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Conserved domains on  [gi|89337263|ref|NP_663408|]
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rRNA methyltransferase 1, mitochondrial precursor [Mus musculus]

Protein Classification

TrmH family RNA methyltransferase( domain architecture ID 13742638)

TrmH family RNA methyltransferase catalyzes the methylation of rRNA or tRNA at specific sites in a S-adenosyl-L-methionine (SAM)-dependent manner

CATH:  3.40.1280.10
EC:  2.1.1.-
Gene Ontology:  GO:0008173|GO:1904047|GO:0003723|GO:0032259
PubMed:  11763972|17338813|30457841|18029778
SCOP:  3001122

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 144-301 2.64e-76

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


:

Pssm-ID: 349978  Cd Length: 158  Bit Score: 230.48  E-value: 2.64e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 144 LWLVLEGLQDPRNLGAVMRSAHFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTV 223
Cdd:cd18105   1 LWLLLDEITDPQNLGAILRSAYFLGVDGVVVSSKNSAPLSPVVSKASAGALELMPIYSVDNLASFLKSSKENGWKVVGTS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 89337263 224 GCPGPEiSQSSKVPITSCLEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTILPRRHLP-PGLESLNVSVATGILLHSI 301
Cdd:cd18105  81 APPSAS-SDKKTIPANELSELLLEKPTILVLGNEGRGLRTNIKNLCDYLVSIPGGRSAEnPGVDSLNVSVAAGILLHSL 158
SpoU_sub_bind pfam08032
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ...
 85-125 2.85e-09

RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.


:

Pssm-ID: 429793 [Multi-domain]  Cd Length: 74  Bit Score: 53.01  E-value: 2.85e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 89337263    85 ELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSPLR 125
Cdd:pfam08032  34 ELLKLAKERGIKVEEVDRKKLDKLSGTANHQGVVAEVKPYE 74
 
Name Accession Description Interval E-value
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 144-301 2.64e-76

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349978  Cd Length: 158  Bit Score: 230.48  E-value: 2.64e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 144 LWLVLEGLQDPRNLGAVMRSAHFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTV 223
Cdd:cd18105   1 LWLLLDEITDPQNLGAILRSAYFLGVDGVVVSSKNSAPLSPVVSKASAGALELMPIYSVDNLASFLKSSKENGWKVVGTS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 89337263 224 GCPGPEiSQSSKVPITSCLEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTILPRRHLP-PGLESLNVSVATGILLHSI 301
Cdd:cd18105  81 APPSAS-SDKKTIPANELSELLLEKPTILVLGNEGRGLRTNIKNLCDYLVSIPGGRSAEnPGVDSLNVSVAAGILLHSL 158
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 78-307 1.83e-59

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 191.56  E-value: 1.83e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263  78 GLQGERAELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSPLRPRPCDEAADTSSGDDpqqLWLVLEGLQDPRNL 157
Cdd:COG0566  53 GALDRLAELLALAKAAGIPVYEVSREVLDKLSGTETHQGVLAVVRPPEYADLEDLLAEAGEPP---LLLVLDGVQDPGNL 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 158 GAVMRSAHFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTVGcpgpeisqSSKVP 237
Cdd:COG0566 130 GAILRSAAAFGVDGVILPKRRADPYNPKVVRASAGALFHVPVARVTNLADALEELKEAGFWVVGTDL--------DGEAS 201

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 238 ITsclEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTIlPrrhLPPGLESLNVSVATGILLHSICSQKKG 307
Cdd:COG0566 202 LY---EVDLPGPVALVLGNEGKGLSRLVLEACDELVRI-P---MAGGVESLNVAVAAAILLYEAARQRRA 264
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 85-305 6.20e-43

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 147.88  E-value: 6.20e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263    85 ELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSPLRPRPCDEAADTS-SGDDPqqLWLVLEGLQDPRNLGAVMRS 163
Cdd:TIGR00186  33 KLIQLAKKQGINIQLVDRQKLDQLTKGGNHQGIAAKVKPILYKDLNDLYKTAkSKKQP--FLLILDEITDPHNLGAILRT 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263   164 AHFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTVGCPGPEISQSSKvpitscle 243
Cdd:TIGR00186 111 AEAFGVDGVILPKRRSAPLNSTVVKTSSGAVEYVPLARVTNLSRTITKLKESGFWTVGTDLDAQDTLYQVKL-------- 182

