NCBI Conserved Domain Search

Conserved domains on [gi|33238922|ref|NP_666867|]

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olfactory receptor family 2 subfamily A member 56 [Mus musculus]

Protein Classification

olfactory receptor subfamily 2A protein( domain architecture ID 11607566)

olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Gene Ontology: GO:0004984|GO:0004930|GO:0007186

PubMed: 12898108|10531047

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

25-300

1.13e-164

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 458.72 E-value: 1.13e-164

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15420   2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15420  82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15420 162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15420 242 NSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

Name

Accession

Description

Interval

E-value

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

25-300

1.13e-164

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 458.72 E-value: 1.13e-164

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15420   2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15420  82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15420 162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15420 242 NSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

30-304

4.04e-55

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 180.39 E-value: 4.04e-55

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922    30 FSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922   110 ECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKLACA 189
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922   190 DTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH--PE 267
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHnvPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 33238922   268 LQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRRSL 304
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

29-304

7.44e-06

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 46.70 E-value: 7.44e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922   29 LFSLFYSFTLLGNGIILVVIClDNRLHIPMYFFLSHLAIVDMSYASNnVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:PHA03087  46 VYSTIFFFGLVGNIIVIYVLT-KTKIKTPMDIYLLNLAVSDLLFVMT-LPFQIYYYILFQWSFGEFACKIVSGLYYIGFY 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGfLLALVHLVLILKLPfcGPHEINHFFCEILSVLKLac 188
Cdd:PHA03087 124 NSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIIS-IIETTPILFVYTTK--KDHETLICCMFYNNKTMN-- 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  189 adttLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLF---FGSAIVMYMAPKSQH 265
Cdd:PHA03087 199 ----WKLFINFEINIIGMLIPLTILLYCYSKILITLKGINKSKKNKKAIKLVLIIVILFVIFwlpFNVSVFVYSLHILHF 274

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 33238922  266 PELQQKILSLFYSLF--------NPMLNPLIYCLRNAEVKGALRRSL 304
Cdd:PHA03087 275 KSGCKAVKYIQYALHvteiislsHCCINPLIYAFVSEFFNKHKKKSL 321

Name

Accession

Description

Interval

E-value

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

25-300

1.13e-164

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 458.72 E-value: 1.13e-164

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15420   2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15420  82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15420 162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15420 242 NSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

25-300

2.29e-143

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 404.92 E-value: 2.29e-143

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15225   2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15225  82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15225 162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15225 242 YSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

25-293

7.86e-141

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 398.19 E-value: 7.86e-141

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15237   2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15237  82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15237 162 KLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHST 241

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15237 242 HSPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

25-293

1.35e-140

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 397.62 E-value: 1.35e-140

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd13954  82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd13954 162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd13954 242 YSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

25-300

6.36e-128

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 365.72 E-value: 6.36e-128

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15421 162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15421 242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

25-293

5.41e-126

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 360.67 E-value: 5.41e-126

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15230   2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15230  82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15230 162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15230 242 YSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

25-293

7.73e-123

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 352.68 E-value: 7.73e-123

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15431   2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHlVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15431  82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIP-VLTMPLHFCGPNVINHFFCEVQALL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15431 161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15431 241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

25-300

5.34e-122

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 350.80 E-value: 5.34e-122

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15231   2 LLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15231  82 SFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15231 162 KLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSG 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15231 242 YSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

25-300

1.10e-121

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 349.97 E-value: 1.10e-121

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15229   2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15229  82 FFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15229 162 PLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSA 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15229 242 SSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

25-293

3.85e-120

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 345.62 E-value: 3.85e-120

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15911   2 LLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15911  82 SLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15911 162 KLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTN 241

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15911 242 TSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

25-300

2.39e-117

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 339.20 E-value: 2.39e-117

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15235   3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFI 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15235  83 AFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15235 163 KLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSS 242

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15235 243 YSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

25-293

2.59e-117

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 338.69 E-value: 2.59e-117

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15912   2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15912  82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15912 162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15912 242 SSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

26-293

6.97e-116

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 334.98 E-value: 6.97e-116

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15947   3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15947  83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15947 163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242

                       250       260
                ....*....|....*....|....*...
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15947 243 SQDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

27-293

7.42e-116

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 334.81 E-value: 7.42e-116

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  27 FGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAF 106
Cdd:cd15227   4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 107 ACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKL 186
Cdd:cd15227  84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 187 ACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQHP 266
Cdd:cd15227 164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243

                       250       260
                ....*....|....*....|....*..
gi 33238922 267 ELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15227 244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

10-304

6.15e-115

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 333.56 E-value: 6.15e-115

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  10 EVTLLGFQADLSVECFLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRR 89
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  90 TISFILCIMQTFLYLAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCG 169
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 170 PHEINHFFCEILSVLKLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGL 249
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 33238922 250 FFGSAIVMYMAPKSQHPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRRSL 304
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

26-300

2.88e-114

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 331.29 E-value: 2.88e-114

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15429  83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15429 243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

11-297

2.30e-113

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 329.28 E-value: 2.30e-113

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  11 VTLLGFQADLSVECFLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRT 90
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  91 ISFILCIMQTFLYLAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGP 170
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 171 HEINHFFCEILSVLKLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLF 250
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 33238922 251 FGSAIVMYMAPKSQHPELQQKILSLFYSLFNPMLNPLIYCLRNAEVK 297
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

26-302

3.61e-113

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 328.51 E-value: 3.61e-113

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15411   3 LFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15411  83 LATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15411 163 LSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSY 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRR 302
Cdd:cd15411 243 SLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

25-293

1.63e-110

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 321.49 E-value: 1.63e-110

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15918   2 LLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15918  82 LFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15918 162 KLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSS 241

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15918 242 HSASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

25-302

1.78e-109

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 319.20 E-value: 1.78e-109

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15417   2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15417  82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15417 162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRR 302
Cdd:cd15417 242 HSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

13-302

1.16e-108

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 317.68 E-value: 1.16e-108

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  13 LLGFQADLSVECFLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTIS 92
Cdd:cd15410   3 LLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKAIS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  93 FILCIMQTFLYLAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHE 172
Cdd:cd15410  83 YSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGSNV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 173 INHFFCEILSVLKLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFG 252
Cdd:cd15410 163 INHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIFHG 242

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 33238922 253 SAIVMYMAPKSQHPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRR 302
Cdd:cd15410 243 TILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRK 292

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

25-293

3.99e-108

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 315.46 E-value: 3.99e-108

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15430   2 LLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15430  82 AMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15430 162 KLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSK 241

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15430 242 NAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

26-300

9.59e-108

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 314.70 E-value: 9.59e-108

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15434   3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15434  83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15434 163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSV 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15434 243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

25-302

1.76e-107

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 313.86 E-value: 1.76e-107

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15419   2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15419  82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15419 162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAV 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRR 302
Cdd:cd15419 242 SSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

26-302

3.29e-106

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 310.79 E-value: 3.29e-106

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15413   3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15413  83 FIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15413 163 LSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSH 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRR 302
Cdd:cd15413 243 SLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

25-293

5.94e-105

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 307.26 E-value: 5.94e-105

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15232   2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15232  82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15232 162 LLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15232 242 YSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

26-293

2.14e-103

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 303.43 E-value: 2.14e-103

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15224   3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15224  83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15224 163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242

                       250       260
                ....*....|....*....|....*...
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15224 243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

26-302

8.13e-103

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 302.36 E-value: 8.13e-103

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15416   3 LFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAAT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15416  83 FGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15416 163 LSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSY 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRR 302
Cdd:cd15416 243 SMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

13-302

2.41e-102

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 301.66 E-value: 2.41e-102

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  13 LLGFQADLSVECFLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTIS 92
Cdd:cd15945   3 LLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  93 FILCIMQTFLYLAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHE 172
Cdd:cd15945  83 FYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGSNT 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 173 INHFFCEILSVLKLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFG 252
Cdd:cd15945 163 INHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLFYG 242

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 33238922 253 SAIVMYMAPKSQHPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRR 302
Cdd:cd15945 243 TLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

25-300

1.31e-101

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 299.11 E-value: 1.31e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15234  82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15234 162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15234 242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

25-302

1.85e-101

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 298.94 E-value: 1.85e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15409   2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15409  82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15409 162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRR 302
Cdd:cd15409 242 YALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

26-300

2.67e-101

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 298.19 E-value: 2.67e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15424   3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15424  83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15424 163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15424 243 TPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

26-302

3.18e-101

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 298.16 E-value: 3.18e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15412   3 LFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15412  83 LVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15412 163 LSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEE 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRR 302
Cdd:cd15412 243 SVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

26-300

4.64e-101

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 297.85 E-value: 4.64e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15432   3 LFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15432  83 LGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15432 163 LSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNS 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15432 243 SHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

26-293

8.88e-101

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 296.70 E-value: 8.88e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15946   3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15946  83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15946 163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242

                       250       260
                ....*....|....*....|....*...
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15946 243 SPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

26-304

3.05e-99

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 293.51 E-value: 3.05e-99

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15406  12 LFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCV 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15406  92 FAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLK 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15406 172 LSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSS 251

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRRSL 304
Cdd:cd15406 252 SMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

25-293

3.61e-99

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 292.58 E-value: 3.61e-99

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15939  82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTiLRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15939 162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPElqQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15939 241 FPI--DKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

25-300

2.40e-98

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 290.92 E-value: 2.40e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15428   2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15428  82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15428 162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15428 242 TSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

24-293

9.03e-98

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 289.21 E-value: 9.03e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  24 CFLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLY 103
Cdd:cd15915   1 IFLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 104 LAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSV 183
Cdd:cd15915  81 HFLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 184 LKLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRI-QSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPK 262
Cdd:cd15915 161 LKLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPS 240

                       250       260       270
                ....*....|....*....|....*....|.
gi 33238922 263 SQHPELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15915 241 SGDSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

25-308

5.77e-97

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 287.40 E-value: 5.77e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15414   2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15414  82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15414 162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSS 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRRSLWKER 308
Cdd:cd15414 242 SSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRKM 285

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

25-302

1.31e-96

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 286.62 E-value: 1.31e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15415   2 PLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15415  82 VFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15415 162 KLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQ 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRR 302
Cdd:cd15415 242 YSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

25-293

6.37e-96

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 284.21 E-value: 6.37e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15913   2 LLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15913  82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15913 162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSG 241

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15913 242 NSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

26-300

3.64e-95

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 282.78 E-value: 3.64e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15228   3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15228  83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPksQH 265
Cdd:cd15228 163 LACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQP--TP 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15228 241 SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

25-293

2.20e-94

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 280.24 E-value: 2.20e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15226   2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15226  82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTIlRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15226 162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFST 240

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPElqQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15226 241 FPV--DKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

13-302

3.21e-93

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 278.21 E-value: 3.21e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  13 LLGFQADLSVECFLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTIS 92
Cdd:cd15944   3 LLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVIS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  93 FILCIMQTFLYLAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHE 172
Cdd:cd15944  83 FSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSNI 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 173 INHFFCEILSVLKLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFG 252
Cdd:cd15944 163 INHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLFYG 242

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 33238922 253 SAIVMYMAPKSQHPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRR 302
Cdd:cd15944 243 TVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKK 292

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

25-293

1.94e-91

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 273.09 E-value: 1.94e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15914   2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15914  82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15914 162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKS 241

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15914 242 YSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

26-302

1.29e-90

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 271.22 E-value: 1.29e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15407   3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15407  83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15407 163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSH 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRR 302
Cdd:cd15407 243 SMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

26-293

4.42e-89

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 267.00 E-value: 4.42e-89

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15940   3 FFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15940  83 FACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTiLRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15940 163 LACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVS-LRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSF 241

                       250       260
                ....*....|....*....|....*...
gi 33238922 266 PElqQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15940 242 SE--DKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

26-300

8.64e-89

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 266.62 E-value: 8.64e-89

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVT-QRRTISFILCIMQTFLYL 104
Cdd:cd15916   3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEpGGKVISFGGCVAQLYFFH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15916  83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15916 163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSK 242

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238922 265 HPelQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15916 243 EA--LDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

27-300

2.07e-88

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 265.48 E-value: 2.07e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  27 FGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAF 106
Cdd:cd15236   4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 107 ACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKL 186
Cdd:cd15236  84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 187 ACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQHP 266
Cdd:cd15236 164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243

                       250       260       270
                ....*....|....*....|....*....|....
gi 33238922 267 ELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15236 244 SDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

26-300

8.14e-87

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 261.26 E-value: 8.14e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15433   3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15433  83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15433 163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRY 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15433 243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

25-302

1.24e-86

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 261.25 E-value: 1.24e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15418   3 ILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15418  83 GLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15418 163 KLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSS 242

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238922 265 HPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRR 302
Cdd:cd15418 243 HTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKK 280

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

26-300

1.39e-85

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 258.18 E-value: 1.39e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15233   3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15233  83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15233 163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15233 243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

26-300

3.80e-85

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 257.35 E-value: 3.80e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15405   3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15405  83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15405 163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238922 266 PELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15405 243 SVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

25-293

3.79e-84

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 254.18 E-value: 3.79e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15936   2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15936  82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTIlRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15936 162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKI-RTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQT 240

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPElqQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15936 241 FPM--DKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

25-300

1.38e-83

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 253.23 E-value: 1.38e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLH-IPMYFFLSHLAIVDMSYASNNVPKMLANLVTQR-RTISFILCIMQTFL 102
Cdd:cd15941   2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHgLPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 103 YLAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILS 182
Cdd:cd15941  82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 183 VLKLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPK 262
Cdd:cd15941 162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238922 263 SQhpELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15941 242 SS--QAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

26-300

1.15e-82

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 250.81 E-value: 1.15e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15942   3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15942  83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15942 163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238922 266 PelQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15942 243 P--LDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

