                         330       340
                  ....*....|....*....|....*..
gi 442621752 1002 sdfwegIKAHNATVTCAIFAPHPEAII 1028
Cdd:cd00200   257 ------LSGHTNSVTSLAWSPDGKRLA 277
WD40 COG2319
WD40 repeat [General function prediction only];
686-988 2.36e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 2.36e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  686 TSAVWCMKFSSCGRLLATAGQDKVLRIWVLKdaypffqdmrnkynadqksspTPSQESLVSQHSAE-EAIA-------MA 757
Cdd:COG2319   120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLA---------------------TGKLLRTLTGHSGAvTSVAfspdgklLA 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  758 TAAE--------KCTGpfmpKPFCTYNGHTSDLLDVSWSKN-YFILSSSMDKTVRLWHISRKECLCCFQ-HIDFVTAIAF 827
Cdd:COG2319   179 SGSDdgtvrlwdLATG----KLLRTLTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAF 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  828 HPrDDRYFLSGSLDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGQFAVVGSYDGRCIFYNTDqlkyhTQIHVRST 907
Cdd:COG2319   255 SP-DGRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-----TGKLLRTL 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  908 RGKNrigRKISGIEPMPGEDKILVTSNDSRVRLYDLRDLNLSCKYKGYLNVSSQIkgSFSHDGKYIIAGSENQCIYIWKT 987
Cdd:COG2319   327 TGHT---GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV--AFSPDGRTLASGSADGTVRLWDL 401


                  .
gi 442621752  988 N 988
Cdd:COG2319   402 A 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 810-848 3.99e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.99e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 442621752    810 KECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 848
Cdd:smart00320    2 GELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
810-848 1.76e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.76e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 442621752   810 KECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 848
Cdd:pfam00400    1 GKLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 771-856 5.61e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  771 PFCTYNGHTSDLLDVSWSKNY--FILSSSMDKTVRLWHISR--------KECLCCFQ-HIDFVTAIAFHPRDDRYFLSGS 839
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPCFseILASGSEDLTIRVWEIPHndesvkeiKDPQCILKgHKKKISIIDWNPMNYYIMCSSG 145

                          90
                  ....*....|....*..
gi 442621752  840 LDGKLRLWNIPDKKVAL 856
Cdd:PTZ00420  146 FDSFVNIWDIENEKRAF 162
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 686-1028 9.31e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 9.31e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  686 TSAVWCMKFSSCGRLLATAGQDKVLRIWVLKDaypffqdmrnkynadqkssptpsqeslvsqhsaeeaiamataaekctg 765
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET------------------------------------------------ 40

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  766 pfmPKPFCTYNGHTSDLLDVSWSKN-YFILSSSMDKTVRLWHISRKECLCCF-QHIDFVTAIAFHPrDDRYFLSGSLDGK 843
Cdd:cd00200    41 ---GELLRTLKGHTGPVRDVAASADgTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSP-DGRILSSSSRDKT 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  844 LRLWNIPDKKVALwnEVDGQTKLITAANFCQNGQFAVVGSYDGRCIFYNTDQLK-YHT-QIHVRStrgknrigrkISGIE 921
Cdd:cd00200   117 IKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKcVATlTGHTGE----------VNSVA 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  922 PMPGEDKILVTSNDSRVRLYDLRDLNLSCKYKGYLNVSSQIkgSFSHDGKYIIAGSENQCIYIWktnhDYSKLSSVRRdr 1001
Cdd:cd00200   185 FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVW----DLRTGECVQT-- 256

                         330       340
                  ....*....|....*....|....*..
gi 442621752 1002 sdfwegIKAHNATVTCAIFAPHPEAII 1028
Cdd:cd00200   257 ------LSGHTNSVTSLAWSPDGKRLA 277
WD40 COG2319
WD40 repeat [General function prediction only];
686-988 2.36e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 2.36e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  686 TSAVWCMKFSSCGRLLATAGQDKVLRIWVLKdaypffqdmrnkynadqksspTPSQESLVSQHSAE-EAIA-------MA 757
Cdd:COG2319   120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLA---------------------TGKLLRTLTGHSGAvTSVAfspdgklLA 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  758 TAAE--------KCTGpfmpKPFCTYNGHTSDLLDVSWSKN-YFILSSSMDKTVRLWHISRKECLCCFQ-HIDFVTAIAF 827
Cdd:COG2319   179 SGSDdgtvrlwdLATG----KLLRTLTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAF 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  828 HPrDDRYFLSGSLDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGQFAVVGSYDGRCIFYNTDqlkyhTQIHVRST 907
Cdd:COG2319   255 SP-DGRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-----TGKLLRTL 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  908 RGKNrigRKISGIEPMPGEDKILVTSNDSRVRLYDLRDLNLSCKYKGYLNVSSQIkgSFSHDGKYIIAGSENQCIYIWKT 987
Cdd:COG2319   327 TGHT---GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV--AFSPDGRTLASGSADGTVRLWDL 401


