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Conserved domains on  [gi|124339857|ref|NP_666291|]
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zinc finger protein 418 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-64 3.38e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 3.38e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 124339857   24 CVTFEDVAVYFSQEEWELLDESQRLLYLDVMLENFTLITSL 64
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
282-639 5.05e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 5.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 282 KPYRCGECGKSFCQSSNLSEHCRVHSGERPFECL--ECGKAFGCHSSLLRHQRTHTG----------------------- 336
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNnpsdlnskslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 337 ----EWPYECGDCGRLFRQIVSLITHQRTHTTEKPYEC---------GQCEKSFSHKATL---------------TVHQR 388
Cdd:COG5048  112 ssssNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNplpgnnsssVNTPQSNSLHPPLpanslskdpssnlslLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 389 VHTGEKPYHCEACGKSFSQSANLIKHSKIHTGEKPYKCGECGLCFRQRATLMKHQRTHTSERPYECRECGKFFK------ 462
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptassq 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 463 ----QYFYLIEHSRIhttTEFYECGQCGKSYTQNATLIRHQR--VHTGES--PYKCKE--CGKAFEYKSRLNRHQRTHTG 532
Cdd:COG5048  272 ssspNESDSSSEKGF---SLPIKSKQCNISFSRSSPLTRHLRsvNHSGESlkPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 533 ERPYECakcgKFFRESYNL-----------AEHQKIHTKAKPYNCD--QCGKCFSRRADLVKHQRVHTGERP--YTCGEC 597
Cdd:COG5048  349 ISPAKE----KLLNSSSKFspllnneppqsLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 124339857 598 GKTFSRTTNLVQHRRIHTGERPYECDQCGKSFSQVSTLTRHQ 639
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-64 3.38e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 3.38e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 124339857   24 CVTFEDVAVYFSQEEWELLDESQRLLYLDVMLENFTLITSL 64
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
25-66 2.13e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 82.26  E-value: 2.13e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 124339857    25 VTFEDVAVYFSQEEWELLDESQRLLYLDVMLENFTLITSLAH 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 25-64 1.30e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.30e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 124339857  25 VTFEDVAVYFSQEEWELLDESQRLLYLDVMLENFTLITSL 64
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
282-639 5.05e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 5.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 282 KPYRCGECGKSFCQSSNLSEHCRVHSGERPFECL--ECGKAFGCHSSLLRHQRTHTG----------------------- 336
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNnpsdlnskslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 337 ----EWPYECGDCGRLFRQIVSLITHQRTHTTEKPYEC---------GQCEKSFSHKATL---------------TVHQR 388
Cdd:COG5048  112 ssssNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNplpgnnsssVNTPQSNSLHPPLpanslskdpssnlslLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 389 VHTGEKPYHCEACGKSFSQSANLIKHSKIHTGEKPYKCGECGLCFRQRATLMKHQRTHTSERPYECRECGKFFK------ 462
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptassq 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 463 ----QYFYLIEHSRIhttTEFYECGQCGKSYTQNATLIRHQR--VHTGES--PYKCKE--CGKAFEYKSRLNRHQRTHTG 532
Cdd:COG5048  272 ssspNESDSSSEKGF---SLPIKSKQCNISFSRSSPLTRHLRsvNHSGESlkPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 533 ERPYECakcgKFFRESYNL-----------AEHQKIHTKAKPYNCD--QCGKCFSRRADLVKHQRVHTGERP--YTCGEC 597
Cdd:COG5048  349 ISPAKE----KLLNSSSKFspllnneppqsLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 124339857 598 GKTFSRTTNLVQHRRIHTGERPYECDQCGKSFSQVSTLTRHQ 639
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
606-631 1.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.65e-04
                          10        20
                  ....*....|....*....|....*.
gi 124339857  606 NLVQHRRIHTGERPYECDQCGKSFSQ 631
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 538-628 7.11e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 39.47  E-value: 7.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 538 CAKCGKFFRESyNLAEHQKIHtkAKPYNCdQCGKCFSRRaDLVKHQRVHTGERPYTCGECGKTFS----------RTTNL 607
Cdd:PLN03086 456 CEKCGQAFQQG-EMEKHMKVF--HEPLQC-PCGVVLEKE-QMVQHQASTCPLRLITCRFCGDMVQaggsamdvrdRLRGM 530

