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Conserved domains on  [gi|34594671|ref|NP_663593|]
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little elongation complex subunit 2 [Mus musculus]

Protein Classification

eukaryotic translation initiation factor 3 subunit D family protein; eukaryotic translation initiation factor 3 subunit D( domain architecture ID 10564709)

eukaryotic translation initiation factor 3 subunit D family protein such as eukaryotic translation initiation factor 3 (eIF-3) subunit D, which is the mRNA cap-binding component of the eIF-3 complex and is required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs| eukaryotic translation initiation factor 3 (eIF-3) subunit D is the mRNA cap-binding component of the eIF-3 complex, which is required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NARG2_C pfam10505
NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from ...
 726-936 9.91e-93

NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2. NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse, six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi.


:

Pssm-ID: 463121  Cd Length: 208  Bit Score: 293.05  E-value: 9.91e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34594671   726 SEYIAPQEGNFVYK----LFSLQDLLLLVRCSIQRVETRPRSKkrkkirrQFPVYVLPKVEYQGCYGVEALTESELCRFW 801
Cdd:pfam10505   1 QEYIAPAEGNVAYKlwslQVGESDLLLLVRSSVDAVRTLPGGK-------LLPVHLLPKLEYQPCYGVEILTKSELCRLW 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34594671   802 TESLLHSNCSFYVGHIDAFTSKLFMLEEIASEELKEKLAALKISSLFNILQHILKKLCSLQEGSYLLSHAAEDSSLLIYK 881
Cdd:pfam10505  74 TELLLRPNTVLYRGRIDAFTSKLLLLEKLTLESLEEELSNFKPANSLNILHHILKKLSSLQPGSYLLRHTPKDPFVTIYK 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 34594671   882 TSDGKVTRTAYNLHKAHCDLPGVPSSLSVPWVPLDPSYLLPYHIHHGRVPCTFPP 936
Cdd:pfam10505 154 SSTEKATRGSYNLHQAHSSLPTVPSSLSVPWVPIDPTLVLPLHRQHGRVPCTFPP 208
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 429-473 9.94e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 9.94e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 34594671   429 AVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATP 473
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775
 
Name Accession Description Interval E-value
NARG2_C pfam10505
NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from ...
 726-936 9.91e-93

NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2. NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse, six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi.


Pssm-ID: 463121  Cd Length: 208  Bit Score: 293.05  E-value: 9.91e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34594671   726 SEYIAPQEGNFVYK----LFSLQDLLLLVRCSIQRVETRPRSKkrkkirrQFPVYVLPKVEYQGCYGVEALTESELCRFW 801
Cdd:pfam10505   1 QEYIAPAEGNVAYKlwslQVGESDLLLLVRSSVDAVRTLPGGK-------LLPVHLLPKLEYQPCYGVEILTKSELCRLW 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34594671   802 TESLLHSNCSFYVGHIDAFTSKLFMLEEIASEELKEKLAALKISSLFNILQHILKKLCSLQEGSYLLSHAAEDSSLLIYK 881
Cdd:pfam10505  74 TELLLRPNTVLYRGRIDAFTSKLLLLEKLTLESLEEELSNFKPANSLNILHHILKKLSSLQPGSYLLRHTPKDPFVTIYK 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 34594671   882 TSDGKVTRTAYNLHKAHCDLPGVPSSLSVPWVPLDPSYLLPYHIHHGRVPCTFPP 936
Cdd:pfam10505 154 SSTEKATRGSYNLHQAHSSLPTVPSSLSVPWVPIDPTLVLPLHRQHGRVPCTFPP 208
PHA03247 PHA03247
large tegument protein UL36; Provisional
 429-473 9.94e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 9.94e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 34594671   429 AVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATP 473
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775
 
Name Accession Description Interval E-value
NARG2_C pfam10505
NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from ...
 726-936 9.91e-93

NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2. NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse, six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi.


