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Conserved domains on  [gi|21704192|ref|NP_663566|]
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zinc finger protein 878 isoform 2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 3.55e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.99  E-value: 3.55e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21704192     4 VTFDDVHVDFTSEEWALLDPSQKSLYKDVMLETYWNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
103-462 3.95e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 3.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 103 YECNPCGKAFAYHCHLRIHKRIHTAEKLYKC--IQCGKAFSEHNTLQKHKRTHSEEKPYECNQCGKAFAHHNILRNHER- 179
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSs 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 180 THIGEKPYQCNECDKAFSQHYYLRIHKRIHTGEKPYECNQC----------------------DKAFACLSYLRVHGRTH 237
Cdd:COG5048 114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 238 TGEKPYKCNQCGKVFASHSNLKRHKRTHTGEKPYECNQCGKAFSDHHTLRIH------ERAHTGEKPFECNQCGKTFKLH 311
Cdd:COG5048 194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSS 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 312 SQLRIHKRTHTG-EKPHECNQCGKTFACPSSFQKHKR--IHTGE--KPYEC--NQCLKAFAYHSRLRKHERTHTGEKPFR 384
Cdd:COG5048 274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 385 C--NQCGKIFSQSN-----SLQVHKRTHTGEKPYECD--RCGKAFPYDSSLRVHKRTHTGVKPYECN--QCGKAFGYNSH 453
Cdd:COG5048 354 EklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYN 433


                ....*....
gi 21704192 454 LQRHERTHT 462
Cdd:COG5048 434 LIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 3.55e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.99  E-value: 3.55e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21704192     4 VTFDDVHVDFTSEEWALLDPSQKSLYKDVMLETYWNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 1.27e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.56  E-value: 1.27e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 21704192      4 VTFDDVHVDFTSEEWALLDPSQKSLYKDVMLETYWNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.52e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.66  E-value: 1.52e-17
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21704192   4 VTFDDVHVDFTSEEWALLDPSQKSLYKDVMLETYWNLT 41
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
103-462 3.95e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 3.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 103 YECNPCGKAFAYHCHLRIHKRIHTAEKLYKC--IQCGKAFSEHNTLQKHKRTHSEEKPYECNQCGKAFAHHNILRNHER- 179
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSs 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 180 THIGEKPYQCNECDKAFSQHYYLRIHKRIHTGEKPYECNQC----------------------DKAFACLSYLRVHGRTH 237
Cdd:COG5048 114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 238 TGEKPYKCNQCGKVFASHSNLKRHKRTHTGEKPYECNQCGKAFSDHHTLRIH------ERAHTGEKPFECNQCGKTFKLH 311
Cdd:COG5048 194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSS 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 312 SQLRIHKRTHTG-EKPHECNQCGKTFACPSSFQKHKR--IHTGE--KPYEC--NQCLKAFAYHSRLRKHERTHTGEKPFR 384
Cdd:COG5048 274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 385 C--NQCGKIFSQSN-----SLQVHKRTHTGEKPYECD--RCGKAFPYDSSLRVHKRTHTGVKPYECN--QCGKAFGYNSH 453
Cdd:COG5048 354 EklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYN 433