                         90       100
                 ....*....|....*....|.
gi 124339857 608 VQHRRIhTGERPYECDQCGKS 628
Cdd:PLN03086 531 SEHESI-CGSRTAPCDSCGRS 550
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-64 3.38e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 3.38e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 124339857   24 CVTFEDVAVYFSQEEWELLDESQRLLYLDVMLENFTLITSL 64
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
25-66 2.13e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 82.26  E-value: 2.13e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 124339857    25 VTFEDVAVYFSQEEWELLDESQRLLYLDVMLENFTLITSLAH 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 25-64 1.30e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.30e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 124339857  25 VTFEDVAVYFSQEEWELLDESQRLLYLDVMLENFTLITSL 64
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
282-639 5.05e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 5.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 282 KPYRCGECGKSFCQSSNLSEHCRVHSGERPFECL--ECGKAFGCHSSLLRHQRTHTG----------------------- 336
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNnpsdlnskslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 337 ----EWPYECGDCGRLFRQIVSLITHQRTHTTEKPYEC---------GQCEKSFSHKATL---------------TVHQR 388
Cdd:COG5048  112 ssssNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNplpgnnsssVNTPQSNSLHPPLpanslskdpssnlslLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 389 VHTGEKPYHCEACGKSFSQSANLIKHSKIHTGEKPYKCGECGLCFRQRATLMKHQRTHTSERPYECRECGKFFK------ 462
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptassq 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 463 ----QYFYLIEHSRIhttTEFYECGQCGKSYTQNATLIRHQR--VHTGES--PYKCKE--CGKAFEYKSRLNRHQRTHTG 532
Cdd:COG5048  272 ssspNESDSSSEKGF---SLPIKSKQCNISFSRSSPLTRHLRsvNHSGESlkPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 533 ERPYECakcgKFFRESYNL-----------AEHQKIHTKAKPYNCD--QCGKCFSRRADLVKHQRVHTGERP--YTCGEC 597
Cdd:COG5048  349 ISPAKE----KLLNSSSKFspllnneppqsLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 124339857 598 GKTFSRTTNLVQHRRIHTGERPYECDQCGKSFSQVSTLTRHQ 639
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
353-650 1.03e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 353 VSLITHQRTHT----TEKPYECGQCEKSFSHKATLTVHQRVHTGEKPYHCEA--CGKSFSQSANLIKHSKIHTGE----- 421
Cdd:COG5048   15 VLSSTPKSTLKslsnAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNpsdln 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 422 ------------------------KPYKCGECGLCFRQRATLMKHQRTHTSERPYECRECGKFFKQYfylIEHSRIHTTT 477
Cdd:COG5048   95 skslplsnskasssslsssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNT---PQSNSLHPPL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 478 EFYEcgQCGKSYTQNATLIRHQRVHTGESPYKCKECGKAFEYKSRLNRHQRTHTGErPYECAKCGKFFRESYNLAEHQKI 557
Cdd:COG5048  172 PANS--LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 558 HTKAKPYNCDQCGKC------FSRRADLVKHQRVHTGER-PYTCGECGKTFSRTTNLVQHRR--IHTGE--RPYECD--Q 624
Cdd:COG5048  249 SSSDSSSSASESPRSslptasSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysL 328

                        330       340
                 ....*....|....*....|....*.
gi 124339857 625 CGKSFSQVSTLTRHQLLHTGEKSYKC 650
Cdd:COG5048  329 CGKLFSRNDALKRHILLHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
606-631 1.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.65e-04
                          10        20
                  ....*....|....*....|....*.
gi 124339857  606 NLVQHRRIHTGERPYECDQCGKSFSQ 631
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
590-652 7.00e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 7.00e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124339857 590 RPYTCGECGKTFSRTTNLVQHRRIHTGERPYEC--DQCGKSFSQVSTLTRHQLLHTGEKSYKCSK 652
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
zf-H2C2_2 pfam13465
Zinc-finger double domain;
495-519 7.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.03e-04
                          10        20
                  ....*....|....*....|....*
gi 124339857  495 LIRHQRVHTGESPYKCKECGKAFEY 519
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-463 9.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.72e-04
                          10        20
                  ....*....|....*....|....*
gi 124339857  439 LMKHQRTHTSERPYECRECGKFFKQ 463
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-293 1.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.56e-03
                          10        20
                  ....*....|....*....|...
gi 124339857  271 LRIHQRRHTGEKPYRCGECGKSF 293
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
522-545 1.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.67e-03
                          10        20
                  ....*....|....*....|....
gi 124339857  522 RLNRHQRTHTGERPYECAKCGKFF 545
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-407 2.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.07e-03
                          10        20
                  ....*....|....*....|....*
gi 124339857  383 LTVHQRVHTGEKPYHCEACGKSFSQ 407
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
578-603 5.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.87e-03
                          10        20
                  ....*....|....*....|....*.
gi 124339857  578 DLVKHQRVHTGERPYTCGECGKTFSR 603
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-321 6.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.10e-03
                          10        20
                  ....*....|....*....|....
gi 124339857  298 NLSEHCRVHSGERPFECLECGKAF 321
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 508-530 6.96e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.96e-03
                          10        20
                  ....*....|....*....|...
gi 124339857  508 YKCKECGKAFEYKSRLNRHQRTH 530
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 538-628 7.11e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 39.47  E-value: 7.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124339857 538 CAKCGKFFRESyNLAEHQKIHtkAKPYNCdQCGKCFSRRaDLVKHQRVHTGERPYTCGECGKTFS----------RTTNL 607
Cdd:PLN03086 456 CEKCGQAFQQG-EMEKHMKVF--HEPLQC-PCGVVLEKE-QMVQHQASTCPLRLITCRFCGDMVQaggsamdvrdRLRGM 530

                         90       100
                 ....*....|....*....|.
gi 124339857 608 VQHRRIhTGERPYECDQCGKS 628
Cdd:PLN03086 531 SEHESI-CGSRTAPCDSCGRS 550
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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