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Conserved domains on  [gi|268607613|ref|NP_667333|]
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olfactory receptor 623 [Mus musculus]

Protein Classification

olfactory receptor family 51 protein( domain architecture ID 11607012)

olfactory receptor family 51 protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
26-300 2.99e-157

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320350  Cd Length: 275  Bit Score: 440.40  E-value: 2.99e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  26 HLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFI 105
Cdd:cd15222    1 HWISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 106 HSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDV 185
Cdd:cd15222   81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 186 IKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRF 265
Cdd:cd15222  161 MKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRF 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607613 266 GKNIPHIVHITMSYICFLFPPFMNPVIFSIKTKQI 300
Cdd:cd15222  241 GKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
26-300 2.99e-157

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 440.40  E-value: 2.99e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  26 HLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFI 105
Cdd:cd15222    1 HWISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 106 HSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDV 185
Cdd:cd15222   81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 186 IKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRF 265
Cdd:cd15222  161 MKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRF 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607613 266 GKNIPHIVHITMSYICFLFPPFMNPVIFSIKTKQI 300
Cdd:cd15222  241 GKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
36-309 2.17e-95

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 283.62  E-value: 2.17e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613   36 YIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVESGV 115
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  116 LLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACADITF 195
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  196 NRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNIPHIVHI 275
Cdd:pfam13853 165 NNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPLLQI 244
                         250       260       270
                  ....*....|....*....|....*....|....
gi 268607613  276 TMSYICFLFPPFMNPVIFSIKTKQIQSGLLRLFS 309
Cdd:pfam13853 245 MMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
26-300 2.99e-157

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 440.40  E-value: 2.99e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  26 HLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFI 105
Cdd:cd15222    1 HWISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 106 HSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDV 185
Cdd:cd15222   81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 186 IKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRF 265
Cdd:cd15222  161 MKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRF 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607613 266 GKNIPHIVHITMSYICFLFPPFMNPVIFSIKTKQI 300
Cdd:cd15222  241 GKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
26-300 6.38e-112

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 325.40  E-value: 6.38e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  26 HLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFI 105
Cdd:cd15917    1 IWLSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 106 HSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDV 185
Cdd:cd15917   81 HSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 186 IKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRF 265
Cdd:cd15917  161 VKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRF 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607613 266 GKNIPHIVHITMSYICFLFPPFMNPVIFSIKTKQI 300
Cdd:cd15917  241 GHHVPPHVHILLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
26-300 1.26e-106

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 311.97  E-value: 1.26e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  26 HLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFI 105
Cdd:cd15951    1 VWISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 106 HSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDV 185
Cdd:cd15951   81 HSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 186 IKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRF 265
Cdd:cd15951  161 VKLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRF 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607613 266 GKNIPHIVHITMSYICFLFPPFMNPVIFSIKTKQI 300
Cdd:cd15951  241 GHNVPPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
28-300 1.58e-98

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 291.50  E-value: 1.58e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  28 ISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHS 107
Cdd:cd15221    3 ISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 108 FSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIK 187
Cdd:cd15221   83 VFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIAR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 188 LACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGK 267
Cdd:cd15221  163 LACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGR 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 268607613 268 NIPHIVHITMSYICFLFPPFMNPVIFSIKTKQI 300
Cdd:cd15221  243 HIPRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
28-300 2.49e-98

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 291.09  E-value: 2.49e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  28 ISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHS 107
Cdd:cd15953    3 ISIPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 108 FSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIK 187
Cdd:cd15953   83 LSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 188 LACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGK 267
Cdd:cd15953  163 LACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRFGQ 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 268607613 268 NIPHIVHITMSYICFLFPPFMNPVIFSIKTKQI 300
Cdd:cd15953  243 GIAPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
25-301 9.81e-97

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 287.19  E-value: 9.81e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  25 HHLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYF 104
Cdd:cd15948    1 HPWISIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 105 IHSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQD 184
Cdd:cd15948   81 LHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 185 VIKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHR 264
Cdd:cd15948  161 VVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHR 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 268607613 265 FGKNIPHIVHITMSYICFLFPPFMNPVIFSIKTKQIQ 301
Cdd:cd15948  241 FARHVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
36-309 2.17e-95

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 283.62  E-value: 2.17e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613   36 YIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVESGV 115
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  116 LLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACADITF 195
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  196 NRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNIPHIVHI 275
Cdd:pfam13853 165 NNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPLLQI 244
                         250       260       270
                  ....*....|....*....|....*....|....
gi 268607613  276 TMSYICFLFPPFMNPVIFSIKTKQIQSGLLRLFS 309
Cdd:pfam13853 245 MMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
28-300 3.40e-95

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 283.15  E-value: 3.40e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  28 ISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHS 107
Cdd:cd15950    3 IAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 108 FSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIK 187
Cdd:cd15950   83 FTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 188 LACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGK 267
Cdd:cd15950  163 LACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRFGQ 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 268607613 268 NIPHIVHITMSYICFLFPPFMNPVIFSIKTKQI 300
Cdd:cd15950  243 GVPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
28-300 1.76e-89

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 268.48  E-value: 1.76e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  28 ISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHS 107
Cdd:cd15952    3 IGFPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 108 FSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIK 187
Cdd:cd15952   83 FTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 188 LACADITFNRLYPIVVVfCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGK 267
Cdd:cd15952  163 LACASIRINIIYGLFAI-SVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGH 241
                        250       260       270
                 ....*....|....*....|....*....|...
gi 268607613 268 NIPHIVHITMSYICFLFPPFMNPVIFSIKTKQI 300
Cdd:cd15952  242 NIPRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
13-301 2.42e-89

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 268.57  E-value: 2.42e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  13 FLLTGFPGLEKSHHLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHRE 92
Cdd:cd15949    4 FILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  93 IGHGACFSQAYFIHSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRS 172
Cdd:cd15949   84 IPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 173 HVLSHAFCLHQDVIKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVF 252
Cdd:cd15949  164 NIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAILAF 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 268607613 253 YVTVVGLTFIHRFGKNIPHIVHITMSYICFLFPPFMNPVIFSIKTKQIQ 301
Cdd:cd15949  244 YVPIAVSSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
26-304 8.97e-89

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 266.85  E-value: 8.97e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  26 HLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFI 105
Cdd:cd15223    1 HWLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 106 HSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDV 185
Cdd:cd15223   81 HFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 186 IKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRF 265
Cdd:cd15223  161 VSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRF 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 268607613 266 GKNIPHIVHITMSYICFLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15223  241 GKTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
28-300 3.40e-77

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 237.07  E-value: 3.40e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  28 ISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHS 107
Cdd:cd15956    3 LSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 108 FSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIK 187
Cdd:cd15956   83 FSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 188 LACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGK 267
Cdd:cd15956  163 LACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGH 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 268607613 268 NIPHIVHITMSYICFLFPPFMNPVIFSIKTKQI 300
Cdd:cd15956  243 SVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
28-300 1.00e-73

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 228.17  E-value: 1.00e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  28 ISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHS 107
Cdd:cd15954    3 ISIPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 108 FSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIK 187
Cdd:cd15954   83 FTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 188 LACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRF-G 266
Cdd:cd15954  163 LACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFgG 242
                        250       260       270
                 ....*....|....*....|....*....|....
gi 268607613 267 KNIPHIVHITMSYICFLFPPFMNPVIFSIKTKQI 300
Cdd:cd15954  243 HHITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
26-300 3.32e-73

