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Conserved domains on  [gi|21450205|ref|NP_659073|]
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telomerase Cajal body protein 1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
161-466 2.11e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.36  E-value: 2.11e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 161 WAPDGSCILTNSADNVLRIYNLPPelyseqeqvdyAEMVPVLRMVEGDTiydycwYSLMSStqPDTSYVASSSRENPIHI 240
Cdd:COG2319 128 FSPDGKTLASGSADGTVRLWDLAT-----------GKLLRTLTGHSGAV------TSVAFS--PDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 241 WDAFTGELRASFRAYNHldeltAAHSLCFSPDGSQLF-CGFNRTVRVFSTSRPgrdcEVRATFakkQGQSGIISCIAFSP 319
Cdd:COG2319 189 WDLATGKLLRTLTGHTG-----AVRSVAFSPDGKLLAsGSADGTVRLWDLATG----KLLRTL---TGHSGSVRSVAFSP 256

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 320 SQPLYACGSYGRTIGLYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARkDAELLCWDLrQPGHLLWSLSREVTTNQ 399
Cdd:COG2319 257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD-DGTVRLWDL-ATGKLLRTLTGHTGAVR 334

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21450205 400 RIYFdlDPSGQFLVSGNTSGVVSVWDISGAlsddsklEPVVTFLPQKDCTNGVSLHPTLPLLATASG 466
Cdd:COG2319 335 SVAF--SPDGKTLASGSDDGTVRLWDLATG-------ELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
161-466 2.11e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.36  E-value: 2.11e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 161 WAPDGSCILTNSADNVLRIYNLPPelyseqeqvdyAEMVPVLRMVEGDTiydycwYSLMSStqPDTSYVASSSRENPIHI 240
Cdd:COG2319 128 FSPDGKTLASGSADGTVRLWDLAT-----------GKLLRTLTGHSGAV------TSVAFS--PDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 241 WDAFTGELRASFRAYNHldeltAAHSLCFSPDGSQLF-CGFNRTVRVFSTSRPgrdcEVRATFakkQGQSGIISCIAFSP 319
Cdd:COG2319 189 WDLATGKLLRTLTGHTG-----AVRSVAFSPDGKLLAsGSADGTVRLWDLATG----KLLRTL---TGHSGSVRSVAFSP 256

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 320 SQPLYACGSYGRTIGLYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARkDAELLCWDLrQPGHLLWSLSREVTTNQ 399
Cdd:COG2319 257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD-DGTVRLWDL-ATGKLLRTLTGHTGAVR 334

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21450205 400 RIYFdlDPSGQFLVSGNTSGVVSVWDISGAlsddsklEPVVTFLPQKDCTNGVSLHPTLPLLATASG 466
Cdd:COG2319 335 SVAF--SPDGKTLASGSDDGTVRLWDLATG-------ELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 159-465 2.67e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.44  E-value: 2.67e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 159 CKWAPDGSCILTNSADNVLRIYNLPPELYSEQEQVDYAEMVPVlrmvegdtiydycwyslmsSTQPDTSYVASSSRENPI 238
Cdd:cd00200  15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDV-------------------AASADGTYLASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 239 HIWDAFTGELRASFRAynHLDELTaahSLCFSPDGSQLF-CGFNRTVRVFSTsrpgRDCEVRATFakkQGQSGIISCIAF 317
Cdd:cd00200  76 RLWDLETGECVRTLTG--HTSYVS---SVAFSPDGRILSsSSRDKTIKVWDV----ETGKCLTTL---RGHTDWVNSVAF 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 318 SPSQPLYACGSYGRTIGLYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARkDAELLCWDLR--QPGHLLWSLSREV 395
Cdd:cd00200 144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLStgKCLGTLRGHENGV 222

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21450205 396 TTNqriyfDLDPSGQFLVSGNTSGVVSVWDIsgalsddSKLEPVVTF-LPQKDCTnGVSLHPTLPLLATAS 465
Cdd:cd00200 223 NSV-----AFSPDGYLLASGSEDGTIRVWDL-------RTGECVQTLsGHTNSVT-SLAWSPDGKRLASGS 280
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 340-380 4.12e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.12e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 21450205    340 DGSPLALLGGHQGGITHLCFHPDGNLFFSGARkDAELLCWD 380
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSD-DGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
341-380 3.22e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 3.22e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 21450205   341 GSPLALLGGHQGGITHLCFHPDGNLFFSGARkDAELLCWD 380
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSD-DGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
161-466 2.11e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.36  E-value: 2.11e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 161 WAPDGSCILTNSADNVLRIYNLPPelyseqeqvdyAEMVPVLRMVEGDTiydycwYSLMSStqPDTSYVASSSRENPIHI 240
Cdd:COG2319 128 FSPDGKTLASGSADGTVRLWDLAT-----------GKLLRTLTGHSGAV------TSVAFS--PDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 241 WDAFTGELRASFRAYNHldeltAAHSLCFSPDGSQLF-CGFNRTVRVFSTSRPgrdcEVRATFakkQGQSGIISCIAFSP 319
Cdd:COG2319 189 WDLATGKLLRTLTGHTG-----AVRSVAFSPDGKLLAsGSADGTVRLWDLATG----KLLRTL---TGHSGSVRSVAFSP 256