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 89337263   244 fvwDRPTLLVLGSEGSGLSQEVFASCQLLLTILPRRHLPpgleSLNVSVATGILLHSICSQK 305
Cdd:TIGR00186 183 ---TKPLALVVGNEGEGVSRLIKENCDFLIKIPMAGKVD----SLNVSVAAGILLFEIKRQR 237
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 146-299 3.96e-36

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 126.88  E-value: 3.96e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263   146 LVLEGLQDPRNLGAVMRSAHFLGVDRV-ITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTvg 224
Cdd:pfam00588   4 VVLDNIQDPGNLGAIIRTAAAFGADGLiLVEPRSADPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVAT-- 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 89337263   225 cpgpeiSQSSKvpitSCLEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTIlPrrhLPPGLESLNVSVATGILLH 299
Cdd:pfam00588  82 ------SLGGK----SLYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRI-P---MSGDVESLNVAVAAAIALY 142
PRK11181 PRK11181
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
86-305 1.74e-27

23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;


Pssm-ID: 183021 [Multi-domain]  Cd Length: 244  Bit Score: 107.36  E-value: 1.74e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263   86 LLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSPLRP-RPCDEAADTSSGDDPqqLWLVLEGLQDPRNLGAVMRSA 164
Cdd:PRK11181  39 LINELEAQGIVIQLANRQTLDEKAEGAVHQGIIARVKPGRQlQENDLPDLLASLEQP--FLLILDGVTDPHNLGACLRSA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263  165 HFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTVGCPGPEISQSSkvpITSclef 244
Cdd:PRK11181 117 DAAGVHAVIVPKDRSAQLNATAKKVACGAAETVPLIRVTNLARTMRMLQEKNIWIVGTAGEADHTLYQSK---LTG---- 189

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 89337263  245 vwdrPTLLVLGSEGSGLSQEVFASCQLLLTIlPrrhLPPGLESLNVSVATGILLHSICSQK 305
Cdd:PRK11181 190 ----PLALVMGAEGEGMRRLTREHCDELISI-P---MAGSVSSLNVSVATGICLFEAVRQR 242
SpoU_sub_bind pfam08032
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ...
 85-125 2.85e-09

RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.


Pssm-ID: 429793 [Multi-domain]  Cd Length: 74  Bit Score: 53.01  E-value: 2.85e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 89337263    85 ELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSPLR 125
Cdd:pfam08032  34 ELLKLAKERGIKVEEVDRKKLDKLSGTANHQGVVAEVKPYE 74
SpoU_sub_bind smart00967
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ...
 78-123 3.07e-08

RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.


Pssm-ID: 214943 [Multi-domain]  Cd Length: 70  Bit Score: 49.84  E-value: 3.07e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 89337263     78 GLQGERAELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSP 123
Cdd:smart00967  25 GRAERLKELLKLAKERGIKVIEVSKKELDKLSGTANHQGVVAVVKP 70
 
Name Accession Description Interval E-value
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 144-301 2.64e-76

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349978  Cd Length: 158  Bit Score: 230.48  E-value: 2.64e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 144 LWLVLEGLQDPRNLGAVMRSAHFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTV 223
Cdd:cd18105   1 LWLLLDEITDPQNLGAILRSAYFLGVDGVVVSSKNSAPLSPVVSKASAGALELMPIYSVDNLASFLKSSKENGWKVVGTS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 89337263 224 GCPGPEiSQSSKVPITSCLEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTILPRRHLP-PGLESLNVSVATGILLHSI 301
Cdd:cd18105  81 APPSAS-SDKKTIPANELSELLLEKPTILVLGNEGRGLRTNIKNLCDYLVSIPGGRSAEnPGVDSLNVSVAAGILLHSL 158
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 78-307 1.83e-59

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 191.56  E-value: 1.83e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263  78 GLQGERAELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSPLRPRPCDEAADTSSGDDpqqLWLVLEGLQDPRNL 157
Cdd:COG0566  53 GALDRLAELLALAKAAGIPVYEVSREVLDKLSGTETHQGVLAVVRPPEYADLEDLLAEAGEPP---LLLVLDGVQDPGNL 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 158 GAVMRSAHFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTVGcpgpeisqSSKVP 237
Cdd:COG0566 130 GAILRSAAAFGVDGVILPKRRADPYNPKVVRASAGALFHVPVARVTNLADALEELKEAGFWVVGTDL--------DGEAS 201