26-293

2.98e-72

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 223.98 E-value: 2.98e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15938  83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 LACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVtilRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH 265
Cdd:cd15938 163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILV---TIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239

                       250       260
                ....*....|....*....|....*...
gi 33238922 266 PelQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15938 240 P--VDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

25-293

2.09e-71

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 221.95 E-value: 2.09e-71

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRL-HIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLY 103
Cdd:cd15935   2 LLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 104 LAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSV 183
Cdd:cd15935  82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 184 LKLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTiLRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKS 263
Cdd:cd15935 162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 33238922 264 QHPelQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15935 241 SSS--VDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

25-293

1.71e-70

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 219.61 E-value: 1.71e-70

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15937   2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15937  82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTiLRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQ 264
Cdd:cd15937 162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRS 240

                       250       260
                ....*....|....*....|....*....
gi 33238922 265 HPelQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15937 241 FP--MDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

30-296

1.99e-69

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 216.77 E-value: 1.99e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  30 FSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:cd15917   7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 110 ECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKLACA 189
Cdd:cd15917  87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 190 DTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH--PE 267
Cdd:cd15917 167 DTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHhvPP 246

                       250       260
                ....*....|....*....|....*....
gi 33238922 268 LQQKILSLFYSLFNPMLNPLIYCLRNAEV 296
Cdd:cd15917 247 HVHILLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

25-300

9.75e-65

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 205.22 E-value: 9.75e-65

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15223   2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15223  82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMA--PK 262
Cdd:cd15223 162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTyrFG 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238922 263 SQHPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15223 242 KTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

29-296

1.77e-63

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 201.87 E-value: 1.77e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15950   6 PFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKLAC 188
Cdd:cd15950  86 VESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLAC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 189 ADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIV-MYMAPKSQH-P 266
Cdd:cd15950 166 ADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQRFGQGvP 245

                       250       260       270
                ....*....|....*....|....*....|
gi 33238922 267 ELQQKILSLFYSLFNPMLNPLIYCLRNAEV 296
Cdd:cd15950 246 PHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

30-296

1.72e-62

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 199.05 E-value: 1.72e-62

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  30 FSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 110 ECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKLACA 189
Cdd:cd15221  87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 190 DTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH--PE 267
Cdd:cd15221 167 DITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGRhiPR 246

                       250       260
                ....*....|....*....|....*....
gi 33238922 268 LQQKILSLFYSLFNPMLNPLIYCLRNAEV 296
Cdd:cd15221 247 HVHILLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

30-296

1.08e-61

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 197.22 E-value: 1.08e-61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  30 FSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:cd15952   7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 110 ECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKLACA 189
Cdd:cd15952  87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 190 DTTLNQVVILAACVFILVGpLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH--PE 267
Cdd:cd15952 167 SIRINIIYGLFAISVLVLD-VILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHniPR 245

                       250       260
                ....*....|....*....|....*....
gi 33238922 268 LQQKILSLFYSLFNPMLNPLIYCLRNAEV 296
Cdd:cd15952 246 YIHILLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

30-296

1.38e-60

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 194.26 E-value: 1.38e-60

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  30 FSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:cd15222   7 FCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 110 ECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKLACA 189
Cdd:cd15222  87 ESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACS 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 190 DTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPK--SQHPE 267
Cdd:cd15222 167 DTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRfgKHASP 246

                       250       260
                ....*....|....*....|....*....
gi 33238922 268 LQQKILSLFYSLFNPMLNPLIYCLRNAEV 296
Cdd:cd15222 247 LVHVLMANVYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

30-296

3.98e-59

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 190.55 E-value: 3.98e-59

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  30 FSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 110 ECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKLACA 189
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 190 DTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH--PE 267
Cdd:cd15953 167 DTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRFGQgiAP 246

                       250       260
                ....*....|....*....|....*....
gi 33238922 268 LQQKILSLFYSLFNPMLNPLIYCLRNAEV 296
Cdd:cd15953 247 HIHIILANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

30-293

9.87e-57

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 184.47 E-value: 9.87e-57

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  30 FSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:cd15951   7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 110 ECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKLACA 189
Cdd:cd15951  87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 190 DTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPK-SQHPEL 268
Cdd:cd15951 167 DTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRfGHNVPP 246

                       250       260
                ....*....|....*....|....*.
gi 33238922 269 QQKIL-SLFYSLFNPMLNPLIYCLRN 293
Cdd:cd15951 247 HVHILiANVYLLVPPMLNPIIYGVRT 272

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

30-304

4.04e-55

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 180.39 E-value: 4.04e-55

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922    30 FSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922   110 ECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKLACA 189
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922   190 DTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH--PE 267
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHnvPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 33238922   268 LQQKILSLFYSLFNPMLNPLIYCLRNAEVKGALRRSL 304
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

30-297

1.09e-53

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 176.63 E-value: 1.09e-53

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  30 FSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:cd15948   8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 110 ECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKLACA 189
Cdd:cd15948  88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 190 DTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAI---VMYMAPKSQHP 266
Cdd:cd15948 168 DTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVlssTMHRFARHVAP 247

                       250       260       270
                ....*....|....*....|....*....|.
gi 33238922 267 ELqQKILSLFYSLFNPMLNPLIYCLRNAEVK 297
Cdd:cd15948 248 HV-HILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

30-296

2.39e-53

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 175.82 E-value: 2.39e-53

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  30 FSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:cd15956   7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 110 ECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKLACA 189
Cdd:cd15956  87 ESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 190 DTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH--PE 267
Cdd:cd15956 167 ATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGHsvPS 246

                       250       260
                ....*....|....*....|....*....
gi 33238922 268 LQQKILSLFYSLFNPMLNPLIYCLRNAEV 296
Cdd:cd15956 247 AAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

30-297

1.78e-46

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 158.40 E-value: 1.78e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  30 FSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:cd15949  23 FCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNEIPLHACLLQMFLIHSFSAI 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 110 ECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKLACA 189
Cdd:cd15949 103 ESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRTNIIAHSYCEHMAVVGLACG 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 190 DTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH--PE 267
Cdd:cd15949 183 DVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAILAFYVPIAVSSLIHRFGQnvPP 262

                       250       260       270
                ....*....|....*....|....*....|
gi 33238922 268 LQQKILSLFYSLFNPMLNPLIYCLRNAEVK 297
Cdd:cd15949 263 PTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

30-296

1.80e-43

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 150.30 E-value: 1.80e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  30 FSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:cd15955   7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 110 ECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLI-LKLPFCGPHEINHFFCEILSVLKLAC 188
Cdd:cd15955  87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIkLRLHHFRSTVISHSYCEHMAVVKLAA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 189 ADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSQH--P 266
Cdd:cd15955 167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHhvA 246

                       250       260       270
                ....*....|....*....|....*....|
gi 33238922 267 ELQQKILSLFYSLFNPMLNPLIYCLRNAEV 296
Cdd:cd15955 247 PYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

30-296

7.59e-41

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 143.43 E-value: 7.59e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  30 FSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:cd15954   7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 110 ECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKLACA 189
Cdd:cd15954  87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 190 DTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPK--SQH-P 266
Cdd:cd15954 167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRfgGHHiT 246

                       250       260       270
                ....*....|....*....|....*....|
gi 33238922 267 ELQQKILSLFYSLFNPMLNPLIYCLRNAEV 296
Cdd:cd15954 247 PHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

40-289

1.01e-37

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 134.35 E-value: 1.01e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922    40 GNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRR-TISFILCIMQTFLYLAFACTECLILVVMS 118
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922   119 YDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCgphEINHFFCEILSVLKLACadttlNQVVI 198
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVP---EGNVTVCFIDFPEDLSK-----PVSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922   199 LAACVFILVGPLCLVLVSYTRILVTILRIQSGEGR-------RKAFSTCSSHLCVVGLFFGSAIVMYM----APKSQHPE 267
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLldslALDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 33238922   268 LQQKILSL--FYSLFNPMLNPLIY 289
Cdd:pfam00001 233 LLDKALSVtlWLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

26-293

5.70e-28

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 109.30 E-value: 5.70e-28

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCeilsvlk 185
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWP------- 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 lacaDTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSH-----------LCVVGLFFGS- 253
Cdd:cd00637 154 ----DLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRrrrerkvtktlLIVVVVFLLCw 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 33238922 254 ----AIVMYMAPKSQHPELQQKILSLFYSL--FNPMLNPLIYCLRN 293
Cdd:cd00637 230 lpyfILLLLDVFGPDPSPLPRILYFLALLLayLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

25-300

2.31e-19

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 85.31 E-value: 2.31e-19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFceilsvl 184
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEF------- 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 klacadtTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRiqsgegRRKAFSTcsshLCVVGL--------FFGSAIV 256
Cdd:cd14967 154 -------TPNKIYVLVSSVISFFIPLLIMIVLYARIFRVARR------ELKAAKT----LAIIVGafllcwlpFFIIYLV 216

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 33238922 257 MYMAPKSQHPELQQKILSLFySLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd14967 217 SAFCPPDCVPPILYAVFFWL-GYLNSALNPIIYALFNRDFRRAF 259

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

36-300

7.59e-14

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 70.31 E-value: 7.59e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  36 FTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECLILV 115
Cdd:cd14969  13 LGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 116 VMSYDRFVAICHPLhYTVIMSWKVCTILAAVSWIAGFLLALvhlvlilkLPFCGpheINHFfceILSVLKLACA-----D 190
Cdd:cd14969  93 ALAFERYLVIVRPL-KAFRLSKRRALILIAFIWLYGLFWAL--------PPLFG---WSSY---VPEGGGTSCSvdwysK 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 191 TTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSH-----------LCVVGLFFGS-----A 254
Cdd:cd14969 158 DPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTkkaekkvakmvLVMIVAFLIAwtpyaV 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 33238922 255 IVMYMApkSQHPELQQKILSLFYSLF---NPMLNPLIYCLRNAEVKGAL 300
Cdd:cd14969 238 VSLYVS--FGGESTIPPLLATIPALFaksSTIYNPIIYVFMNKQFRRAL 284

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

36-300

3.23e-12

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 65.33 E-value: 3.23e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  36 FTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA--FACTecLI 113
Cdd:cd15196  13 LALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQLIWDITYRFYGGDLLCRLVKYLQVVgmYASS--YV 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 114 LVVMSYDRFVAICHPLHYtviMSW--KVCTILAAVSWIAGFLLALVHLVlILKLPFCGPheiNHFFCeilsvlkLACADT 191
Cdd:cd15196  91 LVATAIDRYIAICHPLSS---HRWtsRRVHLMVAIAWVLSLLLSIPQLF-IFSYQEVGS---GVYDC-------WATFEP 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 192 TL-NQVVILAACVFILVGPLCLVLVSYTRILVTIlriqsgegRRKAFSTCSSHLCVVGL-------FFGSAIVMYMAPKS 263
Cdd:cd15196 157 PWgLRAYITWFTVAVFVVPLIILAFCYGRICYVV--------WRAKIKTVKLTLVVVACyivcwtpFFVVQMWAAWDPTA 228

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238922 264 QHPELQQKILSLFYSLfNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15196 229 PIEGPAFVIIMLLASL-NSCTNPWIYLAFSGNLRRAL 264

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

26-226

1.04e-11

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 64.28 E-value: 1.04e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLF-SLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15083   2 VLGIFiLIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVhlvlilklPFCGpheINHFfceILSVL 184
Cdd:cd15083  82 LFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLP--------PLFG---WSRY---VLEGL 147

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 33238922 185 KLAC-----ADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILR 226
Cdd:cd15083 148 LTSCsfdylSRDDANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRR 194

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

29-235

1.18e-11

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 64.00 E-value: 1.18e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15012   5 LYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYT 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEInhfFCEILSVlkLAC 188
Cdd:cd15012  85 ASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDG---QEEEICV--LDR 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 33238922 189 ADTTLNQVVILAACVFILVgPLCLVLVSYTRILVTILRIQSGEGRRK 235
Cdd:cd15012 160 EMFNSKLYDTINFIVWYLI-PLLIMTVLYSKISIVLWKSSSIEARRK 205

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

29-291

1.17e-10

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 61.13 E-value: 1.17e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFT----LLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNnVPKMLANLVTQRRTI-SFILCIMQTFLY 103
Cdd:cd14982   2 LFPIVYSLIfilgLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLT-LPFRIYYYLNGGWWPfGDFLCRLTGLLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 104 LAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIagFLLALVHLVLILKLPFCGPHEINHFFcEILSV 183
Cdd:cd14982  81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWI--LVLVASVPLLLLRSTIAKENNSTTCF-EFLSE 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 184 LKlacadtTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEG----RRKAFSTCSSHLCVVGLFFG---SAIV 256
Cdd:cd14982 158 WL------ASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQksvrKRKALRMILIVLAVFLVCFLpyhVTRI 231

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 33238922 257 MYMAPKSQHPE--LQQKILSLFYSL------FNPMLNPLIYCL 291
Cdd:cd14982 232 LYLLVRLSFIAdcSARNSLYKAYRItlclasLNSCLDPLIYYF 274

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

29-299

1.47e-10

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 60.42 E-value: 1.47e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCimQTFLYLAFAC 108
Cdd:cd15064   6 LLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLC--DIWISLDVTC 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 109 TECLI--LVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLvlilkLPFCGPHEINHFFCEIlsvlkl 186
Cdd:cd15064  84 CTASIlhLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPL-----FGWRTPDSEDPSECLI------ 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 187 acadttlNQVVILAacVFILVG----PLCLVLVSYTRILVTILRiqsgegRRKAFSTCSSHLCVVGL----FFGSAIVMY 258
Cdd:cd15064 153 -------SQDIGYT--IFSTFGafyiPLLLMLILYWKIYRAAAR------ERKAAKTLGIILGAFIVcwlpFFLVALIVP 217

