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Conserved domains on  [gi|27881421|ref|NP_666358|]
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retinitis pigmentosa 1-like 1 protein [Mus musculus]

Protein Classification

ubiquitin family protein( domain architecture ID 1000087)

ubiquitin family protein belongs to an diverse class of protein modifier and gene expression regulatory proteins that participate in a number of cellular processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ubl1_cv_Nsp3_N-like super family cl28922
first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV ...
 42-120 1.99e-45

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.


The actual alignment was detected with superfamily member cd17146:

Pssm-ID: 475130  Cd Length: 79  Bit Score: 158.45  E-value: 1.99e-45
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27881421   42 KKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQRMPLSFGVRSVTTPRGLHGLSALEQLQDGGCYLCSDRKPPKT 120
Cdd:cd17146    1 KKITFYKSGDPQFGGVKMAVNKRTFKSFSALLDDLSQRVPLPFGVRTITTPRGTHSISRLEQLEDGGCYLCSDKKYVKP 79
Ubl1_cv_Nsp3_N-like super family cl28922
first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV ...
 160-234 1.18e-32

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.


The actual alignment was detected with superfamily member cd17148:

Pssm-ID: 475130  Cd Length: 76  Bit Score: 121.80  E-value: 1.18e-32
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27881421  160 RRLTLVKNGDPRRQQTVVLSHKNTRSLAAFLGKASELLRFPVKQVYTTRGKKVDSLQTLLDGPSVLVCAGNEAFR 234
Cdd:cd17148    1 KKITLVKNGDPDVRRSIILNRRNARNLRTFLDEISDLLQFPVKKLYTLEGRKIDSIQALLHCPSVLVCVGREPFK 75
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 687-926 2.56e-04

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421   687 DTQSSLDTALQMPMPQEREQaCPGSPAPQSPSNSPSAGNQASEDLRSPFSSSldlqepqatskattiavsgsdcvCHSTR 766
Cdd:PHA03307  165 DAASSRQAALPLSSPEETAR-APSSPPAEPPPSTPPAAASPRPPRRSSPISA-----------------------SASSP 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421   767 SVEPAGDTKCQAHSSTPTPAHRGELGCLWDKAGTTPEPFSFSVLLDRCPEADDPRTYHDCCCLQAVPSSPLAAPSGQTQT 846
Cdd:PHA03307  221 APAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSP 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421   847 SISeaclGGSSFCPTPPKEQTCFGRESASNGSTSSGHSRADGFAGPrrtllvkspgvRGSLEEREADGGVTPSALPYASP 926
Cdd:PHA03307  301 SSP----GSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVS-----------PGPSPSRSPSPSRPPPPADPSSP 365
 
Name Accession Description Interval E-value
DCX1_RP1L1 cd17146
Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a ...
 42-120 1.99e-45

Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a member of the doublecortin (DCX) family. Its DCX domains occur in double tandem repeats. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX-domain of RP1L1 localizes to the photoreceptor and is genetically associated with retinitis pigmentosa.


Pssm-ID: 340666  Cd Length: 79  Bit Score: 158.45  E-value: 1.99e-45
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27881421   42 KKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQRMPLSFGVRSVTTPRGLHGLSALEQLQDGGCYLCSDRKPPKT 120
Cdd:cd17146    1 KKITFYKSGDPQFGGVKMAVNKRTFKSFSALLDDLSQRVPLPFGVRTITTPRGTHSISRLEQLEDGGCYLCSDKKYVKP 79
DCX2_RP1L1 cd17148
Dublecortin-like domain 2 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a ...
 160-234 1.18e-32

Dublecortin-like domain 2 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a member of doublecortin (DCX) family. Its protein domains occur in tandem repeats. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX-domain of RP1L1 localizes to the photoreceptor and is genetically associated with retinitis pigmentosa.