                ....*....
gi 21704192 454 LQRHERTHT 462
Cdd:COG5048 434 LIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-281 1.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.53e-04
                          10        20
                  ....*....|....*....|....*
gi 21704192   257 NLKRHKRTHTGEKPYECNQCGKAFS 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 3.55e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.99  E-value: 3.55e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21704192     4 VTFDDVHVDFTSEEWALLDPSQKSLYKDVMLETYWNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 1.27e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.56  E-value: 1.27e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 21704192      4 VTFDDVHVDFTSEEWALLDPSQKSLYKDVMLETYWNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.52e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.66  E-value: 1.52e-17
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21704192   4 VTFDDVHVDFTSEEWALLDPSQKSLYKDVMLETYWNLT 41
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
103-462 3.95e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 3.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 103 YECNPCGKAFAYHCHLRIHKRIHTAEKLYKC--IQCGKAFSEHNTLQKHKRTHSEEKPYECNQCGKAFAHHNILRNHER- 179
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSs 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 180 THIGEKPYQCNECDKAFSQHYYLRIHKRIHTGEKPYECNQC----------------------DKAFACLSYLRVHGRTH 237
Cdd:COG5048 114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 238 TGEKPYKCNQCGKVFASHSNLKRHKRTHTGEKPYECNQCGKAFSDHHTLRIH------ERAHTGEKPFECNQCGKTFKLH 311
Cdd:COG5048 194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSS 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 312 SQLRIHKRTHTG-EKPHECNQCGKTFACPSSFQKHKR--IHTGE--KPYEC--NQCLKAFAYHSRLRKHERTHTGEKPFR 384
Cdd:COG5048 274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 385 C--NQCGKIFSQSN-----SLQVHKRTHTGEKPYECD--RCGKAFPYDSSLRVHKRTHTGVKPYECN--QCGKAFGYNSH 453
Cdd:COG5048 354 EklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYN 433


                ....*....
gi 21704192 454 LQRHERTHT 462
Cdd:COG5048 434 LIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
143-441 1.37e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 143 HNTLQKHKRTHSEE----KPYECNQCGKAFAHHNILRNHERTHIGEKPYQCN--ECDKAFSQHYYLRIHKRIHTGEKPYE 216
Cdd:COG5048  14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 217 CNQ--CDKAFACLSYLRVHGRTHTgEKPYKCNQCGKVFASHSNLKRHKRTHTGEKPYECNQCGKAF-------------- 280
Cdd:COG5048  94 NSKslPLSNSKASSSSLSSSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplp 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 281 --------SDHHTLRIHERAHTGEKPFECNQCGKTF-KLHSQLRIHKRTH--TGEKPHECNQCG-KTFACPSSFQKHKRI 348
Cdd:COG5048 173 anslskdpSSNLSLLISSNVSTSIPSSSENSPLSSSySIPSSSSDQNLENssSSLPLTTNSQLSpKSLLSQSPSSLSSSD 252

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 349 HTGEKP--YECNQCLKAFAYHSRLRKHERTHTG-EKPFRCNQCGKIFSQSNSLQVHKRT--HTGE--KPYECD--RCGKA 419
Cdd:COG5048 253 SSSSASesPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKL 332

                       330       340
                ....*....|....*....|..
gi 21704192 420 FPYDSSLRVHKRTHTGVKPYEC 441
Cdd:COG5048 333 FSRNDALKRHILLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
96-346 1.41e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192  96 IHTGKKFYECNPCGKAFAYHcHLRIHKRIHTAEKLYKCIQCGKAFSEHNTLQKHKRTHSEEKP------YECNQCGKAFA 169
Cdd:COG5048 193 STSIPSSSENSPLSSSYSIP-SSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSssasesPRSSLPTASSQ 271