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 226.96  E-value: 3.32e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  26 HLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFI 105
Cdd:cd15955    1 HWIGIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 106 HSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMP----IIIRLNWFpycRSHVLSHAFCL 181
Cdd:cd15955   81 HTLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPcpllIKLRLHHF---RSTVISHSYCE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 182 HQDVIKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTF 261
Cdd:cd15955  158 HMAVVKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFF 237
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 268607613 262 IHRFGKNIPHIVHITMSYICFLFPPFMNPVIFSIKTKQI 300
Cdd:cd15955  238 AHRFGHHVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-296 3.64e-63

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 200.79  E-value: 3.64e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd13954    2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVI 186
Cdd:cd13954   82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 187 KLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFG 266
Cdd:cd13954  162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241
                        250       260       270
                 ....*....|....*....|....*....|
gi 268607613 267 KNIPHIVHITMSYIcfLFPPFMNPVIFSIK 296
Cdd:cd13954  242 YSSDLDKVVSVFYT--VVTPMLNPIIYSLR 269
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
32-304 1.88e-52

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 173.41  E-value: 1.88e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15225    7 FLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACA 191
Cdd:cd15225   87 ECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 192 DITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTvVGLTFIHRFGKNIPH 271
Cdd:cd15225  167 DTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGC-ASFTYLRPKSSYSPE 245
                        250       260       270
                 ....*....|....*....|....*....|....
gi 268607613 272 IVH-ITMSYIcfLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15225  246 TDKlLSLFYT--VVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
27-296 5.87e-52

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 172.17  E-value: 5.87e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd15914    2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVI 186
Cdd:cd15914   82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 187 KLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTvVGLTFIhRFG 266
Cdd:cd15914  162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGS-VSFMYL-RLS 239
                        250       260       270
                 ....*....|....*....|....*....|
gi 268607613 267 KNIPHIVHITMSYICFLFPPFMNPVIFSIK 296
Cdd:cd15914  240 KSYSLDYDRAIAVVYAVLTPFFNPIIYSLR 269
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
13-308 1.16e-46

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 158.98  E-value: 1.16e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  13 FLLTGFPGLEKSHHLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHRE 92
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  93 IGHGACFSQAYFIHSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRS 172
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 173 HVLSHAFCLHQDVIKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVF 252
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 268607613 253 YVTVVGLTFIHRfGKNIPHIVHITmSYICFLFPPFMNPVIFSIKTKQIQSGLLRLF 308
Cdd:cd15410  241 HGTILFMYCRPS-SSYSLDTDKVA-SVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
25-304 4.00e-46

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 157.38  E-value: 4.00e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  25 HHLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYF 104
Cdd:cd15235    1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 105 IHSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQD 184
Cdd:cd15235   81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 185 VIKLACADITFNRLypivVVFCMGLLD----FLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLT 260
Cdd:cd15235  161 LLKLSCSDTSLNEL----LIFTEGAVVvlgpFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVY 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 268607613 261 FIHRFGKNIPHIVHITMSYIcfLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15235  237 FQPSSSYSADKDRVATVMYT--VVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
33-256 1.03e-44

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 153.43  E-value: 1.03e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15230    8 LLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACAD 192
Cdd:cd15230   88 CFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSD 167
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 268607613 193 ITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTV 256
Cdd:cd15230  168 THINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTL 231
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
27-296 1.32e-44

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 153.02  E-value: 1.32e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd15912    2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVI 186
Cdd:cd15912   82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 187 KLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVgltFIH--- 263
Cdd:cd15912  162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCI---FMYvrp 238
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607613 264 --RFGKNIPHIVHITMSYICflfpPFMNPVIFSIK 296
Cdd:cd15912  239 sqSSSLDLNKVVALLNTVVT----PLLNPFIYTLR 269
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
33-296 1.65e-44

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 152.61  E-value: 1.65e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15227    8 LLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGL-SIM--PIIIRLnwfPYCRSHVLSHAFCLHQDVIKLA 189
Cdd:cd15227   88 LALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLyGALhtANTFSL---PFCGSNVIHQFFCDIPQLLKLS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 190 CADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVvglTFIH-RFGKN 268
Cdd:cd15227  165 CSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTG---SFAYlKPPSD 241
                        250       260
                 ....*....|....*....|....*...
gi 268607613 269 IPHIVHITMSYICFLFPPFMNPVIFSIK 296
Cdd:cd15227  242 SPSLLDLLLSVFYSVVPPTLNPIIYSLR 269
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
27-296 9.86e-44

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 150.84  E-value: 9.86e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMaYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd15918    3 LFGLFLGM-YLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVI 186
Cdd:cd15918   82 LFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 187 KLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTF----I 262
Cdd:cd15918  162 KLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLsppsS 241
                        250       260       270
                 ....*....|....*....|....*....|....
gi 268607613 263 HRFGKNIPHIVHITMsyicflFPPFMNPVIFSIK 296
Cdd:cd15918  242 HSASKDSVAAVMYTV------VTPMLNPFIYSLR 269
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
32-257 4.12e-42

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 146.65  E-value: 4.12e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15237    7 FLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACA 191
Cdd:cd15237   87 ECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACA 166
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 268607613 192 DITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVV 257
Cdd:cd15237  167 DTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAI 232
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
27-304 8.74e-42

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 145.87  E-value: 8.74e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd15231    2 LLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVI 186
Cdd:cd15231   82 SFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 187 KLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVgLTFIhRFG 266
Cdd:cd15231  162 KLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAI-FNYN-RPS 239
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 268607613 267 KNIPHIVHITMSYICFLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15231  240 SGYSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
33-296 1.06e-41

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 145.53  E-value: 1.06e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15915    8 LLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACAD 192
Cdd:cd15915   88 AMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGD 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 193 ITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIA-STDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNIPH 271
Cdd:cd15915  168 TSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLEQ 247
                        250       260
                 ....*....|....*....|....*
gi 268607613 272 IVHITMSYIcfLFPPFMNPVIFSIK 296
Cdd:cd15915  248 DRIVALLYT--VVTPVLNPLIYTLR 270
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
36-304 1.67e-41

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 145.16  E-value: 1.67e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  36 YIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVESGV 115
Cdd:cd15420   11 YIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 116 LLAMAYDRFIAIRNPLRYTTILTdIKVIKIGIGVVMRAGLSIMPIIIRLNW-FPYCRSHVLSHAFCLHQDVIKLACADIT 194
Cdd:cd15420   91 LAVMSYDRYVAICHPLRYTVIMN-WRVCTTLAATSWACGFLLALVHVVLLLrLPFCGPNEVNHFFCEILAVLKLACADTW 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 195 FNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNIPHIVH 274
Cdd:cd15420  170 INEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSAEQEKI 249
                        250       260       270
                 ....*....|....*....|....*....|
gi 268607613 275 ITMSYIcfLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15420  250 LSLFYS--LFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
13-308 3.40e-41

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 144.81  E-value: 3.40e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  13 FLLTGFPGLEKSHHLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHRE 92
Cdd:cd15943    2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  93 IGHGACFSQAYFIHSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRS 172
Cdd:cd15943   82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 173 HVLSHAFCLHQDVIKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVF 252
Cdd:cd15943  162 NVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIF 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268607613 253 YVTVVgltFIH-----RFGKNIPHIVHITMSYICflfpPFMNPVIFSIKTKQIQSGLLRLF 308
Cdd:cd15943  242 YGTTL---FMYlrpssSYSLDQDKVVSVFYTVVI----PMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
33-306 3.67e-41