Pssm-ID: 340668  Cd Length: 76  Bit Score: 121.80  E-value: 1.18e-32
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27881421  160 RRLTLVKNGDPRRQQTVVLSHKNTRSLAAFLGKASELLRFPVKQVYTTRGKKVDSLQTLLDGPSVLVCAGNEAFR 234
Cdd:cd17148    1 KKITLVKNGDPDVRRSIILNRRNARNLRTFLDEISDLLQFPVKKLYTLEGRKIDSIQALLHCPSVLVCVGREPFK 75
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 41-117 5.24e-16

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 74.99  E-value: 5.24e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27881421      41 AKKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQ--RMPLSFGVRSVTTPRGLHGLSaLEQLQDGGCYLCSDRKP 117
Cdd:smart00537    5 PKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEvvKLDLPHGVRKLYTLDGKKVTS-LDELEDGGSYVASGTEA 82
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 156-237 2.45e-13

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 67.28  E-value: 2.45e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421     156 PVAPRRLTLVKNGDP-RRQQTVVLSHKNTRSLAAFLGKASELLR----FPVKQVYTTRGKKVDSLQTLLDGpSVLVCAGN 230
Cdd:smart00537    2 LVKPKRIRFYRNGDRfFKGVRLVVNRKRFKSFEALLQDLTEVVKldlpHGVRKLYTLDGKKVTSLDELEDG-GSYVASGT 80


                    ....*..
gi 27881421     231 EAFRCLE 237
Cdd:smart00537   81 EAFKKVD 87
DCX pfam03607
Doublecortin;
60-117 2.92e-13

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 65.93  E-value: 2.92e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421     60 AVHQRTFKTFSSLMDELSQRMP-LSFG-VRSVTTPRGlHGLSALEQLQDGGCYLCSDRKP 117
Cdd:pfam03607    1 VVNKRRFRSFDALLDELTEKVVkLPFGaVRKLYTLDG-KRVTSLDELEDGGVYVAAGREK 59
DCX pfam03607
Doublecortin;
177-233 2.95e-10

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 57.46  E-value: 2.95e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27881421    177 VLSHKNTRSLAAFLGKASEL---LRFP-VKQVYTTRGKKVDSLQTLLDGpSVLVCAGNEAF 233
Cdd:pfam03607    1 VVNKRRFRSFDALLDELTEKvvkLPFGaVRKLYTLDGKRVTSLDELEDG-GVYVAAGREKF 60
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 687-926 2.56e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421   687 DTQSSLDTALQMPMPQEREQaCPGSPAPQSPSNSPSAGNQASEDLRSPFSSSldlqepqatskattiavsgsdcvCHSTR 766
Cdd:PHA03307  165 DAASSRQAALPLSSPEETAR-APSSPPAEPPPSTPPAAASPRPPRRSSPISA-----------------------SASSP 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421   767 SVEPAGDTKCQAHSSTPTPAHRGELGCLWDKAGTTPEPFSFSVLLDRCPEADDPRTYHDCCCLQAVPSSPLAAPSGQTQT 846
Cdd:PHA03307  221 APAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSP 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421   847 SISeaclGGSSFCPTPPKEQTCFGRESASNGSTSSGHSRADGFAGPrrtllvkspgvRGSLEEREADGGVTPSALPYASP 926
Cdd:PHA03307  301 SSP----GSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVS-----------PGPSPSRSPSPSRPPPPADPSSP 365
 
Name Accession Description Interval E-value
DCX1_RP1L1 cd17146
Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a ...
 42-120 1.99e-45

Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a member of the doublecortin (DCX) family. Its DCX domains occur in double tandem repeats. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX-domain of RP1L1 localizes to the photoreceptor and is genetically associated with retinitis pigmentosa.


Pssm-ID: 340666  Cd Length: 79  Bit Score: 158.45  E-value: 1.99e-45
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27881421   42 KKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQRMPLSFGVRSVTTPRGLHGLSALEQLQDGGCYLCSDRKPPKT 120
Cdd:cd17146    1 KKITFYKSGDPQFGGVKMAVNKRTFKSFSALLDDLSQRVPLPFGVRTITTPRGTHSISRLEQLEDGGCYLCSDKKYVKP 79
DCX1_RP_like cd16110
Doublecortin-like domain 1 found in retinitis pigmentosa (RP)-like protein; RP-like protein ...
 42-116 3.34e-37

Doublecortin-like domain 1 found in retinitis pigmentosa (RP)-like protein; RP-like protein family is part of doublecortin (DCX) family. It has double tandem DCX repeats that are associated with retinitis pigmentosa. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. RP-like proteins are colocalized to the photoreceptor and share a function in outer segment disc morphogenesis.