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 320 SQPLYACGSYGRTIGLYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARkDAELLCWDLrQPGHLLWSLSREVTTNQ 399
Cdd:COG2319 257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD-DGTVRLWDL-ATGKLLRTLTGHTGAVR 334

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21450205 400 RIYFdlDPSGQFLVSGNTSGVVSVWDISGAlsddsklEPVVTFLPQKDCTNGVSLHPTLPLLATASG 466
Cdd:COG2319 335 SVAF--SPDGKTLASGSDDGTVRLWDLATG-------ELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 159-465 2.67e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.44  E-value: 2.67e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 159 CKWAPDGSCILTNSADNVLRIYNLPPELYSEQEQVDYAEMVPVlrmvegdtiydycwyslmsSTQPDTSYVASSSRENPI 238
Cdd:cd00200  15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDV-------------------AASADGTYLASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 239 HIWDAFTGELRASFRAynHLDELTaahSLCFSPDGSQLF-CGFNRTVRVFSTsrpgRDCEVRATFakkQGQSGIISCIAF 317
Cdd:cd00200  76 RLWDLETGECVRTLTG--HTSYVS---SVAFSPDGRILSsSSRDKTIKVWDV----ETGKCLTTL---RGHTDWVNSVAF 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 318 SPSQPLYACGSYGRTIGLYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARkDAELLCWDLR--QPGHLLWSLSREV 395
Cdd:cd00200 144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLStgKCLGTLRGHENGV 222

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21450205 396 TTNqriyfDLDPSGQFLVSGNTSGVVSVWDIsgalsddSKLEPVVTF-LPQKDCTnGVSLHPTLPLLATAS 465
Cdd:cd00200 223 NSV-----AFSPDGYLLASGSEDGTIRVWDL-------RTGECVQTLsGHTNSVT-SLAWSPDGKRLASGS 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 134-425 9.03e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.29  E-value: 9.03e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 134 FSQVPRYL-SGS-------WSEFSTRSENFLKG-------CKWAPDGSCILTNSADNVLRIYNLppelyseqeqvdyaEM 198
Cdd:cd00200  17 FSPDGKLLaTGSgdgtikvWDLETGELLRTLKGhtgpvrdVAASADGTYLASGSSDKTIRLWDL--------------ET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 199 VPVLRMVEGDTIYdycWYSLMSStqPDTSYVASSSRENPIHIWDAFTGELRASFRAynHLDeltAAHSLCFSPDGSQLFC 278
Cdd:cd00200  83 GECVRTLTGHTSY---VSSVAFS--PDGRILSSSSRDKTIKVWDVETGKCLTTLRG--HTD---WVNSVAFSPDGTFVAS 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 279 G-FNRTVRVFSTsrpgRDCEVRATFakkQGQSGIISCIAFSPSQPLYACGSYGRTIGLYAWDDGSPLALLGGHQGGITHL 357
Cdd:cd00200 153 SsQDGTIKLWDL----RTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 358 CFHPDGNLFFSGArKDAELLCWDLRqpghlLWSLSREVT-TNQRIY-FDLDPSGQFLVSGNTSGVVSVWD 425
Cdd:cd00200 226 AFSPDGYLLASGS-EDGTIRVWDLR-----TGECVQTLSgHTNSVTsLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
224-465 9.82e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.87  E-value: 9.82e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 224 PDTSYVASSSRENPIHIWDAFTGELRASFRAYNHldeltAAHSLCFSPDGSQLFCG-FNRTVRVFSTSRPgrdcEVRATF 302
Cdd:COG2319  88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTG-----AVRSVAFSPDGKTLASGsADGTVRLWDLATG----KLLRTL 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 303 akkQGQSGIISCIAFSPSQPLYACGSYGRTIGLYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARkDAELLCWDLR 382
Cdd:COG2319 159 ---TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA-DGTVRLWDLA 234

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 383 QpGHLLWSLSREVTTNQRIYFdlDPSGQFLVSGNTSGVVSVWDISGAlsddsklEPVVTFLPQKDCTNGVSLHPTLPLLA 462
Cdd:COG2319 235 T-GKLLRTLTGHSGSVRSVAF--SPDGRLLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGKLLA 304