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 33238922 259 MAPKSQHPELQQKILsLFYSLFNPMLNPLIYCLRNAEVKGA 299
Cdd:cd15064 218 LCSHCWIPLALKSFF-LWLGYFNSLINPLIYTFFNKDFRKA 257

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

24-293

2.11e-10

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 60.31 E-value: 2.11e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  24 CFLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLY 103
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 104 LAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVL--ILKLPFCGPHEINHFFC-EI 180
Cdd:cd14993  81 GVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVyeLEEIISSEPGTITIYICtED 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 181 LSvlklACADTTLNQVVILaacVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSH------------LCVVG 248
Cdd:cd14993 161 WP----SPELRKAYNVALF---VVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRilrskkkvarmlIVVVV 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 33238922 249 LFFGS-------AIVMYMAPKS-QHPELQQKILSLFYSLF---NPMLNPLIYCLRN 293
Cdd:cd14993 234 LFALSwlpyyvlSILLDFGPLSsEESDENFLLILPFAQLLgysNSAINPIIYCFMS 289

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

38-224

7.22e-10

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 58.91 E-value: 7.22e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  38 LLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRR-TISFILCIMQTFLYLAFACTECLILVV 116
Cdd:cd14979  15 IVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPwAFGDGGCKLYYFLFEACTYATVLTIVA 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 117 MSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLI----LKLPFCGPHEiNHFFCEILSvlklacADTT 192
Cdd:cd14979  95 LSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMgiqyLNGPLPGPVP-DSAVCTLVV------DRST 167

                       170       180       190
                ....*....|....*....|....*....|..
gi 33238922 193 LNQVVILAACVFILVgPLCLVLVSYTRILVTI 224
Cdd:cd14979 168 FKYVFQVSTFIFFVL-PMFVISILYFRIGVKL 198

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

27-161

7.70e-10

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 58.59 E-value: 7.70e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  27 FGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYAsnnvpkmLANLVTQ---RRTISF----ILCIMQ 99
Cdd:cd15197   4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVG-------LINVLTDiiwRITVEWragdFACKVI 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33238922 100 TFLYLAFACTECLILVVMSYDRFVAICHPLHYTviMSWKVCTILAAVSWIAGFLLALVHLVL 161
Cdd:cd15197  77 RYLQVVVTYASTYVLVALSIDRYDAICHPMNFS--QSGRQARVLICVAWILSALFSIPMLII 136

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

39-300

1.26e-09

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 58.04 E-value: 1.26e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  39 LGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPkmLANLVTQRRTISFILCIMQTFLYLAFACTECLILVVMS 118
Cdd:cd14968  16 LGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLVLVLTQSSIFSLLAIA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 119 YDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLV-LILKLPFCGPHEINHFFCEILSVLklacaDTTLNQVV 197
Cdd:cd14968  94 IDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFgWNNGAPLESGCGEGGIQCLFEEVI-----PMDYMVYF 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 198 ILAACVFIlvgPLCLVLVSYTRILVTI--------LRIQSGEGRR---KAFSTCSSHLCVVGLFFGSAI-------VMYM 259
Cdd:cd14968 169 NFFACVLV---PLLIMLVIYLRIFRVIrkqlrqieSLLRSRRSRStlqKEVKAAKSLAIILFLFALCWLplhiincITLF 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 33238922 260 APKSQHPELQQKILsLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd14968 246 CPECKVPKILTYIA-ILLSHANSAVNPIVYAYRIRKFRQTF 285

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

36-300

2.54e-09

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 56.92 E-value: 2.54e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  36 FTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECLiLV 115
Cdd:cd14972  11 FIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLASAYS-LL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 116 VMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALvhlvlilkLPFCGPHEINHFFCEILSVLKLacadTTLNQ 195
Cdd:cd14972  90 AIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL--------LPVLGWNCVLCDQESCSPLGPG----LPKSY 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 196 VVILAACVFIlvgPLCLVLVSYTRILV--------TILRIQSGEGRRKAFSTCSSHLCVV--GLFFGS--AIVMYMAPKS 263
Cdd:cd14972 158 LVLILVFFFI---ALVIIVFLYVRIFWclwrhanaIAARQEAAVPAQPSTSRKLAKTVVIvlGVFLVCwlPLLILLVLDV 234

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 33238922 264 QHPELQQKILSLFYSLF----NPMLNPLIYCLRNAEVKGAL 300
Cdd:cd14972 235 LCPSVCDIQAVFYYFLVlallNSAINPIIYAFRLKEMRRAV 275

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

29-294

3.81e-09

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 56.53 E-value: 3.81e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15390   6 VFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTviMSWKVCTILAAVSWIAGFLLALVHLVL--ILKLPFCGPHEINHFFCEiLSVLKL 186
Cdd:cd15390  86 ASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLASFLLALPQLLYstTETYYYYTGSERTVCFIA-WPDGPN 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 187 ACADTTLNQVVIlaacVFILVGPLCLVLVSYTRILVTIL--RIQSGEGRRKAFSTCSSH-----LCVVGLFFGSA----- 254
Cdd:cd15390 163 SLQDFVYNIVLF----VVTYFLPLIIMAVAYTRVGVELWgsKTIGENTPRQLESVRAKRkvvkmMIVVVVIFAICwlpyh 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 33238922 255 ---IVMYMAPKSQHPELQQKILSLFYSLF--NPMLNPLIYCLRNA 294
Cdd:cd15390 239 lyfILTYLYPDINSWKYIQQIYLAIYWLAmsNSMYNPIIYCWMNK 283

7tmA_D2-like_dopamine_R

cd15053

D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...

32-299

1.47e-08

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320181 [Multi-domain] Cd Length: 263 Bit Score: 54.66 E-value: 1.47e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  32 LFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRR-TISFILCimqtFLYLAFACTE 110
Cdd:cd15053   9 LLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGKwYLGPILC----DIYIAMDVMC 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 111 C----LILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEinhffCEIlsvlkl 186
Cdd:cd15053  85 StasiFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEE-----CRF------ 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 187 acadttLNQVVILAACVFILVGPLCLVLVSYTRILVTILRiqsgegRRKAFSTCSSHLCVVGL----FFGSAIVMYMAPK 262
Cdd:cd15053 154 ------YNPDFIIYSSISSFYIPCIVMLLLYYRIFRALRR------EKKATKTLAIVLGVFLFcwlpFFTLNILNAICPK 221

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 33238922 263 SQHPELQQKILSLFYSLF----NPMLNPLIYCLRNAEVKGA 299
Cdd:cd15053 222 LQNQSCHVGPALFSLTTWlgyvNSFLNPIIYTIFNIEFRKA 262

7tmA_capaR

cd15134

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...

38-226

2.38e-08

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.

Pssm-ID: 320262 [Multi-domain] Cd Length: 298 Bit Score: 54.26 E-value: 2.38e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  38 LLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRR-TISFILCIMQTFLYLAFACTECLILVV 116
Cdd:cd15134  15 VVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPwVFGEVFCKLRAFLSEMSSYASVLTITA 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 117 MSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLAlvhlvlilkLPFCGPHEINHFFCEILSVLKLA----CA--- 189
Cdd:cd15134  95 FSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCA---------LPFAIQTRIVYLEYPPTSGEALEesafCAmln 165

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 33238922 190 DTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILR 226
Cdd:cd15134 166 EIPPITPVFQLSTFLFFIIPMIAIIVLYVLIGLQLRR 202

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

38-220

3.76e-08

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 53.43 E-value: 3.76e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  38 LLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECLILVVM 117
Cdd:cd15001  14 LIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICSVLTLTAI 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 118 SYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEilsvlkLACADTTLNQVV 197
Cdd:cd15001  94 SIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQ------KAWPSTLYSRLY 167

                       170       180
                ....*....|....*....|...
gi 33238922 198 ILAACVFILVGPLCLVLVSYTRI 220
Cdd:cd15001 168 VVYLAIVIFFIPLIVMTFAYARD 190

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

25-220

6.38e-08

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 53.12 E-value: 6.38e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15065   1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALvhlvLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15065  81 MCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISF----LPIHLGWHRLSQDEIKGLNHASNP 156

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 33238922 185 KLACA-DTTLNQVVILAACVFILvgPLCLVLVSYTRI 220
Cdd:cd15065 157 KPSCAlDLNPTYAVVSSLISFYI--PCLVMLLIYSRL 191

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

25-295

6.88e-08

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 52.75 E-value: 6.88e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFllalvhlvLILKLPFCGPHEinHFFCEILSvl 184
Cdd:cd15061  81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISL--------LITSPPLVGPSW--HGRRGLGS-- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 185 klaCADTTLNQVVILAAcVFILVGPLCLVLVSYTRILVTILRiqsgegRRKAFSTcsshLCVVGL--------FFGSAIV 256
Cdd:cd15061 149 ---CYYTYDKGYRIYSS-MGSFFLPLLLMLFVYLRIFRVIAK------ERKTAKT----LAIVVGcfivcwlpFFIMYLI 214

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238922 257 MYMAPKSQHPELQQKILSLFYslFNPMLNPLIYCLRNAE 295
Cdd:cd15061 215 EPFCDCQFSEALSTAFTWLGY--FNSVINPFIYAFYNKD 251

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

94-291

9.87e-08

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 52.17 E-value: 9.87e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  94 ILCIMQTFLYLAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVhlVLILKLPFCGPHEI 173
Cdd:cd15055  71 TFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSV--LLYDNLNQPGLIRY 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 174 NHFFCEILSVlklacadttLNQVVILAACVFILVGPLCLVLVSYTRILV----------TILRIQSGEGRRKAFSTCSSH 243
Cdd:cd15055 149 NSCYGECVVV---------VNFIWGVVDLVLTFILPCTVMIVLYMRIFVvarsqarairSHTAQVSLEGSSKKVSKKSER 219

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 33238922 244 LC------VVGLFFGS----AIVMYMAPKSQHPELQQKILS-LFYslFNPMLNPLIYCL 291
Cdd:cd15055 220 KAaktlgiVVGVFLLCwlpyYIVSLVDPYISTPSSVFDVLIwLGY--FNSCLNPLIYAL 276

7tmA_TACR_family

cd14992

tachykinin receptor and closely related proteins, member of the class A family of ...

29-293

1.15e-07

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320123 [Multi-domain] Cd Length: 291 Bit Score: 52.05 E-value: 1.15e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd14992   6 ALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVY 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLV---LILKLPFCGPHEInhFFCEILSVlk 185
Cdd:cd14992  86 ASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYyatTEVLFSVKNQEKI--FCCQIPPV-- 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 186 lacADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTI-LRIQSGEGRRKAFS--------TCSSHLCVVGLFF----G 252
Cdd:cd14992 162 ---DNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELwFRKVPGFSIKEVERkrlkckrrVIKMLVCVVVLFVicwlP 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 33238922 253 SAIVMYMAPKSQHPELQQKILSLFY-----SLFNPMLNPLIYCLRN 293
Cdd:cd14992 239 FHLFFLLRDFFPLIMKEKHTLQVYYflhwiAMSNSMYNPIIYVTLN 284

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

36-242

1.52e-07

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 51.99 E-value: 1.52e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  36 FTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFL--YLAFACTecLI 113
Cdd:cd14986  13 FTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLqvVGLFAST--YI 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 114 LVVMSYDRFVAICHPLHyTVIMSWKVCTILaAVSWIAGFLLALVHLVLilklpfcgpheinhFFCEILSVLKLACADTTL 193
Cdd:cd14986  91 LVSMSLDRYQAIVKPMS-SLKPRKRARLMI-VVAWVLSFLFSIPQLVI--------------FVERELGDGVHQCWSSFY 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 33238922 194 N----QVVILAACVFILVGPLCLVLVSYTRILVTI-LRIQSGEGRRKAFSTCSS 242
Cdd:cd14986 155 TpwqrKVYITWLATYVFVIPLIILSYCYGRILRTIwIRSRQKTDRPIAPTAMSC 208

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

31-156

1.55e-07

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 52.07 E-value: 1.55e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  31 SLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTI-SFILCIMQTFLYLAFACT 109
Cdd:cd15005   8 GLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFH 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 33238922 110 ECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLAL 156
Cdd:cd15005  88 SAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAF 134

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

29-299

3.42e-07

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 50.45 E-value: 3.42e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15066   5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFST 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALV-----------HLVLILKLPFCGPHEINHFF 177
Cdd:cd15066  85 ASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLpiflgwytteeHLQYRKTHPDQCEFVVNKIY 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 178 ceilsvlklacadttlnqVVILAACVFILvgPLCLVLVSYTRILVTILRiqsgegRRKAFSTC-----SSHLCVVGLFFG 252
Cdd:cd15066 165 ------------------ALISSSVSFWI--PCIVMIFTYYRIYLEAKR------EHKAAKTLgiimgAFILCWLPFFLW 218

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 33238922 253 SAIVMYMAPKSQHPELQQKILsLFYSLFNPMLNPLIYCLRNAEVKGA 299
Cdd:cd15066 219 YVTTTLCGDACPYPPILVSIL-FWIGYFNSTLNPLIYAYFNRDFREA 264

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

38-292

5.71e-07

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 50.16 E-value: 5.71e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  38 LLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPkmLANLVTQRRTISFILCIMQTFLYLAFACTECLILVVM 117
Cdd:cd15070  15 VVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHASIMSLLAI 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 118 SYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKlacadttLNQVV 197
Cdd:cd15070  93 AVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQFTSVMR-------MDYMV 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 198 ILAACVFILVgPLCLVLVSYTRILVTILR---------IQSGEGRRKAFSTCSSHLCVVGLFFGSAI-------VMYMAP 261
Cdd:cd15070 166 YFSFFTWILI-PLVIMCALYVDIFYIIRNklsqnatgfRETGAFYGREFKTAKSLALVLFLFAVCWLplsiincVVYFNP 244