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 238 ITsclEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTIlPrrhLPPGLESLNVSVATGILLHSICSQKKG 307
Cdd:COG0566 202 LY---EVDLPGPVALVLGNEGKGLSRLVLEACDELVRI-P---MAGGVESLNVAVAAAILLYEAARQRRA 264
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 144-301 2.12e-43

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 146.03  E-value: 2.12e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 144 LWLVLEGLQDPRNLGAVMRSAHFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTV 223
Cdd:cd18095   1 LVLVLDGVQDPGNLGTIIRTAAAFGVDGVILSKGTVDPYNPKVVRASMGALFRLPIIRVDDLEELLEELKEAGYKVVAAD 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 89337263 224 GCPGpeisqsskvpiTSCLEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTIlPrrhLPPGLESLNVSVATGILLHSI 301
Cdd:cd18095  81 LDGG-----------SSLYDLDLPKPVALVLGNEGNGLSDELLELCDKRVTI-P---MSGGVESLNVAVAAAILLYEL 143
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 85-305 6.20e-43

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 147.88  E-value: 6.20e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263    85 ELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSPLRPRPCDEAADTS-SGDDPqqLWLVLEGLQDPRNLGAVMRS 163
Cdd:TIGR00186  33 KLIQLAKKQGINIQLVDRQKLDQLTKGGNHQGIAAKVKPILYKDLNDLYKTAkSKKQP--FLLILDEITDPHNLGAILRT 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263   164 AHFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTVGCPGPEISQSSKvpitscle 243
Cdd:TIGR00186 111 AEAFGVDGVILPKRRSAPLNSTVVKTSSGAVEYVPLARVTNLSRTITKLKESGFWTVGTDLDAQDTLYQVKL-------- 182

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 89337263   244 fvwDRPTLLVLGSEGSGLSQEVFASCQLLLTILPRRHLPpgleSLNVSVATGILLHSICSQK 305
Cdd:TIGR00186 183 ---TKPLALVVGNEGEGVSRLIKENCDFLIKIPMAGKVD----SLNVSVAAGILLFEIKRQR 237
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 144-301 2.06e-42

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 143.29  E-value: 2.06e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 144 LWLVLEGLQDPRNLGAVMRSAHFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTv 223
Cdd:cd18103   1 LLLILDGITDPHNLGAIIRSAEAFGVDGVIIPKRRSAPLTPTVAKASAGALEHLPIARVTNLARALEELKEAGFWIYGA- 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 89337263 224 gcpgpeiSQSSKVPITsclEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTIlPrrhLPPGLESLNVSVATGILLHSI 301
Cdd:cd18103  80 -------DGEAEKSLY---DVDLTGPLALVLGSEGKGLRRLVLKNCDFLVKI-P---MAGKVDSLNVSVAAGIILYEI 143
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 146-299 3.96e-36

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 126.88  E-value: 3.96e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263   146 LVLEGLQDPRNLGAVMRSAHFLGVDRV-ITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTvg 224
Cdd:pfam00588   4 VVLDNIQDPGNLGAIIRTAAAFGADGLiLVEPRSADPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVAT-- 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 89337263   225 cpgpeiSQSSKvpitSCLEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTIlPrrhLPPGLESLNVSVATGILLH 299
Cdd:pfam00588  82 ------SLGGK----SLYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRI-P---MSGDVESLNVAVAAAIALY 142
PRK11181 PRK11181
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
86-305 1.74e-27

23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;


Pssm-ID: 183021 [Multi-domain]  Cd Length: 244  Bit Score: 107.36  E-value: 1.74e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263   86 LLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSPLRP-RPCDEAADTSSGDDPqqLWLVLEGLQDPRNLGAVMRSA 164
Cdd:PRK11181  39 LINELEAQGIVIQLANRQTLDEKAEGAVHQGIIARVKPGRQlQENDLPDLLASLEQP--FLLILDGVTDPHNLGACLRSA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263  165 HFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTVGCPGPEISQSSkvpITSclef 244
Cdd:PRK11181 117 DAAGVHAVIVPKDRSAQLNATAKKVACGAAETVPLIRVTNLARTMRMLQEKNIWIVGTAGEADHTLYQSK---LTG---- 189