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 144.38  E-value: 3.67e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15411    8 LVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACAD 192
Cdd:cd15411   88 CFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSD 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 193 ITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTvvgLTFIHRFGKNIPHI 272
Cdd:cd15411  168 THVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGT---GIFTYLRPSSSYSL 244
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607613 273 VHITMSYICF-LFPPFMNPVIFSIKTKQIQSGLLR 306
Cdd:cd15411  245 GQDKVASVFYtVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
33-306 5.61e-41

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 143.94  E-value: 5.61e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15417    8 LGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACAD 192
Cdd:cd15417   88 CFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSD 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 193 ITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNIPHI 272
Cdd:cd15417  168 TFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHSQDQD 247
                        250       260       270
                 ....*....|....*....|....*....|....
gi 268607613 273 VHITMSYIcfLFPPFMNPVIFSIKTKQIQSGLLR 306
Cdd:cd15417  248 KVASVFYT--VVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
32-255 7.33e-41

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 143.13  E-value: 7.33e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15431    7 LLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGIT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILTdiKVIKIGIGVVMRAG---LSIMPIIIRLNWFpyCRSHVLSHAFCLHQDVIKL 188
Cdd:cd15431   87 ECLLLAVMAYDRFVAICNPLRYTLIMS--WRVCIQLAAGSWVSaflLTVIPVLTMPLHF--CGPNVINHFFCEVQALLKL 162
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 268607613 189 ACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVT 255
Cdd:cd15431  163 ACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGT 229
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
13-300 1.39e-40

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 143.23  E-value: 1.39e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  13 FLLTGFPGLEKSHHLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHRE 92
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  93 IGHGACFSQAYFIHSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDikvikiGIGVVMRAGLSIMPII---------IR 163
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQ------RVCVSLVAGSYLAGFLnstvhtgfiLR 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 164 LnwfPYCRSHVLSHAFCLHQDVIKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCV 243
Cdd:cd15408  155 L---SFCGSNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCA 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 268607613 244 SHICCILVFYVTvvgLTFIH-RFGKNIPHIVHITMSYICFLFPPFMNPVIFSIKTKQI 300
Cdd:cd15408  232 SHLTAVTLFYGS---LAFMYlRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEV 286
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
33-306 1.76e-40

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 142.54  E-value: 1.76e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15412    8 LVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGL-SIMPIIIRLNwFPYCRSHVLSHAFCLHQDVIKLACA 191
Cdd:cd15412   88 YYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLnGLIQTILTFR-LSFCGSNVINHFYCADPPLIKLSCS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 192 DiTFNRLYPIVVVFCMGLL-DFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNIP 270
Cdd:cd15412  167 D-TYVKETAMFIVAGFNLSsSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESVE 245
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607613 271 HIVHITMSYIcfLFPPFMNPVIFSIKTKQIQSGLLR 306
Cdd:cd15412  246 QSKIVAVFYT--FVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
27-300 1.95e-40

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 142.30  E-value: 1.95e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMaYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd15421    3 LFSLILLI-FLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVI 186
Cdd:cd15421   82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 187 KLACADITfnrLYPIVVVFC---MGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHIccilvfyvTVVGLTfih 263
Cdd:cd15421  162 KLSCADTS---AYETVVYVSgvlFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHL--------TVVSLY--- 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 268607613 264 rFGKNI-----PHIVH-----ITMSYICFLFPPFMNPVIFSIKTKQI 300
Cdd:cd15421  228 -YGPAIftymrPGSYHspeqdKVVSVFYTILTPMLNPLIYSLRNKEV 273
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
27-294 1.27e-39

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 139.93  E-value: 1.27e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd15911    2 LLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVI 186
Cdd:cd15911   82 SLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 187 KLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRfg 266
Cdd:cd15911  162 KLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPS-- 239
                        250       260
                 ....*....|....*....|....*...
gi 268607613 267 KNIPHIVHITMSYICFLFPPFMNPVIFS 294
Cdd:cd15911  240 TNTSRDLNKVFSLFYTVLTPLVNPLIYS 267
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
33-304 3.46e-39

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 139.10  E-value: 3.46e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15228    8 LAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACAD 192
Cdd:cd15228   88 CLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACAD 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 193 ITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNIPHI 272
Cdd:cd15228  168 TSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSPVLVTP 247
                        250       260       270
                 ....*....|....*....|....*....|..
gi 268607613 273 VHITMSyicfLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15228  248 VQIFNN----VVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
27-306 4.16e-39

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 138.98  E-value: 4.16e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd15419    2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVI 186
Cdd:cd15419   82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 187 KLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVvglTFIHRFG 266
Cdd:cd15419  162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTV---FFMYAQP 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 268607613 267 KNIPHIVHITMSYICF-LFPPFMNPVIFSIKTKQIQSGLLR 306
Cdd:cd15419  239 GAVSSPEQSKVVSVFYtLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
32-302 7.41e-39

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 138.33  E-value: 7.41e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15424    7 ILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGST 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACA 191
Cdd:cd15424   87 ECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 192 DITFNRlypiVVVFCMG----LLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGK 267
Cdd:cd15424  167 DTHITE----AIVFGAGvlilLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607613 268 NIPHIVHITMSYIcfLFPPFMNPVIFSIKTKQIQS 302
Cdd:cd15424  243 TPDRDKQIAVFYI--VITPLLNPIIYTLRNKDVHG 275
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
32-257 1.41e-38

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 137.37  E-value: 1.41e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15947    7 VLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGST 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILtDIKVIKIGIGVVMRAGL--SIMPIIIRLnWFPYCRSHVLSHAFCLHQDVIKLA 189
Cdd:cd15947   87 ECVLLAVMAFDRYVAVCRPLHYTVIM-HPRLCVQLAALSWLSGLanSLLQTTLTL-QLPLCGHHTLDHFFCEVPALIKLA 164
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268607613 190 CADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVV 257
Cdd:cd15947  165 CVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAI 232
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
27-308 1.47e-38

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 137.94  E-value: 1.47e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd15414    2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVI 186
Cdd:cd15414   82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 187 KLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTvvgLTFIH-RF 265
Cdd:cd15414  162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGT---LFFIYvRP 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 268607613 266 GKNIPHIVHITMSYICFLFPPFMNPVIFSIKTKQIQSGLLRLF 308
Cdd:cd15414  239 SSSSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTI 281
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
33-304 2.69e-38

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 136.82  E-value: 2.69e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15236    8 LAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLD 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACAD 192
Cdd:cd15236   88 SFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSS 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 193 ITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNipHI 272
Cdd:cd15236  168 TSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS--SD 245
                        250       260       270
                 ....*....|....*....|....*....|..
gi 268607613 273 VHITMSYICFLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15236  246 KDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
27-304 3.67e-38

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 136.55  E-value: 3.67e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMaYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd15234    3 LFGLFLSM-YLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRYTTI----LTDIKVIKIGIGVVMRAGLSIMpIIIRLNwfpYCRSHVLSHAFCLH 182
Cdd:cd15234   82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVImnpcLCGLLVLLSLLISILDSLLHSL-MVLQLS---FCTDVEIPHFFCEL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 183 QDVIKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTfi 262
Cdd:cd15234  158 AQVLKLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVY-- 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 268607613 263 hrFGKNIPHIVHITM--SYICFLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15234  236 --ISSAVTHSSRKTAvaSVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
33-304 6.48e-38

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 135.80  E-value: 6.48e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15229    8 LVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACAD 192
Cdd:cd15229   88 AFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSD 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 193 ITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVG--LTFIHRFGKNIP 270
Cdd:cd15229  168 TFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFryLRPNSASSSVLD 247
                        250       260       270
                 ....*....|....*....|....*....|....
gi 268607613 271 HIVHITMSYICflfpPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15229  248 RVFSIQYSILT----PMLNPIIYSLKNKEVKAAL 277
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
32-296 7.36e-38