                       250       260       270
                ....*....|....*....|....*....|.
gi 33238922 262 KSQHPELqqkILSLFYSLFNPMLNPLIYCLR 292
Cdd:cd15070 245 KVPKIAL---YLGILLSHANSMMNPIVYACK 272

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

36-155

7.48e-07

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 49.66 E-value: 7.48e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  36 FTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECLILV 115
Cdd:cd15312  13 LTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHLC 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 33238922 116 VMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLA 155
Cdd:cd15312  93 FIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFA 132

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

29-224

1.23e-06

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 49.04 E-value: 1.23e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYS----FTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15202   2 LLIVAYSfiivFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVimSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVL 184
Cdd:cd15202  82 CSVHVSAYTLTAIAVDRYQAIMHPLKPRI--SKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLEDWPE 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 33238922 185 KLACADTTLNQVVIlaacVFILVGPLCLVLVSYTRILVTI 224
Cdd:cd15202 160 RADLFWKYYDLALF----ILQYFLPLLVISFAYARVGIKL 195

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

31-293

1.26e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 48.81 E-value: 1.26e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  31 SLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTE 110
Cdd:cd15074   8 TVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 111 CLILVVMSYDRFVAICHPLHYTVIMSWKVCtILAAVSWIAGFLLALVHLVLILKLPFcgphEINHFFCEILSVLKLAcad 190
Cdd:cd15074  88 INTLTAISIYRYLKICHPPYGPKLSRRHVC-IVIVAIWLYALFWAVAPLVGWGSYGP----EPFGTSCSIDWTGASA--- 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 191 TTLNQVVILAACVFILVGPLCLVLVSYTRILVTI----LRIQSGEGRRKAFSTCSSHL----CVVGLFFGS-----AIVM 257
Cdd:cd15074 160 SVGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVkssrKRVAGFDSRSKRQHKIERKVtkvaVLICAGFLIawtpyAVVS 239

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238922 258 YMAPKSQhPELQQKILSLFYSLF---NPMLNPLIYCLRN 293
Cdd:cd15074 240 MWSAFGS-PDSVPILASILPALFaksSCMYNPIIYLLFS 277

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

36-293

1.29e-06

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 48.85 E-value: 1.29e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  36 FTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVP-KMLANLVTQRRTISFILCIMQTFLYLAFACTECLIL 114
Cdd:cd15052  13 ATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDVLFCTASIMHL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 115 VVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLAlvhlvliLKLPFCGPHEINHFFCEIlsvlklACADTTLN 194
Cdd:cd15052  93 CTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGIS-------SPIPVLGIIDTTNVLNNG------TCVLFNPN 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 195 QVVILAACVFILvgPLCLVLVSYTrilvtiLRIQSGEGRRKAFStcsshlcVVGLFFGSAIVMYmAP-----------KS 263
Cdd:cd15052 160 FVIYGSIVAFFI--PLLIMVVTYA------LTIRLLSNEQKASK-------VLGIVFAVFVICW-CPffitniltglcEE 223

                       250       260       270
                ....*....|....*....|....*....|..
gi 33238922 264 QHPELQQKILSLFYSL--FNPMLNPLIYCLRN 293
Cdd:cd15052 224 CNCRISPWLLSVFVWLgyVSSTINPIIYTIFN 255

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

32-294

2.67e-06

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 48.13 E-value: 2.67e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  32 LFYSFTLL----GNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVP-KMLANLVTQRRTISFILCIMQTFLYLAF 106
Cdd:cd15392   5 LMYSTIFVlavgGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPfSFIALLILQYWPFGEFMCPVVNYLQAVS 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 107 ACTECLILVVMSYDRFVAICHPLhyTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEIlsvlkl 186
Cdd:cd15392  85 VFVSAFTLVAISIDRYVAIMWPL--RPRMTKRQALLLIAVIWIFALATALPIAITSRLFEDSNASCGQYICTES------ 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 187 acaDTTLNQVVILAACVFIL--VGPLCLVLVSYTRILVTIL-----------RIQS-GEGRRKAFSTCSSHLCVVGLFFG 252
Cdd:cd15392 157 ---WPSDTNRYIYSLVLMILqyFVPLAVLVFTYTRIGIVVWakrtpgeaennRDQRmAESKRKLVKMMITVVAIFALCWL 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 33238922 253 SAIVMYMAPKSQHPELQQKILSLFYSLF------NPMLNPLIYCLRNA 294
Cdd:cd15392 234 PLNILNLVGDHDESIYSWPYIPYLWLAAhwlamsHCCYNPFIYCWMNA 281

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

37-150

2.76e-06

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 47.83 E-value: 2.76e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  37 TLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECLILVV 116
Cdd:cd15317  14 TVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTTSIFHLCF 93

                        90       100       110
                ....*....|....*....|....*....|....
gi 33238922 117 MSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIA 150
Cdd:cd15317  94 IAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLV 127

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

29-155

2.78e-06

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 47.89 E-value: 2.78e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15385   6 VLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLGMF 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 33238922 109 TECLILVVMSYDRFVAICHPLHyTVIMSWKVCTILAAVSWIAGFLLA 155
Cdd:cd15385  86 ASTYMLVMMTADRYIAICHPLK-TLQQPTKRSYLMIGSAWALSFILS 131

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

29-145

3.01e-06

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 47.89 E-value: 3.01e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15387   6 VLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCRLVKYLQVVGMF 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 33238922 109 TECLILVVMSYDRFVAICHPLH--------YTVIMSWKVCTILAA 145
Cdd:cd15387  86 ASTYMLLLMSIDRCLAICQPLRslhrrsdrVYVLFSWLLSLVFSI 130

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

29-160

3.81e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 47.63 E-value: 3.81e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHI--PMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTI-SFILCIMQTFLYLA 105
Cdd:cd14981   6 PPALMFVFGVLGNLLALIVLARSSKSHKwsVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWDgGQPLCDYFGFMMSF 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLV 160
Cdd:cd14981  86 FGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLL 140

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

29-299

3.91e-06

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 47.35 E-value: 3.91e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTI-SFILCIMQTFLYLAFA 107
Cdd:cd15067   5 VLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWLfGRDWCDVWHSFDVLAS 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 108 CTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIagfLLALVHLVLILKLPFCGPHEinhffceilsVLKLA 187
Cdd:cd15067  85 TASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI---CSALISFPAIAWWRAVDPGP----------SPPNQ 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 188 CADTTLNQVVILAACVFILVgPLCLVLVSYTRILVTILRiqsgegRRKAFSTCSshlCVVGLF-------FGSAIVMYMA 260
Cdd:cd15067 152 CLFTDDSGYLIFSSCVSFYI-PLVVMLFTYYRIYRAAAK------EQKAAKTLG---IVMGVFilcwlpfFVTNILIGFC 221

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 33238922 261 PKS--QHPELqqkILSLFYSL--FNPMLNPLIYCLRNAEVKGA 299
Cdd:cd15067 222 PSNcvSNPDI---LFPLVTWLgyINSGMNPIIYACSSRDFRRA 261

7tmA_NPR-like_invertebrate

cd15391

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...

29-159

4.57e-06

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.

Pssm-ID: 320513 [Multi-domain] Cd Length: 289 Bit Score: 47.51 E-value: 4.57e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15391   6 LYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVT 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTIlaAVSWIAGFLLALVHL 159
Cdd:cd15391  86 ASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCII--ASIWAISFSLSSVQL 134

7tmA_leucokinin-like

cd15393

leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...

24-224

5.22e-06

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.

Pssm-ID: 320515 [Multi-domain] Cd Length: 288 Bit Score: 47.02 E-value: 5.22e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  24 CFLFGLFSLFysfTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLY 103
Cdd:cd15393   4 SILYGIISLV---AVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 104 LAFACTECLILVVMSYDRFVAICHPLHYTviMSWKVCTILAAVSWIAGFLLALVHLVLI-----------LKLPFCGPHE 172
Cdd:cd15393  81 VLSVNVSVFTLTVIAVDRYRAVIHPLKAR--CSKKSAKIIILIIWILALLVALPVALALrveeltdktnnGVKPFCLPVG 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 33238922 173 INhffceilsvlklacaDTTLNQVVILAACVFILVgPLCLVLVSYTRILVTI 224
Cdd:cd15393 159 PS---------------DDWWKIYNLYLVCVQYFV-PLVIICYAYTRIAVKI 194

7tmA_Histamine_H3R_H4R

cd15048

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...

29-154

5.44e-06

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320176 [Multi-domain] Cd Length: 296 Bit Score: 47.30 E-value: 5.44e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCImqtfLYLAF-- 106
Cdd:cd15048   6 LISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCK----AWLVVdy 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 33238922 107 -ACTECLILVVM-SYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLL 154
Cdd:cd15048  82 tLCTASALTIVLiSLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLL 131

7tmA_AstA_R_insect

cd15096

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...

25-289

5.76e-06

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320224 [Multi-domain] Cd Length: 284 Bit Score: 46.91 E-value: 5.76e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFysfTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILC-IMQTFLY 103
Cdd:cd15096   5 VIFGLIFIV---GLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCkIVQYLVY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 104 LAFACTeCLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAgFLLALVHLVLILKLPFCGPHEINHFFCEILSV 183
Cdd:cd15096  82 VTAYAS-VYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIV-ILVANIPVLFLHGVVSYGFSSEAYSYCTFLTE 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 184 LKLACadttlnQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSH-----LCVVGLFFGSA---- 254
Cdd:cd15096 160 VGTAA------QTFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPGGRRSAESQRGKRrvtrlVVVVVVVFAICwlpi 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 33238922 255 -IVMYMAPKSQHPE--LQQKILSLFYSL--FNPMLNPLIY 289
Cdd:cd15096 234 hIILLLKYYGVLPEtvLYVVIQILSNCLayGNSCVNPILY 273

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

29-304

7.44e-06

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 46.70 E-value: 7.44e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922   29 LFSLFYSFTLLGNGIILVVIClDNRLHIPMYFFLSHLAIVDMSYASNnVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:PHA03087  46 VYSTIFFFGLVGNIIVIYVLT-KTKIKTPMDIYLLNLAVSDLLFVMT-LPFQIYYYILFQWSFGEFACKIVSGLYYIGFY 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGfLLALVHLVLILKLPfcGPHEINHFFCEILSVLKLac 188
Cdd:PHA03087 124 NSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIIS-IIETTPILFVYTTK--KDHETLICCMFYNNKTMN-- 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  189 adttLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLF---FGSAIVMYMAPKSQH 265
Cdd:PHA03087 199 ----WKLFINFEINIIGMLIPLTILLYCYSKILITLKGINKSKKNKKAIKLVLIIVILFVIFwlpFNVSVFVYSLHILHF 274

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 33238922  266 PELQQKILSLFYSLF--------NPMLNPLIYCLRNAEVKGALRRSL 304
Cdd:PHA03087 275 KSGCKAVKYIQYALHvteiislsHCCINPLIYAFVSEFFNKHKKKSL 321

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

29-300

8.11e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 46.60 E-value: 8.11e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHI-PMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFA 107
Cdd:cd15104   5 ILAVLSPLIITGNLLVIVALLKLIRKKDtKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSC 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 108 CTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLvLILKLPFCGPHEINHFFCEILsvlkla 187
Cdd:cd15104  85 AASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPL-ISPQFQQTSYKGKCSFFAAFH------ 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 188 cadttLNQVVILAACVFIlvgPLCLVLVS-YTRIL-------VTILRIQSGEGRRKAFSTCSSH-------LCVVGLF-- 250
Cdd:cd15104 158 -----PRVLLVLSCMVFF---PALLLFVFcYCDILkiarvhsRAIYKVEHALARQIHPRRTLSDfkaartvAVLIGCFll 229

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 33238922 251 ----FGSAIVMYMAPKSQHPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15104 230 swlpFQITGLVQALCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283

7tmA_V2R

cd15388

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...

29-156

8.12e-06

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320510 [Multi-domain] Cd Length: 295 Bit Score: 46.69 E-value: 8.12e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15388   6 VLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVGMF 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 33238922 109 TECLILVVMSYDRFVAICHPLhYTVIMSWKVCTILAAVSWIAGFLLAL 156
Cdd:cd15388  86 ASSYMIVAMTFDRHQAICRPM-VTFQKGRARWNGPVCVAWAISLILSL 132

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

38-149

1.08e-05

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 46.25 E-value: 1.08e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  38 LLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECLILVVM 117
Cdd:cd15336  15 MLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITLLAI 94

                        90       100       110
                ....*....|....*....|....*....|..
gi 33238922 118 SYDRFVAICHPLHYTVIMSWKVCTILAAVSWI 149
Cdd:cd15336  95 SLDRYLVITKPLASIRWVSKKRAMIIILLVWL 126

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

37-148

1.09e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 46.01 E-value: 1.09e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  37 TLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECLILVV 116
Cdd:cd15318  14 IVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCF 93

                        90       100       110
                ....*....|....*....|....*....|..
gi 33238922 117 MSYDRFVAICHPLHYTVIMSWKVCTILAAVSW 148
Cdd:cd15318  94 ISIDRHCAICDPLLYPSKFTIRVACIFIAAGW 125

7tmA_GPR83

cd15389

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...

30-160

1.11e-05

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.

