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Conserved domains on  [gi|23312394|ref|NP_663771|]
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tigger transposable element-derived protein 3 [Homo sapiens]

Protein Classification

tigger transposable element derived family protein( domain architecture ID 10405131)

tigger transposable element derived family protein belongs to the pogo superfamily of DNA-mediated transposons

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DDE_3 super family cl46863
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 193-360 2.71e-13

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.


The actual alignment was detected with superfamily member pfam03184:

Pssm-ID: 481203  Cd Length: 177  Bit Score: 67.80  E-value: 2.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23312394   193 DQVQVLLCANSRGTEKRRVLLGGLQAAPRCF-FGIRSEALPASYH--------PDLGIPWL-EWlaqFDRDMGQQ-GRQV 261
Cdd:pfam03184   2 ERLTVMLCCNAAGSEKLPPLVIGKGKNPRAFkNEKTPKPLPVEYKsngkawmtTSIFEEWLqKW---FDPRMRESpGRKV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23312394   262 ALLL---AARVVEELAGLPGLYHVKL--LPLAASSTTPPLPSSVVRAFKAHYRHRLLGKLAAIQSerdgtSLAEAGAGIT 336
Cdd:pfam03184  79 LLLLdgsGSHPTVELIRSCGLQNIFLvfLPANSTSILQPLDQGVVSTFKANYRRQWLQYLLAGNN-----LLSPPWKKLT 153

                         170       180
                  ....*....|....*....|....
gi 23312394   337 VLDALHVASAAWAKVPPQLIFSSF 360
Cdd:pfam03184 154 LLDALKWIAKAWNAVSPSTITSGF 177
HTH_Tnp_Tc5 pfam03221
Tc5 transposase DNA-binding domain;
76-133 6.87e-12

Tc5 transposase DNA-binding domain;


:

Pssm-ID: 460850  Cd Length: 63  Bit Score: 60.34  E-value: 6.87e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23312394    76 YSGIDEALLCWYHIARAKAWDVTGPMLLHKAKELA----DIMGQDFVPSIGWLVRWKRRNNV 133
Cdd:pfam03221   1 YPDLEKALYEWILQLRARGIPITGPMIREKALELAqlaaDLGEPDFKASKGWLDRFKKRHGI 62
CENP-B_N super family cl47877
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ...
 6-57 5.78e-09

CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure.


The actual alignment was detected with superfamily member pfam04218:

Pssm-ID: 461229  Cd Length: 53  Bit Score: 52.03  E-value: 5.78e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 23312394     6 KKKLHALSLAEKIQVLELLDESkMSQSEVARRFQVSQPQISRICKNKEKLLA 57
Cdd:pfam04218   1 RRKRRSLTLREKIAIIQRYEEG-ESKASLARRFGVPASTLRRILKNKKKLLQ 51
 
Name Accession Description Interval E-value
DDE_1 pfam03184
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 193-360 2.71e-13

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere.


Pssm-ID: 367380  Cd Length: 177  Bit Score: 67.80  E-value: 2.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23312394   193 DQVQVLLCANSRGTEKRRVLLGGLQAAPRCF-FGIRSEALPASYH--------PDLGIPWL-EWlaqFDRDMGQQ-GRQV 261
Cdd:pfam03184   2 ERLTVMLCCNAAGSEKLPPLVIGKGKNPRAFkNEKTPKPLPVEYKsngkawmtTSIFEEWLqKW---FDPRMRESpGRKV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23312394   262 ALLL---AARVVEELAGLPGLYHVKL--LPLAASSTTPPLPSSVVRAFKAHYRHRLLGKLAAIQSerdgtSLAEAGAGIT 336
Cdd:pfam03184  79 LLLLdgsGSHPTVELIRSCGLQNIFLvfLPANSTSILQPLDQGVVSTFKANYRRQWLQYLLAGNN-----LLSPPWKKLT 153

                         170       180
                  ....*....|....*....|....
gi 23312394   337 VLDALHVASAAWAKVPPQLIFSSF 360
Cdd:pfam03184 154 LLDALKWIAKAWNAVSPSTITSGF 177
HTH_Tnp_Tc5 pfam03221
Tc5 transposase DNA-binding domain;
76-133 6.87e-12

Tc5 transposase DNA-binding domain;


Pssm-ID: 460850  Cd Length: 63  Bit Score: 60.34  E-value: 6.87e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23312394    76 YSGIDEALLCWYHIARAKAWDVTGPMLLHKAKELA----DIMGQDFVPSIGWLVRWKRRNNV 133
Cdd:pfam03221   1 YPDLEKALYEWILQLRARGIPITGPMIREKALELAqlaaDLGEPDFKASKGWLDRFKKRHGI 62
CENP-B_N pfam04218
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ...
 6-57 5.78e-09

CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure.


Pssm-ID: 461229  Cd Length: 53  Bit Score: 52.03  E-value: 5.78e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 23312394     6 KKKLHALSLAEKIQVLELLDESkMSQSEVARRFQVSQPQISRICKNKEKLLA 57
Cdd:pfam04218   1 RRKRRSLTLREKIAIIQRYEEG-ESKASLARRFGVPASTLRRILKNKKKLLQ 51
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
74-133 2.14e-08

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


Pssm-ID: 197828  Cd Length: 66  Bit Score: 50.75  E-value: 2.14e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23312394     74 SKYSGIDEALLCWYHIARAKAWDVTGPMLLHKAKELADIMG-QDFVPSIGWLVRWKRRNNV 133
Cdd:smart00674   2 RLYPLLEKALYEWILRQEALGIPISGEDIREKALEILQRLGlENFKASKGWLTRFKKRHNI 62
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
 22-66 1.69e-04

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 40.18  E-value: 1.69e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 23312394  22 ELLDESKMSQSEVARRFQVSQPQISRICKNKEKLLADwcsgTANR 66
Cdd:COG3093  16 EFLEPLGLSQTELAKALGVSRQRISEILNGKRAITAD----TALR 56
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 9-50 3.03e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.51  E-value: 3.03e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 23312394   9 LHALSLAEKIQVLELLDESKMSQSEVARRFQVSQPQISRICK 50
Cdd:cd00090   1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLK 42
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
22-52 3.69e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 35.57  E-value: 3.69e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 23312394     22 ELLDESKMSQSEVARRFQVSQPQISRICKNK 52
Cdd:smart00530   4 ELREEKGLTQEELAEKLGVSRSTLSRIENGK 34
 
Name Accession Description Interval E-value
DDE_1 pfam03184
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 193-360 2.71e-13

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere.