Pssm-ID: 463121  Cd Length: 208  Bit Score: 293.05  E-value: 9.91e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34594671   726 SEYIAPQEGNFVYK----LFSLQDLLLLVRCSIQRVETRPRSKkrkkirrQFPVYVLPKVEYQGCYGVEALTESELCRFW 801
Cdd:pfam10505   1 QEYIAPAEGNVAYKlwslQVGESDLLLLVRSSVDAVRTLPGGK-------LLPVHLLPKLEYQPCYGVEILTKSELCRLW 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34594671   802 TESLLHSNCSFYVGHIDAFTSKLFMLEEIASEELKEKLAALKISSLFNILQHILKKLCSLQEGSYLLSHAAEDSSLLIYK 881
Cdd:pfam10505  74 TELLLRPNTVLYRGRIDAFTSKLLLLEKLTLESLEEELSNFKPANSLNILHHILKKLSSLQPGSYLLRHTPKDPFVTIYK 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 34594671   882 TSDGKVTRTAYNLHKAHCDLPGVPSSLSVPWVPLDPSYLLPYHIHHGRVPCTFPP 936
Cdd:pfam10505 154 SSTEKATRGSYNLHQAHSSLPTVPSSLSVPWVPIDPTLVLPLHRQHGRVPCTFPP 208
PHA03247 PHA03247
large tegument protein UL36; Provisional
 429-473 9.94e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 9.94e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 34594671   429 AVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATP 473
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775
PHA03247 PHA03247
large tegument protein UL36; Provisional
 429-473 1.62e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.62e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 34594671   429 AVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATP 473
Cdd:PHA03247 2740 APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT 2784
PHA02030 PHA02030
hypothetical protein
 427-469 3.55e-04

hypothetical protein


Pssm-ID: 222843 [Multi-domain]  Cd Length: 336  Bit Score: 43.81  E-value: 3.55e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 34594671  427 VHAVPKI--AAVPLAPATPVAPTMP--------VAPATPVTPTMPMAPATPEA 469
Cdd:PHA02030 284 VPAAAAAvaQAAPSVPQVPNVAVLPdvpqvapvAAPAAPEVPAVPVVPAAPQV 336
PHA03247 PHA03247
large tegument protein UL36; Provisional
 431-476 1.47e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 34594671   431 PKIAAVPLAPATPVA----PTMPVAPATPVTPTMPMAPATPEASATPNIT 476
Cdd:PHA03247 2714 ALVSATPLPPGPAAArqasPALPAAPAPPAVPAGPATPGGPARPARPPTT 2763
PHA03247 PHA03247
large tegument protein UL36; Provisional
 429-473 3.27e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 3.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 34594671   429 AVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATP 473
Cdd:PHA03247 2749 ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSE 2793
PHA02030 PHA02030
hypothetical protein
 426-477 5.96e-03

hypothetical protein


Pssm-ID: 222843 [Multi-domain]  Cd Length: 336  Bit Score: 39.96  E-value: 5.96e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 34594671  426 DVHAVPkiaAVPlAPATPVAPTMPVAPATPVTPTMP--------MAPATPEASATPNITD 477
Cdd:PHA02030 277 GSAAAP---AVP-AAAAAVAQAAPSVPQVPNVAVLPdvpqvapvAAPAAPEVPAVPVVPA 332
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 424-473 6.10e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.44  E-value: 6.10e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 34594671  424 MTDVHAVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATP 473
Cdd:PTZ00449 617 LLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPP 666
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 433-475 7.63e-03

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 38.30  E-value: 7.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 34594671  433 IAAVPLAPATPVAPTMPVAPATPvTPTMPMAPATPEASATPNI 475
Cdd:PRK05641  45 LSAVQEQVPTPAPAPAPAVPSAP-TPVAPAAPAPAPASAGENV 86
PHA03247 PHA03247
large tegument protein UL36; Provisional
 429-473 7.66e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 7.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 34594671   429 AVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATP 473
Cdd:PHA03247 2752 GGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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