Pssm-ID: 320511 [Multi-domain] Cd Length: 285 Bit Score: 46.18 E-value: 1.11e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  30 FSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:cd15389   7 YSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYV 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 33238922 110 ECLILVVMSYDRFVAICHPLHYTviMSWKVCTILAAVSWIAGFLLALVHLV 160
Cdd:cd15389  87 STLTLTAIALDRHRVILHPLKPR--ITPCQGVVVIAIIWIMASCLSLPHAI 135

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

33-300

1.15e-05

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 46.04 E-value: 1.15e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  33 FYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECL 112
Cdd:cd15326  10 FILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASIL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 113 ILVVMSYDRFVAICHPLHYTVIMSWKVcTILAAVS-WIAGFLLALVHLvlilkLPFCGPHEINHFFCEIlsvlklacadt 191
Cdd:cd15326  90 SLCAISIDRYIGVRHSLQYPTIVTRKR-AILALLGvWVLSTVISIGPL-----LGWKEPAPPDDKVCEI----------- 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 192 TLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSgegRRKAFSTCSshlCVVGLFFGSAIVMYMA-------PKSQ 264
Cdd:cd15326 153 TEEPFYALFSSLGSFYIPLIVILVMYCRVYIVALKFSR---EKKAAKTLG---IVVGMFILCWLPFFIAlplgslfSHLK 226

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238922 265 HPELQQKILsLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15326 227 PPETLFKII-FWLGYFNSCLNPIIYPCSSKEFKRAF 261

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

36-297

1.97e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 45.31 E-value: 1.97e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  36 FTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLAnlVTQRRTISFILCIMQTFLYLAFACTECLILV 115
Cdd:cd15068  13 LAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 116 VMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLvliLKLPFCGPHEINHFFCEILSVLKLAC---ADTT 192
Cdd:cd15068  91 AIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPM---LGWNNCGQPKEGKNHSQGCGEGQVAClfeDVVP 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 193 LNQVVILA--ACVFIlvgPLCLVLVSYTRILVTI--------LRIQSGEGRR----KAFSTCSSHLCVVGLFFGSAIVMY 258
Cdd:cd15068 168 MNYMVYFNffACVLV---PLLLMLGVYLRIFLAArrqlkqmeSQPLPGERARstlqKEVHAAKSLAIIVGLFALCWLPLH 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 33238922 259 M-------APKSQHPELQQKILSLFYSLFNPMLNPLIYCLRNAEVK 297
Cdd:cd15068 245 IincftffCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFR 290

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

29-291

2.12e-05

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 45.15 E-value: 2.12e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd14971   6 FFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMH 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIagfllalvhLVLILKLPFCGPHEINHFFCEILSVLKLAC 188
Cdd:cd14971  86 ASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWV---------VSLAVAAPVLALHRLRNYTPGNRTVCSEAW 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 189 ADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRI--------QSGEGRRKAFSTCsshLCVVGLFFGS-----AI 255
Cdd:cd14971 157 PSRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVavrpvlseGSRRAKRKVTRLV---LVVVVLFAACwgpihAI 233

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238922 256 VMYMAPKSQH---PELQQKILSLFYSLFNPMLNPLIYCL 291
Cdd:cd14971 234 LLLVALGPFPltyATYALRIWAHCLAYSNSAVNPVLYAF 272

7tmA_KiSS1R

cd15095

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...

29-156

2.35e-05

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.

Pssm-ID: 320223 [Multi-domain] Cd Length: 288 Bit Score: 44.97 E-value: 2.35e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15095   6 IFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVTVQ 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLAL 156
Cdd:cd15095  86 ATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSI 133

7tmA_AstC_insect

cd15094

somatostatin-like receptor for allatostatin C, member of the class A family of ...

29-289

2.43e-05

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.

Pssm-ID: 320222 [Multi-domain] Cd Length: 282 Bit Score: 45.16 E-value: 2.43e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNnVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15094   6 LYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIG-LPFLIVTMILKYWPFGAAMCKIYMVLTSINQF 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFCEILSVLKLAc 188
Cdd:cd15094  85 TSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDSSAVNGQK- 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 189 adttlnqVVILAACVFILVGPLCLVLVSYTRILVTILR----IQSGEGRRKAFSTCSSHLCVVGLFF--------GSAIV 256
Cdd:cd15094 164 -------AFTLYTFLLGFAIPLLLISVFYTLVILRLRTvgpkNKSKEKRRSHRKVTRLVLTVISVYIicwlpywaFQVHL 236

                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238922 257 MYMAPKSQHPELQQKILSLF--YSLFNPMLNPLIY 289
Cdd:cd15094 237 IFLPPGTDMPKWEILMFLLLtvLSYANSMVNPLLY 271

7tmA_5-HT1A_vertebrates

cd15330

serotonin receptor subtype 1A from vertebrates, member of the class A family of ...

38-300

2.74e-05

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320453 [Multi-domain] Cd Length: 260 Bit Score: 44.97 E-value: 2.74e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  38 LLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECLILVVM 117
Cdd:cd15330  15 IFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAI 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 118 SYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLvlilkLPFCGPHEINHFFCEILSVLKLACADTTLNQVV 197
Cdd:cd15330  95 ALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPM-----LGWRTPEDRSDPDACTISKDPGYTIYSTFGAFY 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 198 IlaacvfilvgPLCLVLVSYTRILVTILRiqsgegRRKAFSTC-----SSHLCVVGLFFGSAIVMYMAPKSQHPELQQKI 272
Cdd:cd15330 170 I----------PLILMLVLYGRIFKAAAR------ERKTVKTLgiimgTFILCWLPFFIVALVLPFCESTCHMPELLGAI 233

                       250       260
                ....*....|....*....|....*....
gi 33238922 273 LS-LFYSlfNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15330 234 INwLGYS--NSLLNPIIYAYFNKDFQSAF 260

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

25-228

3.59e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 44.55 E-value: 3.59e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYS-FTLLGNGIILVVIClDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANL-----VTQRRTISFILCIM 98
Cdd:cd14978   1 VLYGYVLPVICiFGIIGNILNLVVLT-RKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYiadysSSFLSYFYAYFLPY 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  99 QTFLYLAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFC 178
Cdd:cd14978  80 IYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYV 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 33238922 179 EILSVLKlacADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQ 228
Cdd:cd14978 160 IPTLLRQ---NETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSK 206

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

29-300

4.06e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 44.11 E-value: 4.06e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15325   6 ILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLvlilkLPFCGPHEINHFFCEIlsvlklac 188
Cdd:cd15325  86 ASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPL-----FGWKEPAPEDETICQI-------- 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 189 aDTTLNQVVILAACVFILvgPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGL-FFGSAIVMYMAPKSQHPE 267
Cdd:cd15325 153 -TEEPGYALFSALGSFYL--PLAIILVMYCRVYVVALKFSREKKAAKTLGIVVGCFVLCWLpFFLVMPIGSIFPAYKPSD 229

                       250       260       270
                ....*....|....*....|....*....|...
gi 33238922 268 LQQKIlSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15325 230 TVFKI-TFWLGYFNSCINPIIYPCSSQEFKKAF 261

7tmA_Histamine_H2R

cd15051

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...

29-300

4.18e-05

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320179 [Multi-domain] Cd Length: 287 Bit Score: 44.25 E-value: 4.18e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLH-IPMYFFLShLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFA 107
Cdd:cd15051   6 VLAVIILLTVIGNVLVCLAVAVNRRLRnLTNYFIVS-LAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLC 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 108 CTECLILVVMSYDRFVAICHPLHYTVIMS-WKVCTILAAVsWIAGFLLALVHLVLILKLPFCGPHEINHffceilsvlKL 186
Cdd:cd15051  85 TASILNLFAISLDRYLAITAPLRYPSRVTpRRVAIALAAI-WVVSLAVSFLPIHLGWNTPDGRVQNGDT---------PN 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 187 ACA-DTTLNQVVILAACVFILvgPLCLVLVSYTRIL---------VTILRIQSGEGRRKAFSTCSSHLCVVGLffgsAIV 256
Cdd:cd15051 155 QCRfELNPPYVLLVAIGTFYL--PLLIMCGVYLRIFriareqakrINALTPASTANSSKSAATAREHKATVTL----AAV 228

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 33238922 257 M---------------YMAPKSQHPELQQKILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15051 229 LgafiicwfpyftyftYRGLCGDNINETALSVVLWLGYANSALNPILYAFLNRDFRRAF 287

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

40-156

4.28e-05

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 44.40 E-value: 4.28e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  40 GNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNV-PKMLANlVTQRRTISFILCIMQTFLYL--AFACTecLILVV 116
Cdd:cd15386  17 GNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVlPQLIWE-ITYRFQGPDLLCRAVKYLQVlsMFAST--YMLIM 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 33238922 117 MSYDRFVAICHPLHyTVIMSWKVCTILAAVSWIAGFLLAL 156
Cdd:cd15386  94 MTVDRYIAVCHPLR-TLQQPSRQAYLMIGATWLLSCILSL 132

7tmA_5-HT1E

cd15335

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...

29-156

4.83e-05

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320457 [Multi-domain] Cd Length: 258 Bit Score: 44.14 E-value: 4.83e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCimQTFLYLAFAC 108
Cdd:cd15335   6 TLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFIC--EIWLSVDMTC 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 33238922 109 TECLI--LVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLAL 156
Cdd:cd15335  84 CTCSIlhLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISI 133

7tmA_D1A_dopamine_R

cd15320

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

24-234

5.49e-05

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320443 [Multi-domain] Cd Length: 319 Bit Score: 44.22 E-value: 5.49e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  24 CFLfglfSLFYSFTLLGNGIILVVICLDNRLHIPMY-FFLSHLAIVDMSYASNNVP-KMLANLVTQRRTISFilCIMQTF 101
Cdd:cd15320   6 CFL----SVLILSTLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMPwKAVAEIAGFWPFGSF--CNIWVA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 102 LYLAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLIL-KLPFCGPHEINhffcEI 180
Cdd:cd15320  80 FDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVQLNWhKAKPTSFLDLN----AS 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 33238922 181 LSVLKLACADTTLNQVVILAACVFILVGPLCLVLVSYTRilvtILRIQSGEGRR 234
Cdd:cd15320 156 LRDLTMDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTR----IYRIAQKQIRR 205

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

29-156

6.06e-05

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 43.96 E-value: 6.06e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTI-SFILCIMQTFLYLAFA 107
Cdd:cd15394   6 LYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRGWVfGRFMCYFVFLMQPVTV 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 33238922 108 CTECLILVVMSYDRFVAICHPLHYTviMSWKVCTILAAVSWIAGFLLAL 156
Cdd:cd15394  86 YVSVFTLTAIAVDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLAL 132

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

25-221

6.45e-05

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 43.72 E-value: 6.45e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFT-LLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNvPKMLANLVTQRRTISFILCIMQTFLY 103
Cdd:cd15079   1 YLLGFIYIFLGIVsLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYNSFYEGWALGPLGCQIYAFLG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 104 LAFACTECLILVVMSYDRFVAICHPLHyTVIMSWKVCTILAAVSWIAGFLLALVHLVLILklpfcgpheiNHFFCE-ILS 182
Cdd:cd15079  80 SLSGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWALLPLLFGW----------GRYVPEgFLT 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 33238922 183 vlklAC-----ADTTLNQVVILAACVFILVGPLCLVLVSYTRIL 221
Cdd:cd15079 149 ----SCsfdylTRDWNTRSFVATIFVFAYVIPLIIIIYCYSFIV 188

7tm_GPCRs

cd14964

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

26-293

6.46e-05

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410628 [Multi-domain] Cd Length: 267 Bit Score: 43.57 E-value: 6.46e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMsyASNNVPKMLANLVTQRRTISF--ILCIMQTFLY 103
Cdd:cd14964   1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDL--LASLVVLVLFFLLGLTEASSRpqALCYLIYLLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 104 LAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPfcgpheinhffceILSV 183
Cdd:cd14964  79 YGANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIP-------------RYNT 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 184 LKLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSH------------LCVVGLFF 251
Cdd:cd14964 146 LTGSCYLICTTIYLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNLkatksllilvitFLLCWLPF 225

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 33238922 252 GSAIVMYMAPKSQHPELQQKILSLFYSLFNPMLNPLIYCLRN 293
Cdd:cd14964 226 SIVFILHALVAAGQGLNLLSILANLLAVLASTLNPFIYCLGN 267

7tmA_alpha1D_AR

cd15327

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

29-300

7.65e-05

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320450 [Multi-domain] Cd Length: 261 Bit Score: 43.36 E-value: 7.65e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15327   6 FLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLvlilkLPFCGPHEINHFFCEILSVLKLAc 188
Cdd:cd15327  86 ASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPL-----LGWKEPPPPDESICSITEEPGYA- 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 189 adttlnqvviLAACVFILVGPLCLVLVSYTRILVTILRIQSgegRRKAFSTCSshlCVVGLFFGSAIVMYMA-------P 261
Cdd:cd15327 160 ----------LFSSLFSFYLPLMVILVMYFRVYVVALKFSR---EKKAAKTLA---IVVGVFILCWFPFFFVlplgsffP 223

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238922 262 KSQHPELQQKILsLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15327 224 ALKPSEMVFKVI-FWLGYFNSCVNPIIYPCSSKEFKRAF 261

7tmA_TAAR6_8_9

cd15316

trace amine-associated receptors 6, 8, and 9, member of the class A family of ...

26-149

9.56e-05

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320439 [Multi-domain] Cd Length: 290 Bit Score: 43.31 E-value: 9.56e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15316   3 LYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVS 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWI 149
Cdd:cd15316  83 FCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWI 126

7tmA_MCHR-like

cd15088

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...