Pssm-ID: 340527  Cd Length: 75  Bit Score: 134.73  E-value: 3.34e-37
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27881421   42 KKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQRMPLSFGVRSVTTPRGLHGLSALEQLQDGGCYLCSDRK 116
Cdd:cd16110    1 KNVTFYKDGDVHFSGVRVAINPRRYRTFDALLDELSRKVPLPFGVRSITTPRGRHSITSLEQLEDGGKYVCSSKR 75
DCX2_RP1L1 cd17148
Dublecortin-like domain 2 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a ...
 160-234 1.18e-32

Dublecortin-like domain 2 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a member of doublecortin (DCX) family. Its protein domains occur in tandem repeats. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX-domain of RP1L1 localizes to the photoreceptor and is genetically associated with retinitis pigmentosa.


Pssm-ID: 340668  Cd Length: 76  Bit Score: 121.80  E-value: 1.18e-32
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27881421  160 RRLTLVKNGDPRRQQTVVLSHKNTRSLAAFLGKASELLRFPVKQVYTTRGKKVDSLQTLLDGPSVLVCAGNEAFR 234
Cdd:cd17148    1 KKITLVKNGDPDVRRSIILNRRNARNLRTFLDEISDLLQFPVKKLYTLEGRKIDSIQALLHCPSVLVCVGREPFK 75
DCX1_RP1 cd17145
Doublecortin-like domain 1 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also ...
 42-119 1.17e-29

Doublecortin-like domain 1 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed oxygen-regulated protein 1, is a member of the doublecortin (DCX) family. Its DCX domains occur in double tandem repeats. RP1 is associated with retinitis pigmentosa, which is a type of inherited blindness. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The RP1 protein is expressed in photoreceptors and is required for correct stacking of outer segment discs. It interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340665  Cd Length: 79  Bit Score: 113.37  E-value: 1.17e-29
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27881421   42 KKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQRMPLSFGVRSVTTPRGLHGLSALEQLQDGGCYLCSDRKPPK 119
Cdd:cd17145    1 KRVCFYKSGDPQFGGLRMVVNSRSFKTFDALLDNLSKKVPLPFGVRNITTPRGVHHITSLEDLEDGKSYICSHQKKVK 78
DCX2_RP_like cd17070
Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein ...
 160-228 3.55e-23

Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein family is part of doublecortin (DCX) superfamily with double tandem DCX repeats that are associated with retinitis pigmentosa. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. RP-like proteins are colocalized to the photoreceptor and share a function in outer segment disc morphogenesis.


Pssm-ID: 340590  Cd Length: 69  Bit Score: 94.62  E-value: 3.55e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27881421  160 RRLTLVKNGDPRRQQTVVLSHKNTRSLAAFLGKASELLRFPVKQVYTTRGKKVDSLQTLLDGPSVLVCA 228
Cdd:cd17070    1 KVITVISNGDPHSRHTILLNRRTTQSFEQVLQDLSELLKGPVRKLYTTDGKKVESLSALFHGPDEYVAA 69
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 42-113 1.08e-18

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 81.89  E-value: 1.08e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27881421   42 KKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQRMPL-SFGVRSVTTPRGLHgLSALEQLQDGGCYLCS 113
Cdd:cd01617    1 KRITVFRNGDKNFKGVKVLVKPRRFRTFDQLLDELTEKLGLpTGGVRKLYTPSGKL-VKSLSDLEDGESYVVC 72
DCX2_RP1 cd17147
Dublecortin-like domain 2 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed ...
 160-234 1.85e-18

