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Conserved domains on  [gi|1496472634|ref|NP_689658|]
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protein FAM161B [Homo sapiens]

Protein Classification

protein FAM161B( domain architecture ID 12107763)

protein FAM161B

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UPF0564 pfam10595
Uncharacterized protein family UPF0564; This family of proteins has no known function. However, ...
167-536 1.81e-90

Uncharacterized protein family UPF0564; This family of proteins has no known function. However, one of the members, Swiss:Q22CP8, is annotated as an EF-hand family protein.


:

Pssm-ID: 431382 [Multi-domain]  Cd Length: 364  Bit Score: 285.13  E-value: 1.81e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634 167 SSITVPRPFRMTLREARKKAEWLGSPASFEQERQRAQRQgeEEAECHRQFRAQPVPAHVYLPLYQEIMERSEARRQAGIQ 246
Cdd:pfam10595   1 FKITVPKPFSFEKREANKKAKKSIRQKKVEEMLLEKQKK--EEAEYNKRFKAKPVPATVKLPLYEEIMEENEKRREEVRE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634 247 KRKELLLSSLKPFSFLEKEEQLKEAARQRDLAATAEAKISKQKAtRRIPKSILEPALGDKLQEAELFRKIRIQMRALDML 326
Cdd:pfam10595  79 ESKAITLQSEKPFSFYERDKQKKEKLPRKYSATVEEREPFKFRA-NPIPWSCSDPLLKDMMQEQEEKRKIRVEKRKQELL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634 327 QMASSPIASSSNRAnpQPRTATRTQQEKLGFLHTNFRFQPRVNPVVPDYEGLYKAFQRRAAKRRETQEATRNKPFLLRTA 406
Cdd:pfam10595 158 RSSSLPPRMAKHEE--KRKIRKQKKEEQKSSKYKEETFRPKRAKSIPDFEKLHKTFQKRLAKKKKKFEPTEPEPFNFQES 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634 407 NLRHPQRPCDAATTGRRQDSPQPPATPLPRSRSLSglASLSANTLPVHITDATRKRESAVRSAL-EKKNKADESIQWLEI 485
Cdd:pfam10595 236 HKSADRDYLDSENELIGETKIKPTKKKLDEDARLA--SIKPKSQPPSGSTKKTRSREKYRRKSRkEKEAKEQQEKKELEQ 313
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1496472634 486 HKKKSQAMSKSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKEL 536
Cdd:pfam10595 314 RKKKLKEMRPRVKQKFAAQDSSKKLQEQRKEKLKKLRQEDRQQEKEYEQEL 364
PTZ00121 super family cl31754
MAEBL; Provisional
456-635 1.90e-07

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 54.76  E-value: 1.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  456 TDATRKRESAVRSALEKKNKADESIQWLEIHKKKSQAMSKSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKE 535
Cdd:PTZ00121  1373 KEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKK 1452
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  536 LEEMKQRIQTRPYLFEQVAKDLAKKEAEQWY-LDTLKQAGLEedfVRNKGQGTRAVQEKETKIKDFPRFQETTKL-SIRD 613
Cdd:PTZ00121  1453 AEEAKKAEEAKKKAEEAKKADEAKKKAEEAKkADEAKKKAEE---AKKKADEAKKAAEAKKKADEAKKAEEAKKAdEAKK 1529
                          170       180
                   ....*....|....*....|..
gi 1496472634  614 PEQGLEGSLEQPASPRKVLEEL 635
Cdd:PTZ00121  1530 AEEAKKADEAKKAEEKKKADEL 1551
 
Name Accession Description Interval E-value
UPF0564 pfam10595
Uncharacterized protein family UPF0564; This family of proteins has no known function. However, ...
167-536 1.81e-90

Uncharacterized protein family UPF0564; This family of proteins has no known function. However, one of the members, Swiss:Q22CP8, is annotated as an EF-hand family protein.