29-291

1.03e-04

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320216 [Multi-domain] Cd Length: 278 Bit Score: 43.21 E-value: 1.03e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNnVPKMLANLVTQRR-TISFILCIMQTFLYLAFA 107
Cdd:cd15088   6 VFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLG-MPFLIHQFAIDGQwYFGEVMCKIITALDANNQ 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 108 CTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEinhfFCeilsVLKLA 187
Cdd:cd15088  85 FTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTT----FC----YVSLP 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 188 CADTTLNQVVILAACVFILvgPLCLVLVSYTRILV----TILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKS 263
Cdd:cd15088 157 SPDDLYWFTIYHFILGFAV--PLVVITVCYILILHrlarGVAPGNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLV 234

                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238922 264 Q----HPELQQKI---LSLFYSLFNPMLNPLIYCL 291
Cdd:cd15088 235 NlamnRPTLAFEVayfLSICLGYANSCLNPFVYIL 269

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

25-224

1.15e-04

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 43.08 E-value: 1.15e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLF-SLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSY-ASNNVPKMLANLVTQRRTISFILCIMQTFL 102
Cdd:cd15337   1 YLIGIYiAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFsAVNGFPLKTISSFNKKWIWGKVACELYGFA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 103 YLAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALvhlvlilkLPFCGpheinhFFCEILS 182
Cdd:cd15337  81 GGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSI--------PPFFG------WGRYVPE 146

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 33238922 183 VLKLACA----DTTLNQvVILAACVFIL--VGPLCLVLVSYTRILVTI 224
Cdd:cd15337 147 GFQTSCTfdylSRDLNN-RLFILGLFIFgfLCPLLIIIFCYVNIIRAV 193

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

25-295

1.31e-04

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 42.64 E-value: 1.31e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMqtflYL 104
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDV----WI 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTEC----LILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLvLILKLPFCGPHEinhffCEI 180
Cdd:cd15329  78 SFDVLLCtasiLNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPL-FGWKNKVNDPGV-----CQV 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 181 lsvlklacadtTLNQVVILAACVFILVGPLCLVLVSYTRilvtILRIQSGEgrRKAFSTCS---SHLCVVGL-FFGSAIV 256
Cdd:cd15329 152 -----------SQDFGYQIYATFGAFYIPLIVMLVLYYK----IYRAAKSE--RKAIKTLGiimGAFTLCWLpFFILALL 214

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 33238922 257 --MYMAPKSQHPELQQKILSLFYSLFNPMLNPLIYCLRNAE 295
Cdd:cd15329 215 rpFLKPIKCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNRE 255

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

14-149

1.34e-04

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 42.86 E-value: 1.34e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  14 LGFQADLSVecflfgLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISF 93
Cdd:cd15333   1 LGLKISLAV------LLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQ 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 33238922  94 ILCIMQTFLYLAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWI 149
Cdd:cd15333  75 VVCDIWLSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWV 130

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

36-293

2.35e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 42.20 E-value: 2.35e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  36 FTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVP-KMLANLVTQRRTISFILCIMQTFLYLAFACTECLIL 114
Cdd:cd15305  13 LTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPvSLIAILYDYAWPLPRYLCPIWISLDVLFSTASIMHL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 115 VVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIagfllalVHLVLILKLPFCGPHEINHFFceilsvLKLACADTTLN 194
Cdd:cd15305  93 CAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWT-------ISIGISMPIPVIGLQDDEKVF------VNGTCVLNDEN 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 195 QVVILAACVFILvgPLCLVLVSYTRILVTILRIQSGEGRRKAfstcSSHLCVVGL--------FFGSAIVMYMAPKSQHP 266
Cdd:cd15305 160 FVLIGSFVAFFI--PLIIMVITYCLTIQVLQRQQAINNERRA----SKVLGIVFFlflimwcpFFITNILSVLCKEACDQ 233

                       250       260
                ....*....|....*....|....*....
gi 33238922 267 ELQQKILSLFY--SLFNPMLNPLIYCLRN 293
Cdd:cd15305 234 KLMEELLNVFVwvGYVSSGINPLVYTLFN 262

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

37-160

2.37e-04

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 42.18 E-value: 2.37e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  37 TLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPK--MLANLVTQRRTISFILC-----IMQTFLYLAFACT 109
Cdd:cd15352  14 SLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLEtiMIAVLNSGYLVISDQFIqhmdnVFDSMICISLVAS 93

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 33238922 110 ECLILVVmSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLV 160
Cdd:cd15352  94 ICNLLAI-AVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIV 143

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

29-294

3.15e-04

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 41.61 E-value: 3.15e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15206   6 LYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPheinhffceilsvLKLAC 188
Cdd:cd15206  86 VSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRP-------------GGHKC 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 189 ADTTLNQVVILAACVF----ILVGPLCLVLVSYTRILVTILriqsgEGRRKAFSTCsshLCVVGLFFGSAIVMYMAP--K 262
Cdd:cd15206 153 REVWPNEIAEQAWYVFldlmLLVIPGLVMSVAYGLISWTLL-----EAKKRVIRML---FVIVVEFFICWTPLYVINtwK 224

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238922 263 SQHPE-LQQKILSLFYSLFNPM------LNPLIYCLRNA 294
Cdd:cd15206 225 AFDPPsAARYVSSTTISLIQLLayisscVNPITYCFMNK 263

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

38-148

3.16e-04

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 41.69 E-value: 3.16e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  38 LLGNGIILVVICLDNRLHIPMYFFLSHLAIVDM----SYASNNVPKMLANLVTQRRTISFILC---IMQTFLYLAFACTE 110
Cdd:cd15350  15 LLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMlgslYKTLENILIILADMGYLNRRGPFETKlddIMDSLFCLSLLGSI 94

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 33238922 111 CLILVVmSYDRFVAICHPLHYTVIMSWKVCTILAAVSW 148
Cdd:cd15350  95 FSILAI-AADRYITIFHALRYHNIMTMRRTLVILAIIW 131

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

29-156

3.33e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 41.86 E-value: 3.33e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRR-TISFILCIMQTFLYLAFA 107
Cdd:cd15217   6 LLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAwTYSVLSCKIVAFMAVLFC 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 33238922 108 CTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLAL 156
Cdd:cd15217  86 FHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAF 134

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

32-154

3.45e-04

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 41.35 E-value: 3.45e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  32 LFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCimQTFL---YLAfAC 108
Cdd:cd15301   9 VLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVC--DTWLaidYLA-SN 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLL 154
Cdd:cd15301  86 ASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLL 131

7tmA_GnRHR-like

cd15195

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...

31-289

4.50e-04

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320323 [Multi-domain] Cd Length: 293 Bit Score: 41.23 E-value: 4.50e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  31 SLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTE 110
Cdd:cd15195   8 WVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 111 CLILVVMSYDRFVAICHPLhyTVIMSWKVCTILAAVSWIAGFLLALVHLVLIlklpfcgpHEINHFFCEILSVlklACAD 190
Cdd:cd15195  88 SFMLVVIALDRVFAILSPL--SANQARKRVKIMLTVAWVLSALCSIPQSFIF--------SVLRKMPEQPGFH---QCVD 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 191 ----TTLNQVVILAACVFIL--VGPLCLVLVSYTRILVTILRIQ------SGEGRRK----------------------A 236
Cdd:cd15195 155 fgsaPTKKQERLYYFFTMILsfVIPLIITVTCYLLILFEISKMAkrardtPISNRRRsrtnslerarmrtlrmtalivlT 234

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 33238922 237 FSTCSSHLCVVGLFFGSAIVMYMAPksqhPELQQKILSLFySLFNPMLNPLIY 289
Cdd:cd15195 235 FIVCWGPYYVLGLWYWFDKESIKNL----PPALSHIMFLL-GYLNPCLHPIIY 282

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

31-299

4.92e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 40.94 E-value: 4.92e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  31 SLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTE 110
Cdd:cd15062   8 GAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTAS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 111 CLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLvlilkLPFCGPHEINHFFCEIlsvlklacaD 190
Cdd:cd15062  88 IMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPL-----LGWKEPAPADEQACGV---------N 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 191 TTLNQVVILAACVFILvgPLCLVLVSYTRILVTILRIQSgegRRKAFSTCSshlCVVGL-------FFGSAIVMYMAPKS 263
Cdd:cd15062 154 EEPGYVLFSSLGSFYL--PLAIILVMYCRVYVVAFKFSR---EKKAAKTLG---IVVGAfvlcwfpFFVVLPLGSLFSTL 225

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238922 264 QHPELQQKILsLFYSLFNPMLNPLIYCLRNAEVKGA 299
Cdd:cd15062 226 KPPEPVFKVV-FWLGYFNSCLNPIIYPCSSREFKRA 260

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

37-300

5.06e-04

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 41.07 E-value: 5.06e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  37 TLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVP-KMLANLVTQRRTISFILCIMQTFLYLAFACTECLILV 115
Cdd:cd15304  14 TIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLC 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 116 VMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIagfllalVHLVLILKLPFCGPHEINHFFCEilsvlkLACADTTLNQ 195
Cdd:cd15304  94 AISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWT-------ISVGISMPIPVFGLQDDSKVFKE------GSCLLADENF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 196 VVILAACVFILvgPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGL--FFGSAIVMYMAPKSQHPELQQKIL 273
Cdd:cd15304 161 VLIGSFVAFFI--PLTIMVITYFLTIKSLQQSISNEQKASKVLGIVFFLFVVMWcpFFITNVMAVICKESCNEVVIGGLL 238

                       250       260
                ....*....|....*....|....*....
gi 33238922 274 SLFY--SLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15304 239 NVFVwiGYLSSAVNPLVYTLFNKTYRSAF 267

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

36-160

5.30e-04

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 40.88 E-value: 5.30e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  36 FTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECLILV 115
Cdd:cd15073  13 ISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLT 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 33238922 116 VMSYDRFVAICHPLHYTViMSWKVCTILAAVSWIAGFLLALVHLV 160
Cdd:cd15073  93 VVAVDRYLTICRPDLGRK-MTTNTYTVMILLAWTNAFFWAAMPLV 136

7tmA_QRFPR

cd15205

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...

26-297

6.10e-04

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.

Pssm-ID: 320333 [Multi-domain] Cd Length: 298 Bit Score: 40.92 E-value: 6.10e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15205   3 FVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQST 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHL-VLILKLPFCGPHEINHFFC-EILSV 183
Cdd:cd15205  83 AVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLfVQQLEVKYDFLYEKRHVCClERWYS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 184 LKLACADTTLNQVVIlaacvFILvgPLCLVLVSYTRI---------------LVTILRIQSGEGRRKAFSTCSSHLCVVG 248
Cdd:cd15205 163 PTQQKIYTTFILVIL-----FLL--PLTTMLFLYSRIgyelwikkrvgdasvLQTIHGIEMSKISRKKKRAVKMMVTVVL 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 249 LF------FGSAIVM--YMAPKSQHPELQQKILSLFYSL---FNPMLNPLIYCLRNAEVK 297
Cdd:cd15205 236 LFavcwapFHVVHMMieYSNLENKYDGVTIKLIFAIVQLigfSNSFNNPIVYAFMNENFK 295

7tmA_mAChR_M2

cd15297

muscarinic acetylcholine receptor subtype M2, member of the class A family of ...

37-154

6.90e-04

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320424 [Multi-domain] Cd Length: 262 Bit Score: 40.72 E-value: 6.90e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  37 TLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECLILVV 116
Cdd:cd15297  14 TIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLI 93

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 33238922 117 MSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLL 154
Cdd:cd15297  94 ISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFIL 131

7tmA_RNL3R

cd14976

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...

29-300

7.45e-04

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.

Pssm-ID: 320107 [Multi-domain] Cd Length: 290 Bit Score: 40.56 E-value: 7.45e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVI--CLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAF 106
Cdd:cd14976   6 VYMVVFTVGLLGNLLVLYLLksNKKLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTKLN 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 107 ACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLAL---VHLVLILKLpfcgpheINHFFCEILSV 183
Cdd:cd14976  86 MYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIpeaIFSTDTWSS-------VNHTLCLLRFP 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 184 LKLACAD-TTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQSGEGRRKAFSTCSSHLCVVGLF-----------F 251
Cdd:cd14976 159 KNSSVTRwYNWLGMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGGSKRRKSRVTKSVFIVVLSFFicwlpnqalslW 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 33238922 252 GSAIVMYMAPKSQHPELQQKI---LSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd14976 239 SALIKFDDVPFSDAFFAFQTYafpVAICLAHSNSCLNPVLYCLVRREFRDAL 290

7tmA_CCR3

cd15185

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...

25-229

7.83e-04

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.

Pssm-ID: 341339 [Multi-domain] Cd Length: 278 Bit Score: 40.58 E-value: 7.83e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASnNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15185   2 FLPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLF-TLPFWIHYVRWNNWVFGHGMCKLLSGFYY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLilklpfcgpHEINHFFCEIL-SV 183
Cdd:cd15185  81 LGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIF---------YETQELFEEFLcSP 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 33238922 184 LKLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVTILRIQS 229
Cdd:cd15185 152 LYPEDTEDSWKRFHALRMNIFGLALPLLIMVICYTGIIKTLLRCPS 197

7tmA_5-HT4

cd15056

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...

31-153

8.55e-04

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320184 [Multi-domain] Cd Length: 294 Bit Score: 40.55 E-value: 8.55e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  31 SLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTE 110
Cdd:cd15056   8 SLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTAS 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 33238922 111 CLILVVMSYDRFVAIC-HPLHY--TVIMSWKVCTILAAVSWIAGFL 153
Cdd:cd15056  88 IMHLCCIALDRYYAICcQPLVYkmTPLRVAVMLGGCWVIPTFISFL 133

7tmA_Gal1_R

cd15098

galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...

29-221

8.66e-04

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320226 [Multi-domain] Cd Length: 282 Bit Score: 40.48 E-value: 8.66e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHI--PMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAF 106
Cdd:cd15098   6 VFGLIFCLGVLGNSLVITVLARVKPGKRrsTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTVS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 107 ACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLA---LVHLVLilklpFCGPHEINHFFCeilsv 183
Cdd:cd15098  86 MLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMAspvAVHQDL-----VHHWTASNQTFC----- 155

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 33238922 184 lKLACADTTLNQVVILAACVFILVGPLCLVLVSYTRIL 221
Cdd:cd15098 156 -WENWPEKQQKPVYVVCTFVFGYLLPLLLITFCYAKVL 192

7tmA_PAR4

cd15372

protease-activated receptor 4, member of the class A family of seven-transmembrane G ...

29-289

1.01e-03

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.

