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Conserved domains on  [gi|21356003|ref|NP_652036|]
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dynactin 3, p24 subunit, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dynactin_p22 super family cl06456
Dynactin subunit p22; This family contains p22, the smallest subunit of dynactin, a complex ...
 7-151 5.49e-12

Dynactin subunit p22; This family contains p22, the smallest subunit of dynactin, a complex that binds to cytoplasmic dynein and is a required activator for cytoplasmic dynein-mediated vesicular transport. Dynactin localizes to the cleavage furrow and to the midbodies of dividing cells, suggesting that it may function in cytokinesis. Family members are approximately 170 residues long.


The actual alignment was detected with superfamily member pfam07426:

Pssm-ID: 462162 [Multi-domain]  Cd Length: 163  Bit Score: 61.09  E-value: 5.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356003     7 LEKRIDAL-TRVLGPVQDSEVG-EGVVDALCSAHAILGEATTGSAALQQCVKRSDELEKYLDPNFLE-EHQQVRSKEVYL 83
Cdd:pfam07426   1 LEERIAELeKRVYGEEKNREKDpNSIIDSLLKVQTKLSSAVSKREKIKQLFKKIPELNKYLDPQYEDsIALPDAAKLELI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21356003    84 QAVAPELHTQAEQLERIKQLEPALGAEYFRSIPaECLEQLKGITQNNGEYAQQSELIEESLVLAMKRY 151
Cdd:pfam07426  81 LASEDELRSTAALLEQLQELKPVLDSEHIKDVP-ELTEKLEKLSQIHLKQQEQANELTEEVKDLLENY 147
 
Name Accession Description Interval E-value
Dynactin_p22 pfam07426
Dynactin subunit p22; This family contains p22, the smallest subunit of dynactin, a complex ...
 7-151 5.49e-12

Dynactin subunit p22; This family contains p22, the smallest subunit of dynactin, a complex that binds to cytoplasmic dynein and is a required activator for cytoplasmic dynein-mediated vesicular transport. Dynactin localizes to the cleavage furrow and to the midbodies of dividing cells, suggesting that it may function in cytokinesis. Family members are approximately 170 residues long.


Pssm-ID: 462162 [Multi-domain]  Cd Length: 163  Bit Score: 61.09  E-value: 5.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356003     7 LEKRIDAL-TRVLGPVQDSEVG-EGVVDALCSAHAILGEATTGSAALQQCVKRSDELEKYLDPNFLE-EHQQVRSKEVYL 83
Cdd:pfam07426   1 LEERIAELeKRVYGEEKNREKDpNSIIDSLLKVQTKLSSAVSKREKIKQLFKKIPELNKYLDPQYEDsIALPDAAKLELI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21356003    84 QAVAPELHTQAEQLERIKQLEPALGAEYFRSIPaECLEQLKGITQNNGEYAQQSELIEESLVLAMKRY 151
Cdd:pfam07426  81 LASEDELRSTAALLEQLQELKPVLDSEHIKDVP-ELTEKLEKLSQIHLKQQEQANELTEEVKDLLENY 147
 
Name Accession Description Interval E-value
Dynactin_p22 pfam07426
Dynactin subunit p22; This family contains p22, the smallest subunit of dynactin, a complex ...
 7-151 5.49e-12

Dynactin subunit p22; This family contains p22, the smallest subunit of dynactin, a complex that binds to cytoplasmic dynein and is a required activator for cytoplasmic dynein-mediated vesicular transport. Dynactin localizes to the cleavage furrow and to the midbodies of dividing cells, suggesting that it may function in cytokinesis. Family members are approximately 170 residues long.


Pssm-ID: 462162 [Multi-domain]  Cd Length: 163  Bit Score: 61.09  E-value: 5.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356003     7 LEKRIDAL-TRVLGPVQDSEVG-EGVVDALCSAHAILGEATTGSAALQQCVKRSDELEKYLDPNFLE-EHQQVRSKEVYL 83
Cdd:pfam07426   1 LEERIAELeKRVYGEEKNREKDpNSIIDSLLKVQTKLSSAVSKREKIKQLFKKIPELNKYLDPQYEDsIALPDAAKLELI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21356003    84 QAVAPELHTQAEQLERIKQLEPALGAEYFRSIPaECLEQLKGITQNNGEYAQQSELIEESLVLAMKRY 151
Cdd:pfam07426  81 LASEDELRSTAALLEQLQELKPVLDSEHIKDVP-ELTEKLEKLSQIHLKQQEQANELTEEVKDLLENY 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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