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Conserved domains on  [gi|21356869|ref|NP_652059|]
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Su(z)12, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VEFS-Box pfam09733
VEFS-Box of polycomb protein; The VEFS-Box (VRN2-EMF2-FIS2-Su(z)12) box is the C-terminal ...
 511-644 3.69e-72

VEFS-Box of polycomb protein; The VEFS-Box (VRN2-EMF2-FIS2-Su(z)12) box is the C-terminal region of these proteins, characterized by an acidic cluster and a tryptophan/methionine-rich sequence, the acidic-W/M domain. Some of these sequences are associated with a zinc-finger domain about 100 residues towards the N-terminus. This protein is one of the polycomb cluster of proteins which control HOX gene transcription as it functions in heterochromatin-mediated repression.


:

Pssm-ID: 462864  Cd Length: 137  Bit Score: 232.96  E-value: 3.69e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356869   511 DEDEISNQRSYITGHNRLYHHTETCLPVHPKEL--DIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRH 588
Cdd:pfam09733   2 LPAERSDPRSYILLHNRQYFHSRTCQPMRLEEVdsDVDSEDEVDPDWLRFETRRMLDEFTDVNEGEKEFMKLWNLFVMKQ 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 21356869   589 GFVGDCQLPIACEMFLDAKGTEIVRKNLYRNFILHMCSLFDYGLIAAETVYKTVQK 644
Cdd:pfam09733  82 RVIADGQIPWACEAFVKLHGQELVQNNLRRNWRLHMIKLWDFGLLDARTINKCNTI 137
C2_II_SUZ12 cd21740
type II C2 domain found in suppressor of zeste 12 protein (SUZ12) and similar proteins; SUZ12, ...
 154-328 2.97e-44

type II C2 domain found in suppressor of zeste 12 protein (SUZ12) and similar proteins; SUZ12, also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein, is a Polycomb group (PcG) protein that is a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. SUZ12 is also involved in various cellular processes, including cell differentiation, proliferation, and apoptosis, and is frequently overexpressed in cancer cells. The model corresponds to the noncanonical type II C2 domain of SUZ12, which shares notable structural homology with the classical C2 domains and plays a role in protein-protein interactions that may contribute to its diverse functions.


:

Pssm-ID: 467848  Cd Length: 167  Bit Score: 157.39  E-value: 2.97e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356869 154 LCEAGESVSVETTLYKITRSKRKDSTLDFQELLSKCSQIVYNPKDR--VGEHATISIPLQTMRPM-GEQHTLYKLLFRIK 230
Cdd:cd21740  15 LKSEGESVKVEVLLLKICHKKRKDSSSPIMQVSLGKSEVPVNPSSDspPSKAPTLSIPSESFTPSnGHLVKSYVLLFRVT 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356869 231 VLspstcndenaetppnkrsrpnekMFGSELILYEK-SSGFITEGEYEAMLQPLNSTSiKSFSPKKCTWETMPDSYIPLS 309
Cdd:cd21740  95 CP-----------------------TYGAELVVYDKnRRCLLTDGEYELALQELNSKS-KSSPKKNASWETIDDGKDLPP 150

                       170
                ....*....|....*....
gi 21356869 310 LtyDVYQQSPMLKFHLTLS 328
Cdd:cd21740 151 F--EVFEKGPTLKFRLSWS 167
ZnB-Zn_SUZ12 cd21750
zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste ...
 388-459 1.51e-41

zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste 12 protein (SUZ12) and similar proteins; Suppressor of zeste 12 protein (SUZ12), also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein, is a Polycomb group (PcG) protein that acts as a component of the Polycomb Repressive Complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. This model corresponds to a unique structural ZnB-Zn platform consisting of zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn), which forms an intramolecular complex that governs the mutual exclusive binding of Jarid2 and EPOP in PRC2 holo complexes.


