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Conserved domains on  [gi|239050813|ref|NP_653213|]
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lipoxygenase homology domain-containing protein 1 isoform 1 [Homo sapiens]

Protein Classification

phospholipase C( domain architecture ID 10109880)

phospholipase C catayzes the hydroysis of a phosphatidylcholine to form 1,2-diacyl-sn-glycerol and phosphocholine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1022-1142 9.06e-62

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 207.02  E-value: 9.06e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1022 NTYEVQVVTGNVPKAGTDANVYLTIYGEeYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRAG 1101
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGE-NGDTGKRKLKKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 239050813 1102 WFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPV 1142
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 2092-2210 1.84e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 191.61  E-value: 1.84e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 2092 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQK-MRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGW 2170
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813 2171 LVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLFPS 2210
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1175-1295 2.79e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 191.23  E-value: 2.79e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1175 TTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSkTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGKAPG 1254
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 239050813 1255 WFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHA 1295
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 554-675 9.38e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 189.69  E-value: 9.38e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  554 RYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCrNNTDLFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGW 633
Cdd:cd01756     2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 239050813  634 YLDRVLVREEGQpeSDNVEFPCLRWLDKDKDDGQLVRELLPS 675
Cdd:cd01756    81 FLDKVEIREPGT--GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 172-289 5.69e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 187.38  E-value: 5.69e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  172 NKYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLE--NEKDNFEKGAEDRFILDAPDLGQLMKINVGHNNKGGSAGW 249
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813  250 FLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVG 289
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1460-1580 2.84e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 185.45  E-value: 2.84e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1460 VLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRtNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCAD 1539
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNK-NKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 239050813 1540 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEK 1580
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1823-1943 1.09e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.91  E-value: 1.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1823 TSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFpDMLSLGHLCKLRVWHDNKGIFPG 1902
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 239050813 1903 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACA 1943
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 684-805 1.08e-51

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 178.13  E-value: 1.08e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  684 FRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNnlKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHA 763
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNN--KNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 239050813  764 SWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYPS 805
Cdd:cd01756    79 GWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 44-162 3.86e-51

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 176.59  E-value: 3.86e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   44 VYEVVTATGDVRGAGTDANVFITLFGENGLSPKLQL-TSKSKSAFEKGNVDVFRVRTNNVGLIYKVRIEHDNTGLNASWY 122
Cdd:cd01756     2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGWF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813  123 LDHVIVTDMKRpHLRYYFNCNNWLSKVEGDRQWCRDLLAS 162
Cdd:cd01756    82 LDKVEIREPGT-GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 425-542 2.82e-48

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 168.12  E-value: 2.82e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  425 FPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNK--WFKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGW 502
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNknKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813  503 HLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAE 542
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1306-1432 5.45e-46

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 161.95  E-value: 5.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1306 VPYEITLYTSDVFAAGTDANIFIIIYGcDAVCTQQKYLCTNKREQKqfFERKSASRFIVELEDVGEiIEKIRIGHNNTGM 1385
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNK--FERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 239050813 1386 NPGWHCSHVDIRRLLPDkdgaETLTFPCDRWLATSEDDKKTIRELVP 1432
Cdd:cd01756    77 GAGWFLDKVEIREPGTG----DEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 296-414 8.42e-46

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 161.18  E-value: 8.42e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  296 ITYIVTVFTGDVRGAGTKSKIYLVMYGARGNknSGKIFLE----GGVFDRGRTDIFHIElAVLLSPLSRVSVGHGNVGVN 371
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGD--TGKRKLKksnnKNKFERGQTDKFTVE-AVDLGKLKKIRIGHDNSGLG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 239050813  372 RGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEM 414
Cdd:cd01756    78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1696-1813 4.21e-45

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 159.26  E-value: 4.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1696 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKK--KARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEW 1773
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813 1774 FLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAV 1813
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT super family cl00011
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 816-896 7.96e-28

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


The actual alignment was detected with superfamily member cd01756:

Pssm-ID: 412108  Cd Length: 120  Bit Score: 109.95  E-value: 7.96e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  816 YEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFL--SSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFV 893
Cdd:cd01756     3 YEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkkSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGWFL 82


                  ...
gi 239050813  894 DTV 896
Cdd:cd01756    83 DKV 85
PLAT super family cl00011
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1956-2057 9.46e-05

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


The actual alignment was detected with superfamily member cd00113:

Pssm-ID: 412108  Cd Length: 116  Bit Score: 43.87  E-value: 9.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1956 YEIVIETGN--GGETRENVWLILEGR-KNRSKEFLMENSSRqraFRKGTTDTFEFDSiyLGDIASLCVGHLAREDrfiPK 2032
Cdd:cd00113     3 YTVTIKTGDkkGAGTDSNISLALYGEnGNSSDIPILDGPGS---FERGSTDTFQIDL--KLDIGDITKVYLRRDG---SG 74

                          90       100
                  ....*....|....*....|....*
gi 239050813 2033 RELAWHVKTITITEMEYGNVYFFNC 2057
Cdd:cd00113    75 LSDGWYCESITVQALGTKKVYTFPV 99
 
Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1022-1142 9.06e-62

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 207.02  E-value: 9.06e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1022 NTYEVQVVTGNVPKAGTDANVYLTIYGEeYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRAG 1101
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGE-NGDTGKRKLKKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 239050813 1102 WFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPV 1142
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 2092-2210 1.84e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 191.61  E-value: 1.84e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 2092 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQK-MRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGW 2170
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813 2171 LVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLFPS 2210
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1175-1295 2.79e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 191.23  E-value: 2.79e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1175 TTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSkTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGKAPG 1254
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 239050813 1255 WFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHA 1295
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 554-675 9.38e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 189.69  E-value: 9.38e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  554 RYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCrNNTDLFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGW 633
Cdd:cd01756     2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 239050813  634 YLDRVLVREEGQpeSDNVEFPCLRWLDKDKDDGQLVRELLPS 675
Cdd:cd01756    81 FLDKVEIREPGT--GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 172-289 5.69e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 187.38  E-value: 5.69e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  172 NKYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLE--NEKDNFEKGAEDRFILDAPDLGQLMKINVGHNNKGGSAGW 249
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813  250 FLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVG 289
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1460-1580 2.84e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 185.45  E-value: 2.84e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1460 VLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRtNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCAD 1539
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNK-NKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 239050813 1540 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEK 1580
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1823-1943 1.09e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.91  E-value: 1.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1823 TSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFpDMLSLGHLCKLRVWHDNKGIFPG 1902
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 239050813 1903 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACA 1943
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 684-805 1.08e-51

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 178.13  E-value: 1.08e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  684 FRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNnlKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHA 763
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNN--KNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 239050813  764 SWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYPS 805
Cdd:cd01756    79 GWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 44-162 3.86e-51

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 176.59  E-value: 3.86e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   44 VYEVVTATGDVRGAGTDANVFITLFGENGLSPKLQL-TSKSKSAFEKGNVDVFRVRTNNVGLIYKVRIEHDNTGLNASWY 122
Cdd:cd01756     2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGWF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813  123 LDHVIVTDMKRpHLRYYFNCNNWLSKVEGDRQWCRDLLAS 162
Cdd:cd01756    82 LDKVEIREPGT-GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 425-542 2.82e-48

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 168.12  E-value: 2.82e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  425 FPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNK--WFKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGW 502
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNknKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813  503 HLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAE 542
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1306-1432 5.45e-46

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 161.95  E-value: 5.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1306 VPYEITLYTSDVFAAGTDANIFIIIYGcDAVCTQQKYLCTNKREQKqfFERKSASRFIVELEDVGEiIEKIRIGHNNTGM 1385
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNK--FERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 239050813 1386 NPGWHCSHVDIRRLLPDkdgaETLTFPCDRWLATSEDDKKTIRELVP 1432
Cdd:cd01756    77 GAGWFLDKVEIREPGTG----DEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 296-414 8.42e-46

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 161.18  E-value: 8.42e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  296 ITYIVTVFTGDVRGAGTKSKIYLVMYGARGNknSGKIFLE----GGVFDRGRTDIFHIElAVLLSPLSRVSVGHGNVGVN 371
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGD--TGKRKLKksnnKNKFERGQTDKFTVE-AVDLGKLKKIRIGHDNSGLG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 239050813  372 RGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEM 414
Cdd:cd01756    78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1696-1813 4.21e-45

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 159.26  E-value: 4.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1696 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKK--KARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEW 1773
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813 1774 FLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAV 1813
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 816-896 7.96e-28

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 109.95  E-value: 7.96e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  816 YEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFL--SSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFV 893
Cdd:cd01756     3 YEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkkSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGWFL 82


                  ...
gi 239050813  894 DTV 896
Cdd:cd01756    83 DKV 85
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1024-1131 1.92e-23

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 97.12  E-value: 1.92e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  1024 YEVQVVTGNVPKAGTDANVYLTIYGEEyGDTGERPLKKSDKSnkFEQGQTDTFTIYAI-DLGALTKIRIRHDNTGNRAGW 1102
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKV-GESAQLEITLDNPD--FERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 239050813  1103 FLDRIDIT-DMNNEITYYFPCQRWLAVEED 1131
Cdd:pfam01477   78 FLKSITVEvPGETGGKYTFPCNSWVYGSKK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1825-1936 9.62e-21