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 89337263  245 vwdrPTLLVLGSEGSGLSQEVFASCQLLLTIlPrrhLPPGLESLNVSVATGILLHSICSQK 305
Cdd:PRK11181 190 ----PLALVMGAEGEGMRRLTREHCDELISI-P---MAGSVSSLNVSVATGICLFEAVRQR 242
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 146-304 1.36e-23

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 94.84  E-value: 1.36e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 146 LVLEGLQDPRNLGAVMRSAHFLGVDRV-ITSQRNScplTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTvg 224
Cdd:cd18092  19 VVLENVHDPHNASAVLRTCDAFGVQDVhVIEPKNK---FKKNRGVAMGADKWLDVHRHDSTEECLAALKEQGYRIVAT-- 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 225 CPGPEisqssKVPITsclEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTIlprrhlpP--GL-ESLNVSVATGILLHSI 301
Cdd:cd18092  94 SLSPD-----AVPLD---ELDYTRPTALVFGNEKDGVSEEALAAADERVYI-------PmyGFvESLNVSVAAAIILYEL 158


                ...
gi 89337263 302 CSQ 304
Cdd:cd18092 159 QRQ 161
SpoU-like_family cd18082
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 146-301 9.79e-22

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349955  Cd Length: 145  Bit Score: 89.21  E-value: 9.79e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 146 LVLEGLQDPRNLGAVMRSAHFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTvgc 225
Cdd:cd18082   2 LVLDNIRSPGNIGSIFRTADAFGVEKIYLVGPTADIFDPKAKRTSRGTHFSVPYERVDNFEEYLKSLKEEGYPLIGL--- 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 89337263 226 pgpEISQSSKvPITSClEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTIlPRRhlpPGLESLNVSVATGILLHSI 301
Cdd:cd18082  79 ---ELTDGSI-PLSEF-KFKKPKKIALIFGNERSGLSPELLALCDYTVHI-PMS---GKNSSLNVSVATGIALYEF 145
SpoU-like_RNA-MTase cd18109
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 146-298 2.03e-20

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349982  Cd Length: 141  Bit Score: 85.67  E-value: 2.03e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 146 LVLEGLQDPRNLGAVMRSAHFLGVDRVITSQRNSCPLTPVVSKASAGAmevmdVFATP----DLPGFLQAkAQQGWLVVG 221
Cdd:cd18109   3 LALDGIQDPGNLGTIIRTADWFGIRQIICSPDTVDPYNPKVVQASMGS-----IFRVQihytDLPALLAE-LKKAFPVYG 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 89337263 222 TVgCPGPEISqsskvpitsclEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTIlPRRhlPPGLESLNVSVATGILL 298
Cdd:cd18109  77 AD-LDGENLY-----------EFTLPEKGILVMGNEGHGISPEVLKLLTHRLTI-PRY--GKGAESLNVAVATAILL 138
SpoU-like cd18097
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 144-298 4.67e-19

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349970  Cd Length: 144  Bit Score: 81.84  E-value: 4.67e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 144 LWLVLEGLQDPRNLGAVMRSAHFLGVDRVITSQRNSCPLTPVVSKASAGAMEVMDVFATPDLPGFLQAKAQQGWLVVGTv 223
Cdd:cd18097   1 LVVVLDNLRSAHNVGSIFRTADAAGVEKIYLCGYTPTPPHPKVAKTALGAEESVPWEHFEDTLEAVRALKARGYTIIAL- 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 89337263 224 gcpgpEISQSSkVPITsclEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTI--LPRRHlppgleSLNVSVATGILL 298
Cdd:cd18097  80 -----ETTENS-VPLH---EARLPRPLALVLGNEVRGVSPEVLALCDAVVEIpmFGRKN------SLNVAVAAAVAL 141
PRK10864 PRK10864
putative methyltransferase; Provisional
 110-298 1.00e-15

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 76.74  E-value: 1.00e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263  110 GYQVHQGVCMEVsplRPRPCDEAADTSSGDDPQQLWLVLEGLQDPRNLGAVMRS-AHFlGVDRVITSQRNSCPLTPVVSK 188
Cdd:PRK10864 168 GTEHHGGVCFLI---KKRNGTDVQQWLAQAGAQDCVLALEDVGNPHNLGGIMRScAHF-GVKGVVVQDAALLESGAAIRT 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263  189 ASAGAMEVMDVFATpDLPGFLQAKAQQGWLVVGTVGCPGPEISQsSKVPitsclefvwdRPTLLVLGSEGSGLSQEVFAS 268
Cdd:PRK10864 244 AEGGAEHVQPITGD-SFVDVLDDFRQAGYTIVTTSSHKGTPLFK-ASLP----------AKMVLVLGQEYDGLSDAARQQ 311