:

Pssm-ID: 439246  Cd Length: 96  Bit Score: 146.69  E-value: 1.51e-41
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21356869 388 HIQIVYNFMYSNNTRQQTEYTQELNCPWCGLDCLRLYALLKHLKLCHARFNFTYQPAGSGARIDVTINDAYD 459
Cdd:cd21750  25 ITRVFYQFLYNNNTRQQTEARDDLRCPWCSLNCRRLYSLLKHLKLCHSRFNFTYVPHPKGARIDVSINECYD 96
ZnB-Zn_SUZ12-like super family cl45905
zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste ...
 54-82 1.02e-11

zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste 12 protein (SUZ12), and similar proteins; This family includes a group of Polycomb group (PcG) proteins from metazoa and plants, such as suppressor of zeste 12 protein (SUZ12), and Polycomb group proteins EMBRYONIC FLOWER 2 (EMF2) and FERTILIZATION-INDEPENDENT SEED 2 (FIS2). SUZ12 (also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein) is a component of the Polycomb Repressive Complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. EMF2 is involved in flowering processes by repressing unknown target genes and preventing reproductive development. It participates in polycomb group (PcG) protein complex-mediated (probably in complex with EMF1) silencing of the flower homeotic genes AGAMOUS (AG), PISTILLATA (PI), and APETALA3 (AP3), as well as of some regulatory genes such as ABSCISIC ACID INSENSITIVE3 (ABI3), LONG VEGETATIVE PHASE1 (LOV1), and FLOWERING LOCUS C (FLC) during vegetative development, by mediating trimethylation of histone 3 lysine 27 on the AG chromatin (H3K27me3). FIS2 is required to prevent the proliferation of the central cell by repressing unknown target genes before fertilization. It regulates the anteroposterior organization of the endosperm. Members in this family contain a unique structural ZnB-Zn platform consisting of zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn).


The actual alignment was detected with superfamily member cd21750:

Pssm-ID: 459250  Cd Length: 96  Bit Score: 61.94  E-value: 1.02e-11
                        10        20
                ....*....|....*....|....*....
gi 21356869  54 EQELFLQAFEKPTQIYRYLRNRHETNPIF 82
Cdd:cd21750   1 DHELFLQAFEKPTQIYRYLRTRHLITRVF 29
 
Name Accession Description Interval E-value
VEFS-Box pfam09733
VEFS-Box of polycomb protein; The VEFS-Box (VRN2-EMF2-FIS2-Su(z)12) box is the C-terminal ...
 511-644 3.69e-72

VEFS-Box of polycomb protein; The VEFS-Box (VRN2-EMF2-FIS2-Su(z)12) box is the C-terminal region of these proteins, characterized by an acidic cluster and a tryptophan/methionine-rich sequence, the acidic-W/M domain. Some of these sequences are associated with a zinc-finger domain about 100 residues towards the N-terminus. This protein is one of the polycomb cluster of proteins which control HOX gene transcription as it functions in heterochromatin-mediated repression.


Pssm-ID: 462864  Cd Length: 137  Bit Score: 232.96  E-value: 3.69e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356869   511 DEDEISNQRSYITGHNRLYHHTETCLPVHPKEL--DIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRH 588
Cdd:pfam09733   2 LPAERSDPRSYILLHNRQYFHSRTCQPMRLEEVdsDVDSEDEVDPDWLRFETRRMLDEFTDVNEGEKEFMKLWNLFVMKQ 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 21356869   589 GFVGDCQLPIACEMFLDAKGTEIVRKNLYRNFILHMCSLFDYGLIAAETVYKTVQK 644
Cdd:pfam09733  82 RVIADGQIPWACEAFVKLHGQELVQNNLRRNWRLHMIKLWDFGLLDARTINKCNTI 137
VEFS-box_SUZ12 cd21551
VEFS (VRN2-EMF2-FIS2-Su(z)12) box found in suppressor of zeste 12 protein (SUZ12) and similar ...
 527-646 1.05e-71

VEFS (VRN2-EMF2-FIS2-Su(z)12) box found in suppressor of zeste 12 protein (SUZ12) and similar proteins; SUZ12, also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein, is a Polycomb group (PcG) protein that acts as a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. This model corresponds to the VEFS (VRN2-EMF2-FIS2-Su(z)12) box at the C-terminus of SUZ12, which is responsible for binding to EED and EZH2.