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 135.49  E-value: 7.36e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15224    7 FLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACA 191
Cdd:cd15224   87 ECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCT 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 192 DITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVgltFIHRFGKNIPH 271
Cdd:cd15224  167 DMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATL---FMYARPKAISS 243
                        250       260
                 ....*....|....*....|....*.
gi 268607613 272 I-VHITMSYICFLFPPFMNPVIFSIK 296
Cdd:cd15224  244 FdSNKLVSVLYTVVTPLLNPIIYCLR 269
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
33-306 7.78e-38

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 135.62  E-value: 7.78e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15415    8 LLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACAD 192
Cdd:cd15415   88 GFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSD 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 193 ITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTvVGLTFIHRFGKNIPHI 272
Cdd:cd15415  168 THINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGS-VSFSYIQPSSQYSLEQ 246
                        250       260       270
                 ....*....|....*....|....*....|....
gi 268607613 273 VHITMSYICfLFPPFMNPVIFSIKTKQIQSGLLR 306
Cdd:cd15415  247 EKVSAVFYT-LVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
33-296 1.21e-37

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 134.81  E-value: 1.21e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15430    8 LIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGL-SIMPIIIRLNWfPYCRSHVLSHAFCLHQDVIKLACA 191
Cdd:cd15430   88 CVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLnSLVETVLAMQL-PFCGNNVINHFTCEILAVLKLACV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 192 DITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNIPH 271
Cdd:cd15430  167 DISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNAQIS 246
                        250       260
                 ....*....|....*....|....*
gi 268607613 272 IVHITMSYIcfLFPPFMNPVIFSIK 296
Cdd:cd15430  247 DKLITLFYG--VVTPMLNPIIYSLR 269
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
33-304 1.20e-36

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 132.52  E-value: 1.20e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15429    8 LVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGL-SIMPIIIRLNwFPYCRSHVLSHAFCLHQDVIKLACA 191
Cdd:cd15429   88 FILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLnSLVQTAFTFR-LPFCGHNTINHFSCELLAVVRLACV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 192 DITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVgLTFIHRFGKNIPH 271
Cdd:cd15429  167 DTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAI-FTYMRPRSGSSAL 245
                        250       260       270
                 ....*....|....*....|....*....|...
gi 268607613 272 IVHITMSYICFLfPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15429  246 QEKMISLFYAVV-TPMLNPLIYSLRNKEVKGAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
33-296 1.81e-36

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 131.83  E-value: 1.81e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15946    8 LLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACAD 192
Cdd:cd15946   88 CTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACAD 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 193 ITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVvglTFIH-RFGKNIPH 271
Cdd:cd15946  168 TSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPA---MFMYmRPGSNYSP 244
                        250       260
                 ....*....|....*....|....*
gi 268607613 272 IVHITMSYICFLFPPFMNPVIFSIK 296
Cdd:cd15946  245 ERDKKISLFYNVFTALLNPVIYSLR 269
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
33-306 1.82e-36

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 132.11  E-value: 1.82e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15416    8 LVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACAD 192
Cdd:cd15416   88 CFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSD 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 193 ITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNIPHI 272
Cdd:cd15416  168 IRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDQN 247
                        250       260       270
                 ....*....|....*....|....*....|....
gi 268607613 273 VHITMSYICFLfpPFMNPVIFSIKTKQIQSGLLR 306
Cdd:cd15416  248 KVVSVFYMVVI--PMLNPLIYSLRNKEVKGALKR 279
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
13-306 2.76e-36

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 131.79  E-value: 2.76e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  13 FLLTGFPGLEKSHHLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHRE 92
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  93 IGHGACFSQAYFIHSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRS 172
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 173 HVLSHAFCLHQDVIKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVF 252
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 268607613 253 YVTVVgLTFIHRFGKNIPHIVHITMSYICFLFpPFMNPVIFSIKTKQIQSGLLR 306
Cdd:cd15945  241 YGTLL-FMYLRPSSSYSLDTDKMTSVFYTLVI-PMLNPLIYSLRNKDVKEALKK 292
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
30-306 1.17e-35

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 129.83  E-value: 1.17e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  30 LPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFS 109
Cdd:cd15409    5 LVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 110 IVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLA 189
Cdd:cd15409   85 TTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKIS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 190 CADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNI 269
Cdd:cd15409  165 CTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYAL 244
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 268607613 270 PHIVHITMSYICFLfpPFMNPVIFSIKTKQIQSGLLR 306
Cdd:cd15409  245 DQDMMDSLFYTIVI--PLLNPFIYSLRNKEVIDALRK 279
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
36-306 3.24e-35

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 128.69  E-value: 3.24e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  36 YIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVESGV 115
Cdd:cd15407   11 YLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 116 LLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACADITF 195
Cdd:cd15407   91 LASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSCSDIHI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 196 NRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNIPHIVHI 275
Cdd:cd15407  171 SEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMDTDKMA 250
                        250       260       270
                 ....*....|....*....|....*....|.
gi 268607613 276 TMSYICFLfpPFMNPVIFSIKTKQIQSGLLR 306
Cdd:cd15407  251 SVFYTMVI--PMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
32-306 5.38e-35

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 128.21  E-value: 5.38e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15413    7 FLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIIS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACA 191
Cdd:cd15413   87 ELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 192 DITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTvvgLTFIHRFGKNIPH 271
Cdd:cd15413  167 DTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGT---LIFMYLQPKSSHS 243
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607613 272 IVHITMSYICF-LFPPFMNPVIFSIKTKQIQSGLLR 306
Cdd:cd15413  244 LDTDKMASVFYtLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
30-307 3.10e-34

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 126.33  E-value: 3.10e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  30 LPL----LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFI 105
Cdd:cd15406   10 LPLfllfLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 106 HSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDV 185
Cdd:cd15406   90 CVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 186 IKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRF 265
Cdd:cd15406  170 LKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSS 249
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 268607613 266 GKNIPHIVHITMSYICFLfpPFMNPVIFSIKTKQIQSGLLRL 307
Cdd:cd15406  250 SSSMTQEKVSSVFYTTVI--PMLNPLIYSLRNKDVKNALKKV 289
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
27-304 6.15e-34

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 125.25  E-value: 6.15e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVL-GVLWFNHREIGHGACFSQAYFI 105
Cdd:cd15916    2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLaGFLEPGGKVISFGGCVAQLYFF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 106 HSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDV 185
Cdd:cd15916   82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 186 IKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVgltFIH-R 264
Cdd:cd15916  162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCV---FIYlR 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 268607613 265 FGKNIPhiVHITMSYICFLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15916  239 PGSKEA--LDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
32-304 1.73e-33

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 124.13  E-value: 1.73e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15233    7 FLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILT-DIKVIKIGIGVVMrAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLAC 190
Cdd:cd15233   87 DCFLLTAMAYDRYLAICQPLTYSVRMSwRVQTALVGISCAC-AFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSC 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 191 ADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVgLTFIhRFGKNIP 270
Cdd:cd15233  166 SSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGV-FSYM-RLGSVYS 243
                        250       260       270
                 ....*....|....*....|....*....|....
gi 268607613 271 HIVHITMSYICFLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15233  244 SDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
32-304 2.84e-33