                ...
gi 21450205 463 TAS 465
Cdd:COG2319 305 SGS 307
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 257-466 2.01e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 2.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 257 HLDELTaahSLCFSPDGSQLF-CGFNRTVRVFSTSrpgrDCEVRATFakkQGQSGIISCIAFSPSQPLYACGSYGRTIGL 335
Cdd:cd00200   8 HTGGVT---CVAFSPDGKLLAtGSGDGTIKVWDLE----TGELLRTL---KGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 336 YAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARkDAELLCWDLRQ-------PGHLLWslsreVTTnqriyFDLDPS 408
Cdd:cd00200  78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSR-DKTIKVWDVETgkclttlRGHTDW-----VNS-----VAFSPD 146

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21450205 409 GQFLVSGNTSGVVSVWDISGalsddskLEPVVTFLPQKDCTNGVSLHPTLPLLATASG 466
Cdd:cd00200 147 GTFVASSSQDGTIKLWDLRT-------GKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 306-465 4.98e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 4.98e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 306 QGQSGIISCIAFSPSQPLYACGSYGRTIGLYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGArKDAELLCWDLRQPg 385
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGS-SDKTIRLWDLETG- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 386 hllwSLSREVTT-NQRIY-FDLDPSGQFLVSGNTSGVVSVWDIsgalsddSKLEPVVTFLPQKDCTNGVSLHPTLPLLAT 463
Cdd:cd00200  84 ----ECVRTLTGhTSYVSsVAFSPDGRILSSSSRDKTIKVWDV-------ETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152


                ..
gi 21450205 464 AS 465
Cdd:cd00200 153 SS 154
WD40 COG2319
WD40 repeat [General function prediction only];
161-339 5.22e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 5.22e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 161 WAPDGSCILTNSADNVLRIYNLPPElyseqeqvdyaemvPVLRMVEGDTiydyCW-YSLMSStqPDTSYVASSSRENPIH 239
Cdd:COG2319 254 FSPDGRLLASGSADGTVRLWDLATG--------------ELLRTLTGHS----GGvNSVAFS--PDGKLLASGSDDGTVR 313

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 240 IWDAFTGELRASFRAYNHldeltAAHSLCFSPDGSQLFCG-FNRTVRVFSTSRPgrdcEVRATFakkQGQSGIISCIAFS 318
Cdd:COG2319 314 LWDLATGKLLRTLTGHTG-----AVRSVAFSPDGKTLASGsDDGTVRLWDLATG----ELLRTL---TGHTGAVTSVAFS 381

                       170       180
                ....*....|....*....|.
gi 21450205 319 PSQPLYACGSYGRTIGLyaWD 339
Cdd:COG2319 382 PDGRTLASGSADGTVRL--WD 400
WD40 COG2319
WD40 repeat [General function prediction only];
306-468 3.15e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 3.15e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 306 QGQSGIISCIAFSPSQPLYACGSYGRTIGLYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARkDAELLCWDLRQpG 385
Cdd:COG2319  75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSA-DGTVRLWDLAT-G 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 386 HLLWSLSREVTTNQRIYFdlDPSGQFLVSGNTSGVVSVWDISGAlsddsklEPVVTFLPQKDCTNGVSLHPTLPLLATAS 465
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAF--SPDGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGKLLASGS 223


                ...
gi 21450205 466 GQR 468
Cdd:COG2319 224 ADG 226
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 347-468 2.85e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 2.85e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 347 LGGHQGGITHLCFHPDGNLFFSGARkDAELLCWDL--RQPGHLLWSLSREVTTnqriyFDLDPSGQFLVSGNTSGVVSVW 424
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSG-DGTIKVWDLetGELLRTLKGHTGPVRD-----VAASADGTYLASGSSDKTIRLW 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 21450205 425 DIsgalsddSKLEPVVTFLPQKDCTNGVSLHPTLPLLATASGQR 468
Cdd:cd00200  79 DL-------ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDK 115
WD40 COG2319
WD40 repeat [General function prediction only];
279-468 1.30e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 1.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 279 GFNRTVRVFSTSRPGRDCEVRATFAKKQGQSGIISCIAFSPSQPLYACGSYGRTIGLYAWDDGSPLALLGGHQGGITHLC 358
Cdd:COG2319   6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450205 359 FHPDGNLFFSGARkDAELLCWDL--RQPGHLLWSLSREVTTnqriyFDLDPSGQFLVSGNTSGVVSVWDISGAlsddskl 436
Cdd:COG2319  86 FSPDGRLLASASA-DGTVRLWDLatGLLLRTLTGHTGAVRS-----VAFSPDGKTLASGSADGTVRLWDLATG------- 152

                       170       180       190
                ....*....|....*....|....*....|..
gi 21450205 437 EPVVTFLPQKDCTNGVSLHPTLPLLATASGQR 468
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG 184
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 340-380 4.12e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.12e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 21450205    340 DGSPLALLGGHQGGITHLCFHPDGNLFFSGARkDAELLCWD 380
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSD-DGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
341-380 3.22e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 3.22e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 21450205   341 GSPLALLGGHQGGITHLCFHPDGNLFFSGARkDAELLCWD 380
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSD-DGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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