Pssm-ID: 439216  Cd Length: 122  Bit Score: 230.94  E-value: 1.05e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356869 527 RLYHHTETCLPVHPKELDIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDA 606
Cdd:cd21551   1 RLYYHSTTCLPIRPQELDVDSEDEDDPEWLREKTQRMIDEFTDVNEGEKELMKLWNLHVMKHGYVADCQMPQACKTFVEE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21356869 607 KGTEIVRKNLYRNFILHMCSLFDYGLIAAETVYKTVQKLQ 646
Cdd:cd21551  81 YGPEIIEKNLRRNFILHLVNLYDFGLISASQILKLVAKLD 120
C2_II_SUZ12 cd21740
type II C2 domain found in suppressor of zeste 12 protein (SUZ12) and similar proteins; SUZ12, ...
 154-328 2.97e-44

type II C2 domain found in suppressor of zeste 12 protein (SUZ12) and similar proteins; SUZ12, also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein, is a Polycomb group (PcG) protein that is a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. SUZ12 is also involved in various cellular processes, including cell differentiation, proliferation, and apoptosis, and is frequently overexpressed in cancer cells. The model corresponds to the noncanonical type II C2 domain of SUZ12, which shares notable structural homology with the classical C2 domains and plays a role in protein-protein interactions that may contribute to its diverse functions.


Pssm-ID: 467848  Cd Length: 167  Bit Score: 157.39  E-value: 2.97e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356869 154 LCEAGESVSVETTLYKITRSKRKDSTLDFQELLSKCSQIVYNPKDR--VGEHATISIPLQTMRPM-GEQHTLYKLLFRIK 230
Cdd:cd21740  15 LKSEGESVKVEVLLLKICHKKRKDSSSPIMQVSLGKSEVPVNPSSDspPSKAPTLSIPSESFTPSnGHLVKSYVLLFRVT 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356869 231 VLspstcndenaetppnkrsrpnekMFGSELILYEK-SSGFITEGEYEAMLQPLNSTSiKSFSPKKCTWETMPDSYIPLS 309
Cdd:cd21740  95 CP-----------------------TYGAELVVYDKnRRCLLTDGEYELALQELNSKS-KSSPKKNASWETIDDGKDLPP 150

                       170
                ....*....|....*....
gi 21356869 310 LtyDVYQQSPMLKFHLTLS 328
Cdd:cd21740 151 F--EVFEKGPTLKFRLSWS 167
ZnB-Zn_SUZ12 cd21750
zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste ...
 388-459 1.51e-41

zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste 12 protein (SUZ12) and similar proteins; Suppressor of zeste 12 protein (SUZ12), also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein, is a Polycomb group (PcG) protein that acts as a component of the Polycomb Repressive Complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. This model corresponds to a unique structural ZnB-Zn platform consisting of zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn), which forms an intramolecular complex that governs the mutual exclusive binding of Jarid2 and EPOP in PRC2 holo complexes.


Pssm-ID: 439246  Cd Length: 96  Bit Score: 146.69  E-value: 1.51e-41
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21356869 388 HIQIVYNFMYSNNTRQQTEYTQELNCPWCGLDCLRLYALLKHLKLCHARFNFTYQPAGSGARIDVTINDAYD 459
Cdd:cd21750  25 ITRVFYQFLYNNNTRQQTEARDDLRCPWCSLNCRRLYSLLKHLKLCHSRFNFTYVPHPKGARIDVSINECYD 96
ZnB-Zn_SUZ12 cd21750
zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste ...
 54-82 1.02e-11

zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste 12 protein (SUZ12) and similar proteins; Suppressor of zeste 12 protein (SUZ12), also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein, is a Polycomb group (PcG) protein that acts as a component of the Polycomb Repressive Complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. This model corresponds to a unique structural ZnB-Zn platform consisting of zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn), which forms an intramolecular complex that governs the mutual exclusive binding of Jarid2 and EPOP in PRC2 holo complexes.


Pssm-ID: 439246  Cd Length: 96  Bit Score: 61.94  E-value: 1.02e-11
                        10        20
                ....*....|....*....|....*....
gi 21356869  54 EQELFLQAFEKPTQIYRYLRNRHETNPIF 82
Cdd:cd21750   1 DHELFLQAFEKPTQIYRYLRTRHLITRVF 29
 
Name Accession Description Interval E-value
VEFS-Box pfam09733
VEFS-Box of polycomb protein; The VEFS-Box (VRN2-EMF2-FIS2-Su(z)12) box is the C-terminal ...
 511-644 3.69e-72

VEFS-Box of polycomb protein; The VEFS-Box (VRN2-EMF2-FIS2-Su(z)12) box is the C-terminal region of these proteins, characterized by an acidic cluster and a tryptophan/methionine-rich sequence, the acidic-W/M domain. Some of these sequences are associated with a zinc-finger domain about 100 residues towards the N-terminus. This protein is one of the polycomb cluster of proteins which control HOX gene transcription as it functions in heterochromatin-mediated repression.