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 89.41  E-value: 9.62e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  1825 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQsaNWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWH 1904
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITL--DNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWF 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 239050813  1905 LSYVDVKDNSRDE-TFHFQCDCWLSKSEGDGQT 1936
Cdd:pfam01477   79 LKSITVEVPGETGgKYTFPCNSWVYGSKKYKET 111
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 45-148 1.74e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 88.64  E-value: 1.74e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813    45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSaFEKGNVDVFRVRT-NNVGLIYKVRIEHDNTGLNASWYL 123
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100
                   ....*....|....*....|....*
gi 239050813   124 DHVIVTDMKRPHLRYYFNCNNWLSK 148
Cdd:pfam01477   80 KSITVEVPGETGGKYTFPCNSWVYG 104
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 174-273 9.52e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 86.72  E-value: 9.52e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   174 YEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDRFILDAP-DLGQLMKINVGHNNKGGSAGWFLS 252
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100
                   ....*....|....*....|..
gi 239050813   253 QIVIEDIG-NKRKYDFPLNRWL 273
Cdd:pfam01477   81 SITVEVPGeTGGKYTFPCNSWV 102
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1177-1284 2.44e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 85.56  E-value: 2.44e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKsskTNSDKFERDSIEIFTVET-LDLGDLWKVRLGHDNTGKAPGW 1255
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEIT---LDNPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 239050813  1256 FVDWVEVDAPSL-GKCMTFPCGRWLAKNED 1284
Cdd:pfam01477   78 FLKSITVEVPGEtGGKYTFPCNSWVYGSKK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1462-1577 6.02e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 84.41  E-value: 6.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRtnkFERGTADTFII-EAADLGVIYKIKLRHDNSKWCADW 1540
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD---FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 239050813  1541 YVEKVEIW-NDTNEDEFLFLCGRWLSlKKEDGRLERLF 1577
Cdd:pfam01477   78 FLKSITVEvPGETGGKYTFPCNSWVY-GSKKYKETRVF 114
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 298-402 2.56e-18

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 82.48  E-value: 2.56e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   298 YIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCE 377
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100
                   ....*....|....*....|....*.
gi 239050813   378 KVVILCP-FTGIQQTFPCSNWLDEKK 402
Cdd:pfam01477   81 SITVEVPgETGGKYTFPCNSWVYGSK 106
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 2094-2203 1.53e-17

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 80.17  E-value: 1.53e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKmRNLFERGSTDRFFLET-LELGELRKVRLEHDSSGYCSGWLV 2172
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLD-NPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 239050813  2173 EKVEVT-NTSTGVATIFNCGRWLDKKRGDGLT 2203
Cdd:pfam01477   80 KSITVEvPGETGGKYTFPCNSWVYGSKKYKET 111
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 686-793 5.96e-17

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 78.63  E-value: 5.96e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   686 YHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNlkdyFERGRVDEFTLET-LNIGNINRLVIGHDSTGMHAS 764
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD----FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDE 76

                           90       100       110
                   ....*....|....*....|....*....|
gi 239050813   765 WFLGSVQIRVPRQ-GKQYTFPANRWLDKNQ 793
Cdd:pfam01477   77 WFLKSITVEVPGEtGGKYTFPCNSWVYGSK 106
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 427-534 1.27e-15

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 74.78  E-value: 1.27e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   427 WSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIELP-DLGRFYKIRVWHDKRSSGSGWHLE 505
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 239050813   506 RMTLM-NTLNKDKYNFNCNRWLDANEDDNE 534
Cdd:pfam01477   81 SITVEvPGETGGKYTFPCNSWVYGSKKYKE 110
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 555-664 1.68e-15

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 74.39  E-value: 1.68e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   555 YHVTVCTGELEGAGTDANVYLCLFGDVGDTGerLLYNCRNNTDlFEKGNADEFTI-ESVTMRNVRRVRIRHDGKGSGSGW 633
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESA--QLEITLDNPD-FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 239050813   634 YLDRVLVREEGQPESdNVEFPCLRWLDKDKD 664
Cdd:pfam01477   78 FLKSITVEVPGETGG-KYTFPCNSWVYGSKK 107
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1179-1282 2.02e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 68.05  E-value: 2.02e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   1179 VTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSdkFERDSIEIFTVET-LDLGDLWKVRLGHDNtgKAPGWFV 1257
Cdd:smart00308    5 VTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGI--FARGSTYEFTFDVdEDFGELGAVKIKNEH--RHPEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 239050813   1258 DWVEVDAPSLGKCMTFPCGRWLAKN 1282
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 816-899 3.13e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 68.23  E-value: 3.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   816 YEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSKVFERASKDTFQL-EAADVGEVYKLRLGHTGEGFGPSWFVD 894
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEWFLK 80


                   ....*
gi 239050813   895 TVWLR 899
Cdd:pfam01477   81 SITVE 85
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
173-273 3.23e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 67.67  E-value: 3.23e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813    173 KYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRL-ENEKDNFEKGAEDRFILDAP-DLGQLMKINVgHNNKGGSAgWF 250
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLdYLFKGIFARGSTYEFTFDVDeDFGELGAVKI-KNEHRHPE-WF 79

                            90       100
                    ....*....|....*....|...
gi 239050813    251 LSQIVIEDIGNKRKYDFPLNRWL 273
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWV 102
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1698-1807 5.09e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 67.46  E-value: 5.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGLGSRPEWFLE 1776
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 239050813  1777 RILL-KNMNTGDLTMFYYGDWLSQ-RKGKKTLV 1807
Cdd:pfam01477   81 SITVeVPGETGGKYTFPCNSWVYGsKKYKETRV 113
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
431-527 1.15e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 66.13  E-value: 1.15e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813    431 VWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKW-FKPGIIEKFRIELP-DLGRFYKIRVWHDKRSSGsgWHLERMT 508
Cdd:smart00308    7 VTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGiFARGSTYEFTFDVDeDFGELGAVKIKNEHRHPE--WFLKSIT 84

                            90
                    ....*....|....*....
gi 239050813    509 LMNTLNKDKYNFNCNRWLD 527
Cdd:smart00308   85 VKDLPTGGKYHFPCNSWVY 103
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
2093-2197 2.07e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 65.36  E-value: 2.07e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   2093 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELGELRKVRLEHDSSGycSGWL 2171
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEHRH--PEWF 79

                            90       100
                    ....*....|....*....|....*.
gi 239050813   2172 VEKVEVTNTSTGVATIFNCGRWLDKK 2197
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1308-1426 3.69e-12

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 65.15  E-value: 3.69e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  1308 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKReqkqfFERKSASRFIVELE-DVGEIIeKIRIGHNNTGMN 1386
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-----FERGAEDSFEIDTDwDVGAIL-KINLHWDNNGLS 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 239050813  1387 PGWHCSHVdirRLLPDKDGAETLTFPCDRWLATSEDDKKT 1426
Cdd:pfam01477   75 DEWFLKSI---TVEVPGETGGKYTFPCNSWVYGSKKYKET 111
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1024-1126 1.31e-11

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 63.04  E-value: 1.31e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   1024 YEVQVVTGNVPKAGTDANVYLTIYGEEyGDTGERPLKKSDKsNKFEQGQTDTFTI-YAIDLGALTKIRIRHDNtgNRAGW 1102
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAE-GDGKESKLDYLFK-GIFARGSTYEFTFdVDEDFGELGAVKIKNEH--RHPEW 78

                            90       100
                    ....*....|....*....|....
gi 239050813   1103 FLDRIDITDMNNEITYYFPCQRWL 1126
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWV 102
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
553-662 1.75e-10

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 59.96  E-value: 1.75e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813    553 ARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNtdLFEKGNADEFTIE-SVTMRNVRRVRIRHDGKgsGS 631
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKG--IFARGSTYEFTFDvDEDFGELGAVKIKNEHR--HP 76

                            90       100       110
                    ....*....|....*....|....*....|.
gi 239050813    632 GWYLDRVLVreEGQPESDNVEFPCLRWLDKD 662
Cdd:smart00308   77 EWFLKSITV--KDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1825-1929 1.12e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 54.57  E-value: 1.12e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   1825 YTVAVKTSDILGAGTDANVFIIIFGENGDSGtLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKgiFPGWH 1904
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGK-ESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHR--HPEWF 79

                            90       100
                    ....*....|....*....|....*
gi 239050813   1905 LSYVDVKDNSRDETFHFQCDCWLSK 1929
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYP 104
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1462-1567 1.85e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 54.18  E-value: 1.85e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENrtNKFERGTADTFIIE-AADLGVIYKIKLRHDNSKwcADW 1540
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFK--GIFARGSTYEFTFDvDEDFGELGAVKIKNEHRH--PEW 78

                            90       100
                    ....*....|....*....|....*..
gi 239050813   1541 YVEKVEIWNDTNEDEFLFLCGRWLSLK 1567
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
298-401 6.05e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 52.64  E-value: 6.05e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813    298 YIVTVFTGDVRGAGTKSKIYLVMYGARG-NKNSGKIFLEGGVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGvnRGWFC 376
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGdGKESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHRH--PEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 239050813    377 EKVVILCPFTGIQQTFPCSNWLDEK 401
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
684-792 9.65e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 51.87  E-value: 9.65e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813    684 FRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLlvsDNNLKDYFERGRVDEFTLET-LNIGNINRLVIGHDSTgmH 762
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKL---DYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEHR--H 75