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 123.74  E-value: 2.84e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15432    7 FLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGST 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACA 191
Cdd:cd15432   87 ECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 192 DITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFihRFGKNIPH 271
Cdd:cd15432  167 DTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYL--QPPSNSSH 244
                        250       260       270
                 ....*....|....*....|....*....|...
gi 268607613 272 IVHITMSYICFLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15432  245 DRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
33-257 3.52e-33

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 123.14  E-value: 3.52e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15232    8 LFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACAD 192
Cdd:cd15232   88 LLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSD 167
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 268607613 193 ITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVV 257
Cdd:cd15232  168 TSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVI 232
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
26-296 4.43e-33

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 122.70  E-value: 4.43e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  26 HLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFI 105
Cdd:cd15226    1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 106 HSFSIVESGVLLAMAYDRFIAIRNPLRYTTIL-----TDIKVIKIGIGVVMraglSIMPIIIRLNwFPYCRSHVLSHAFC 180
Cdd:cd15226   81 HFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMsprmcILLVVASWIIGFIH----SLSQLAFVVN-LPFCGPNVVDSFFC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 181 LHQDVIKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGiASTDERAKALNTCVSHICCILVFYVTVVglt 260
Cdd:cd15226  156 DLPLVIKLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCI--- 231
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 268607613 261 FIHRFgkniPHIVHIT---MSYICFLFPPFMNPVIFSIK 296
Cdd:cd15226  232 FIYVW----PFSTFPVdkfLAVFYTVITPLLNPIIYTLR 266
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
27-304 9.27e-33

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 122.20  E-value: 9.27e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd15428    2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRYTTILTdiKVIKIGIGVVMRAGLSIMPIIIRLNWF--PYCRSHVLSHAFCLHQD 184
Cdd:cd15428   82 SFGITECALLSVMSYDRYVAICLPLRYSLIMT--WKVCISLATGSWVGGLLVSAVDTAFTLnlSFGGHNKINHFLCEMPA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 185 VIKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHR 264
Cdd:cd15428  160 LLKLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPK 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 268607613 265 FGKNIPHIVHITMSYIcfLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15428  240 SSTSKEYDKMISVFYI--IVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
13-308 1.13e-32

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 122.59  E-value: 1.13e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  13 FLLTGFPGLEKSHHLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHRE 92
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  93 IGHGACFSQAYFIHSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRS 172
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 173 HVLSHAFCLHQDVIKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVF 252
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268607613 253 YVTVVgltfihrFGKNIPHIVHIT-----MSYICFLFPPFMNPVIFSIKTKQIQSGLLRLF 308
Cdd:cd15944  241 YGTVI-------FMYLRPTSVYSLdqdkwASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
26-304 6.06e-32

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 120.18  E-value: 6.06e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  26 HLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFI 105
Cdd:cd15434    1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 106 HSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTD---IKVIKIGIGVVMRAGLSIMPIIIRLnwfPYCRSHVLSHAFCLH 182
Cdd:cd15434   81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPrlcWKLVAMSWLIGFGNSLVLSPLTLSL---PRCGHHRVDHFFCEM 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 183 QDVIKLACADITfnRLYPIVVVFCMGLLDF--LIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVglt 260
Cdd:cd15434  158 PALIKLACVDTT--AYEATIFALGVFILLFplSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTII--- 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 268607613 261 FIHRFGKNIP-HIVHITMSYICFLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15434  233 YMYLQPKNSVsQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
30-304 1.64e-31

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 119.07  E-value: 1.64e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  30 LPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFS 109
Cdd:cd15942    5 LFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 110 IVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLA 189
Cdd:cd15942   85 CAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 190 CADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTvvgLTFIH-RFGKN 268
Cdd:cd15942  165 CADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVP---LTFIYlRPGSQ 241
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607613 269 IPHIVHITMSYIcfLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15942  242 DPLDGVVAVFYT--TVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
33-296 3.83e-31

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 117.70  E-value: 3.83e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15939    8 LLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACAD 192
Cdd:cd15939   88 IFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTD 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 193 ITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGiASTDERAKALNTCVSHICCILVFYVTVVgltFIH-RFGKNIPH 271
Cdd:cd15939  168 TYVIGLLVVANSGLICLLSFLILLISYIVILYSLRT-HSSEGRRKALSTCGSHITVVVLFFVPCI---FIYmRPVTTFPI 243
                        250       260
                 ....*....|....*....|....*
gi 268607613 272 IVHITMSYIcfLFPPFMNPVIFSIK 296
Cdd:cd15939  244 DKVVAVFYT--IITPMLNPLIYTLR 266
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
33-253 4.03e-31

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 117.54  E-value: 4.03e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15940    8 LVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILtDIKVIKIGIGVVMRAG----LSIMPIIIRLnwfPYCRSHVLSHAFCLHQDVIKL 188
Cdd:cd15940   88 IFLLTIMAYDRYVAICNPLHYPTVM-NHKVCLWLVAALWLGGtvhsLAQTFLTIRL---PYCGPNEIDSFFCDVPPVIKL 163
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 268607613 189 ACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIaSTDERAKALNTCVSHICCILVFY 253
Cdd:cd15940  164 ACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFF 227
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
33-304 3.13e-30

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 115.59  E-value: 3.13e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15405    8 LGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRA---GLSIMPIIIRLNwfpYCRSHVLSHAFCLHQDVIKLA 189
Cdd:cd15405   88 CYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGfagAMAHTGCMLRLT---FCDSNIINHYMCDILPLLQLS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 190 CADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNI 269
Cdd:cd15405  165 CTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSV 244
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607613 270 PHIVHITMSYICFLfpPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15405  245 NQGKVSSVFYTNVV--PMLNPLIYSLRNKDVKLAL 277
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
33-307 1.50e-29

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 113.72  E-value: 1.50e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVE 112
Cdd:cd15418    9 LLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSE 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 113 SGVLLAMAYDRFIAIRNPLRYTTILTdiKVIKIGIGVVMRAGLSIMPIIIRLNWF--PYCRSHVLSHAFCLHQDVIKLAC 190
Cdd:cd15418   89 CFLLAAMAYDRYVAICNPLLYSSAMS--KKLCMGLVAASYLGGFANAIIHTSNTFrlHFCGDNIIDHFFCDLPPLVKLAC 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 191 ADI-TFNRLYPIVVVFCMGLLDFLIICfSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVgltFIHrfgkNI 269
Cdd:cd15418  167 DDTrVYELILYFILGFNVIAPTALILA-SYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSIL---FIY----SR 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 268607613 270 PHIVHI-----TMSYICFLFPPFMNPVIFSIKTKQIQSGLLRL 307
Cdd:cd15418  239 PSSSHTpdrdkVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
27-296 2.29e-29

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 112.94  E-value: 2.29e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIK-DDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFI 105
Cdd:cd15935    2 LLFVLVLACYAAILLGNLLIVVTVHaDPHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 106 HSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIgIGVVMRAGL--SIMPIIIRLNwFPYCRSHVLSHAFCLHQ 183
Cdd:cd15935   82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKL-LAACWAGGFlhSATQAALVLR-LPFCGPNELDNFYCDVP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 184 DVIKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGiASTDERAKALNTCVSHICCILVFYVTVVGLTFIH 263
Cdd:cd15935  160 QVIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRG-RFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRP 238
                        250       260       270
                 ....*....|....*....|....*....|...
gi 268607613 264 RFGKNIPHIVHITMSYICflfpPFMNPVIFSIK 296
Cdd:cd15935  239 FSSSSVDKVASVFYTLIT----PALNPLIYTLR 267
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
32-296 2.30e-29