Pssm-ID: 462864  Cd Length: 137  Bit Score: 232.96  E-value: 3.69e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356869   511 DEDEISNQRSYITGHNRLYHHTETCLPVHPKEL--DIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRH 588
Cdd:pfam09733   2 LPAERSDPRSYILLHNRQYFHSRTCQPMRLEEVdsDVDSEDEVDPDWLRFETRRMLDEFTDVNEGEKEFMKLWNLFVMKQ 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 21356869   589 GFVGDCQLPIACEMFLDAKGTEIVRKNLYRNFILHMCSLFDYGLIAAETVYKTVQK 644
Cdd:pfam09733  82 RVIADGQIPWACEAFVKLHGQELVQNNLRRNWRLHMIKLWDFGLLDARTINKCNTI 137
VEFS-box_SUZ12 cd21551
VEFS (VRN2-EMF2-FIS2-Su(z)12) box found in suppressor of zeste 12 protein (SUZ12) and similar ...
 527-646 1.05e-71

VEFS (VRN2-EMF2-FIS2-Su(z)12) box found in suppressor of zeste 12 protein (SUZ12) and similar proteins; SUZ12, also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein, is a Polycomb group (PcG) protein that acts as a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. This model corresponds to the VEFS (VRN2-EMF2-FIS2-Su(z)12) box at the C-terminus of SUZ12, which is responsible for binding to EED and EZH2.


Pssm-ID: 439216  Cd Length: 122  Bit Score: 230.94  E-value: 1.05e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356869 527 RLYHHTETCLPVHPKELDIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDA 606
Cdd:cd21551   1 RLYYHSTTCLPIRPQELDVDSEDEDDPEWLREKTQRMIDEFTDVNEGEKELMKLWNLHVMKHGYVADCQMPQACKTFVEE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21356869 607 KGTEIVRKNLYRNFILHMCSLFDYGLIAAETVYKTVQKLQ 646
Cdd:cd21551  81 YGPEIIEKNLRRNFILHLVNLYDFGLISASQILKLVAKLD 120
C2_II_SUZ12 cd21740
type II C2 domain found in suppressor of zeste 12 protein (SUZ12) and similar proteins; SUZ12, ...
 154-328 2.97e-44

type II C2 domain found in suppressor of zeste 12 protein (SUZ12) and similar proteins; SUZ12, also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein, is a Polycomb group (PcG) protein that is a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. SUZ12 is also involved in various cellular processes, including cell differentiation, proliferation, and apoptosis, and is frequently overexpressed in cancer cells. The model corresponds to the noncanonical type II C2 domain of SUZ12, which shares notable structural homology with the classical C2 domains and plays a role in protein-protein interactions that may contribute to its diverse functions.


Pssm-ID: 467848  Cd Length: 167  Bit Score: 157.39  E-value: 2.97e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356869 154 LCEAGESVSVETTLYKITRSKRKDSTLDFQELLSKCSQIVYNPKDR--VGEHATISIPLQTMRPM-GEQHTLYKLLFRIK 230
Cdd:cd21740  15 LKSEGESVKVEVLLLKICHKKRKDSSSPIMQVSLGKSEVPVNPSSDspPSKAPTLSIPSESFTPSnGHLVKSYVLLFRVT 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356869 231 VLspstcndenaetppnkrsrpnekMFGSELILYEK-SSGFITEGEYEAMLQPLNSTSiKSFSPKKCTWETMPDSYIPLS 309
Cdd:cd21740  95 CP-----------------------TYGAELVVYDKnRRCLLTDGEYELALQELNSKS-KSSPKKNASWETIDDGKDLPP 150

                       170
                ....*....|....*....
gi 21356869 310 LtyDVYQQSPMLKFHLTLS 328
Cdd:cd21740 151 F--EVFEKGPTLKFRLSWS 167
ZnB-Zn_SUZ12 cd21750
zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste ...
 388-459 1.51e-41

zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste 12 protein (SUZ12) and similar proteins; Suppressor of zeste 12 protein (SUZ12), also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein, is a Polycomb group (PcG) protein that acts as a component of the Polycomb Repressive Complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. This model corresponds to a unique structural ZnB-Zn platform consisting of zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn), which forms an intramolecular complex that governs the mutual exclusive binding of Jarid2 and EPOP in PRC2 holo complexes.