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 170 HHNILRNHERTHIG-EKPYQCNECDKAFSQHYYLRIHKR--IHTGE--KPYEC--NQCDKAFACLSYLRVHGRTHTGEKP 242
Cdd:COG5048 272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 243 YKC--NQCGKVFASHSNLKRHKRTH-----TGEKPYEC--NQCGKAFSDHHTLRIHERAHTGEKP--FECNQCGKTFKLH 311
Cdd:COG5048 352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                       250       260       270
                ....*....|....*....|....*....|....*
gi 21704192 312 SQLRIHKRTHTGEKPHECNQCGKTFACPSSFQKHK 346
Cdd:COG5048 432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
250-430 1.52e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 250 KVFASHSNLKRHKRTHTG-EKPYECNQCGKAFSDHHTLRIHERA--HTGE--KPFEC--NQCGKTFKLHSQLRIHKRTHT 322
Cdd:COG5048 268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 323 GEKPHEC--NQCGKTF------ACPSSFQKHKRIHTgEKPYEC--NQCLKAFAYHSRLRKHERTHTGEKP--FRCNQCGK 390
Cdd:COG5048 348 SISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 21704192 391 IFSQSNSLQVHKRTHTGEKPYECDRCGKAFPYDSSLRVHK 430
Cdd:COG5048 427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
73-233 1.39e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192  73 KPYEEIKYGEAFAHHGSLQIHKR--IHTGKKFYEC----NPCGKAFAYHCHLRIHKRIHTAEKLYKCIQC-------GKA 139
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFscpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 140 FSEHNTLQKHKRTHSEEKPYEC--NQCGKAFAHHNILRNHERTHIGEKPYQCN--ECDKAFSQHYYLRIHKRIHTGEKPY 215
Cdd:COG5048 368 NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|....*...
gi 21704192 216 ECNQCDKAFACLSYLRVH 233
Cdd:COG5048 448 LCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
241-467 5.85e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 5.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 241 KPYKCNQCGKVFASHSNLKRHKRTHTGEKPYECNQ--CGKAFSDHHTLRIHERAHTGEKPFECNQCGKT----------- 307
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 308 -----------------------------------------------------FKLHSQLR---------------IHKR 319
Cdd:COG5048 112 ssssnsndnnllsshslppssrdpqlpdllsisnlrnnplpgnnsssvntpqsNSLHPPLPanslskdpssnlsllISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 320 THTGEKPHECNQCGKTFACPSSFQKHKRIHTGEKPYECNQCLKAFAYHSRLR------KHERTHTGEKPFRCNQCGKIFS 393
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQspsslsSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 394 QSNSLQVHKRTHTG-EKPYECDRCGKAFPYDSSLRVHKRT--HTG--VKPYEC--NQCGKAFGYNSHLQRHERTHTGEKP 466
Cdd:COG5048 272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351


                .
gi 21704192 467 Y 467
Cdd:COG5048 352 A 352
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-281 1.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.53e-04
                          10        20
                  ....*....|....*....|....*
gi 21704192   257 NLKRHKRTHTGEKPYECNQCGKAFS 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 9.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.79e-04
                          10        20
                  ....*....|....*....|....*.
gi 21704192   201 YLRIHKRIHTGEKPYECNQCDKAFAC 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
174-198 2.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|....*
gi 21704192   174 LRNHERTHIGEKPYQCNECDKAFSQ 198
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-338 2.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.35e-03
                          10        20
                  ....*....|....*....|....*
gi 21704192   314 LRIHKRTHTGEKPHECNQCGKTFAC 338
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 3.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 21704192   369 RLRKHERTHTGEKPFRCNQCGKIFSQ 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-170 4.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.11e-03
                          10        20
                  ....*....|....*....|....*
gi 21704192   146 LQKHKRTHSEEKPYECNQCGKAFAH 170
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 182-266 4.43e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 4.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704192 182 IGEKPYQCN--ECDKAFSQHYYLRIHKRI-HTGEKPYECNQCDKafaclsylrvHGRTHTGEKPYKCNQCGKVFASHSNL 258
Cdd:COG5189 345 KDGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGL 414


                ....*...
gi 21704192 259 KRHkRTHT 266
Cdd:COG5189 415 KYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-448 4.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.53e-03
                          10        20
                  ....*....|....*....|....
gi 21704192   425 SLRVHKRTHTGVKPYECNQCGKAF 448
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 5.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.46e-03
                          10        20
                  ....*....|....*....|....*.
gi 21704192   341 SFQKHKRIHTGEKPYECNQCLKAFAY 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
397-420 5.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.46e-03
                          10        20
                  ....*....|....*....|....
gi 21704192   397 SLQVHKRTHTGEKPYECDRCGKAF 420
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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