                            90       100       110
                    ....*....|....*....|....*....|
gi 239050813    763 ASWFLGSVQIRVPRQGKQYTFPANRWLDKN 792
Cdd:smart00308   76 PEWFLKSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
45-148 2.14e-07

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 51.10  E-value: 2.14e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813     45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRTN-NVGLIYKVRIEHDNTGlnASWYL 123
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVDeDFGELGAVKIKNEHRH--PEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 239050813    124 DHVIVTDMKrPHLRYYFNCNNWLSK 148
Cdd:smart00308   81 KSITVKDLP-TGGKYHFPCNSWVYP 104
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1698-1798 3.41e-05

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 44.94  E-value: 3.41e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDK-KKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGlgSRPEWFL 1775
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYlFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEH--RHPEWFL 80

                            90       100
                    ....*....|....*....|...
gi 239050813   1776 ERILLKNMNTGDLTMFYYGDWLS 1798
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVY 103
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1956-2057 9.46e-05

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 43.87  E-value: 9.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1956 YEIVIETGN--GGETRENVWLILEGR-KNRSKEFLMENSSRqraFRKGTTDTFEFDSiyLGDIASLCVGHLAREDrfiPK 2032
Cdd:cd00113     3 YTVTIKTGDkkGAGTDSNISLALYGEnGNSSDIPILDGPGS---FERGSTDTFQIDL--KLDIGDITKVYLRRDG---SG 74

                          90       100
                  ....*....|....*....|....*
gi 239050813 2033 RELAWHVKTITITEMEYGNVYFFNC 2057
Cdd:cd00113    75 LSDGWYCESITVQALGTKKVYTFPV 99
 
Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1022-1142 9.06e-62

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 207.02  E-value: 9.06e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1022 NTYEVQVVTGNVPKAGTDANVYLTIYGEeYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRAG 1101
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGE-NGDTGKRKLKKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 239050813 1102 WFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPV 1142
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 2092-2210 1.84e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 191.61  E-value: 1.84e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 2092 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQK-MRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGW 2170
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813 2171 LVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLFPS 2210
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1175-1295 2.79e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 191.23  E-value: 2.79e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1175 TTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSkTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGKAPG 1254
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 239050813 1255 WFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHA 1295
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 554-675 9.38e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 189.69  E-value: 9.38e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  554 RYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCrNNTDLFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGW 633
Cdd:cd01756     2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 239050813  634 YLDRVLVREEGQpeSDNVEFPCLRWLDKDKDDGQLVRELLPS 675
Cdd:cd01756    81 FLDKVEIREPGT--GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 172-289 5.69e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 187.38  E-value: 5.69e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  172 NKYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLE--NEKDNFEKGAEDRFILDAPDLGQLMKINVGHNNKGGSAGW 249
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813  250 FLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVG 289
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1460-1580 2.84e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 185.45  E-value: 2.84e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1460 VLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRtNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCAD 1539
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNK-NKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 239050813 1540 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEK 1580
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1823-1943 1.09e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.91  E-value: 1.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1823 TSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFpDMLSLGHLCKLRVWHDNKGIFPG 1902
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 239050813 1903 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACA 1943
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 684-805 1.08e-51

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 178.13  E-value: 1.08e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  684 FRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNnlKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHA 763
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNN--KNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 239050813  764 SWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYPS 805
Cdd:cd01756    79 GWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 44-162 3.86e-51

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 176.59  E-value: 3.86e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   44 VYEVVTATGDVRGAGTDANVFITLFGENGLSPKLQL-TSKSKSAFEKGNVDVFRVRTNNVGLIYKVRIEHDNTGLNASWY 122
Cdd:cd01756     2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGWF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813  123 LDHVIVTDMKRpHLRYYFNCNNWLSKVEGDRQWCRDLLAS 162
Cdd:cd01756    82 LDKVEIREPGT-GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 425-542 2.82e-48

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 168.12  E-value: 2.82e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  425 FPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNK--WFKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGW 502
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNknKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813  503 HLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAE 542
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1306-1432 5.45e-46

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 161.95  E-value: 5.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1306 VPYEITLYTSDVFAAGTDANIFIIIYGcDAVCTQQKYLCTNKREQKqfFERKSASRFIVELEDVGEiIEKIRIGHNNTGM 1385
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNK--FERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 239050813 1386 NPGWHCSHVDIRRLLPDkdgaETLTFPCDRWLATSEDDKKTIRELVP 1432
Cdd:cd01756    77 GAGWFLDKVEIREPGTG----DEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 296-414 8.42e-46

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 161.18  E-value: 8.42e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  296 ITYIVTVFTGDVRGAGTKSKIYLVMYGARGNknSGKIFLE----GGVFDRGRTDIFHIElAVLLSPLSRVSVGHGNVGVN 371
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGD--TGKRKLKksnnKNKFERGQTDKFTVE-AVDLGKLKKIRIGHDNSGLG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 239050813  372 RGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEM 414
Cdd:cd01756    78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1696-1813 4.21e-45

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 159.26  E-value: 4.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1696 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKK--KARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEW 1773
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813 1774 FLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAV 1813
Cdd:cd01756    81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1698-1808 7.82e-31

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 118.21  E-value: 7.82e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGLGSRPEWFLE 1776
Cdd:cd00113     3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGWYCE 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 239050813 1777 RILLKNMNTGDLTMFYYGDWLSQRKGKKTLVC 1808
Cdd:cd00113    83 SITVQALGTKKVYTFPVNRWVLGGKWYTSVRS 114
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 173-288 1.61e-30

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 117.76  E-value: 1.61e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  173 KYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDN-FEKGAEDRFILDAP-DLGQLMKINVGHNNKGGSAGWF 250
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPiFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWY 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 239050813  251 LSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILV 288
Cdd:cd01752    82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPV 119
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 45-154 1.29e-29

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 115.07  E-value: 1.29e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRT-NNVGLIYKVRIEHDNTGLNASWYL 123
Cdd:cd01752     3 YLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPIFERGSVDSFLLTTpFPLGELQSIRLWHDNSGLSPSWYL 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 239050813  124 DHVIVTDMKRPHlRYYFNCNNWLSKVEGDRQ 154
Cdd:cd01752    83 SRVIVRDLQTGK-KWFFLCNDWLSVEEGDGT 112
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1024-1140 6.48e-29

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 113.14  E-value: 6.48e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1024 YEVQVVTGNVPKAGTDANVYLTIYGEEyGDTGERPLKKSDKSnKFEQGQTDTFTI-YAIDLGALTKIRIRHDNTGNRAGW 1102
Cdd:cd01752     3 YLVTVFTGWRRGAGTTAKVTITLYGAE-GESEPHHLRDPEKP-IFERGSVDSFLLtTPFPLGELQSIRLWHDNSGLSPSW 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 239050813 1103 FLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELL 1140
Cdd:cd01752    81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1824-1943 1.13e-28

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 112.37  E-value: 1.13e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1824 SYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSaNWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGW 1903
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDP-EKPIFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813 1904 HLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACA 1943
Cdd:cd01752    81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPVA 120
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1461-1578 1.66e-28

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 111.98  E-value: 1.66e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1461 LYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTnkFERGTADTFIIEAA-DLGVIYKIKLRHDNSKWCAD 1539
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPI--FERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPS 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 239050813 1540 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFY 1578
Cdd:cd01752    80 WYLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 816-896 7.96e-28

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 109.95  E-value: 7.96e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  816 YEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFL--SSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFV 893
Cdd:cd01756     3 YEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkkSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGWFL 82


                  ...
gi 239050813  894 DTV 896
Cdd:cd01756    83 DKV 85
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 2093-2208 1.67e-27

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 108.90  E-value: 1.67e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 2093 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLE-LGELRKVRLEHDSSGYCSGWL 2171
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPIFERGSVDSFLLTTPFpLGELQSIRLWHDNSGLSPSWY 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 239050813 2172 VEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLF 2208
Cdd:cd01752    82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1024-1131 1.92e-23

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 97.12  E-value: 1.92e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  1024 YEVQVVTGNVPKAGTDANVYLTIYGEEyGDTGERPLKKSDKSnkFEQGQTDTFTIYAI-DLGALTKIRIRHDNTGNRAGW 1102
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKV-GESAQLEITLDNPD--FERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 239050813  1103 FLDRIDIT-DMNNEITYYFPCQRWLAVEED 1131
Cdd:pfam01477   78 FLKSITVEvPGETGGKYTFPCNSWVYGSKK 107
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1179-1295 3.17e-23

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 96.58  E-value: 3.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1179 VTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSdkFERDSIEIFTVETL-DLGDLWKVRLGHDNTGKAPGWFV 1257
Cdd:cd01752     5 VTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPI--FERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWYL 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 239050813 1258 DWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHA 1295
Cdd:cd01752    83 SRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPVA 120
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1177-1287 3.81e-21