Pssm-ID: 431382 [Multi-domain]  Cd Length: 364  Bit Score: 285.13  E-value: 1.81e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634 167 SSITVPRPFRMTLREARKKAEWLGSPASFEQERQRAQRQgeEEAECHRQFRAQPVPAHVYLPLYQEIMERSEARRQAGIQ 246
Cdd:pfam10595   1 FKITVPKPFSFEKREANKKAKKSIRQKKVEEMLLEKQKK--EEAEYNKRFKAKPVPATVKLPLYEEIMEENEKRREEVRE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634 247 KRKELLLSSLKPFSFLEKEEQLKEAARQRDLAATAEAKISKQKAtRRIPKSILEPALGDKLQEAELFRKIRIQMRALDML 326
Cdd:pfam10595  79 ESKAITLQSEKPFSFYERDKQKKEKLPRKYSATVEEREPFKFRA-NPIPWSCSDPLLKDMMQEQEEKRKIRVEKRKQELL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634 327 QMASSPIASSSNRAnpQPRTATRTQQEKLGFLHTNFRFQPRVNPVVPDYEGLYKAFQRRAAKRRETQEATRNKPFLLRTA 406
Cdd:pfam10595 158 RSSSLPPRMAKHEE--KRKIRKQKKEEQKSSKYKEETFRPKRAKSIPDFEKLHKTFQKRLAKKKKKFEPTEPEPFNFQES 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634 407 NLRHPQRPCDAATTGRRQDSPQPPATPLPRSRSLSglASLSANTLPVHITDATRKRESAVRSAL-EKKNKADESIQWLEI 485
Cdd:pfam10595 236 HKSADRDYLDSENELIGETKIKPTKKKLDEDARLA--SIKPKSQPPSGSTKKTRSREKYRRKSRkEKEAKEQQEKKELEQ 313
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1496472634 486 HKKKSQAMSKSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKEL 536
Cdd:pfam10595 314 RKKKLKEMRPRVKQKFAAQDSSKKLQEQRKEKLKKLRQEDRQQEKEYEQEL 364
PTZ00121 PTZ00121
MAEBL; Provisional
456-635 1.90e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 54.76  E-value: 1.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  456 TDATRKRESAVRSALEKKNKADESIQWLEIHKKKSQAMSKSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKE 535
Cdd:PTZ00121  1373 KEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKK 1452
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  536 LEEMKQRIQTRPYLFEQVAKDLAKKEAEQWY-LDTLKQAGLEedfVRNKGQGTRAVQEKETKIKDFPRFQETTKL-SIRD 613
Cdd:PTZ00121  1453 AEEAKKAEEAKKKAEEAKKADEAKKKAEEAKkADEAKKKAEE---AKKKADEAKKAAEAKKKADEAKKAEEAKKAdEAKK 1529
                          170       180
                   ....*....|....*....|..
gi 1496472634  614 PEQGLEGSLEQPASPRKVLEEL 635
Cdd:PTZ00121  1530 AEEAKKADEAKKAEEKKKADEL 1551
PTZ00121 PTZ00121
MAEBL; Provisional
181-642 1.28e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.07  E-value: 1.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  181 EARKKAEWLGSPASFEQERQRAQRQGEEE---AECHRQFRAQPVPAHVYLPLYQEIMERSEARRQAGIQKRKELLLsslK 257
Cdd:PTZ00121  1375 EAKKKADAAKKKAEEKKKADEAKKKAEEDkkkADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAK---K 1451
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  258 PFSFLEKEEQLKEAARQRDLAATAEAKISKQKATRRIPKSILEPAlgdklQEAELFRKIRIQMRALDMLQMASSPIASSS 337
Cdd:PTZ00121  1452 KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAK-----KKADEAKKAAEAKKKADEAKKAEEAKKADE 1526
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  338 NRANPQPRTATRTQQEKlgflhtnfrfQPRVNPVVPDYEGLYKAFQRRAAKRRETQEATRNKPfLLRTANLRHPQRPCDA 417
Cdd:PTZ00121  1527 AKKAEEAKKADEAKKAE----------EKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMA-LRKAEEAKKAEEARIE 1595
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  418 ATTGRRQDSPQPPATPLPRSRSlsglASLSANTLpvhitdatrKRESAVRSALE--KKNKADESIQWLEIHKKKSQAMSK 495
Cdd:PTZ00121  1596 EVMKLYEEEKKMKAEEAKKAEE----AKIKAEEL---------KKAEEEKKKVEqlKKKEAEEKKKAEELKKAEEENKIK 1662
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  496 SVTLRAKAMDPHKSLEEVFKAKLKEnrnndRKRAKEYKKELEEMKQRIQTRPYLFEQVAKDLAKKEAEQWYLDTLKQAGL 575
Cdd:PTZ00121  1663 AAEEAKKAEEDKKKAEEAKKAEEDE-----KKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKK 1737
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1496472634  576 EEDFVRNKGQGTRAVQEKETKIKDFPRFQETTKLSIRDPEQGL--EGSLEQPASPRKVLEELSHQSPEN 642
Cdd:PTZ00121  1738 EAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVieEELDEEDEKRRMEVDKKIKDIFDN 1806
 