Pssm-ID: 439246  Cd Length: 96  Bit Score: 146.69  E-value: 1.51e-41
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21356869 388 HIQIVYNFMYSNNTRQQTEYTQELNCPWCGLDCLRLYALLKHLKLCHARFNFTYQPAGSGARIDVTINDAYD 459
Cdd:cd21750  25 ITRVFYQFLYNNNTRQQTEARDDLRCPWCSLNCRRLYSLLKHLKLCHSRFNFTYVPHPKGARIDVSINECYD 96
VEFS-box cd21521
VEFS (VRN2-EMF2-FIS2-Su(z)12) box family; This family corresponds to a group of polycomb ...
 527-646 1.19e-37

VEFS (VRN2-EMF2-FIS2-Su(z)12) box family; This family corresponds to a group of polycomb cluster proteins which control HOX gene transcription, as they function in heterochromatin-mediated repression. They are characterized by containing a VEFS-box in the C-terminal region, which is an acidic cluster and a tryptophan/methionine-rich sequence, the acidic-W/M domain. Some of these sequences are associated with a zinc-finger domain about 100 residues towards the N-terminus. Members include suppressor of zeste 12 protein (SUZ12) from vertebrates, plants, insects and fungi, as well as Polycomb group protein EMBRYONIC FLOWER 2 (EMF2), Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2 (FIS2), and Polycomb group protein VERNALIZATION 2 (VRN2) from plants.


Pssm-ID: 439215  Cd Length: 121  Bit Score: 136.67  E-value: 1.19e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356869 527 RLYHHTETCLPVHPKELDIDSEgESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDA 606
Cdd:cd21521   1 RQYFHPRSCVPLLPEVDLSDLD-EIDDEWLQEYLRRQIEDFVDVNPGEKEFMKLWNAFLLKLRPLGDSHLPDTCRRFVRK 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21356869 607 KGTEIVRKNLYRNFILHMCSLFDYGLIAAETVYKTVQKLQ 646
Cdd:cd21521  80 HGQEIELKNLYREFVLHLTTLHEDGLLDADEVYELIQRLR 119
VEFS-box_EMF2-like cd21553
VEFS (VRN2-EMF2-FIS2-Su(z)12) box found in Arabidopsis thaliana Polycomb group protein ...
 524-648 9.34e-30

VEFS (VRN2-EMF2-FIS2-Su(z)12) box found in Arabidopsis thaliana Polycomb group protein EMBRYONIC FLOWER 2 (EMF2) and similar proteins; This subfamily includes a group of proteins similar to Arabidopsis thaliana Polycomb group (PcG) proteins, EMF2, Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2 (FIS2), and Polycomb group protein VERNALIZATION 2 (VRN2). EMF2 is involved in flowering processes by repressing unknown target genes and preventing reproductive development. It participates in PcG protein complex-mediated (probably in complex with EMF1) silencing of the flower homeotic genes AGAMOUS (AG), PISTILLATA (PI), and APETALA3 (AP3), as well as of some regulatory genes such as ABSCISIC ACID INSENSITIVE3 (ABI3), LONG VEGETATIVE PHASE1 (LOV1), and FLOWERING LOCUS C (FLC) during vegetative development, by mediating trimethylation of histone 3 lysine 27 on the AG chromatin (H3K27me3). FIS2 is required to prevent the proliferation of the central cell by repressing unknown target genes before fertilization. It regulates the anteroposterior organization of the endosperm. VRN2 plays a central role in vernalization by maintaining repressed the homeotic gene FLC, a floral repressor, after cold treatment. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. Members of this family contain a VEFS (VRN2-EMF2-FIS2-Su(z)12) box.