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 113.18  E-value: 2.30e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15913    7 FSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFCLHQDVIKLACA 191
Cdd:cd15913   87 ECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 192 DITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGlTFIHRFGKNiph 271
Cdd:cd15913  167 PAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMV-MYVSPGSGN--- 242
                        250       260
                 ....*....|....*....|....*....
gi 268607613 272 ivHITMSYICFLF----PPFMNPVIFSIK 296
Cdd:cd15913  243 --STGMQKIVTLFysvvTPLLNPLIYSLR 269
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
32-304 6.24e-29

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 112.19  E-value: 6.24e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15433    7 VLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILTD-----IKVIKIGIGV---VMRAGLSImpiiirlnWFPYCRSHVLSHAFCLHQ 183
Cdd:cd15433   87 ECVLLAVMAFDRYAAVCRPLHYAALMSPrlcqtLASISWLSGFvnsVAQTGLLA--------ERPLCGHRLLDHFFCEMP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 184 DVIKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFY--VTVVGLTF 261
Cdd:cd15433  159 VFLKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYgsAIYTYLQP 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 268607613 262 IHRFgkNIPHIVHITMSYIcfLFPPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15433  239 IHRY--SQAHGKFVSLFYT--VMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
27-304 1.59e-28

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 111.09  E-value: 1.59e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIKDDHNLHE-PMYYFLGMLAATDLGVTLTTMPTVL-GVLWFNHREIGHGACFSQAYF 104
Cdd:cd15941    2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLaGLLTLSGRTISFEGCVVQLYA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 105 IHSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTdiKVIKIGI-GVVMRAGLSIMPIIIRLNW-FPYCRSHVLSHAFCLH 182
Cdd:cd15941   82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMN--RRMCAGLaGGTWATGATHAAIHTSLTFrLPYCGPCQIAYFFCDI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 183 QDVIKLACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFI 262
Cdd:cd15941  160 PPVLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQ 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 268607613 263 HRFGKNIPHIVHITMSYICflfpPFMNPVIFSIKTKQIQSGL 304
Cdd:cd15941  240 PSSSQAGAGAPAVFYTIVT----PMLNPFIYTLRNKEVKRAL 277
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
32-296 5.42e-28

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 109.35  E-value: 5.42e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15936    7 FLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGL-SIMPIIIRLNwFPYCRSHVLSHAFCLHQDVIKLAC 190
Cdd:cd15936   87 EVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAhSIVQVALLLQ-LPFCGPNVLDNFYCDVPQVIKLAC 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 191 ADitfNRLYPIVVVFCMGLLD---FLIICFSYILILKTVMgIASTDERAKALNTCVSHIccilvfyvTVVGLTFI----- 262
Cdd:cd15936  166 TD---TFLLELLMVSNSGLVTlliFFILLISYTVILVKIR-THVTEGKRKALSTCASQI--------TVVTLIFVpciyi 233
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 268607613 263 -HRFGKNIPHIVHITMSYIcfLFPPFMNPVIFSIK 296
Cdd:cd15936  234 yARPFQTFPMDKAVSVLYT--VITPMLNPMIYTLR 266
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
32-296 1.79e-26

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 105.34  E-value: 1.79e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15938    7 FLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILTDiKVIKIGIGVVMRAGL--SIMPIIIRLNwFPYCRSHVLSHAFCLHQDVIKLA 189
Cdd:cd15938   87 EMFLLTVMAYDRYVAICKPLHYTTIMSR-RLCWVLVAASWAGGFlhSIVQTLLTIQ-LPFCGPNQVNNFFCDVPPVIKLA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 190 CADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTvmgIASTDERAKALNTCVSHICCILVFYVTVVgltFIH-RFGKN 268
Cdd:cd15938  165 CTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVT---IRSTEGRRKALSTCASHLMVVTLFFGPCI---FIYaRPFST 238
                        250       260
                 ....*....|....*....|....*...
gi 268607613 269 IPHIVHITMSYIcfLFPPFMNPVIFSIK 296
Cdd:cd15938  239 FPVDKHVSVLYN--VITPMLNPLIYTLR 264
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
32-254 7.08e-25

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 100.97  E-value: 7.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15937    7 FLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILTDiKVIKIGIGVVMRAGL--SIMPI--IIRLnwfPYCRSHVLSHAFCLHQDVIK 187
Cdd:cd15937   87 EMFLLVAMAYDRYVAICKPLHYTTVVNR-RVCCVLVGASWAGGFihSIIQValIIRL---PFCGPNVLDNFFCDITQVIK 162
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 268607613 188 LACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTVMgIASTDERAKALNTCVSHICCILVFYV 254
Cdd:cd15937  163 LACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLR-THSSKGKSKAASTCITHIIIVFVMFG 228
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
42-292 1.10e-20

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 89.28  E-value: 1.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613   42 GNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMP-TVLGVLWFNHREIGHGACFSQAYFIHSFSIVESGVLLAMA 120
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPfWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  121 YDRFIAIRNPLRYTTILTDIKVIKIGIGV-VMRAGLSIMPIIIRLNwfpyCRSHVLSHAFCLHQDVIKLACaditfNRLY 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIwVLALLLSLPPLLFGWT----LTVPEGNVTVCFIDFPEDLSK-----PVSY 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  200 PIVVVFCMGLLDFLIICFSYILILKTVMGIAS-------TDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNIPHI 272
Cdd:pfam00001 152 TLLISVLGFLLPLLVILVCYTLIIRTLRKSASkqksserTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELS 231
                         250       260
                  ....*....|....*....|
gi 268607613  273 VHITMSYICFLFPPFMNPVI 292
Cdd:pfam00001 232 RLLDKALSVTLWLAYVNSCL 251
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
37-296 7.11e-19

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 84.65  E-value: 7.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  37 IFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVESGVL 116
Cdd:cd00637   10 VVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 117 LAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPIIIRLNWFPYCRSHVLSHAFClhqdviklacaDITFN 196
Cdd:cd00637   90 TAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWP-----------DLTLS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 197 RLYPIVVVFCMGLLDFLIICFSYILILKTV--------------MGIASTDERAKALNTCVSHICCILVFYVTVVGLTFI 262
Cdd:cd00637  159 KAYTIFLFVLLFLLPLLVIIVCYVRIFRKLrrhrrrirssssnsSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLL 238
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 268607613 263 HRFGKNIPHIVHITMSYICFL--FPPFMNPVIFSIK 296
Cdd:cd00637  239 DVFGPDPSPLPRILYFLALLLayLNSAINPIIYAFF 274
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
27-295 1.40e-10

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 60.65  E-value: 1.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKV-IKIGIGVVMRAGLSIMPIIirlNWFPYCRSHVLSHAFCLhqdv 185
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRAlIMIAAVWVYSLLISLPPLV---GWRDETQPSVVDCECEF---- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 186 iklacadiTFNRLYPIVVVFCMGLLDFLIICFSYILILKtvmgIASTDERA-KALNTCV-SHICCILVFYVTVVGLTFIH 263
Cdd:cd14967  154 --------TPNKIYVLVSSVISFFIPLLIMIVLYARIFR----VARRELKAaKTLAIIVgAFLLCWLPFFIIYLVSAFCP 221
                        250       260       270
                 ....*....|....*....|....*....|..
gi 268607613 264 RFgkNIPHIVHITMSYICFlFPPFMNPVIFSI 295
Cdd:cd14967  222 PD--CVPPILYAVFFWLGY-LNSALNPIIYAL 250
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
32-226 1.06e-09

