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Conserved domains on  [gi|24586140|ref|NP_652646|]
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tetraspanin 42Ea, isoform B [Drosophila melanogaster]

Protein Classification

tetraspanin family protein( domain architecture ID 11992908)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0016020
PubMed:  15763890|11756464|19709882|16024509|32974937
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
8-215 4.33e-32

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 115.11  E-value: 4.33e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586140     8 VKYILFIFNLLCSICGILLIVFGALLFSKVRNmDDFAEALRTQQVPVTMIILGTIILLISWFGCCGAIRESYCMSMTYSI 87
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSL-LLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586140    88 LLFVLMIGQLALVIYMWVQKDKYLEI--------MGDVVEKAWNHRTSRSDYMDAIQISMKCCGrsgytdyayqgkfpps 159
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDKLSGLlsnwlkksLEDGYRDWLDLYSCLNSALDSLQSEFGCCG---------------- 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 24586140   160 ccsdtnncrwetvyrrGCKVTFVEFWDRNSDIIKYAGLVIAAIEFVGFVFACCLAN 215
Cdd:pfam00335 144 ----------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
8-215 4.33e-32

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 115.11  E-value: 4.33e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586140     8 VKYILFIFNLLCSICGILLIVFGALLFSKVRNmDDFAEALRTQQVPVTMIILGTIILLISWFGCCGAIRESYCMSMTYSI 87
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSL-LLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586140    88 LLFVLMIGQLALVIYMWVQKDKYLEI--------MGDVVEKAWNHRTSRSDYMDAIQISMKCCGrsgytdyayqgkfpps 159
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDKLSGLlsnwlkksLEDGYRDWLDLYSCLNSALDSLQSEFGCCG---------------- 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 24586140   160 ccsdtnncrwetvyrrGCKVTFVEFWDRNSDIIKYAGLVIAAIEFVGFVFACCLAN 215
Cdd:pfam00335 144 ----------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 104-188 4.26e-23

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 89.10  E-value: 4.26e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586140 104 WVQKDKYLEIMGDVVEKAWNHRTSRSDY---MDAIQISMKCCGRSGYTDYA-YQGKFPPSCCSDTNNCRWETVYRRGCKV 179
Cdd:cd03127   1 FVYRDQLESLVSDTLNDAWDEYYVDDDFqeaMDALQSTFECCGVNGPTDYLdLRLLVPSSCCKGTDGNCGLNLYTEGCLE 80


                ....*....
gi 24586140 180 TFVEFWDRN 188
Cdd:cd03127  81 KLVDFLRSN 89
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
8-215 4.33e-32

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 115.11  E-value: 4.33e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586140     8 VKYILFIFNLLCSICGILLIVFGALLFSKVRNmDDFAEALRTQQVPVTMIILGTIILLISWFGCCGAIRESYCMSMTYSI 87
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSL-LLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586140    88 LLFVLMIGQLALVIYMWVQKDKYLEI--------MGDVVEKAWNHRTSRSDYMDAIQISMKCCGrsgytdyayqgkfpps 159
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDKLSGLlsnwlkksLEDGYRDWLDLYSCLNSALDSLQSEFGCCG---------------- 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 24586140   160 ccsdtnncrwetvyrrGCKVTFVEFWDRNSDIIKYAGLVIAAIEFVGFVFACCLAN 215
Cdd:pfam00335 144 ----------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 104-188 4.26e-23

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 89.10  E-value: 4.26e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586140 104 WVQKDKYLEIMGDVVEKAWNHRTSRSDY---MDAIQISMKCCGRSGYTDYA-YQGKFPPSCCSDTNNCRWETVYRRGCKV 179
Cdd:cd03127   1 FVYRDQLESLVSDTLNDAWDEYYVDDDFqeaMDALQSTFECCGVNGPTDYLdLRLLVPSSCCKGTDGNCGLNLYTEGCLE 80


                ....*....
gi 24586140 180 TFVEFWDRN 188
Cdd:cd03127  81 KLVDFLRSN 89
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 107-183 1.03e-09