Dublecortin-like domain 2 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed oxygen-regulated protein 1, is a member of doublecortin (DCX) superfamily that contains double tandem repeats of the DCX domains. RP1 is associated with retinitis pigmentosa, which is a type of inherited blindness. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The RP1 protein is expressed in photoreceptors that is required for correct stacking of outer segment discs. RP1 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340667  Cd Length: 76  Bit Score: 81.34  E-value: 1.85e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27881421  160 RRLTLVKNGDPRRQQTVVLSHKNTRSLAAFLGKASELLRFPVKQVYTTRGKKVDSLQTLLDGPSVLVCAGNEAFR 234
Cdd:cd17147    1 RKLIVFKNGDPGFKHTLILNKKTTQSFEALLDHVSELMQFPVVKLYTTDGRRVDSLQALILSSGAVVAAGREPFK 75
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 41-117 5.24e-16

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 74.99  E-value: 5.24e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27881421      41 AKKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQ--RMPLSFGVRSVTTPRGLHGLSaLEQLQDGGCYLCSDRKP 117
Cdd:smart00537    5 PKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEvvKLDLPHGVRKLYTLDGKKVTS-LDELEDGGSYVASGTEA 82
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 160-228 6.55e-14

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 68.41  E-value: 6.55e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27881421  160 RRLTLVKNGDPRRQQTVVLSHKN-TRSLAAFLGKASELLR---FPVKQVYTTRGKKVDSLQTLLDGPSVLVCA 228
Cdd:cd01617    1 KRITVFRNGDKNFKGVKVLVKPRrFRTFDQLLDELTEKLGlptGGVRKLYTPSGKLVKSLSDLEDGESYVVCG 73
DCX1_DCDC2_like cd17071
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and ...
 42-110 1.40e-13

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and similar proteins; DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340591  Cd Length: 80  Bit Score: 67.63  E-value: 1.40e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421   42 KKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQRMPLSFG-VRSVTTPRGLHGLSALEQLQDGGCY 110
Cdd:cd17071    1 KIIVVYKNGDPFFPGKKFVVNERQVRTFDAFLNEVTSGIKAPFGaVRSIYTPTGGHRVKDLDSLQNGGVY 70
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 156-237 2.45e-13

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 67.28  E-value: 2.45e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421     156 PVAPRRLTLVKNGDP-RRQQTVVLSHKNTRSLAAFLGKASELLR----FPVKQVYTTRGKKVDSLQTLLDGpSVLVCAGN 230
Cdd:smart00537    2 LVKPKRIRFYRNGDRfFKGVRLVVNRKRFKSFEALLQDLTEVVKldlpHGVRKLYTLDGKKVTSLDELEDG-GSYVASGT 80


                    ....*..
gi 27881421     231 EAFRCLE 237
Cdd:smart00537   81 EAFKKVD 87
DCX pfam03607
Doublecortin;
60-117 2.92e-13

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 65.93  E-value: 2.92e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421     60 AVHQRTFKTFSSLMDELSQRMP-LSFG-VRSVTTPRGlHGLSALEQLQDGGCYLCSDRKP 117
Cdd:pfam03607    1 VVNKRRFRSFDALLDELTEKVVkLPFGaVRKLYTLDG-KRVTSLDELEDGGVYVAAGREK 59
DCX1 cd16109
Dublecortin-like domain 1; Members of the doublecortin (DCX) gene family are ...
 41-113 3.20e-12

Dublecortin-like domain 1; Members of the doublecortin (DCX) gene family are microtubule-associated proteins (MAPs). Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its protein domains can occur in double tandem or single repeats. The family represents the first repeat of the DCX domain which has a stable ubiquitin-like tertiary fold. Proteins with DCX double tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK).