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 90.48  E-value: 3.81e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSsktNSDKFERDSIEIFTVET-LDLGDLWKVRLGHDNTGKAPGW 1255
Cdd:cd00113     3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILD---GPGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGW 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 239050813 1256 FVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGS 1287
Cdd:cd00113    80 YCESITVQALGTKKVYTFPVNRWVLGGKWYTS 111
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1825-1936 9.62e-21

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 89.41  E-value: 9.62e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  1825 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQsaNWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWH 1904
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITL--DNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWF 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 239050813  1905 LSYVDVKDNSRDE-TFHFQCDCWLSKSEGDGQT 1936
Cdd:pfam01477   79 LKSITVEVPGETGgKYTFPCNSWVYGSKKYKET 111
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 45-148 1.74e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 88.64  E-value: 1.74e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813    45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSaFEKGNVDVFRVRT-NNVGLIYKVRIEHDNTGLNASWYL 123
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100
                   ....*....|....*....|....*
gi 239050813   124 DHVIVTDMKRPHLRYYFNCNNWLSK 148
Cdd:pfam01477   80 KSITVEVPGETGGKYTFPCNSWVYG 104
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 43-148 3.32e-20

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 88.16  E-value: 3.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   43 RVYEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKsKSAFEKGNVDVFRVRT-NNVGLIYKVRIEHDNTGLNASW 121
Cdd:cd00113     1 CRYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDG-PGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGW 79

                          90       100
                  ....*....|....*....|....*..
gi 239050813  122 YLDHVIVTDMKRPHlRYYFNCNNWLSK 148
Cdd:cd00113    80 YCESITVQALGTKK-VYTFPVNRWVLG 105
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1024-1126 7.29e-20

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 87.01  E-value: 7.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1024 YEVQVVTGNVPKAGTDANVYLTIYGEeYGDTGERPLkkSDKSNKFEQGQTDTFTIYA-IDLGALTKIRIRHDNTGNRAGW 1102
Cdd:cd00113     3 YTVTIKTGDKKGAGTDSNISLALYGE-NGNSSDIPI--LDGPGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGW 79

                          90       100
                  ....*....|....*....|....
gi 239050813 1103 FLDRIDITDMNNEITYYFPCQRWL 1126
Cdd:cd00113    80 YCESITVQALGTKKVYTFPVNRWV 103
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 684-803 7.92e-20

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 86.95  E-value: 7.92e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  684 FRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDnnlKDYFERGRVDEFTLETL-NIGNINRLVIGHDSTGMH 762
Cdd:cd01752     1 YLYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPE---KPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 239050813  763 ASWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELY 803
Cdd:cd01752    78 PSWYLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 174-273 9.52e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 86.72  E-value: 9.52e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   174 YEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDRFILDAP-DLGQLMKINVGHNNKGGSAGWFLS 252
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100
                   ....*....|....*....|..
gi 239050813   253 QIVIEDIG-NKRKYDFPLNRWL 273
Cdd:pfam01477   81 SITVEVPGeTGGKYTFPCNSWV 102
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 173-280 1.11e-19

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 86.62  E-value: 1.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  173 KYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDRFILDAP-DLGQLMKINVGHNNKGGSAGWFL 251
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKlDIGDITKVYLRRDGSGLSDGWYC 81

                          90       100
                  ....*....|....*....|....*....
gi 239050813  252 SQIVIEDIGNKRKYDFPLNRWLALDEDDG 280
Cdd:cd00113    82 ESITVQALGTKKVYTFPVNRWVLGGKWYT 110
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1825-1938 1.16e-19

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 86.24  E-value: 1.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1825 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLalKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWH 1904
Cdd:cd00113     3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSDI--PILDGPGSFERGSTDTFQIDLKLDIGDITKVYLRRDGSGLSDGWY 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 239050813 1905 LSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVR 1938
Cdd:cd00113    81 CESITVQALGTKKVYTFPVNRWVLGGKWYTSVRS 114
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1177-1284 2.44e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 85.56  E-value: 2.44e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKsskTNSDKFERDSIEIFTVET-LDLGDLWKVRLGHDNTGKAPGW 1255
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEIT---LDNPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 239050813  1256 FVDWVEVDAPSL-GKCMTFPCGRWLAKNED 1284
Cdd:pfam01477   78 FLKSITVEVPGEtGGKYTFPCNSWVYGSKK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1462-1577 6.02e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 84.41  E-value: 6.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRtnkFERGTADTFII-EAADLGVIYKIKLRHDNSKWCADW 1540
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD---FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 239050813  1541 YVEKVEIW-NDTNEDEFLFLCGRWLSlKKEDGRLERLF 1577
Cdd:pfam01477   78 FLKSITVEvPGETGGKYTFPCNSWVY-GSKKYKETRVF 114
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 2093-2203 1.45e-18

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 83.16  E-value: 1.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 2093 KYEVIVTTGYEPGAGTDANVFVTIFGANGdtgKRELKQKMRNL--FERGSTDRFFLET-LELGELRKVRLEHDSSGYCSG 2169
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYGENG---NSSDIPILDGPgsFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDG 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 239050813 2170 WLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLT 2203
Cdd:cd00113    79 WYCESITVQALGTKKVYTFPVNRWVLGGKWYTSV 112
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 298-402 2.56e-18

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 82.48  E-value: 2.56e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   298 YIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCE 377
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100
                   ....*....|....*....|....*.
gi 239050813   378 KVVILCP-FTGIQQTFPCSNWLDEKK 402
Cdd:pfam01477   81 SITVEVPgETGGKYTFPCNSWVYGSK 106
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1308-1430 5.67e-18

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 81.55  E-value: 5.67e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1308 YEITLYTSDVFAAGTDANIFIIIYGCDAvcTQQKYLCTNkrEQKQFFERKSASRFIVE-LEDVGEIiEKIRIGHNNTGMN 1386
Cdd:cd01752     3 YLVTVFTGWRRGAGTTAKVTITLYGAEG--ESEPHHLRD--PEKPIFERGSVDSFLLTtPFPLGEL-QSIRLWHDNSGLS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 239050813 1387 PGWHCSHVDIRRLLPDKdgaeTLTFPCDRWLATSEDDKKTIREL 1430
Cdd:cd01752    78 PSWYLSRVIVRDLQTGK----KWFFLCNDWLSVEEGDGTVERTF 117
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 298-400 1.23e-17

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 80.46  E-value: 1.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  298 YIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCE 377
Cdd:cd00113     3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKLDIGDITKVYLRRDGSGLSDGWYCE 82

                          90       100
                  ....*....|....*....|...
gi 239050813  378 KVVILCPFTGIQQTFPCSNWLDE 400
Cdd:cd00113    83 SITVQALGTKKVYTFPVNRWVLG 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 2094-2203 1.53e-17

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 80.17  E-value: 1.53e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKmRNLFERGSTDRFFLET-LELGELRKVRLEHDSSGYCSGWLV 2172
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLD-NPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 239050813  2173 EKVEVT-NTSTGVATIFNCGRWLDKKRGDGLT 2203
Cdd:pfam01477   80 KSITVEvPGETGGKYTFPCNSWVYGSKKYKET 111
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 554-673 3.32e-17

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 79.63  E-value: 3.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  554 RYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNcrNNTDLFEKGNADEFTIESV-TMRNVRRVRIRHDGKGSGSG 632
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRD--PEKPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 239050813  633 WYLDRVLVREegqPESDNV-EFPCLRWLDKDKDDGQLVRELL 673
Cdd:cd01752    80 WYLSRVIVRD---LQTGKKwFFLCNDWLSVEEGDGTVERTFP 118
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 686-793 5.96e-17

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 78.63  E-value: 5.96e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   686 YHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNlkdyFERGRVDEFTLET-LNIGNINRLVIGHDSTGMHAS 764
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD----FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDE 76

                           90       100       110
                   ....*....|....*....|....*....|
gi 239050813   765 WFLGSVQIRVPRQ-GKQYTFPANRWLDKNQ 793
Cdd:pfam01477   77 WFLKSITVEVPGEtGGKYTFPCNSWVYGSK 106
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 554-670 1.39e-16

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 77.76  E-value: 1.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  554 RYHVTVCTGELEGAGTDANVYLCLFGDVGDTGErllYNCRNNTDLFEKGNADEFTIE-SVTMRNVRRVRIRHDGKGSGSG 632
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSD---IPILDGPGSFERGSTDTFQIDlKLDIGDITKVYLRRDGSGLSDG 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 239050813  633 WYLDRVLVREEGqpESDNVEFPCLRWLDKDKDDGQLVR 670
Cdd:cd00113    79 WYCESITVQALG--TKKVYTFPVNRWVLGGKWYTSVRS 114
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 298-412 1.44e-16

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 77.70  E-value: 1.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  298 YIVTVFTGDVRGAGTKSKIYLVMYGArgNKNSGKIFLEGG---VFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGW 374
Cdd:cd01752     3 YLVTVFTGWRRGAGTTAKVTITLYGA--EGESEPHHLRDPekpIFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSW 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 239050813  375 FCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLY 412
Cdd:cd01752    81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 426-533 1.92e-16

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 77.38  E-value: 1.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  426 PWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIELP-DLGRFYKIRVWHDKRSSGSGWHL 504
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKlDIGDITKVYLRRDGSGLSDGWYC 81