Pssm-ID: 367380  Cd Length: 177  Bit Score: 67.80  E-value: 2.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23312394   193 DQVQVLLCANSRGTEKRRVLLGGLQAAPRCF-FGIRSEALPASYH--------PDLGIPWL-EWlaqFDRDMGQQ-GRQV 261
Cdd:pfam03184   2 ERLTVMLCCNAAGSEKLPPLVIGKGKNPRAFkNEKTPKPLPVEYKsngkawmtTSIFEEWLqKW---FDPRMRESpGRKV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23312394   262 ALLL---AARVVEELAGLPGLYHVKL--LPLAASSTTPPLPSSVVRAFKAHYRHRLLGKLAAIQSerdgtSLAEAGAGIT 336
Cdd:pfam03184  79 LLLLdgsGSHPTVELIRSCGLQNIFLvfLPANSTSILQPLDQGVVSTFKANYRRQWLQYLLAGNN-----LLSPPWKKLT 153

                         170       180
                  ....*....|....*....|....
gi 23312394   337 VLDALHVASAAWAKVPPQLIFSSF 360
Cdd:pfam03184 154 LLDALKWIAKAWNAVSPSTITSGF 177
HTH_Tnp_Tc5 pfam03221
Tc5 transposase DNA-binding domain;
76-133 6.87e-12

Tc5 transposase DNA-binding domain;


Pssm-ID: 460850  Cd Length: 63  Bit Score: 60.34  E-value: 6.87e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23312394    76 YSGIDEALLCWYHIARAKAWDVTGPMLLHKAKELA----DIMGQDFVPSIGWLVRWKRRNNV 133
Cdd:pfam03221   1 YPDLEKALYEWILQLRARGIPITGPMIREKALELAqlaaDLGEPDFKASKGWLDRFKKRHGI 62
CENP-B_N pfam04218
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ...
 6-57 5.78e-09

CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure.


Pssm-ID: 461229  Cd Length: 53  Bit Score: 52.03  E-value: 5.78e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 23312394     6 KKKLHALSLAEKIQVLELLDESkMSQSEVARRFQVSQPQISRICKNKEKLLA 57
Cdd:pfam04218   1 RRKRRSLTLREKIAIIQRYEEG-ESKASLARRFGVPASTLRRILKNKKKLLQ 51
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
74-133 2.14e-08

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


Pssm-ID: 197828  Cd Length: 66  Bit Score: 50.75  E-value: 2.14e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23312394     74 SKYSGIDEALLCWYHIARAKAWDVTGPMLLHKAKELADIMG-QDFVPSIGWLVRWKRRNNV 133
Cdd:smart00674   2 RLYPLLEKALYEWILRQEALGIPISGEDIREKALEILQRLGlENFKASKGWLTRFKKRHNI 62
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
 22-66 1.69e-04

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 40.18  E-value: 1.69e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 23312394  22 ELLDESKMSQSEVARRFQVSQPQISRICKNKEKLLADwcsgTANR 66
Cdd:COG3093  16 EFLEPLGLSQTELAKALGVSRQRISEILNGKRAITAD----TALR 56
COG5606 COG5606
Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];
14-52 2.69e-03

Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];


Pssm-ID: 444337  Cd Length: 105  Bit Score: 37.17  E-value: 2.69e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 23312394  14 LAEKIQvlELLDESKMSQSEVARRFQVSQPQISRICKNK 52
Cdd:COG5606  33 LMAAIR--KLIKERGLTQAEAAELLGITQPRVSDLLRGK 69
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 9-50 3.03e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.51  E-value: 3.03e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 23312394   9 LHALSLAEKIQVLELLDESKMSQSEVARRFQVSQPQISRICK 50
Cdd:cd00090   1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLK 42
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
22-52 3.69e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 35.57  E-value: 3.69e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 23312394     22 ELLDESKMSQSEVARRFQVSQPQISRICKNK 52
Cdd:smart00530   4 ELREEKGLTQEELAEKLGVSRSTLSRIENGK 34
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 22-52 8.32e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 34.84  E-value: 8.32e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 23312394  22 ELLDESKMSQSEVARRFQVSQPQISRICKNK 52
Cdd:cd00093   6 ELRKEKGLTQEELAEKLGVSRSTISRIENGK 36
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 16-71 8.78e-03

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 34.49  E-value: 8.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 23312394    16 EKIQVLELLDEsKMSQSEVARRFQVSQPQISRICKnkeKLLADWCSGTANRERKRK 71
Cdd:pfam13518   1 ERLKIVLLALE-GESIKEAARLFGISRSTVYRWIR---RYREGGLEGLLPRRRRPK 52
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
22-54 9.84e-03

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 34.73  E-value: 9.84e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 23312394  22 ELLDESKMSQSEVARRFQVSQPQISRICKNKEK 54
Cdd:COG3655   8 ELLAERGMTKKELAEATGISRATLSRLKNGKAK 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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