Pssm-ID: 340526  Cd Length: 85  Bit Score: 63.86  E-value: 3.20e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27881421   41 AKKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDEL----SQRMPLSFGVRSVTTPRGLHGLSALEQLQDGGCYLCS 113
Cdd:cd16109    2 AKKVRFYRNGDRFFKGIVYAVSSERFRSFEALLADLtrslSDNVNLPQGVRTIFTIDGSRKITSLDELEDGESYVCA 78
DCX1_DCDC2 cd17149
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 42-116 2.38e-10

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340669  Cd Length: 80  Bit Score: 58.63  E-value: 2.38e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27881421   42 KKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQRMPLSFG-VRSVTTPRGLHGLSALEQLQDGGCYLCSDRK 116
Cdd:cd17149    1 KNVLVYRNGDPFYAGRRLVINEKRVSSFEVFLKEVTGGVQAPFGaVRNIYTPRGGHRVRSLEQLQSGEQYVAAGRE 76
DCX pfam03607
Doublecortin;
177-233 2.95e-10

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 57.46  E-value: 2.95e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27881421    177 VLSHKNTRSLAAFLGKASEL---LRFP-VKQVYTTRGKKVDSLQTLLDGpSVLVCAGNEAF 233
Cdd:pfam03607    1 VVNKRRFRSFDALLDELTEKvvkLPFGaVRKLYTLDGKRVTSLDELEDG-GVYVAAGREKF 60
DCX1_DCDC2C cd17151
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 42-116 4.46e-10

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340671  Cd Length: 79  Bit Score: 57.49  E-value: 4.46e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27881421   42 KKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQRMPLSFGVRSVTTPRGLHGLSALEQLQDGGCYLCSDRK 116
Cdd:cd17151    1 KTILVYRNGDPFYQAHKVVIHRRRVKTFDALLRQLTETVKVPFGVRCLYTPRNGHRVKGLDDLQGGGKYVAAGRE 75
DCX1_DCDC2B cd17150
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 42-111 4.92e-10

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340670  Cd Length: 79  Bit Score: 57.50  E-value: 4.92e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421   42 KKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQRMPLSFGVRSVTTPRGLHGLSALEQLQDGGCYL 111
Cdd:cd17150    1 KNVVVYRNGDPFFTGRKFVVNQRQFLTFEAFLNEVTSNIQAPVAVRNLYTPREGHRVTELGDLQNGGHYV 70
DCX1_DCLK1 cd17140
Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of ...
 41-119 7.48e-10

Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule-binding domains, DCLK encodes a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340660  Cd Length: 89  Bit Score: 57.32  E-value: 7.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421   41 AKKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDELSQRMP----LSFGVRSVTTPRGLHGLSALEQLQDGGCYLCSDRK 116
Cdd:cd17140    2 AKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSdnvnLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIE 81


                 ...
gi 27881421  117 PPK 119
Cdd:cd17140   82 PFK 84
DCX1_DCLK2 cd17141
Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of ...
 41-117 7.90e-10

Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains, which typically occur in tandem. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier (Ubiquitination) in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. Molecular actions of DCX members are less well characterized and it shows that DCLK2 members regulate cyclic AMP signaling. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340661  Cd Length: 85  Bit Score: 57.22  E-value: 7.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421   41 AKKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDEL----SQRMPLSFGVRSVTTPRGLHGLSALEQLQDGGCYLCSDRK 116
Cdd:cd17141    2 AKKVRFYRNGDRYFKGLVYAVSSDRFRSFDALLMELtrslSDNVNLPQGVRTIYTIDGSKKITSLDELLEGESYVCASNE 81


                 .
gi 27881421  117 P 117
Cdd:cd17141   82 P 82
DCX1_DCX cd16112
Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX); DCX, also ...
 41-113 1.03e-08

Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX); DCX, also termed doublin or lissencephalin-X (Lis-XDCX), is a microtubule-associated protein (MAP). It belongs to the doublecortin (DCX) family, has double tandem DCX repeats, and is expressed in migrating neurons. Structure studies show that the N-terminal DCX domain has a stable ubiquitin-like fold. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in the human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340529  Cd Length: 89  Bit Score: 54.15  E-value: 1.03e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27881421   41 AKKITFLKRGDPQFAGVRLAVHQRTFKTFSSLMDEL----SQRMPLSFGVRSVTTPRGLHGLSALEQLQDGGCYLCS 113
Cdd:cd16112    2 AKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLtrslSDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCS 78
DCX_DCLK3 cd16111
Doublecortin-like domain found in doublecortin-like kinase 3 (DCLK3); DCLK3 is a member of ...
 159-231 5.77e-06

Doublecortin-like domain found in doublecortin-like kinase 3 (DCLK3); DCLK3 is a member of doublecortin (DCX) protein family. It functions as a microtubule-associated protein (MAP). DCLK3 contains only one N-terminal doublecortin domain (DCX), unlike DCLK1 and DCLK2 which each have two conserved DCX domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK3 has a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases.