                          90       100
                  ....*....|....*....|....*....
gi 239050813  505 ERMTLMNTLNKDKYNFNCNRWLDANEDDN 533
Cdd:cd00113    82 ESITVQALGTKKVYTFPVNRWVLGGKWYT 110
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 427-534 1.27e-15

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 74.78  E-value: 1.27e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   427 WSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIELP-DLGRFYKIRVWHDKRSSGSGWHLE 505
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 239050813   506 RMTLM-NTLNKDKYNFNCNRWLDANEDDNE 534
Cdd:pfam01477   81 SITVEvPGETGGKYTFPCNSWVYGSKKYKE 110
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1462-1577 1.28e-15

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 75.07  E-value: 1.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGErylGKSENRTNKFERGTADTFIIEAA-DLGVIYKIKLRHDNSKWCADW 1540
Cdd:cd00113     3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSD---IPILDGPGSFERGSTDTFQIDLKlDIGDITKVYLRRDGSGLSDGW 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 239050813 1541 YVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLF 1577
Cdd:cd00113    80 YCESITVQALGTKKVYTFPVNRWVLGGKWYTSVRSLK 116
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 815-906 1.33e-15

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 75.00  E-value: 1.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  815 HYEVEIWTGDVGGAGTSARVYMQIYGEKGKTEV-LFLSSRSKVFERASKDTFQLEAA-DVGEVYKLRLGHTGEGFGPSWF 892
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPhHLRDPEKPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWY 81

                          90
                  ....*....|....
gi 239050813  893 VDTVWLRHLVVREV 906
Cdd:cd01752    82 LSRVIVRDLQTGKK 95
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 685-792 1.52e-15

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 74.68  E-value: 1.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  685 RYHISLKTGDVSGASTDSRVYIKLYGDKSDTiKQVLLVSDNnlkDYFERGRVDEFTLET-LNIGNINRLVIGHDSTGMHA 763
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYGENGNS-SDIPILDGP---GSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSD 77

                          90       100
                  ....*....|....*....|....*....
gi 239050813  764 SWFLGSVQIRVPRQGKQYTFPANRWLDKN 792
Cdd:cd00113    78 GWYCESITVQALGTKKVYTFPVNRWVLGG 106
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 555-664 1.68e-15

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 74.39  E-value: 1.68e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   555 YHVTVCTGELEGAGTDANVYLCLFGDVGDTGerLLYNCRNNTDlFEKGNADEFTI-ESVTMRNVRRVRIRHDGKGSGSGW 633
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESA--QLEITLDNPD-FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 239050813   634 YLDRVLVREEGQPESdNVEFPCLRWLDKDKD 664
Cdd:pfam01477   78 FLKSITVEVPGETGG-KYTFPCNSWVYGSKK 107
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 437-542 2.09e-15

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 74.23  E-value: 2.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  437 KKAGTNSPIFIQIYGQKGRTD-EILLNPNNKWFKPGIIEKFRIELP-DLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLN 514
Cdd:cd01752    13 RGAGTTAKVTITLYGAEGESEpHHLRDPEKPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWYLSRVIVRDLQT 92

                          90       100
                  ....*....|....*....|....*...
gi 239050813  515 KDKYNFNCNRWLDANEDDNEIVREMTAE 542
Cdd:cd01752    93 GKKWFFLCNDWLSVEEGDGTVERTFPVA 120
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 815-906 5.12e-15

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 73.14  E-value: 5.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  815 HYEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSKVFERASKDTFQLEAA-DVGEVYKLRLGHTGEGFGPSWFV 893
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKlDIGDITKVYLRRDGSGLSDGWYC 81

                          90
                  ....*....|...
gi 239050813  894 DTVWLRHLVVREV 906
Cdd:cd00113    82 ESITVQALGTKKV 94
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1697-1806 5.92e-15

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 73.08  E-value: 5.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1697 LYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEildiAPF-----TKMRIRIDGLGSR 1770
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLrDPEKPIFERGSVDSFLLT----TPFplgelQSIRLWHDNSGLS 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 239050813 1771 PEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTL 1806
Cdd:cd01752    78 PSWYLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTV 113
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1177-1286 1.49e-14

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 71.80  E-value: 1.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1177 FSVTIKTGVK-KNAGTDANVFITLFGTQDDTGMTLLKssktnsdkfeRDSIEiFTVETLDLGDLWKVRLGHDNTGKAPGW 1255
Cdd:cd01757     3 YHVVIVPSKKlGGSMFTANPWICVSGELGETPPLQIP----------KNSLE-MTFDCQNLGKLTTVQIGHDNSGLLAKW 71

                          90       100       110
                  ....*....|....*....|....*....|.
gi 239050813 1256 FVDWVEVDAPSLGKCMTFPCGRWLAKNEDDG 1286
Cdd:cd01757    72 LVEYVMVRNEITGHTYKFPCGRWLGEGVDDG 102
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1179-1282 2.02e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 68.05  E-value: 2.02e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   1179 VTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSdkFERDSIEIFTVET-LDLGDLWKVRLGHDNtgKAPGWFV 1257
Cdd:smart00308    5 VTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGI--FARGSTYEFTFDVdEDFGELGAVKIKNEH--RHPEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 239050813   1258 DWVEVDAPSLGKCMTFPCGRWLAKN 1282
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 816-899 3.13e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 68.23  E-value: 3.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   816 YEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSKVFERASKDTFQL-EAADVGEVYKLRLGHTGEGFGPSWFVD 894
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEWFLK 80


                   ....*
gi 239050813   895 TVWLR 899
Cdd:pfam01477   81 SITVE 85
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
173-273 3.23e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 67.67  E-value: 3.23e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813    173 KYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRL-ENEKDNFEKGAEDRFILDAP-DLGQLMKINVgHNNKGGSAgWF 250
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLdYLFKGIFARGSTYEFTFDVDeDFGELGAVKI-KNEHRHPE-WF 79

                            90       100
                    ....*....|....*....|...
gi 239050813    251 LSQIVIEDIGNKRKYDFPLNRWL 273
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWV 102
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1698-1807 5.09e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 67.46  E-value: 5.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGLGSRPEWFLE 1776
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 239050813  1777 RILL-KNMNTGDLTMFYYGDWLSQ-RKGKKTLV 1807
Cdd:pfam01477   81 SITVeVPGETGGKYTFPCNSWVYGsKKYKETRV 113
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
431-527 1.15e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 66.13  E-value: 1.15e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813    431 VWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKW-FKPGIIEKFRIELP-DLGRFYKIRVWHDKRSSGsgWHLERMT 508
Cdd:smart00308    7 VTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGiFARGSTYEFTFDVDeDFGELGAVKIKNEHRHPE--WFLKSIT 84

                            90
                    ....*....|....*....
gi 239050813    509 LMNTLNKDKYNFNCNRWLD 527
Cdd:smart00308   85 VKDLPTGGKYHFPCNSWVY 103
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 44-152 1.33e-12

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 66.18  E-value: 1.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   44 VYEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKsAFEKGNVDVFRVR-TNNVGLIYKVRIEHDNTGLNASWY 122
Cdd:cd01753     2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGY-DFERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFDAWF 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 239050813  123 LDHVIVTDmkrPHLRYY-FNCNNWlskVEGD 152
Cdd:cd01753    81 CNYITVTG---PGGDEYhFPCYRW---IEGY 105
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 44-150 1.61e-12

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 66.41  E-value: 1.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   44 VYEVVTATGDVRGAGTDANVFITLFGENG-------LSPKLQLTSKSKSAFEKGNVDVFRVRTNNV-GLIYKVRIEHDNT 115
Cdd:cd01754     2 VYTIYVQTGSIWKAGTDSRISLQIYDADGpglrianLEAWGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGT 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 239050813  116 GLNASWYLDHVIVTdMKRPHLR---YYFNCNNWLSKVE 150
Cdd:cd01754    82 GNHPGWYVNYVEVT-QAGQHAPcmqHLFAVEQWLATDE 118
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
2093-2197 2.07e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 65.36  E-value: 2.07e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   2093 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELGELRKVRLEHDSSGycSGWL 2171
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEHRH--PEWF 79

                            90       100
                    ....*....|....*....|....*.
gi 239050813   2172 VEKVEVTNTSTGVATIFNCGRWLDKK 2197
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 2096-2203 2.62e-12

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 65.25  E-value: 2.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 2096 VIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKqkmRNLFErgstdrFFLETLELGELRKVRLEHDSSGYCSGWLVEKV 2175
Cdd:cd01757     6 VIVPSKKLGGSMFTANPWICVSGELGETPPLQIP---KNSLE------MTFDCQNLGKLTTVQIGHDNSGLLAKWLVEYV 76

                          90       100
                  ....*....|....*....|....*...
gi 239050813 2176 EVTNTSTGVATIFNCGRWLDKKRGDGLT 2203
Cdd:cd01757    77 MVRNEITGHTYKFPCGRWLGEGVDDGNG 104
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1024-1140 3.24e-12