Name Accession Description Interval E-value
UPF0564 pfam10595
Uncharacterized protein family UPF0564; This family of proteins has no known function. However, ...
167-536 1.81e-90

Uncharacterized protein family UPF0564; This family of proteins has no known function. However, one of the members, Swiss:Q22CP8, is annotated as an EF-hand family protein.


Pssm-ID: 431382 [Multi-domain]  Cd Length: 364  Bit Score: 285.13  E-value: 1.81e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634 167 SSITVPRPFRMTLREARKKAEWLGSPASFEQERQRAQRQgeEEAECHRQFRAQPVPAHVYLPLYQEIMERSEARRQAGIQ 246
Cdd:pfam10595   1 FKITVPKPFSFEKREANKKAKKSIRQKKVEEMLLEKQKK--EEAEYNKRFKAKPVPATVKLPLYEEIMEENEKRREEVRE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634 247 KRKELLLSSLKPFSFLEKEEQLKEAARQRDLAATAEAKISKQKAtRRIPKSILEPALGDKLQEAELFRKIRIQMRALDML 326
Cdd:pfam10595  79 ESKAITLQSEKPFSFYERDKQKKEKLPRKYSATVEEREPFKFRA-NPIPWSCSDPLLKDMMQEQEEKRKIRVEKRKQELL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634 327 QMASSPIASSSNRAnpQPRTATRTQQEKLGFLHTNFRFQPRVNPVVPDYEGLYKAFQRRAAKRRETQEATRNKPFLLRTA 406
Cdd:pfam10595 158 RSSSLPPRMAKHEE--KRKIRKQKKEEQKSSKYKEETFRPKRAKSIPDFEKLHKTFQKRLAKKKKKFEPTEPEPFNFQES 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634 407 NLRHPQRPCDAATTGRRQDSPQPPATPLPRSRSLSglASLSANTLPVHITDATRKRESAVRSAL-EKKNKADESIQWLEI 485
Cdd:pfam10595 236 HKSADRDYLDSENELIGETKIKPTKKKLDEDARLA--SIKPKSQPPSGSTKKTRSREKYRRKSRkEKEAKEQQEKKELEQ 313
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1496472634 486 HKKKSQAMSKSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKEL 536
Cdd:pfam10595 314 RKKKLKEMRPRVKQKFAAQDSSKKLQEQRKEKLKKLRQEDRQQEKEYEQEL 364
PTZ00121 PTZ00121
MAEBL; Provisional
456-635 1.90e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 54.76  E-value: 1.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  456 TDATRKRESAVRSALEKKNKADESIQWLEIHKKKSQAMSKSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKE 535
Cdd:PTZ00121  1373 KEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKK 1452
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  536 LEEMKQRIQTRPYLFEQVAKDLAKKEAEQWY-LDTLKQAGLEedfVRNKGQGTRAVQEKETKIKDFPRFQETTKL-SIRD 613
Cdd:PTZ00121  1453 AEEAKKAEEAKKKAEEAKKADEAKKKAEEAKkADEAKKKAEE---AKKKADEAKKAAEAKKKADEAKKAEEAKKAdEAKK 1529
                          170       180
                   ....*....|....*....|..
gi 1496472634  614 PEQGLEGSLEQPASPRKVLEEL 635
Cdd:PTZ00121  1530 AEEAKKADEAKKAEEKKKADEL 1551
PTZ00121 PTZ00121
MAEBL; Provisional