Pssm-ID: 340528  Cd Length: 85  Bit Score: 46.27  E-value: 5.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421  159 PRRLTLVKNGD-PRRQQTVVLSHKNTRSLAAFLGKASELLRFP------VKQVYTTRGKKVDSLQTLLDGPSVLVCAGNE 231
Cdd:cd16111    2 PKVITVVRNGGqPRTKITILLNRRSVQTFEQLMADISEALGFPrwkndrVRKLYSLRGREVRSVSDFFREDDVFIATGRE 81
DCX2 cd17069
Dublecortin-like domain 2; Members in doublecortin (DCX) gene family are ...
 157-234 9.89e-06

Dublecortin-like domain 2; Members in doublecortin (DCX) gene family are microtubule-associated proteins (MAPs). Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its protein domains can occur in double tandem or as a single repeat. The first repeat of DCX domain has a stable ubiquitin-like tertiary fold. Proteins with DCX double tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK).


Pssm-ID: 340589  Cd Length: 84  Bit Score: 45.45  E-value: 9.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421  157 VAPRRLTLVKNG-DPRRQQTVVLSHKNTRSLAAFLGKASELLRF---PVKQVYTTRGKKVDSLQTLLDGPSVLVCAGNEA 232
Cdd:cd17069    2 IKPKLVTVIRNGtKPRKAVRILLNKKTAHSFEQVLTDITEAIKLdsgAVRKLFTLDGRQVTCLQDFFGDDDVFIAYGPEK 81


                 ..
gi 27881421  233 FR 234
Cdd:cd17069   82 FS 83
DCX2_DCX cd17142
Dublecortin-like domain 2 found in neuronal migration protein doublecortin (DCX); DCX, also ...
 157-234 1.53e-05

Dublecortin-like domain 2 found in neuronal migration protein doublecortin (DCX); DCX, also termed doublin or lissencephalin-X (Lis-XDCX), is a microtubule-associated protein (MAP). It belongs to the doublecortin (DCX) family, has double tandem DCX repeats, and is expressed in migrating neurons. Structure studies show that the N-terminal DCX domain has a stable ubiquitin-like fold. DCX is not only a unique MAP in terms of its structure, but also interacts with multiple additional proteins. Mutations in the human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340662  Cd Length: 84  Bit Score: 45.04  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421  157 VAPRRLTLVKNG-DPRRQQTVVLSHKNTRSLAAFLGKASELLRFP---VKQVYTTRGKKVDSLQTLLDGPSVLVCAGNEA 232
Cdd:cd17142    2 VRPKLVTIIRSGvKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLEtgvVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEK 81


                 ..
gi 27881421  233 FR 234
Cdd:cd17142   82 FR 83
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 687-926 2.56e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421   687 DTQSSLDTALQMPMPQEREQaCPGSPAPQSPSNSPSAGNQASEDLRSPFSSSldlqepqatskattiavsgsdcvCHSTR 766
Cdd:PHA03307  165 DAASSRQAALPLSSPEETAR-APSSPPAEPPPSTPPAAASPRPPRRSSPISA-----------------------SASSP 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421   767 SVEPAGDTKCQAHSSTPTPAHRGELGCLWDKAGTTPEPFSFSVLLDRCPEADDPRTYHDCCCLQAVPSSPLAAPSGQTQT 846
Cdd:PHA03307  221 APAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSP 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421   847 SISeaclGGSSFCPTPPKEQTCFGRESASNGSTSSGHSRADGFAGPrrtllvkspgvRGSLEEREADGGVTPSALPYASP 926
Cdd:PHA03307  301 SSP----GSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVS-----------PGPSPSRSPSPSRPPPPADPSSP 365
KHA cd17073
KHA, dimerization domain of potassium ion channel, similar to doublecortin-like domain, found ...
 160-220 8.20e-04