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 65.25  E-value: 3.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1024 YEVQVVTGN-VPKAGTDANVYLTIYGEeYGDTGERPLKKsdksNKFEqgqtdtFTIYAIDLGALTKIRIRHDNTGNRAGW 1102
Cdd:cd01757     3 YHVVIVPSKkLGGSMFTANPWICVSGE-LGETPPLQIPK----NSLE------MTFDCQNLGKLTTVQIGHDNSGLLAKW 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 239050813 1103 FLDRIditDMNNEI---TYYFPCQRWLA-----VEEDDGQLSRELL 1140
Cdd:cd01757    72 LVEYV---MVRNEItghTYKFPCGRWLGegvddGNGEDGSLERVLV 114
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1308-1426 3.69e-12

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 65.15  E-value: 3.69e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  1308 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKReqkqfFERKSASRFIVELE-DVGEIIeKIRIGHNNTGMN 1386
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-----FERGAEDSFEIDTDwDVGAIL-KINLHWDNNGLS 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 239050813  1387 PGWHCSHVdirRLLPDKDGAETLTFPCDRWLATSEDDKKT 1426
Cdd:pfam01477   75 DEWFLKSI---TVEVPGETGGKYTFPCNSWVYGSKKYKET 111
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1024-1126 1.31e-11

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 63.04  E-value: 1.31e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   1024 YEVQVVTGNVPKAGTDANVYLTIYGEEyGDTGERPLKKSDKsNKFEQGQTDTFTI-YAIDLGALTKIRIRHDNtgNRAGW 1102
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAE-GDGKESKLDYLFK-GIFARGSTYEFTFdVDEDFGELGAVKIKNEH--RHPEW 78

                            90       100
                    ....*....|....*....|....
gi 239050813   1103 FLDRIDITDMNNEITYYFPCQRWL 1126
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWV 102
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1825-1931 1.35e-11

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 63.71  E-value: 1.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1825 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQS------ANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKG 1898
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIANLEAwgglmgAGHDYFERGNLDRFSGRGPCLPSPPCWMNLTSDGTG 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 239050813 1899 IFPGWHLSYVDVK---DNSRDETFHFQCDCWLSKSE 1931
Cdd:cd01754    83 NHPGWYVNYVEVTqagQHAPCMQHLFAVEQWLATDE 118
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1307-1417 2.03e-11

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 62.74  E-value: 2.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1307 PYEITLYTSDVFAAGTDANIFIIIYGcdAVCTQQKYLCTNKreqKQFFERKSASRFIVELE-DVGeIIEKIRIGHNNTGM 1385
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYG--ENGNSSDIPILDG---PGSFERGSTDTFQIDLKlDIG-DITKVYLRRDGSGL 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 239050813 1386 NPGWHCSHVDIRRLlpdkDGAETLTFPCDRWL 1417
Cdd:cd00113    76 SDGWYCESITVQAL----GTKKVYTFPVNRWV 103
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 685-790 2.93e-11

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 62.33  E-value: 2.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  685 RYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLvsdnNLKDYFERGRVDEFTLE-TLNIGNINRLVIGHDSTGMHA 763
Cdd:cd01753     2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLD----RPGYDFERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFD 77

                          90       100
                  ....*....|....*....|....*..
gi 239050813  764 SWFLGSVQIRVPRQGKqYTFPANRWLD 790
Cdd:cd01753    78 AWFCNYITVTGPGGDE-YHFPCYRWIE 103
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 553-663 3.01e-11

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 62.33  E-value: 3.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  553 ARYHVTVCTGELEGAGTDANVYLCLfgdVGDTGERLLYNCRNNTDLFEKGNADEFTIESVT-MRNVRRVRIRHDGKGSGS 631
Cdd:cd01753     1 AEYKVTVATGSSLFAGTDDYIYLTL---VGTAGESEKQLLDRPGYDFERGAVDEYKVKVPEdLGELLLVRLRKRKYLLFD 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 239050813  632 GWYLDRVLVREegqPESDNVEFPCLRWLDKDK 663
Cdd:cd01753    78 AWFCNYITVTG---PGGDEYHFPCYRWIEGYG 106
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1023-1136 4.07e-11

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 61.94  E-value: 4.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1023 TYEVQVVTGNVPKAGTDANVYLTIYGEEygdtGERPLKKSDKSNK-FEQGQTDTFTIYA-IDLGALTKIRIRHDNTGNRA 1100
Cdd:cd01753     2 EYKVTVATGSSLFAGTDDYIYLTLVGTA----GESEKQLLDRPGYdFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFD 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 239050813 1101 GWFLDRIDITDMNNEiTYYFPCQRWLaveEDDGQLS 1136
Cdd:cd01753    78 AWFCNYITVTGPGGD-EYHFPCYRWI---EGYGTLE 109
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 173-280 4.81e-11

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 61.56  E-value: 4.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  173 KYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDRFILDAP-DLGQLMKINVgHNNKGGS-AGWF 250
Cdd:cd01753     2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVPeDLGELLLVRL-RKRKYLLfDAWF 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 239050813  251 LSQIVIEDIGNkRKYDFPLNRWLaldEDDG 280
Cdd:cd01753    81 CNYITVTGPGG-DEYHFPCYRWI---EGYG 106
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1176-1289 5.56e-11

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 61.56  E-value: 5.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1176 TFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNsdkFERDSIEIFTVE-TLDLGDLWKVRLGHDNTGKAPG 1254
Cdd:cd01753     2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYD---FERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFDA 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 239050813 1255 WFVDWVEVDAPSlGKCMTFPCGRWLaknEDDGSII 1289
Cdd:cd01753    79 WFCNYITVTGPG-GDEYHFPCYRWI---EGYGTLE 109
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
553-662 1.75e-10

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 59.96  E-value: 1.75e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813    553 ARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNtdLFEKGNADEFTIE-SVTMRNVRRVRIRHDGKgsGS 631
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKG--IFARGSTYEFTFDvDEDFGELGAVKIKNEHR--HP 76

                            90       100       110
                    ....*....|....*....|....*....|.
gi 239050813    632 GWYLDRVLVreEGQPESDNVEFPCLRWLDKD 662
Cdd:smart00308   77 EWFLKSITV--KDLPTGGKYHFPCNSWVYPD 105
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 686-798 2.50e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 60.25  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  686 YHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLK----DYFERGRVDEFT--LETLNiGNINRLVIGHDST 759
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIANLEAWGGLMgaghDYFERGNLDRFSgrGPCLP-SPPCWMNLTSDGT 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 239050813  760 GMHASWFLGSVQIRVPRQGK---QYTFPANRWLDKNQADGRL 798
Cdd:cd01754    82 GNHPGWYVNYVEVTQAGQHApcmQHLFAVEQWLATDESPYML 123
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1176-1283 4.25e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 59.48  E-value: 4.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1176 TFSVTIKTGVKKNAGTDANVFITLFGTQDDTG-MTLLKS----SKTNSDKFERDSIEIFTVETLDL-GDLWKVRLGHDNT 1249
Cdd:cd01754     2 VYTIYVQTGSIWKAGTDSRISLQIYDADGPGLrIANLEAwgglMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGT 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 239050813 1250 GKAPGWFVDWVEVDAPSLGK-CMT--FPCGRWLAKNE 1283
Cdd:cd01754    82 GNHPGWYVNYVEVTQAGQHApCMQhlFAVEQWLATDE 118
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 174-277 5.42e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 59.09  E-value: 5.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  174 YEVKVYTGDVIGAGTDADVFINIFGEYGDTGE-RRLEN-------EKDNFEKGAEDRFILDAPDL-GQLMKINVGHNNKG 244
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRiANLEAwgglmgaGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 239050813  245 GSAGWFLSQIVIEDIGNKR---KYDFPLNRWLALDE 277
Cdd:cd01754    83 NHPGWYVNYVEVTQAGQHApcmQHLFAVEQWLATDE 118
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 555-666 7.31e-10

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 58.32  E-value: 7.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  555 YHVTVCTGE-LEGAGTDANVYLCLFGDVGDTGERLLyncrnntdlfeKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGW 633
Cdd:cd01757     3 YHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQI-----------PKNSLEMTFDCQNLGKLTTVQIGHDNSGLLAKW 71

                          90       100       110
                  ....*....|....*....|....*....|...
gi 239050813  634 YLDRVLVREEgqPESDNVEFPCLRWLDKDKDDG 666
Cdd:cd01757    72 LVEYVMVRNE--ITGHTYKFPCGRWLGEGVDDG 102
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 686-799 1.17e-09

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 57.93  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  686 YHISLKTGD-VSGASTDSRVYIKLYGDKSDTikQVLLVSDNNLkdyfergrvdEFTLETLNIGNINRLVIGHDSTGMHAS 764
Cdd:cd01757     3 YHVVIVPSKkLGGSMFTANPWICVSGELGET--PPLQIPKNSL----------EMTFDCQNLGKLTTVQIGHDNSGLLAK 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 239050813  765 WFLGSVQIRVPRQGKQYTFPANRWL-----DKNQADGRLE 799
Cdd:cd01757    71 WLVEYVMVRNEITGHTYKFPCGRWLgegvdDGNGEDGSLE 110
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 45-148 1.58e-09

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 57.55  E-value: 1.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   45 YEVVTATGD-VRGAGTDANVFITLFGENGLSPKLQLTSKSKSafekgnvdvFRVRTNNVGLIYKVRIEHDNTGLNASWYL 123
Cdd:cd01757     3 YHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQIPKNSLE---------MTFDCQNLGKLTTVQIGHDNSGLLAKWLV 73