                        170       180       190
                 ....*....|....*....|....*....|...
gi 89337263  269 CQLLLTIlprrhlpPG---LESLNVSVATGILL 298
Cdd:PRK10864 312 GDLSVSI-------DGtgnVESLNVSVATGVLL 337
SpoU-like_RNA-MTase cd18104
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 144-298 5.58e-12

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349977  Cd Length: 146  Bit Score: 62.60  E-value: 5.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 144 LWLVLEGLQDPRNLGAVMRSAHFLGVDRVITSQRNSCPLTPVVSKASAGAmevmdVFATP-------DLPGFLQakaQQG 216
Cdd:cd18104   1 LILVLEGLEKPGNLGAILRSADAAGADAVILCDPKTDLFNPNVIRASLGA-----VFTLPvaeasseETLAWLK---ENK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 217 WLVVGTvgCPGPEISqsskvpitsclefVWD----RPTLLVLGSEGSGLSQEVFASCQLLLTIlprrhlpP---GLESLN 289
Cdd:cd18104  73 IRILAT--TPKAEKL-------------YYEadlrGPIAIVVGSESEGLSEFWLKAADERVRI-------PmagQADSLN 130


                ....*....
gi 89337263 290 VSVATGILL 298
Cdd:cd18104 131 VSVAAAILL 139
SpoU-like cd18096
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 144-300 7.04e-12

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349969  Cd Length: 140  Bit Score: 62.23  E-value: 7.04e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 144 LWLVLEGLQDPRNLGAVMRSAHFLGVDRVItsqrnscpltpVVSK---ASAGAMEVMDVFATPDLPGFLQAKA---QQGW 217
Cdd:cd18096   1 LYLVLHNVAKRHNIGTIVRSANAFGVKEVH-----------LVGRrkfNPFGAMGTDRHVKFRHFDTLAEAKEylkERGI 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 218 LVVGTvgcpgpEISQSSKvPITSCLefvWDRPTLLVLGSEGSGLSQEVFASCQLLLTIlprRHLPPGLESLNVSVATGIL 297
Cdd:cd18096  70 RLVGV------EIVPGAE-PIETHP---FPGDTAFVLGNEGTGLSDEQLAICDGFVYI---PQYGSGTASLNVSVAASIV 136


                ...
gi 89337263 298 LHS 300
Cdd:cd18096 137 LHH 139
SpoU-like_TRM3-like cd18091
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ...
 151-299 3.50e-11

SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.


Pssm-ID: 349964  Cd Length: 145  Bit Score: 60.24  E-value: 3.50e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 151 LQDPRNLGAVMRSAHFLGVDRVITSqRNSCPLTPVVSKASAGAMEVMDVFATP--DLPGFLQAKAQQGWLVVGtvgcpgp 228
Cdd:cd18091   8 IDKPPNLGGLCRTCEIFGVSKLVLP-NLAVVEDKQFKALSVSAEKWLPIEEVKpeDLLPYLKEKKQEGYTIVG------- 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 89337263 229 eISQSSK-VPITsclEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTI----LPRrhlppgleSLNVSVATGILLH 299
Cdd:cd18091  80 -LEQTANsVSLH---DFQFPKKTVLVLGNEKEGIPAELLSLLDVCVEIpqlgVIR--------SLNVHVSGAIAIY 143
SpoU-like_AviRb cd18107
SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes ...
 144-301 1.58e-10

SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of U2479 of the 23S ribosomal RNA. AviRb is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349980  Cd Length: 148  Bit Score: 58.55  E-value: 1.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 144 LWLVLEGLQDPRNLGAVMRSAHFLGVDRVITSQRNSCPLTPVVSKASAGAmevmdVFATP--------DLPGFLQA--KA 213
Cdd:cd18107   1 LVVLFDRPTSPGNLGTIIRSADALGAHGLVVTGHAADVYDPKTIRASTGS-----LFSLPivrvpsnrELEDWVEArkAR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 214 QQGWLVVGTvgcpgpeiSQSSKVPITsclEFVWDRPTLLVLGSEGSGLSQEVFASCQLLLTIlPrrhLPPGLESLNVSVA 293
Cdd:cd18107  76 GTPLQLVGT--------DEHGDHQIA---DHDFTRPTLLLIGNETAGLSAAWRELCDETVSI-P---MAGSASSLNAACA 140


                ....*...
gi 89337263 294 TGILLHSI 301
Cdd:cd18107 141 ASIFLYEA 148
SpoU_sub_bind pfam08032
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ...
 85-125 2.85e-09

RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.