KHA, dimerization domain of potassium ion channel, similar to doublecortin-like domain, found in potassium channel tetramerization domain containing 9 (KCTD9) and similar proteins; This family corresponds to KHA, the tetramerization domain of eukaryotic voltage-dependent potassium ion-channel proteins, mainly found in vertebrates KCTD9 and plants AKT proteins. In plants the domain lies at the C-terminus whereas in many chordates it lies at the N-terminus. KHA shows high sequence similarity with doublecortin-like domain, which has a stable ubiquitin-like tertiary fold. KCTD9, also termed BTB/POZ domain-containing protein 9, belongs to the KCTD protein family, which corresponds to potassium channel tetramerization domain proteins, a class of BTB-domain-containing proteins. It is involved in potassium channel formation. Moreover, KCTD9 contributes to liver injury through NK cell activation during hepatitis B virus (HBV)-induced acute-on-chronic liver failure. AKT proteins play crucial roles in K+ uptake and translocation in plant cells.


Pssm-ID: 340593  Cd Length: 65  Bit Score: 39.51  E-value: 8.20e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27881421  160 RRLTLVKNGDPRRQQTVVLSHkntrSLAAFLGKASELLRFPVKQVYTTRGKKVDSLQTLLD 220
Cdd:cd17073    1 KRVTVFVNGSSSGGKVIALPS----TLSELLKIASEKLGIPAKRLYTGSGGEIDDIALIRD 57
DCX2_DCLK1 cd17143
Dublecortin-like domain 2 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of ...
 157-234 9.94e-04

Dublecortin-like domain 2 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein family that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, the DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340663  Cd Length: 84  Bit Score: 39.94  E-value: 9.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421  157 VAPRRLTLVKNG-DPRRQQTVVLSHKNTRSLAAFLGKASELLRF---PVKQVYTTRGKKVDSLQTLLDGPSVLVCAGNEA 232
Cdd:cd17143    2 IRPKLVTIIRSGvKPRKAVRILLNKKTAHSFEQVLTDITDAIKLdsgVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEK 81


                 ..
gi 27881421  233 FR 234
Cdd:cd17143   82 FR 83
DCX2_DCLK2 cd17144
Dublecortin-like domain 2 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of ...
 157-234 1.14e-03

Dublecortin-like domain 2 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of doublecortin (DCX) protein family that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains, which typically occur in double tandem. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK2 members regulate cyclic AMP signaling. Unlike DCX, the DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340664  Cd Length: 84  Bit Score: 39.63  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421  157 VAPRRLTLVKNG-DPRRQQTVVLSHKNTRSLAAFLGKASELLRFP---VKQVYTTRGKKVDSLQTLLDGPSVLVCAGNEA 232
Cdd:cd17144    2 IKPKLVTVIRSGvKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDsgvVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEK 81


                 ..
gi 27881421  233 FR 234
Cdd:cd17144   82 YR 83
DCX1_DCLK2 cd17141
Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of ...
 160-234 6.09e-03

Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains, which typically occur in tandem. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier (Ubiquitination) in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. Molecular actions of DCX members are less well characterized and it shows that DCLK2 members regulate cyclic AMP signaling. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340661  Cd Length: 85  Bit Score: 37.58  E-value: 6.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881421  160 RRLTLVKNGDPRRQQTV-VLSHKNTRSLAAFLGKA----SELLRFP--VKQVYTTRG-KKVDSLQTLLDGPSvLVCAGNE 231
Cdd:cd17141    3 KKVRFYRNGDRYFKGLVyAVSSDRFRSFDALLMELtrslSDNVNLPqgVRTIYTIDGsKKITSLDELLEGES-YVCASNE 81


                 ...
gi 27881421  232 AFR 234
Cdd:cd17141   82 PFR 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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