                          90       100
                  ....*....|....*....|....*
gi 239050813  124 DHVIVTDMKRPHLrYYFNCNNWLSK 148
Cdd:cd01757    74 EYVMVRNEITGHT-YKFPCGRWLGE 97
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 297-399 1.91e-09

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 57.32  E-value: 1.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  297 TYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFC 376
Cdd:cd01753     2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVPEDLGELLLVRLRKRKYLLFDAWFC 81

                          90       100
                  ....*....|....*....|...
gi 239050813  377 EKVVILCPFTGIqQTFPCSNWLD 399
Cdd:cd01753    82 NYITVTGPGGDE-YHFPCYRWIE 103
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1023-1136 3.03e-09

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 57.17  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1023 TYEVQVVTGNVPKAGTDANVYLTIYGEEyGDTG-----ER--PLKKSDkSNKFEQGQTDTFTIYAIDL-GALTKIRIRHD 1094
Cdd:cd01754     2 VYTIYVQTGSIWKAGTDSRISLQIYDAD-GPGLrianlEAwgGLMGAG-HDYFERGNLDRFSGRGPCLpSPPCWMNLTSD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 239050813 1095 NTGNRAGWFLDRIDITDMNNEI---TYYFPCQRWLAVEEDDGQLS 1136
Cdd:cd01754    80 GTGNHPGWYVNYVEVTQAGQHApcmQHLFAVEQWLATDESPYMLT 124
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 2092-2201 3.88e-09

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 56.16  E-value: 3.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 2092 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNlFERGSTDRFFLE-TLELGELRKVRLEHDSSGYCSGW 2170
Cdd:cd01753     1 AEYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYD-FERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFDAW 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 239050813 2171 LVEKVEVTNTSTGVATiFNCGRWLDkkrGDG 2201
Cdd:cd01753    80 FCNYITVTGPGGDEYH-FPCYRWIE---GYG 106
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1460-1576 4.04e-09

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 56.39  E-value: 4.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1460 VLYSVQIFTGN-IPGAGTDAKVYITIYGDLGDTGERYLGKsenrtNKFErgtadtFIIEAADLGVIYKIKLRHDNSKWCA 1538
Cdd:cd01757     1 MPYHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQIPK-----NSLE------MTFDCQNLGKLTTVQIGHDNSGLLA 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 239050813 1539 DWYVEKVEIWNDTNEDEFLFLCGRWLS-----LKKEDGRLERL 1576
Cdd:cd01757    70 KWLVEYVMVRNEITGHTYKFPCGRWLGegvddGNGEDGSLERV 112
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1825-1929 1.12e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 54.57  E-value: 1.12e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   1825 YTVAVKTSDILGAGTDANVFIIIFGENGDSGtLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKgiFPGWH 1904
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGK-ESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHR--HPEWF 79

                            90       100
                    ....*....|....*....|....*
gi 239050813   1905 LSYVDVKDNSRDETFHFQCDCWLSK 1929
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYP 104
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1462-1567 1.85e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 54.18  E-value: 1.85e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENrtNKFERGTADTFIIE-AADLGVIYKIKLRHDNSKwcADW 1540
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFK--GIFARGSTYEFTFDvDEDFGELGAVKIKNEHRH--PEW 78

                            90       100
                    ....*....|....*....|....*..
gi 239050813   1541 YVEKVEIWNDTNEDEFLFLCGRWLSLK 1567
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 174-287 2.53e-08

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 54.08  E-value: 2.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  174 YEVKVYTGD-VIGAGTDADVFINIFGEYGDTGerRLENEKDNFEkgaedrFILDAPDLGQLMKINVGHNNKGGSAGWFLS 252
Cdd:cd01757     3 YHVVIVPSKkLGGSMFTANPWICVSGELGETP--PLQIPKNSLE------MTFDCQNLGKLTTVQIGHDNSGLLAKWLVE 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 239050813  253 QIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDIL 287
Cdd:cd01757    75 YVMVRNEITGHTYKFPCGRWLGEGVDDGNGEDGSL 109
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
298-401 6.05e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 52.64  E-value: 6.05e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813    298 YIVTVFTGDVRGAGTKSKIYLVMYGARG-NKNSGKIFLEGGVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGvnRGWFC 376
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGdGKESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHRH--PEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 239050813    377 EKVVILCPFTGIQQTFPCSNWLDEK 401
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 2094-2194 6.76e-08

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 53.31  E-value: 6.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGK-------RELKQKMRNLFERGSTDRFFLETLEL-GELRKVRLEHDSSG 2165
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRianleawGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 239050813 2166 YCSGWLVEKVEVtnTSTGVAT-----IFNCGRWL 2194
Cdd:cd01754    83 NHPGWYVNYVEV--TQAGQHApcmqhLFAVEQWL 114
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1461-1547 8.52e-08

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 52.93  E-value: 8.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1461 LYSVQIFTGNIPGAGTDAKVYITIYGDLGDTG-----ERYLGKSENRTNKFERGTADTFIIEAADL-GVIYKIKLRHDNS 1534
Cdd:cd01754     2 VYTIYVQTGSIWKAGTDSRISLQIYDADGPGLrianlEAWGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGT 81

                          90
                  ....*....|...
gi 239050813 1535 KWCADWYVEKVEI 1547
Cdd:cd01754    82 GNHPGWYVNYVEV 94
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
684-792 9.65e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 51.87  E-value: 9.65e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813    684 FRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLlvsDNNLKDYFERGRVDEFTLET-LNIGNINRLVIGHDSTgmH 762
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKL---DYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEHR--H 75

                            90       100       110
                    ....*....|....*....|....*....|
gi 239050813    763 ASWFLGSVQIRVPRQGKQYTFPANRWLDKN 792
Cdd:smart00308   76 PEWFLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 297-398 1.02e-07

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 52.93  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  297 TYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKiFLE--GGV-------FDRGRTDIFHIELAVLLSPLSRVSVGHGN 367
Cdd:cd01754     2 VYTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIA-NLEawGGLmgaghdyFERGNLDRFSGRGPCLPSPPCWMNLTSDG 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 239050813  368 VGVNRGWFCEKVVILCpfTGI-----QQTFPCSNWL 398
Cdd:cd01754    81 TGNHPGWYVNYVEVTQ--AGQhapcmQHLFAVEQWL 114
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1827-1936 1.23e-07

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 52.16  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1827 VAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNtdtfnfpdmlsLGHLCKLRVWHDNKGIFPGWHLS 1906
Cdd:cd01757     6 VIVPSKKLGGSMFTANPWICVSGELGETPPLQIPKNSLEMTFDCQN-----------LGKLTTVQIGHDNSGLLAKWLVE 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 239050813 1907 YVDVKDNSRDETFHFQCDCWLSKSEGDGQT 1936
Cdd:cd01757    75 YVMVRNEITGHTYKFPCGRWLGEGVDDGNG 104
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
45-148 2.14e-07

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 51.10  E-value: 2.14e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813     45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRTN-NVGLIYKVRIEHDNTGlnASWYL 123
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVDeDFGELGAVKIKNEHRH--PEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 239050813    124 DHVIVTDMKrPHLRYYFNCNNWLSK 148
Cdd:smart00308   81 KSITVKDLP-TGGKYHFPCNSWVYP 104
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 431-530 2.50e-07

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 51.16  E-value: 2.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  431 VWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIELP-DLGRFYKIRVWHDKRSSGSGWHLERMTL 509
Cdd:cd01753     7 VATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVPeDLGELLLVRLRKRKYLLFDAWFCNYITV 86

                          90       100
                  ....*....|....*....|.
gi 239050813  510 mNTLNKDKYNFNCNRWLDANE 530
Cdd:cd01753    87 -TGPGGDEYHFPCYRWIEGYG 106
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 555-668 6.80e-07

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 50.23  E-value: 6.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  555 YHVTVCTGELEGAGTDANVYLCLFGDVGDTG-----ERLLYNCRNNTDLFEKGNADEFTIESVTMRN-VRRVRIRHDGKG 628
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLrianlEAWGGLMGAGHDYFERGNLDRFSGRGPCLPSpPCWMNLTSDGTG 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 239050813  629 SGSGWYLDRVLVREEGQPESDNVE-FPCLRWLDKDKDDGQL 668
Cdd:cd01754    83 NHPGWYVNYVEVTQAGQHAPCMQHlFAVEQWLATDESPYML 123
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1460-1565 7.27e-07

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 49.61  E-value: 7.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1460 VLYSVQIFTGNIPGAGTDAKVYITIygdLGDTGERYLGKSENRTNKFERGTADTFIIEA-ADLGVIYKIKLRHDNSKWCA 1538
Cdd:cd01753     1 AEYKVTVATGSSLFAGTDDYIYLTL---VGTAGESEKQLLDRPGYDFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFD 77

                          90       100
                  ....*....|....*....|....*..
gi 239050813 1539 DWYVEKVEIwNDTNEDEFLFLCGRWLS 1565
Cdd:cd01753    78 AWFCNYITV-TGPGGDEYHFPCYRWIE 103
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 1023-1126 1.25e-06