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 58.50  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIV 111
Cdd:cd15083    7 ILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 112 ESGVLLAMAYDRFIAIRNPLRYTTILTDIK-VIKIGIGVVMRAGLSIMPIiirLNWFPYCRSHVLshafclhqdvikLAC 190
Cdd:cd15083   87 SINTLAAIAVDRYLVITRPMKASVRISHRRaLIVIAVVWLYSLLWVLPPL---FGWSRYVLEGLL------------TSC 151
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 268607613 191 -----ADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTV 226
Cdd:cd15083  152 sfdylSRDDANRSYVICLLIFGFVLPLLIIIYCYSFIFRAV 192
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
32-226 2.28e-07

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 51.35  E-value: 2.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFI----LLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHS 107
Cdd:cd15202    3 LIVAYSFIivfsLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 108 FSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVmrAGLSIMPIIIRLNWFPYCRSHVLSHAFCLhqdvIK 187
Cdd:cd15202   83 SVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVIWTL--ALAFALPHAICSKLETFKYSEDIVRSLCL----ED 156
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 268607613 188 LACADITFNRLYPIVVVFCMGLLDFLIICFSYILILKTV 226
Cdd:cd15202  157 WPERADLFWKYYDLALFILQYFLPLLVISFAYARVGIKL 195
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
31-160 1.79e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 48.51  E-value: 1.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  31 PLLMAYIFI----LLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHRE-IGHGACFSQAYFI 105
Cdd:cd14979    2 LVTAIYVAIfvvgIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPWaFGDGGCKLYYFLF 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 268607613 106 HSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPI 160
Cdd:cd14979   82 EACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPI 136
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
37-160 4.95e-06

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 47.29  E-value: 4.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  37 IFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFsIVESGVL 116
Cdd:cd14972   10 VFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSL-LASAYSL 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 268607613 117 LAMAYDRFIAIRNPLRYTTILTDIKV-IKIGIGVVMRAGLSIMPI 160
Cdd:cd14972   89 LAIAVDRYISIVHGLTYVNNVTNKRVkVLIALVWVWSVLLALLPV 133
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
28-138 1.14e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 46.08  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  28 ISLPLLMAYIFILlGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVlwfnhrEIGHGACFSQAYFIHS 107
Cdd:cd15068    4 ITVELAIAVLAIL-GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI------STGFCAACHGCLFIAC 76
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 268607613 108 FSIV--ESGV--LLAMAYDRFIAIRNPLRYTTILT 138
Cdd:cd15068   77 FVLVltQSSIfsLLAIAIDRYIAIRIPLRYNGLVT 111
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
28-138 4.07e-05

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 44.54  E-value: 4.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  28 ISLPLLMAYIFILlGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVlwfnhrEIGHGACFSQAYFIHS 107
Cdd:cd15069    4 VALELIIAALSVA-GNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITI------SLGFCTDFHSCLFLAC 76
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 268607613 108 FSIV--ESGV--LLAMAYDRFIAIRNPLRYTTILT 138
Cdd:cd15069   77 FVLVltQSSIfsLLAVAVDRYLAIKVPLRYKSLVT 111
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
28-138 1.92e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 42.24  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  28 ISLPLLMAyIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMP-TVLGVLWFNHReighgacFSQAYFIH 106
Cdd:cd14968    4 IVLEVLIA-VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPlAILISLGLPTN-------FHGCLFMA 75
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 268607613 107 SFSIV--ESGV--LLAMAYDRFIAIRNPLRYTTILT 138
Cdd:cd14968   76 CLVLVltQSSIfsLLAIAIDRYLAIKIPLRYKSLVT 111
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
33-149 1.93e-04

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 42.47  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  33 LMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAY------FIH 106
Cdd:cd15351    8 LFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnvidtMIC 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGV 149
Cdd:cd15351   88 SSVVSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGI 130
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
30-155 4.54e-04

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 41.36  E-value: 4.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  30 LPLLMAYIFILL----GNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHR-EIGHGACFSQAYF 104
Cdd:cd15133    1 FPVCLTYLLIFVvgvvGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNYPfLLGSGGCYFKTFL 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 268607613 105 IHSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIgIGVVMRAGL 155
Cdd:cd15133   81 FETVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRV-LGCVWGVSM 130
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
37-226 5.89e-04

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 40.77  E-value: 5.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  37 IFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREI-GHGACFSQAYFIHSFSIVESGV 115
Cdd:cd15337   12 ILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGFPLKTISSFNKKWIwGKVACELYGFAGGIFGFMSITT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 116 LLAMAYDRFIAIRNPLRYTTILTDIKV-IKIGIGVVMRAGLSIMPIiirLNWFPYCRSHVL-SHAFclhqDVIKLACADI 193
Cdd:cd15337   92 LAAISIDRYLVIAKPLEAMKKMTFKRAfIMIIIIWLWSLLWSIPPF---FGWGRYVPEGFQtSCTF----DYLSRDLNNR 164
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 268607613 194 TFNrlypivvvFCMGLLDF----LIICFSYILILKTV 226
Cdd:cd15337  165 LFI--------LGLFIFGFlcplLIIIFCYVNIIRAV 193
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
30-159 7.07e-04

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 40.91  E-value: 7.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  30 LPLLMAYIFIL----LGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHR-EIGHGACFSQAYF 104
Cdd:cd15358    1 TPVCVTYLLIFvvgaVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNYPfLLGAGGCYFKTLL 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 268607613 105 IHSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMP 159
Cdd:cd15358   81 FETVCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIP 135
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
26-136 9.17e-04

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 40.27  E-value: 9.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  26 HLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFI 105
Cdd:cd14969    1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80
                         90       100       110
                 ....*....|....*....|....*....|.
gi 268607613 106 HSFSIVESGVLLAMAYDRFIAIRNPLRYTTI 136
Cdd:cd14969   81 TFLGLVSISTLAALAFERYLVIVRPLKAFRL 111
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
31-160 1.42e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 39.50  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  31 PLLMAYIFILL---GNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMP-TVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd15305    3 PALLILIIIILtigGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPvSLIAILYDYAWPLPRYLCPIWISLDV 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVI-KIGIGVVMRAGLSiMPI 160
Cdd:cd15305   83 LFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMmKIAAVWTISIGIS-MPI 136
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
59-161 1.48e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 39.54  E-value: 1.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  59 PMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVESG-VLLAMAYDRFIAIRNPLRYTTIL 137
Cdd:cd14981   36 VFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWDGGQPLCDYFGFMMSFFGLSSLlIVCAMAVERFLAITHPFFYNSHV 115
                         90       100
                 ....*....|....*....|....*
gi 268607613 138 TDIKVIKIGIGVVMRAGL-SIMPII 161
Cdd:cd14981  116 KKRRARLMLGAVWAFALLiASLPLL 140
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
37-160 1.61e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 39.64  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  37 IFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVESGVL 116
Cdd:cd15065   11 VLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASILNL 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 268607613 117 LAMAYDRFIAIRNPLRYTTILTDiKVIKIGIGVV--MRAGLSIMPI 160
Cdd:cd15065   91 CAISLDRYIHIKKPLKYERWMTT-RRALVVIASVwiLSALISFLPI 135
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
37-227 3.03e-03