Pssm-ID: 320494 [Multi-domain] Cd Length: 274 Bit Score: 40.12 E-value: 1.01e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRlHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQT-FLYLAFA 107
Cdd:cd15372   6 LYTLVFLVGLPANGLALWVLATQVK-RLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTaFFYGNMY 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 108 CTeCLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFcgpHEINHFFCEilSVLKLA 187
Cdd:cd15372  85 CS-VLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPL---ERLNITLCH--DVLPLD 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 188 CADT-TLNQVVILAACVFILvgPLCLVLVSYTRILVTILRiqsgEGRRKAFS---TCSSHLCVVGLFFGSAIVMYMAPKS 263
Cdd:cd15372 159 EQDTyLFYYFACLAVLGFLL--PLVVILFCYGSVLHTLLR----SGQRYGHAmklTVLVLVSFVLCFTPSNLLLLLHYSD 232

                       250       260       270
                ....*....|....*....|....*....|.
gi 33238922 264 QHPELQQK-----ILSLFYSLFNPMLNPLIY 289
Cdd:cd15372 233 PTLDDGGNlyivyMVSLAISTLNSCVDPFIY 263

7tmA_D1-like_dopamine_R

cd15057

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...

36-289

1.02e-03

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320185 [Multi-domain] Cd Length: 299 Bit Score: 40.11 E-value: 1.02e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  36 FTLLGNG-IILVVICLDN-RLHIPMYFFLShLAIVDMsyasnnvpkMLANLVTQRRTISFIL--------CimQTFLYLA 105
Cdd:cd15057  13 LTLLGNAlVIAAVLRFRHlRSKVTNYFIVS-LAVSDL---------LVAILVMPWAAVNEVAgywpfgsfC--DVWVSFD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLIL--VVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLilklpfcGPHEINHFFCEILSV 183
Cdd:cd15057  81 IMCSTASILnlCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQL-------GWHRADDTSEALALY 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 184 LKLACADTTLNQVVILAACVFILVGPLCLVLVSYTRILVT----ILRIQSGEGR------------------RKAFSTCS 241
Cdd:cd15057 154 ADPCQCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIarrqIRRIAALERAaqestnpdsslrsslrreTKALKTLS 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 33238922 242 shlCVVGLFFGSAIVMYMA---------PKSQHPELQQKILSLFYSL--FNPMLNPLIY 289
Cdd:cd15057 234 ---IIMGVFVCCWLPFFILncvlpfcdlRTAQFPCVPDTTFIVFVWLgwANSSLNPIIY 289

7tmA_GPR84-like

cd15210

G protein-coupled receptor 84 and similar proteins, member of the class A family of ...

39-299

1.03e-03

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.

Pssm-ID: 320338 [Multi-domain] Cd Length: 254 Bit Score: 39.94 E-value: 1.03e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  39 LGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECLILVVMS 118
Cdd:cd15210  16 PGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLIT 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 119 YDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLlalvhLVLILKLPFCGPHEINH--FFCEILSVLKLACADTTLNQV 196
Cdd:cd15210  96 LNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFG-----SFLPLWLGIWGRFGLDPkvCSCSILRDKKGRSPKTFLFVF 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 197 VILAACVFILVgplCLVLVSYTRILVTILRIqsgegrrkafstcssHLCVVGLFFGSAIVMYMAPKSQHPELQqkILSLF 276
Cdd:cd15210 171 GFVLPCLVIII---CYARREDRRLTRMMLVI---------------FLCFLVCYLPITLVNVFDDEVAPPVLH--IIAYV 230

                       250       260
                ....*....|....*....|...
gi 33238922 277 YSLFNPMLNPLIYCLRNAEVKGA 299
Cdd:cd15210 231 LIWLSSCINPIIYVAMNRQYRQA 253

7tmA_D1B_dopamine_R

cd15319

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

29-245

1.04e-03

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320442 [Multi-domain] Cd Length: 317 Bit Score: 40.33 E-value: 1.04e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMY-FFLSHLAIVDMSYASNNVP-KMLANLVTQRRTISFilCIMQTFLYLAF 106
Cdd:cd15319   6 LLSLLILWTLLGNILVCAAVVRFRHLRSKVTnIFIVSLAVSDLFVALLVMPwKAVAEVAGYWPFGAF--CDVWVAFDIMC 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 107 ACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINHFFcEILSVLKL 186
Cdd:cd15319  84 STASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQLNWHKDSGDDWVGLHNS-SISRQVEE 162

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33238922 187 ACaDTTLNQVVILAACVFILVGPLCLVLVSYTRIL----VTILRIQSGEGRRKAFSTC-SSHLC 245
Cdd:cd15319 163 NC-DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYriaqIQIRRISSLERAAEHAQSCrSNRID 225

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

27-233

1.06e-03

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 39.94 E-value: 1.06e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  27 FGLFSLFYSF-TLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15307   3 WALLALVLVLgTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIagfllalvhLVLILKLPFCGPHEINHFFCEILSVLK 185
Cdd:cd15307  83 FCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWL---------LSIAMSLPLSLMYSKDHASVLVNGTCQ 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 33238922 186 LAcadTTLNQVVILAACVFIlvgPLCLVLVSYTRILVTILRIQSGEGR 233
Cdd:cd15307 154 IP---DPVYKLVGSIVCFYI---PLGVMLLTYCLTVRLLARQRSRHGR 195

7tmA_Chemokine_R

cd14984

classical and atypical chemokine receptors, member of the class A family of ...

25-234

1.11e-03

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.

Pssm-ID: 341319 [Multi-domain] Cd Length: 278 Bit Score: 39.89 E-value: 1.11e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNnVPKMLANLVTQRRTISFiLCIMQTFLYL 104
Cdd:cd14984   2 FLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLT-LPFWAVYAADGWVFGSF-LCKLVSALYT 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHY----TVIMSWKVCTILaavsWIAGFLLALVHLVLILKlpfcgPHEINHFFCEI 180
Cdd:cd14984  80 INFYSGILFLACISIDRYLAIVHAVSAlrarTLLHGKLTCLGV----WALALLLSLPEFIFSQV-----SEENGSSICSY 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 33238922 181 LSVLKLACADTTLNQVVILAACVFIlvgPLCLVLVSYTRILVTILRIQSGEGRR 234
Cdd:cd14984 151 DYPEDTATTWKTLLRLLQNILGFLL---PLLVMLFCYSRIIRTLLRARNHKKHR 201

7tmA_GnRHR_vertebrate

cd15383

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...

96-291

1.16e-03

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320505 [Multi-domain] Cd Length: 295 Bit Score: 40.04 E-value: 1.16e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  96 CIMQTFLYLAFACTECLILVVMSYDRFVAICHPLhyTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPHEINH 175
Cdd:cd15383  74 CRLLMFLKLFAMYSSAFVTVVISLDRHAAILNPL--AIGSARRRNRIMLCAAWGLSALLALPQLFLFHTVTATPPVNFTQ 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 176 ffCEILSVLKLACADTTLNQVVILaaCVFILvgPLCLVLVSYTRILVTILRIQ--SGEGRRKAFSTCSSH---------- 243
Cdd:cd15383 152 --CATHGSFPAHWQETLYNMFTFF--CLFLL--PLLIMIFCYTRILLEISRRMkeKKDSAKNEVALRSSSdnipkarmrt 225

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33238922 244 ------------LC-----VVGL---FFGSAIVMYMAPKSQHpelqqkILSLFySLFNPMLNPLIYCL 291
Cdd:cd15383 226 lkmtivivssfiVCwtpyyLLGLwywFSPEMLEQTVPESLSH------ILFLF-GLLNACLDPLIYGL 286

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

24-224

1.19e-03

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 39.90 E-value: 1.19e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  24 CFLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLY 103
Cdd:cd15203   1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 104 LAFACTECLILVVMSYDRFVAICHPLHYtvIMSWKVCTILAAVSWIAGFLLAL-------VHLVLILKLPFCGPheinhf 176
Cdd:cd15203  81 GVSIFVSTLTLTAIAIDRYQLIVYPTRP--RMSKRHALLIIALIWILSLLLSLplaifqeLSDVPIEILPYCGY------ 152

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 33238922 177 FCE---ILSVLKLACADTTLnqvvilaacVFILVGPLCLVLVSYTRILVTI 224
Cdd:cd15203 153 FCTeswPSSSSRLIYTISVL---------VLQFVIPLLIISFCYFRISLKL 194

7tmA_GPR61_GPR62-like

cd15220

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...

38-222

1.21e-03

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.

Pssm-ID: 410633 [Multi-domain] Cd Length: 264 Bit Score: 39.74 E-value: 1.21e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  38 LLGNGIILVVICLDNRLHipMYFFLSHLAIVDMSYASNNVPKML--ANLVTQRRTISFILCIMQTFLYLAFACTECLILV 115
Cdd:cd15220  14 LVGNTAVMVVIAKTPHLR--KFAFVCHLCVVDLLAALLLMPLGIlsSSPFFLGVVFGEAECRVYIFLSVCLVSASILTIS 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 116 VMSYDRFVAICHPLHYTVIMS-WKVCTILAAVsWIAGFLLALVHLVliLKLPFCGPHEINHFFCEILSVLKLACadttln 194
Cdd:cd15220  92 AISVERYYYIVHPMRYEVKMTiGLVAAVLVGV-WVKALLLGLLPVL--GWPSYGGPAPIAARHCSLHWSHSGHR------ 162

                       170       180
                ....*....|....*....|....*...
gi 33238922 195 QVVILAACVFILVGPLCLVLVSYTRILV 222
Cdd:cd15220 163 GVFVVLFALVCFLLPLLLILVVYCGVFK 190

7tmA_GPR26_GPR78-like

cd15219

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...

37-161

1.29e-03

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320347 [Multi-domain] Cd Length: 264 Bit Score: 39.75 E-value: 1.29e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  37 TLLGNgiILVVICL----DNRLHIPMYFFLShLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECL 112
Cdd:cd15219  13 SLLSN--LLVLLCFlysaELRKQVPGIFLLN-LSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAML 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 33238922 113 ILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVL 161
Cdd:cd15219  90 SMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFL 138

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

37-299

1.50e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 39.33 E-value: 1.50e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  37 TLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCimQTFLYLAFACTECLI--L 114
Cdd:cd15050  14 TVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVC--LFWLSMDYVASTASIfsL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 115 VVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLAlvhlvlilkLPFCGPHeinHFFCEILSVLKLACADTTLN 194
Cdd:cd15050  92 FILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWV---------IPILGWH---HFARGGERVVLEDKCETDFH 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 195 QVVILAACVFIL--VGPLCLVLVSYTRILVTILRiQSGEGRRKAFSTCSSHLCVVGlFFGSAIVMYMAPKSQHPELQQKI 272
Cdd:cd15050 160 DVTWFKVLTAILnfYIPSLLMLWFYAKIFKAVNR-ERKAAKQLGFIMAAFILCWIP-YFILFMVIAFCKNCCNENLHMFT 237

                       250       260
                ....*....|....*....|....*..
gi 33238922 273 LSLFYslFNPMLNPLIYCLRNAEVKGA 299
Cdd:cd15050 238 IWLGY--INSTLNPFIYPLCNENFKKT 262

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

38-161

1.53e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 39.40 E-value: 1.53e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  38 LLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECLILVVM 117
Cdd:cd15063  15 VLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCAI 94

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 33238922 118 SYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVL 161
Cdd:cd15063  95 SLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVG 138

7tmA_UII-R

cd14999

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...

29-162

1.82e-03

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.

Pssm-ID: 320130 [Multi-domain] Cd Length: 282 Bit Score: 39.35 E-value: 1.82e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASnnvpkmlanlvtqrrTISFILC--IMQTFLYLAF 106
Cdd:cd14999   5 VLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLL---------------TIPFYVStyFLKKWYFGDV 69

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33238922 107 AC------------TECLILVVMSYDRFVAICHPLHyTVIMSWKVCTILAAVSWIAGFLLALVHLVLI 162
Cdd:cd14999  70 GCrllfsldfltmhASIFTLTVMSTERYLAVVKPLD-TVKRSKSYRKLLAGVIWLLSLLLTLPMAIMI 136

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

29-167

1.83e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 39.41 E-value: 1.83e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15979   6 LYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVS 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPF 167
Cdd:cd15979  86 VSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPV 144

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

37-302

2.36e-03

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 39.04 E-value: 2.36e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  37 TLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLAN-LVTQRRTISFILCIMQTFLYLAFACTECLILV 115
Cdd:cd15306  14 TIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTiLFEAMWPLPLVLCPIWLFLDVLFSTASIMHLC 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 116 VMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWiagfllaLVHLVLILKLPFCGPHEINHFFCEILSVLKlacadTTLNQ 195
Cdd:cd15306  94 AISLDRYIAIKKPIQASQYNSRATAFIKITVVW-------LISIGIAIPVPIKGIETDVDNPNNITCVLT-----KERFG 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 196 VVILAACVFILVGPLCLVLVSYTrILVTILRIQSGEGRRKAFStcsshlcVVGLFFGSAIVMY----------MAPKSQH 265
Cdd:cd15306 162 DFILFGSLAAFFTPLAIMIVTYF-LTIHALRKQTITNEQRASK-------VLGIVFFLFLLMWcpffitnitsVLCDSCN 233

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238922 266 PELQQKILSLF--YSLFNPMLNPLIYCLRNAEVKGALRR 302
Cdd:cd15306 234 QTTLQMLMEIFvwIGYVSSGVNPLVYTLFNKTFRDAFGR 272

7tmA_GPR6

cd15962

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...

41-300

2.49e-03

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.