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 49.00  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1023 TYEVQVVTGNVPKAGTDANVYLTIYGEEyGDTGERPLKKSdksnkFEQGQTDTFTIYAIDLGALTKIRIRhdNTGNRAGW 1102
Cdd:cd02899     2 TYTASVQTGKDKEAGTNGTIEITLLGSS-GRSNPKTLSQG-----FYPGSLKRIRFRAADVGDINAIILS--NTALNDPW 73

                          90       100
                  ....*....|....*....|....
gi 239050813 1103 FLDRIDITDMNNEItYYFPCQRWL 1126
Cdd:cd02899    74 YCDYVRIKSEDGKV-FAFNVKRWI 96
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1824-1934 1.52e-06

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 48.84  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1824 SYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKqsaNWNK-FERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 1902
Cdd:cd01753     2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLD---RPGYdFERGAVDEYKVKVPEDLGELLLVRLRKRKYLLFDA 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 239050813 1903 WHLSYVDVKDNSRDEtFHFQCDCWLsksEGDG 1934
Cdd:cd01753    79 WFCNYITVTGPGGDE-YHFPCYRWI---EGYG 106
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1308-1421 1.59e-06

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 49.46  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1308 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCT---NKREQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTG 1384
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIANLEAwggLMGAGHDYFERGNLDRFSGRGPCLPSPPCWMNLTSDGTG 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 239050813 1385 MNPGWHCSHVDIRRLLPDKDGAETLtFPCDRWLATSE 1421
Cdd:cd01754    83 NHPGWYVNYVEVTQAGQHAPCMQHL-FAVEQWLATDE 118
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1308-1428 6.58e-06

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 46.92  E-value: 6.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1308 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKReqkqfFERKSASRFIVEL-EDVGEIIeKIRIGHNNTGMN 1386
Cdd:cd01753     3 YKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYD-----FERGAVDEYKVKVpEDLGELL-LVRLRKRKYLLF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 239050813 1387 PGWHCSHVDIRRLlpdkdGAETLTFPCDRWLatseDDKKTIR 1428
Cdd:cd01753    77 DAWFCNYITVTGP-----GGDEYHFPCYRWI----EGYGTLE 109
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 1461-1564 2.08e-05

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 45.53  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1461 LYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLgksenrTNKFERGTADTFIIEAADLGVIYKIKLRhdNSKWCADW 1540
Cdd:cd02899     2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTL------SQGFYPGSLKRIRFRAADVGDINAIILS--NTALNDPW 73

                          90       100
                  ....*....|....*....|....
gi 239050813 1541 YVEKVEIWNDTNEdEFLFLCGRWL 1564
Cdd:cd02899    74 YCDYVRIKSEDGK-VFAFNVKRWI 96
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 816-892 2.58e-05

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 45.38  E-value: 2.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 239050813  816 YEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSKVFERASKDTFQLEA-ADVGEVYKLRLGHTGEGFGPSWF 892
Cdd:cd01753     3 YKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFDAWF 80
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1698-1798 3.41e-05

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 44.94  E-value: 3.41e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDK-KKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGlgSRPEWFL 1775
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYlFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEH--RHPEWFL 80

                            90       100
                    ....*....|....*....|...
gi 239050813   1776 ERILLKNMNTGDLTMFYYGDWLS 1798
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVY 103
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1956-2057 9.46e-05

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 43.87  E-value: 9.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1956 YEIVIETGN--GGETRENVWLILEGR-KNRSKEFLMENSSRqraFRKGTTDTFEFDSiyLGDIASLCVGHLAREDrfiPK 2032
Cdd:cd00113     3 YTVTIKTGDkkGAGTDSNISLALYGEnGNSSDIPILDGPGS---FERGSTDTFQIDL--KLDIGDITKVYLRRDG---SG 74

                          90       100
                  ....*....|....*....|....*
gi 239050813 2033 RELAWHVKTITITEMEYGNVYFFNC 2057
Cdd:cd00113    75 LSDGWYCESITVQALGTKKVYTFPV 99
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 2093-2196 1.04e-04

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 43.61  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 2093 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKmrnlFERGSTDRFFLETLELGELRKVRLEHDSSGycSGWLV 2172
Cdd:cd02899     2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTLSQG----FYPGSLKRIRFRAADVGDINAIILSNTALN--DPWYC 75

                          90       100
                  ....*....|....*....|....
gi 239050813 2173 EKVEVtNTSTGVATIFNCGRWLDK 2196
Cdd:cd02899    76 DYVRI-KSEDGKVFAFNVKRWIGY 98
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1696-1807 1.04e-04

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 43.45  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1696 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGLGSRPEWF 1774
Cdd:cd01753     1 AEYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFDAWF 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 239050813 1775 LERILLKNMNtGDLTMFYYGDWLSqrkGKKTLV 1807
Cdd:cd01753    81 CNYITVTGPG-GDEYHFPCYRWIE---GYGTLE 109
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 43-148 1.09e-04

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 43.61  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813   43 RVYEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLtsksKSAFEKGNVDVFRVRTNNVGLIYKVRIEhdNTGLNASWY 122
Cdd:cd02899     1 KTYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTL----SQGFYPGSLKRIRFRAADVGDINAIILS--NTALNDPWY 74

                          90       100
                  ....*....|....*....|....*..
gi 239050813  123 LDHV-IVTDMKRphlRYYFNCNNWLSK 148
Cdd:cd02899    75 CDYVrIKSEDGK---VFAFNVKRWIGY 98
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 816-896 1.14e-04

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 44.07  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  816 YEVEIWTGDVGGAGTSARVYMQIYGEKGKT-EVLFLSSRSKV-------FERASKDTFQLEAADV-GEVYKLRLGHTGEG 886
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGlRIANLEAWGGLmgaghdyFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82

                          90
                  ....*....|
gi 239050813  887 FGPSWFVDTV 896
Cdd:cd01754    83 NHPGWYVNYV 92
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1956-2059 2.00e-04

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 43.03  E-value: 2.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1956 YEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQrAFRKGTTDTF----EFDsiyLGDIASLCVGHLAREDRf 2029
Cdd:cd01752     3 YLVTVFTGwrRGAGTTAKVTITLYGAEGESEPHHLRDPEKP-IFERGSVDSFllttPFP---LGELQSIRLWHDNSGLS- 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 239050813 2030 iPkrelAWHVKTITITEMEYGNVYFFNCDC 2059
Cdd:cd01752    78 -P----SWYLSRVIVRDLQTGKKWFFLCND 102
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 355-411 2.64e-04

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 42.53  E-value: 2.64e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 239050813  355 LSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWL-----DEKKADGLIERQL 411
Cdd:cd01757    52 LGKLTTVQIGHDNSGLLAKWLVEYVMVRNEITGHTYKFPCGRWLgegvdDGNGEDGSLERVL 113
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 1308-1419 1.34e-03

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 40.52  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1308 YEITLYTSDVFAAGTDANIFIIIYGCDAVctqqkylcTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIghnNTGMNP 1387
Cdd:cd02899     3 YTASVQTGKDKEAGTNGTIEITLLGSSGR--------SNPKTLSQGFYPGSLKRIRFRAADVGDINAIILS---NTALND 71

                          90       100       110
                  ....*....|....*....|....*....|..
gi 239050813 1388 GWHCSHVDIRrllpdKDGAETLTFPCDRWLAT 1419
Cdd:cd02899    72 PWYCDYVRIK-----SEDGKVFAFNVKRWIGY 98
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 173-273 1.47e-03

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 40.14  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  173 KYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLeneKDNFEKGAEDRFILDAPDLGQLMKINVghNNKGGSAGWFLS 252
Cdd:cd02899     2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTL---SQGFYPGSLKRIRFRAADVGDINAIIL--SNTALNDPWYCD 76

                          90       100
                  ....*....|....*....|.
gi 239050813  253 QIVIEDiGNKRKYDFPLNRWL 273
Cdd:cd02899    77 YVRIKS-EDGKVFAFNVKRWI 96
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 1176-1281 3.63e-03

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 38.98  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813 1176 TFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSktnsdkFERDSIEIFTVETLDLGDLWKVRLGhdNTGKAPGW 1255
Cdd:cd02899     2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTLSQG------FYPGSLKRIRFRAADVGDINAIILS--NTALNDPW 73

                          90       100
                  ....*....|....*....|....*.
gi 239050813 1256 FVDWVEVDAPSlGKCMTFPCGRWLAK 1281
Cdd:cd02899    74 YCDYVRIKSED-GKVFAFNVKRWIGY 98
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 816-899 6.20e-03

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 38.67  E-value: 6.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  816 YEVEIWTGD-VGGAGTSARVYMQIYGEKGKTEVLFLssRSKVFEraskdtFQLEAADVGEVYKLRLGHTGEGFGPSWFVD 894
Cdd:cd01757     3 YHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQI--PKNSLE------MTFDCQNLGKLTTVQIGHDNSGLLAKWLVE 74


                  ....*
gi 239050813  895 TVWLR 899
Cdd:cd01757    75 YVMVR 79
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 816-896 6.43e-03

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 38.60  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050813  816 YEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSsrsKVFERASKDTFQLEAADVGEVYKLRLGHTGEgfGPSWFVDT 895
Cdd:cd02899     3 YTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTLS---QGFYPGSLKRIRFRAADVGDINAIILSNTAL--NDPWYCDY 77


                  .
gi 239050813  896 V 896
Cdd:cd02899    78 V 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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