Pssm-ID: 429793 [Multi-domain]  Cd Length: 74  Bit Score: 53.01  E-value: 2.85e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 89337263    85 ELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSPLR 125
Cdd:pfam08032  34 ELLKLAKERGIKVEEVDRKKLDKLSGTANHQGVVAEVKPYE 74
SpoU_sub_bind smart00967
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ...
 78-123 3.07e-08

RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.


Pssm-ID: 214943 [Multi-domain]  Cd Length: 70  Bit Score: 49.84  E-value: 3.07e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 89337263     78 GLQGERAELLRVAEARGIPVLRPRRQKLDALCGYQVHQGVCMEVSP 123
Cdd:smart00967  25 GRAERLKELLKLAKERGIKVIEVSKKELDKLSGTANHQGVVAVVKP 70
SpoU-like_RNMTL1 cd18106
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) ...
 146-298 5.13e-08

SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349979  Cd Length: 148  Bit Score: 51.48  E-value: 5.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 146 LVLEGLQDPRNLGAVMRSAHFLGVDRVITSQRNSCPLTPVVSKASAGA---MEVMDVFATPDLPGFLQAKAQqgwLVVGT 222
Cdd:cd18106   3 VICDNIRDPGNLGSILRSAAAAGCSKVLLTKGCVDPWEPKVLRAGAGAhfrLPIYGNLSWDDIPNYLPDDSK---VFLAD 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 89337263 223 VGCPgpeISQSSKVPITSClefvwdrPTLLVLGSEGSGLSQEvfaSCQLL-LTILPRRHLP--PGLESLNVSVATGILL 298
Cdd:cd18106  80 NNLP---VQPYDSIDYCSG-------PIVLVIGGETHGVSPE---AYKLAhSTGGSRVHIPlaNGVDSLNSAVAASILL 145
SpoU-like_NHR cd18108
Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) ...
 146-299 1.20e-04

Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) confers resistance to the thiazole antibiotic nosiheptide via catalyzing 2'O-methylation of 23S rRNA at the nucleotide A1067. NHR is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349981  Cd Length: 144  Bit Score: 41.69  E-value: 1.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 146 LVLEGLQDPRNLGAVMRSAHFLGVDRVITSQRNscpLTPV----VSKASAGAmevmdVFATP-------DLPGFLQAKAQ 214
Cdd:cd18108   3 VVLDGVRIVGNIGAIVRTSLALGAAGIVLVDSD---LATVadrrLLRASRGY-----VFSLPvvladreEAVAFLRDNDI 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89337263 215 QgwLVVGTVGCPGPeISQSSKVPitsclefvwdRPTLLVLGSEGSGLSQEVFASCQLLLTIlprrHLPPGLESLNVSVAT 294
Cdd:cd18108  75 P--LMTLDADGDVP-VKELGDRP----------DRLALVFGSEKGGPSGLFEEAAAGTVSI----PMSSSTESLNVSVSA 137


                ....*
gi 89337263 295 GILLH 299
Cdd:cd18108 138 GIALH 142
SpoU-like_TrmL cd18094
SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL ...
 252-298 7.12e-04

SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349967  Cd Length: 145  Bit Score: 39.36  E-value: 7.12e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 89337263 252 LVLGSEGSGLSQEVFASC-QLLLTIlPrrhLPPGLESLNVSVATGILL 298
Cdd:cd18094  95 LVFGRESTGLPEEILDAFpDRRLRI-P---MRPKVRSLNLSNSVAIVL 138
TrmL COG0219
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ...
 252-298 2.60e-03

tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439989  Cd Length: 153  Bit Score: 37.71  E-value: 2.60e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 89337263 252 LVLGSEGSGLSQEVFAS-CQLLLTIlPRRhlpPGLESLNVSVATGILL 298
Cdd:COG0219  97 LLFGRETAGLPEEVLAApADQRLRI-PMR---PGVRSLNLSNAVAIVL 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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