                  .
gi 442621752  988 N 988
Cdd:COG2319   402 A 402
WD40 COG2319
WD40 repeat [General function prediction only];
676-945 1.80e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 1.80e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  676 QHVQDLSGeDTSAVWCMKFSSCGRLLATAGQDKVLRIWVLKDAyPFFQDMRNKYNADQKSSPTPSQESLVSqHSAEEAIA 755
Cdd:COG2319   153 KLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKLLAS-GSADGTVR 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  756 MATAAekcTGpfmpKPFCTYNGHTSDLLDVSWSKN-YFILSSSMDKTVRLWHISRKECLCCFQ-HIDFVTAIAFHPrDDR 833
Cdd:COG2319   230 LWDLA---TG----KLLRTLTGHSGSVRSVAFSPDgRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSP-DGK 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  834 YFLSGSLDGKLRLWNIPDKKVAlwNEVDGQTKLITAANFCQNGQFAVVGSYDGRCIFYNTDqlkyhTQIHVRSTRGKnri 913
Cdd:COG2319   302 LLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA-----TGELLRTLTGH--- 371

                         250       260       270
                  ....*....|....*....|....*....|..
gi 442621752  914 GRKISGIEPMPGEDKILVTSNDSRVRLYDLRD 945
Cdd:COG2319   372 TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
774-1022 5.16e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 5.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  774 TYNGHTSDLLDVSWSKNY-FILSSSMDKTVRLWHISRKECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWNIPD 851
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGrLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  852 KKvaLWNEVDGQTKLITAANFCQNGQFAVVGSYDGRCIFYNTDQLKyhtqiHVRSTRGKNRIgrkISGIEPMPGEDKILV 931
Cdd:COG2319   152 GK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----LLRTLTGHTGA---VRSVAFSPDGKLLAS 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  932 TSNDSRVRLYDLRDLNLSCKYKGYLNVSSQIkgSFSHDGKYIIAGSENQCIYIWKTNHDysklSSVRRdrsdfwegIKAH 1011
Cdd:COG2319   222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSV--AFSPDGRLLASGSADGTVRLWDLATG----ELLRT--------LTGH 287

                         250
                  ....*....|.
gi 442621752 1012 NATVTCAIFAP 1022
Cdd:COG2319   288 SGGVNSVAFSP 298
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 686-942 1.61e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.95  E-value: 1.61e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  686 TSAVWCMKFSSCGRLLATAGQDKVLRIWvlkdaypffqDMRNKynadqkssptpsqeslvsqhsaeeaiamataaeKCTG 765
Cdd:cd00200    93 TSYVSSVAFSPDGRILSSSSRDKTIKVW----------DVETG---------------------------------KCLT 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  766 pfmpkpfcTYNGHTSDLLDVSWSK-NYFILSSSMDKTVRLWHISRKECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGK 843
Cdd:cd00200   130 --------TLRGHTDWVNSVAFSPdGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSP-DGEKLLSSSSDGT 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  844 LRLWNIPDKKVALWNEvdGQTKLITAANFCQNGQFAVVGSYDGRCIFYNTDQLKYHTQIHVRSTRgknrigrkISGIEPM 923
Cdd:cd00200   201 IKLWDLSTGKCLGTLR--GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNS--------VTSLAWS 270

                         250
                  ....*....|....*....
gi 442621752  924 PGEDKILVTSNDSRVRLYD 942
Cdd:cd00200   271 PDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 670-887 8.27e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 8.27e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  670 YEFTKLQHVQDLSGEdTSAVWCMKFSSCGRLLATAGQDKVLRIWvlkdaypffqDMRNkynadqkssptpsqeslvsqhs 749
Cdd:cd00200   120 WDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTIKLW----------DLRT---------------------- 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  750 aeeaiamataaEKCTGpfmpkpfcTYNGHTSDLLDVSWS-KNYFILSSSMDKTVRLWHISRKECLCCFQ-HIDFVTAIAF 827
Cdd:cd00200   167 -----------GKCVA--------TLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAF 227

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  828 HPrDDRYFLSGSLDGKLRLWNIpdKKVALWNEVDGQTKLITAANFCQNGQFAVVGSYDGR 887
Cdd:cd00200   228 SP-DGYLLASGSEDGTIRVWDL--RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT 284
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 810-848 3.99e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.99e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 442621752    810 KECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 848
Cdd:smart00320    2 GELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
810-848 1.76e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.76e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 442621752   810 KECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 848
Cdd:pfam00400    1 GKLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 770-806 1.83e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.83e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 442621752    770 KPFCTYNGHTSDLLDVSWSKN-YFILSSSMDKTVRLWH 806
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
770-805 4.90e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 4.90e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 442621752   770 KPFCTYNGHTSDLLDVSWSKN-YFILSSSMDKTVRLW 805
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 674-713 4.93e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 4.93e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 442621752    674 KLQHVQDLSGeDTSAVWCMKFSSCGRLLATAGQDKVLRIW 713
Cdd:smart00320    1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
686-713 2.53e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.53e-04
                           10        20
                   ....*....|....*....|....*...
gi 442621752   686 TSAVWCMKFSSCGRLLATAGQDKVLRIW 713
Cdd:pfam00400   11 TGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 771-856 5.61e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621752  771 PFCTYNGHTSDLLDVSWSKNY--FILSSSMDKTVRLWHISR--------KECLCCFQ-HIDFVTAIAFHPRDDRYFLSGS 839
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPCFseILASGSEDLTIRVWEIPHndesvkeiKDPQCILKgHKKKISIIDWNPMNYYIMCSSG 145

                          90
                  ....*....|....*..
gi 442621752  840 LDGKLRLWNIPDKKVAL 856
Cdd:PTZ00420  146 FDSFVNIWDIENEKRAF 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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