181-642 1.28e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.07  E-value: 1.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  181 EARKKAEWLGSPASFEQERQRAQRQGEEE---AECHRQFRAQPVPAHVYLPLYQEIMERSEARRQAGIQKRKELLLsslK 257
Cdd:PTZ00121  1375 EAKKKADAAKKKAEEKKKADEAKKKAEEDkkkADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAK---K 1451
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  258 PFSFLEKEEQLKEAARQRDLAATAEAKISKQKATRRIPKSILEPAlgdklQEAELFRKIRIQMRALDMLQMASSPIASSS 337
Cdd:PTZ00121  1452 KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAK-----KKADEAKKAAEAKKKADEAKKAEEAKKADE 1526
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  338 NRANPQPRTATRTQQEKlgflhtnfrfQPRVNPVVPDYEGLYKAFQRRAAKRRETQEATRNKPfLLRTANLRHPQRPCDA 417
Cdd:PTZ00121  1527 AKKAEEAKKADEAKKAE----------EKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMA-LRKAEEAKKAEEARIE 1595
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  418 ATTGRRQDSPQPPATPLPRSRSlsglASLSANTLpvhitdatrKRESAVRSALE--KKNKADESIQWLEIHKKKSQAMSK 495
Cdd:PTZ00121  1596 EVMKLYEEEKKMKAEEAKKAEE----AKIKAEEL---------KKAEEEKKKVEqlKKKEAEEKKKAEELKKAEEENKIK 1662
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  496 SVTLRAKAMDPHKSLEEVFKAKLKEnrnndRKRAKEYKKELEEMKQRIQTRPYLFEQVAKDLAKKEAEQWYLDTLKQAGL 575
Cdd:PTZ00121  1663 AAEEAKKAEEDKKKAEEAKKAEEDE-----KKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKK 1737
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1496472634  576 EEDFVRNKGQGTRAVQEKETKIKDFPRFQETTKLSIRDPEQGL--EGSLEQPASPRKVLEELSHQSPEN 642
Cdd:PTZ00121  1738 EAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVieEELDEEDEKRRMEVDKKIKDIFDN 1806
PTZ00121 PTZ00121
MAEBL; Provisional
458-635 2.37e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 2.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  458 ATRKRESAVRSALEKKNKADESIQWLEIHKKKSQAMSKSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKELE 537
Cdd:PTZ00121  1362 AEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAE 1441
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496472634  538 EMKQRIQTRPYLFE-QVAKDLAKKEAEQWYLDTLKQAGLEEdfvRNKGQGTRAVQEKETKIKDFPRFQETTKLS--IRDP 614
Cdd:PTZ00121  1442 EAKKADEAKKKAEEaKKAEEAKKKAEEAKKADEAKKKAEEA---KKADEAKKKAEEAKKKADEAKKAAEAKKKAdeAKKA 1518
                          170       180
                   ....*....|....*....|.
gi 1496472634  615 EQGLEGSLEQPASPRKVLEEL 635
Cdd:PTZ00121  1519 EEAKKADEAKKAEEAKKADEA 1539
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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