Pssm-ID: 439218  Cd Length: 128  Bit Score: 114.35  E-value: 9.34e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356869 524 GHNRLYHHTETCLPVHPKEL--DIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACE 601
Cdd:cd21553   1 LPKRQFYHSRTAQPMTLEEVdsDSDSEDEVDEEWADEEDRRLLDEFVDVSPDEKEFMHLWNSFVRRQRVLADGHVPWACE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 21356869 602 MFLDAKGTEIVRK-NLYRNFILHMCSLFDYGLIAAETVYKTVQKLQGL 648
Cdd:cd21553  81 AFAREHGKELVADpGLRRCFRLHLINLWNFGLLDAKTIADCLQILDQL 128
ZnB-Zn_SUZ12-like cd21735
zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste ...
 388-459 1.80e-22

zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste 12 protein (SUZ12), and similar proteins; This family includes a group of Polycomb group (PcG) proteins from metazoa and plants, such as suppressor of zeste 12 protein (SUZ12), and Polycomb group proteins EMBRYONIC FLOWER 2 (EMF2) and FERTILIZATION-INDEPENDENT SEED 2 (FIS2). SUZ12 (also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein) is a component of the Polycomb Repressive Complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. EMF2 is involved in flowering processes by repressing unknown target genes and preventing reproductive development. It participates in polycomb group (PcG) protein complex-mediated (probably in complex with EMF1) silencing of the flower homeotic genes AGAMOUS (AG), PISTILLATA (PI), and APETALA3 (AP3), as well as of some regulatory genes such as ABSCISIC ACID INSENSITIVE3 (ABI3), LONG VEGETATIVE PHASE1 (LOV1), and FLOWERING LOCUS C (FLC) during vegetative development, by mediating trimethylation of histone 3 lysine 27 on the AG chromatin (H3K27me3). FIS2 is required to prevent the proliferation of the central cell by repressing unknown target genes before fertilization. It regulates the anteroposterior organization of the endosperm. Members in this family contain a unique structural ZnB-Zn platform consisting of zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn).


Pssm-ID: 439244  Cd Length: 96  Bit Score: 92.59  E-value: 1.80e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21356869 388 HIQ--IVYNFMYSNNTRQQTEYTQELNCPWCGLDCLRLYALLKHLKLCHARFNFTYQPAGSGARIDVTINDAYD 459
Cdd:cd21735  23 HLQgnVWFHFLYYNNLRQKTEVREDLSCPWCNMKCASLRGLLYHLPSSHDRFNFEFWVGHEFPHINVSLKEETM 96
VEFS-box_ctSUZ12-like cd21552
VEFS (VRN2-EMF2-FIS2-Su(z)12) box found in Chaetomium thermophilum suppressor of zeste 12 ...
 529-647 5.70e-17

VEFS (VRN2-EMF2-FIS2-Su(z)12) box found in Chaetomium thermophilum suppressor of zeste 12 protein (ctSUZ12) and similar proteins; SUZ12 is a Polycomb group (PcG) protein that acts as a component of the Polycomb Repressive Complex 2 (PRC2), a histone methyltransferase complex composed of core subunits EZH2 (or EZH1), EED, SUZ12 and Rbbp4. PRC2 trimethylates histone H3K27 (H3K27me3) to mark developmentally repressed chromatin. This model corresponds to the VEFS (VRN2-EMF2-FIS2-Su(z)12) box at the C-terminus of SUZ12, which is responsible for binding to EED and EZH2 (or EZH1).


Pssm-ID: 439217  Cd Length: 123  Bit Score: 77.60  E-value: 5.70e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356869 529 YHHTETCLPVHPKELDIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDAKG 608
Cdd:cd21552   3 FYRSISKRPLEPGEELSESDDEIDESWLIQKHRDEIDDFTDVTPAEKEFIKLWDAFILEERLSSDVYLPDALVRFVRKKA 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21356869 609 TEIVRK-NLYRNFILHMCSLFDYGLIAAETVYKTVQKLQG 647
Cdd:cd21552  83 EWLVASpSRLVEFGKHLAELLARGVIDEEVVRECLEILRE 122
ZnB-Zn_SUZ12 cd21750
zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste ...
 54-82 1.02e-11

zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste 12 protein (SUZ12) and similar proteins; Suppressor of zeste 12 protein (SUZ12), also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein, is a Polycomb group (PcG) protein that acts as a component of the Polycomb Repressive Complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. This model corresponds to a unique structural ZnB-Zn platform consisting of zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn), which forms an intramolecular complex that governs the mutual exclusive binding of Jarid2 and EPOP in PRC2 holo complexes.