Pssm-ID: 320628 [Multi-domain] Cd Length: 268 Bit Score: 38.76 E-value: 2.49e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  41 NGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCimqTFLYLAFACTECLILVVmSYD 120
Cdd:cd15962  18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETISLITV---GFLVASFTASVSSLLAI-TVD 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 121 RFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALvhlvlilkLPFCGPHEINHFF-CEILSVLklacadtTLNQVVIL 199
Cdd:cd15962  94 RYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGL--------LPVLGWNCLEERAsCSIVRPL-------TKSNVTLL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 200 AACVFILVGplcLVLVSYTRILVTILRIQSGEGRRKAFSTCS---------SHLCVVGLFFGSAIVMY----MAPKSQHP 266
Cdd:cd15962 159 SASFFFIFI---LMLHLYIKICKIVCRHAHQIALQQHFLTAShyvatkkgvSTLAIILGTFGASWLPFaiycVVGDHEYP 235

                       250       260       270
                ....*....|....*....|....*....|....
gi 33238922 267 ELQQkILSLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15962 236 AVYT-YATLLPATYNSMINPIIYAYRNQEIQRSM 268

7tmA_Relaxin_R

cd15137

relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...

112-162

2.54e-03

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.

Pssm-ID: 320265 [Multi-domain] Cd Length: 284 Bit Score: 38.72 E-value: 2.54e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 33238922 112 LILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVsWIAGFLLALVHLVLI 162
Cdd:cd15137  96 LILTLITLDRFICIVFPFSGRRLGLRRAIIVLACI-WLIGLLLAVLPLLPW 145

7tmA_PSP24-like

cd15213

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...

62-292

2.62e-03

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320341 [Multi-domain] Cd Length: 262 Bit Score: 38.89 E-value: 2.62e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  62 LSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKvct 141
Cdd:cd15213  39 LANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLIIVQRQDKLNPHRAK--- 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 142 ILAAVSWIAGFLLALVHLV--LILKLPFCGPHEInhffceilsvlkLACADTTLNQVVILAACVFILVGPLCLVLVSYTR 219
Cdd:cd15213 116 ILIAVSWVLSFCVSFPPLVgwGKYEFPPRAPQCV------------LGYTESPADRIYVVLLLVAVFFIPFLIMLYSYFC 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 220 ILVTILRIQSgegrrKAFSTcsshlcVVGLFFG-------SAIVMYMAPKSQHPELQQKILS--LFYSLFNPMLNPLIYC 290
Cdd:cd15213 184 ILNTVRSFKT-----RAFTT------ILILFIGfsvcwlpYTVYSLLSVFSRYSSSFYVISTclLWLSYLKSAFNPVIYC 252


                ..
gi 33238922 291 LR 292
Cdd:cd15213 253 WR 254

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

37-150

2.86e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 38.74 E-value: 2.86e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  37 TLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNN-----VPKMLANLVTQRRTISF-ILCIMQTFLYLAFACTE 110
Cdd:cd15353  14 SLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNgsetvVITLLNGNDTDAQSFTVnIDNVIDSVICSSLLASI 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 33238922 111 CLILVVmSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIA 150
Cdd:cd15353  94 CSLLSI-AVDRYFTIFYALQYHNIMTVRRAGVIITCIWTA 132

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

37-150

2.88e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 38.62 E-value: 2.88e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  37 TLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDM----SYASNNVPKMLAN---LVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:cd15103  14 SLLENILVILAIAKNKNLHSPMYFFICSLAVADMlvsvSNALETIVIILLNngyLVPRDSFEQHIDNVIDSMICSSLLAS 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 33238922 110 ECLILVVmSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIA 150
Cdd:cd15103  94 ICSLLAI-AVDRYITIFYALRYHSIMTVRRAGVIITAIWVF 133

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

37-148

2.99e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 38.76 E-value: 2.99e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  37 TLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNN-----VPKMLAN--LVTQRRTISFILCIMQTFLYLAFACT 109
Cdd:cd15354  14 SLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNawetiTIYLLNNrhLVIEDAFVRHIDNVFDSLICISVVAS 93

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 33238922 110 ECLILVVmSYDRFVAICHPLHYTVIMSWKVCTILAAVSW 148
Cdd:cd15354  94 MCSLLAI-AVDRYVTIFYALRYHNIMTVRRAGIIIACIW 131

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

35-160

3.27e-03

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 38.76 E-value: 3.27e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  35 SFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPkmLANLVTQRRTISFILCIMQTFLYLAFACTECLIL 114
Cdd:cd15069  12 ALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIP--FAITISLGFCTDFHSCLFLACFVLVLTQSSIFSL 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 33238922 115 VVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLV 160
Cdd:cd15069  90 LAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFL 135

7tmA_PGE2_EP4

cd15142

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...

34-131

3.33e-03

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320270 [Multi-domain] Cd Length: 302 Bit Score: 38.64 E-value: 3.33e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  34 YSFTLLGNGIILVVICLD--NRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFACTEC 111
Cdd:cd15142  11 FIFGVVGNLIAIVVLCKSrkEQKETTFYTLVCGLAVTDLLGTCLASPVTIATYLKGRWPGGQPLCEYFSFILLFFSLSGL 90

                        90       100
                ....*....|....*....|
gi 33238922 112 LILVVMSYDRFVAICHPLHY 131
Cdd:cd15142  91 SIICAMSIERYLAINHAYFY 110

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

28-150

3.57e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 38.24 E-value: 3.57e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  28 GLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTF------ 101
Cdd:cd15351   5 GLFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnvidt 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 33238922 102 LYLAFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIA 150
Cdd:cd15351  85 MICSSVVSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLA 133

7tmA_GPR17

cd15161

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...

29-129

4.53e-03

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.

Pssm-ID: 320289 [Multi-domain] Cd Length: 277 Bit Score: 38.15 E-value: 4.53e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYS----FTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFL-Y 103
Cdd:cd15161   2 LFALFYIlvfiLAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLfY 81

                        90       100
                ....*....|....*....|....*.
gi 33238922 104 LAFACTeCLILVVMSYDRFVAICHPL 129
Cdd:cd15161  82 LNMYAS-LYFLACISVDRFLAIVHPV 106

7tmA_Histamine_H3R

cd15296

histamine receptor subtypes H3R and H3R-like, member of the class A family of ...

25-154

4.81e-03

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320423 [Multi-domain] Cd Length: 271 Bit Score: 37.85 E-value: 4.81e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15296   2 ILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDY 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVS-WIAGFLL 154
Cdd:cd15296  82 LLCTASVFNIVLISYDRFLSVTRAVSYRAQKGMTRQAVLKMVLvWVLAFLL 132

7tmA_mAChR_M1

cd17790

muscarinic acetylcholine receptor subtype M1, member of the class A family of ...

28-154

4.81e-03

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341356 [Multi-domain] Cd Length: 262 Bit Score: 38.03 E-value: 4.81e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  28 GLFSLFysfTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFA 107
Cdd:cd17790   8 GILSLV---TVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVAS 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 33238922 108 CTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLL 154
Cdd:cd17790  85 NASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVL 131

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

25-154

5.21e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 38.01 E-value: 5.21e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFysfTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15299   8 FLTGILALV---TIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDY 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLL 154
Cdd:cd15299  85 VASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVL 134

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

36-156

5.41e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 37.71 E-value: 5.41e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  36 FTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMqtflYLA---FACTECL 112
Cdd:cd15059  13 LIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEI----WLAldvLFCTASI 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 33238922 113 I-LVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLAL 156
Cdd:cd15059  89 VnLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISL 133

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

29-221

5.46e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 37.66 E-value: 5.46e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNnVPKMLANLVTQRRTISFILC--IMQTFLYLAF 106
Cdd:cd14970   6 VYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLG-LPFLATSYLLGYWPFGEVMCkiVLSVDAYNMF 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 107 acTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPFCGPheinhffcEILSVLKL 186
Cdd:cd14970  85 --TSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGG--------TISCNLQW 154

                       170       180       190
                ....*....|....*....|....*....|....*
gi 33238922 187 ACADTTLNQVVILAACVFILVGPLCLVLVSYTRIL 221
Cdd:cd14970 155 PDPPDYWGRVFTIYTFVLGFAVPLLVITVCYSLII 189

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

29-220

5.55e-03

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 38.04 E-value: 5.55e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLL----GNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTI-SFILCIMQTFLY 103
Cdd:cd14997   2 LVSVVYGVIFVvgvlGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWLlGEFMCKLVPFVE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 104 LAFACTECLILVVMSYDRFVAICHPLH--YTVIMSWKVCTILAAvsWIAGFLLAL-VHLVLILKLpfcgpheiNHFFCEI 180
Cdd:cd14997  82 LTVAHASVLTILAISFERYYAICHPLQakYVCTKRRALVIIALI--WLLALLTSSpVLFITEFKE--------EDFNDGT 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 33238922 181 LSVLKLACADTTLNQVVILAACVFILVGPLCLVLVSYTRI 220
Cdd:cd14997 152 PVAVCRTPADTFWKVAYILSTIVVFFVVPLAILSGLYSVI 191

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

26-300

6.08e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 37.61 E-value: 6.08e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  26 LFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15323   3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 106 FACTECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILK------LPFCGPHEINHFfce 179
Cdd:cd15323  83 FCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRdpegdvYPQCKLNDETWY--- 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 180 ilsvlklacadttlnqvvILAACVFILVGPLCLVLVSYTRILvtilriQSGEGRRKAFSTCSS------HLCVVGLFFGS 253
Cdd:cd15323 160 ------------------ILSSCIGSFFAPCLIMILVYIRIY------RVAKAREKRFTFVLAvvmgvfVVCWFPFFFSY 215

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 33238922 254 AIVMYMAPKSQHPELQQKILsLFYSLFNPMLNPLIYCLRNAEVKGAL 300
Cdd:cd15323 216 SLYGICREACEVPEPLFKFF-FWIGYCNSSLNPVIYTIFNQDFRRSF 261

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

29-167

6.36e-03

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 37.54 E-value: 6.36e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15978   6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVS 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLVLILKLPF 167
Cdd:cd15978  86 VSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPF 144

7tmA_GPR101

cd15215

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...

29-153

6.43e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320343 [Multi-domain] Cd Length: 261 Bit Score: 37.52 E-value: 6.43e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15215   5 LIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAF 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFL 153
Cdd:cd15215  85 AGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVL 129

7tmA_CCR8

cd15187

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...

25-160

6.70e-03

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.

Pssm-ID: 320315 [Multi-domain] Cd Length: 276 Bit Score: 37.47 E-value: 6.70e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNnVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15187   2 FLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFS-LPFQAYYLLDQWVFGNAMCKIVSGAYYI 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 33238922 105 AFACTECLIlVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLALVHLV 160
Cdd:cd15187  81 GFYSSMFFI-TLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLV 135

7tmA_NTSR1

cd15355

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...

29-155

7.18e-03

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320477 [Multi-domain] Cd Length: 310 Bit Score: 37.52 E-value: 7.18e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNR---LHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLA 105
Cdd:cd15355   6 IYLALFVVGTVGNSITLYTLARKKSlqhLQSTVHYHLASLALSDLLILLLAMPVELYNFIWVHHPWAFGDAACRGYYFLR 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 33238922 106 FACTECLILVV--MSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLLA 155
Cdd:cd15355  86 DACTYATALNVasLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLA 137

7tmA_GPR150

cd15198

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...

38-246

8.31e-03

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.

Pssm-ID: 320326 [Multi-domain] Cd Length: 299 Bit Score: 37.48 E-value: 8.31e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  38 LLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLA-NLVTQRRTISFILCIMQTFLYLAFACTECLILVV 116
Cdd:cd15198  15 VAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIwELLGDRWMAGDVACRLLKLLQASARGASANLVVL 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 117 MSYDRFVAICHPlHYTVIMSWKvctiLAAVSWIAGFLLAL--VHLVLILKLPFCGPHEINHFFCEILsvlkLACADTTLN 194
Cdd:cd15198  95 LALDRHQAIRAP-LGQPLRAWK----LAALGWLLALLLALpqAYVFRVDFPDDPASAWPGHTLCRGI----FAPLPRWHL 165

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 33238922 195 QVVILAACVFILVGPLCLVLVSYTRILVTI-LRIQSGEGRRKAFSTCSSHLCV 246
Cdd:cd15198 166 QVYATYEAVVGFVAPVVILGVCYGRLLLKWwERANQAPGAKKPWKKPSKSHLR 218

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

29-157

8.40e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 37.43 E-value: 8.40e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  29 LFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYLAFAC 108
Cdd:cd15058   6 LLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVT 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 33238922 109 TECLILVVMSYDRFVAICHPLHYTVIMS-WKVCTILAAVsWIAGFLLALV 157
Cdd:cd15058  86 ASIETLCVIAVDRYIAITRPLRYQVLLTkRRARVIVCVV-WIVSALVSFV 134

7tmA_mAChR

cd15049

muscarinic acetylcholine receptor subfamily, member of the class A family of ...

24-154

9.23e-03

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341322 [Multi-domain] Cd Length: 262 Bit Score: 36.91 E-value: 9.23e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  24 CFLFGLFSLFysfTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCimQTFLY 103
Cdd:cd15049   4 CIATGSLSLV---TVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLC--DLWLA 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 33238922 104 LAFACTECLI--LVVMSYDRFVAICHPLHYTVIMSWKVCTILAAVSWIAGFLL 154
Cdd:cd15049  79 LDYVASNASVmnLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVL 131

7tmA_PAR

cd15162

protease-activated receptors, member of the class A family of seven-transmembrane G ...

25-164

9.58e-03

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.

Pssm-ID: 341328 [Multi-domain] Cd Length: 280 Bit Score: 37.04 E-value: 9.58e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922  25 FLFGLFSLFYSFTLLGNGIILVVICLDNRLHIPMYFFLSHLAIVDMSYASNNVPKMLANLVTQRRTISFILCIMQTFLYL 104
Cdd:cd15162   2 FLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFY 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238922 105 AFACTECLILVVMSYDRFVAICHPLHYtviMSWKVCTILAAVSWIAGFLLALVHLVLILK 164
Cdd:cd15162  82 GNMYCSILLLTCISIDRYLAIVHPMGH---RRLRARRYALGTCLAIWLLALLVTLPLYLV 138

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01