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 53.90  E-value: 1.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586140 107 KDKYLEIMGDVVeKAWNHRTSRSDYMDAIQISMKCCGRSGYTD-----YAYQGKFPPSCCSDTNNCRWET---------- 171
Cdd:cd03161   8 KGTFLRTYNEAV-SNYNGDDERSDAVDTVQRTLHCCGVENYTDwlnspYFLEKGIPLSCCKNRSDCSPQDlknltkaatk 86

                        90
                ....*....|....*
gi 24586140 172 VYRRGC--KVT-FVE 183
Cdd:cd03161  87 VYQQGCftLVTsFME 101
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 118-177 1.07e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 42.74  E-value: 1.07e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24586140 118 VEKAWNHrtsrsdymdaIQISMKCCGRSGYTD---YAYQGKFPPSCCSDTN-NCR---WETVYRRGC 177
Cdd:cd03165  30 LTNAWDI----------TQTEFRCCGVTNYTDwyeVLGENRVPDSCCQEDSqDCGrnpTELWWKTGC 86
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 106-177 1.08e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 43.14  E-value: 1.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586140 106 QKDKYLEIMGDVVEK------AWNHRTSRSDYMDAIQISMKCCGRSGYTDYAYQGK--------FPPSC----------- 160
Cdd:cd03160   4 QRDKLKQEMGDIVEKviqnygGNPENKTAEEAWDYVQFQLQCCGWTGPQDWTDNSLiknsseplYPCSCcnssatadspr 83

                        90       100
                ....*....|....*....|..
gi 24586140 161 -----CSDTNNCRWeTVYRRGC 177
Cdd:cd03160  84 pskgfCEAPASLDW-PVYQEGC 104
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 132-189 4.05e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 41.75  E-value: 4.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586140 132 MDAIQISMKCCGRSGYTDYAYQGKF-----------PPSCCSDTNNCRWET-----------VYRRGCKVTFVEFWDRNS 189
Cdd:cd03156  35 WNRVMIELKCCGVNGPTDFVDSTSFfrqknepnspyPESCCKRNSNSQIVDldcpklgspnsYNKKGCYEKLSNPIERYA 114
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 102-177 5.27e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 40.54  E-value: 5.27e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24586140 102 YMWVQK-DKYL-EIMGDVVEKAWNHRTSRSDYmDAIQISMKCCGRSGYTDYayqGKFPP-SCCSDTNNcrwetVYRRGC 177
Cdd:cd03164   1 FVYEKKlNNYVkEGLTDSLEQYHKDNNTSEAW-DMIQSNLQCCGINGTTDW---GSGVPsSCCSSDTE-----YKVEGC 70
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 108-183 4.82e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 38.56  E-value: 4.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586140 108 DKYLEIMGDVVEKAWNHRTSRSDYMDAIQISMKCCGRSGYTD------YAYQGKF--PPSCCSDT-NNC-----RWETVY 173
Cdd:cd03163   9 EDELNPSIDKVFNKYNGTNAESRAVDYLQRQLQCCGIHNYTDwentpwFKESKNNsvPLSCCKETfTSCtgsltQPKDLY 88

                        90
                ....*....|
gi 24586140 174 RRGCKVTFVE 183
Cdd:cd03163  89 QEGCEAKLVK 98
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 132-187 1.85e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 36.68  E-value: 1.85e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24586140 132 MDAIQISMKCCGRSGYTDYAY-----QGKFPPSCC-SDTNNC----RWETVYRRGCkVTFVEFWDR 187
Cdd:cd03166  32 LDRMQKDLKCCGANNYTDWENipsldTDSVPDSCCiNVTKGCginfDEKVIHLEGC-VTKIEGWLK 96
TM4SF3_like_LEL cd03154
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. ...
 130-184 6.15e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 3 (TM4SF3) or D6.1a and related proteins. D6.1a associates with alpha6beta4 integrin and supports cell motility, it has been ascribed a role in tumor progression and metastasis.


Pssm-ID: 239407 [Multi-domain]  Cd Length: 100  Bit Score: 35.09  E-value: 6.15e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24586140 130 DYMDAIQISMKCCG-RSGYTDYAyqGKFPPSC-CSDTNNCRW------ETVYRRGCKVTFVEF 184
Cdd:cd03154  35 KSLEKFQKELKCCGlVNGADDWG--NDIPASCnCTTTQSDCVvayyggSNVYKEPCISKIKDF 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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