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 38.73  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  37 IFI--LLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVESG 114
Cdd:cd14993   10 VFLlaLVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGVSVSASVL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 115 VLLAMAYDRFIAIRNPLRYTTILTdIKVIKIGIGVVMRAGLSIM-PIIIRLNWFPYCRSHVLSHAFCLHQDVIklacADI 193
Cdd:cd14993   90 TLVAISIDRYLAICYPLKARRVST-KRRARIIIVAIWVIAIIIMlPLLVVYELEEIISSEPGTITIYICTEDW----PSP 164
                        170       180       190
                 ....*....|....*....|....*....|....
gi 268607613 194 TFNRLYPIVVVFCMGLLDFLIICFSYILILKTVM 227
Cdd:cd14993  165 ELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLW 198
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
40-138 3.25e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 38.38  E-value: 3.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  40 LLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIghgaCFSQAYFIHSFSIVESGV---- 115
Cdd:cd15354   15 LLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHL----VIEDAFVRHIDNVFDSLIcisv 90
                         90       100
                 ....*....|....*....|....*....
gi 268607613 116 ------LLAMAYDRFIAIRNPLRYTTILT 138
Cdd:cd15354   91 vasmcsLLAIAVDRYVTIFYALRYHNIMT 119
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
27-127 3.36e-03

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 38.56  E-value: 3.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd15073    2 IVAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNI 81
                         90       100
                 ....*....|....*....|.
gi 268607613 107 SFSIVESGVLLAMAYDRFIAI 127
Cdd:cd15073   82 FFGMASIGLLTVVAVDRYLTI 102
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
32-133 4.38e-03

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 37.98  E-value: 4.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  32 LLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLgvLW-FNHREIGHGACFSQAYFIHSFSI 110
Cdd:cd15196    7 LATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQL--IWdITYRFYGGDLLCRLVKYLQVVGM 84
                         90       100
                 ....*....|....*....|....
gi 268607613 111 VESG-VLLAMAYDRFIAIRNPLRY 133
Cdd:cd15196   85 YASSyVLVATAIDRYIAICHPLSS 108
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
30-168 6.09e-03

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 37.92  E-value: 6.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  30 LPLLMAYIFILL----GNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREI-GHGACFSQAYF 104
Cdd:cd15357    1 LPMSLVYAVIFVvgviGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNYPFLfGPVGCYFKTAL 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268607613 105 IHSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIgigVVMRAGLSIMPII-------IRLNWFP 168
Cdd:cd15357   81 FETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKI---IVVLWVLSVLFSIpntsihgIKLQYFP 148
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
37-138 6.84e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 37.47  E-value: 6.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  37 IFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTT-MPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVESGV 115
Cdd:cd15103   12 IVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNaLETIVIILLNNGYLVPRDSFEQHIDNVIDSMICSSLL 91
                         90       100
                 ....*....|....*....|....*...
gi 268607613 116 -----LLAMAYDRFIAIRNPLRYTTILT 138
Cdd:cd15103   92 asicsLLAIAVDRYITIFYALRYHSIMT 119
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
38-254 6.96e-03

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 37.41  E-value: 6.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  38 FILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVESGVLL 117
Cdd:cd14992   13 VSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 118 AMAYDRFIAIRNPLRY---------TTILTDIKVIKI--GIGVVMRAGLSIMPIIIRLNWFPYCRshvlshaFCLHQDVI 186
Cdd:cd14992   93 AIAFDRYFAIIHPLKPrhrqsytttVIIIITIWVVSLllAIPQLYYATTEVLFSVKNQEKIFCCQ-------IPPVDNKT 165
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 268607613 187 KLacadiTFNRLYPIVVVFCMGLLdFLIICFSYI---LILKTVMGIASTD---ERAKALNTCVSHICCILVFYV 254
Cdd:cd14992  166 YE-----KVYFLLIFVVIFVLPLI-VMTLAYARIsreLWFRKVPGFSIKEverKRLKCKRRVIKMLVCVVVLFV 233
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
31-222 7.22e-03

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 37.26  E-value: 7.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  31 PLLMAYIFILL----GNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYfIH 106
Cdd:cd15001    1 PVIIVYVITFVlgliGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAY-LQ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 107 SFSIVESGV-LLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGV-VMRAGLSIMPIIIRLNWFPYCRSHVLSHAFClhqd 184
Cdd:cd15001   80 LLSFICSVLtLTAISIERYYVILHPMKAKSFCTIGRARKVALLIwILSAILASPVLFGQGLVRYESENGVTVYHCQ---- 155
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 268607613 185 vikLACADITFNRLYPIVVVFCMGLLDFLIICFSYILI 222
Cdd:cd15001  156 ---KAWPSTLYSRLYVVYLAIVIFFIPLIVMTFAYARD 190
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
29-169 7.32e-03

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 37.33  E-value: 7.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  29 SLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWfNHREIGHGACFSQAYFIHSF 108
Cdd:cd15053    4 ALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEV-NGGKWYLGPILCDIYIAMDV 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 268607613 109 SIVESGV--LLAMAYDRFIAIRNPLRYTTILTDIKV-IKIGIGVVMRAGLSImPIIIRLNWFPY 169
Cdd:cd15053   83 MCSTASIfnLCAISIDRYIAVTQPIKYARQKNSKRVlLTIAIVWVVSAAIAC-PLLFGLNNVPY 145
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
30-245 7.46e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 37.70  E-value: 7.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  30 LPLLMAYIFI----LLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREI-GHGACFSQAYF 104
Cdd:cd15134    1 IPITIIYGIIfvtgVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPWVfGEVFCKLRAFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 105 IHSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGVVMRAGLSIMPI-----IIRLNWFPYCRSHVLSHAF 179
Cdd:cd15134   81 SEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFaiqtrIVYLEYPPTSGEALEESAF 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 268607613 180 ClhqdviklacadiTFNRLYP-IVVVFCMGLLDFLIICFSYILILKTVMGIASTDERAKALNTCVSH 245
Cdd:cd15134  161 C-------------AMLNEIPpITPVFQLSTFLFFIIPMIAIIVLYVLIGLQLRRSTLLRRGQRSVS 214
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
27-160 7.49e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 37.43  E-value: 7.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGAC---FSQAY 103
Cdd:cd15058    2 GLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCelwTSVDV 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 268607613 104 FIHSFSIvesGVLLAMAYDRFIAIRNPLRYTTILTDIKViKIGIGVV--MRAGLSIMPI 160
Cdd:cd15058   82 LCVTASI---ETLCVIAVDRYIAITRPLRYQVLLTKRRA-RVIVCVVwiVSALVSFVPI 136
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
37-161 7.86e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 37.18  E-value: 7.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  37 IFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIHSFSIVESGVL 116
Cdd:cd15326   12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 268607613 117 LAMAYDRFIAIRNPLRYTTILTDIKVIKIGIGV-VMRAGLSIMPII 161
Cdd:cd15326   92 CAISIDRYIGVRHSLQYPTIVTRKRAILALLGVwVLSTVISIGPLL 137
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
27-133 8.54e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 37.12  E-value: 8.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  27 LISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHREIGHGACFSQAYFIH 106
Cdd:cd15008    1 AASLVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQY 80
                         90       100
                 ....*....|....*....|....*..
gi 268607613 107 SFSIVESGVLLAMAYDRFIAIRNPLRY 133
Cdd:cd15008   81 LTPGVQIYVLLSICVDRFYTIVYPLSF 107
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
26-163 9.08e-03

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 37.12  E-value: 9.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613  26 HLISLPLLMAYIFILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWFNHR-EIGHGACFSQAYF 104
Cdd:cd15306    1 HWAALLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMwPLPLVLCPIWLFL 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607613 105 IHSFSIVESGVLLAMAYDRFIAIRNPLRYTTILTDIKV-IKIGIGVVMRAGLSImPIIIR 163
Cdd:cd15306   81 DVLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAfIKITVVWLISIGIAI-PVPIK 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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