Pssm-ID: 439246  Cd Length: 96  Bit Score: 61.94  E-value: 1.02e-11
                        10        20
                ....*....|....*....|....*....
gi 21356869  54 EQELFLQAFEKPTQIYRYLRNRHETNPIF 82
Cdd:cd21750   1 DHELFLQAFEKPTQIYRYLRTRHLITRVF 29
ZnB-Zn_EMF2-like cd21749
zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in Arabidopsis thaliana ...
 391-455 4.20e-10

zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in Arabidopsis thaliana Polycomb group protein EMBRYONIC FLOWER 2 (EMF2), and similar proteins; This family includes a group of plant proteins similar to Arabidopsis thaliana Polycomb group (PcG) proteins EMF2 and FERTILIZATION-INDEPENDENT SEED 2 (FIS2). EMF2 is involved in flowering processes by repressing unknown target genes and preventing reproductive development. It participates in polycomb group (PcG) protein complex-mediated (probably in complex with EMF1) silencing of the flower homeotic genes AGAMOUS (AG), PISTILLATA (PI), and APETALA3 (AP3), as well as of some regulatory genes such as ABSCISIC ACID INSENSITIVE3 (ABI3), LONG VEGETATIVE PHASE1 (LOV1), and FLOWERING LOCUS C (FLC) during vegetative development, by mediating trimethylation of histone 3 lysine 27 on the AG chromatin (H3K27me3). FIS2 is required to prevent the proliferation of the central cell by repressing unknown target genes before fertilization. It regulates the anteroposterior organization of the endosperm. Members in this family show high sequence similarity with a unique structural ZnB-Zn platform found in metazoan, which consists of zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn).


Pssm-ID: 439245  Cd Length: 100  Bit Score: 57.28  E-value: 4.20e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21356869 391 IVYNFMYSNNTRQQTEYTQELNCPWCGLDCLRLYALLKHLKLCHARFNFTYQPAGSGARIDVTIN 455
Cdd:cd21749  32 VVFNYRYYNNKLRKTEVTEDFSCPFCLVKCGSFKGLRCHLKASHDLFNFEFSVSEDYQSVNVSVK 96
ZnB-Zn_SUZ12-like cd21735
zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste ...
 55-95 2.51e-05

zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste 12 protein (SUZ12), and similar proteins; This family includes a group of Polycomb group (PcG) proteins from metazoa and plants, such as suppressor of zeste 12 protein (SUZ12), and Polycomb group proteins EMBRYONIC FLOWER 2 (EMF2) and FERTILIZATION-INDEPENDENT SEED 2 (FIS2). SUZ12 (also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein) is a component of the Polycomb Repressive Complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. EMF2 is involved in flowering processes by repressing unknown target genes and preventing reproductive development. It participates in polycomb group (PcG) protein complex-mediated (probably in complex with EMF1) silencing of the flower homeotic genes AGAMOUS (AG), PISTILLATA (PI), and APETALA3 (AP3), as well as of some regulatory genes such as ABSCISIC ACID INSENSITIVE3 (ABI3), LONG VEGETATIVE PHASE1 (LOV1), and FLOWERING LOCUS C (FLC) during vegetative development, by mediating trimethylation of histone 3 lysine 27 on the AG chromatin (H3K27me3). FIS2 is required to prevent the proliferation of the central cell by repressing unknown target genes before fertilization. It regulates the anteroposterior organization of the endosperm. Members in this family contain a unique structural ZnB-Zn platform consisting of zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn).


Pssm-ID: 439244  Cd Length: 96  Bit Score: 43.67  E-value: 2.51e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 21356869  55 QELFLQAFEKPTQIYRYLRNRHETNPIFLNRTLSYMKERMS 95
Cdd:cd21735   2 EEEFLAAYHKPTALYKILEVRHLQGNVWFHFLYYNNLRQKT 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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